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Wolfgang A. Linke

university of munster

81H-index
326Paper Count
2.2WCitation Count
Published Papers 174
Publication Date
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Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis
errNature Cardiovascular Research
IF10.8
err2026-06-16
err0
errOAAI
errJohanna K. Freundt; Paulina Hartmann; Christine M. Loescher; Andreas Unger; Franziska Koser; Annika J. Klotz; Lena Wildschütz; Lydia Wachsmuth; Susanne Hille; Michaela M. Door; Anne Helfen; Richard Holtmeier; Cornelius Faber; Jonathan A. Kirk; Verena Hoerr; Oliver J. Müller; Wolfgang A. Linke
errShare
errSave
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6
errNature Communications
IF15.7
err2026-04-11
err0
errOAAI
errKerstin Filippi; Kathrin Graf-Riesen; Maithreyan Kuppusamy; Andreas Unger; Kenichi Kimura; Martin Matijass; Henrique Baeta; Magdalena Podlacha; Daniel Haertter; Alexei P. Kudin; Martin Wiemann; Grzegorz Węgrzyn; Cornelia Kornblum; Jens Reimann; Wolfgang A. Linke; Pitter F. Huesgen; Wolfram S. Kunz; Bernd K. Fleischmann; Michael Hesse
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errSave
Highlights from the cellular biology and function of the Heart Biennial Meeting 2025
errEuropean Heart Journal
IF35.6
err2026-04-01
err0
PREAI
errLinke, Wolfgang A.; Pesce, Maurizio
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errSave
PO29 Quantification of titin protein isoforms in patients with dilated cardiomyopathy
errEuropean Journal of Preventive Cardiology
IF7.5
err2026-03-19
err0
PREAI
errMarketa Adamova; Franziska Koser; Mate Andrik; Milos Kubanek; Alice Krebsova; Vojtech Melenovsky; Wolfgang Linke
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errSave
Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities: A scientific statement of the ESC Council on Basic Cardiovascular Science, the ESC Working Group on Atherosclerosis and Vascular Biology, the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Myocardial Function, and the ESC Working Group on Cardiac Cellular Electrophysiology
errEuropean Heart Journal
IF35.6
err2026-03-06
err0
errOAAI
errPaul C Evans; Gemma Vilahur; Petra Kleinbongard; Elena Osto; Carol Ann Remme; Rosalinda Madonna; Dunja Aksentijevic; Harald Sourij; Sean M Davidson; Donato Santovito; Jürgen Gindlhuber; Christian Weber; Wolfgang A Linke; Esther Lutgens; Luc Bertrand; Dana Dawson; Magnus Bäck; G Danilo Norata; Johann Wojta; Cinzia Perrino
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errSave
Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle
errPHYSIOLOGICAL REPORTS
IF1.9
err2025-10-27
err0
errOAAI
errKuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Harris, Samantha P.; Irving, Thomas C.; Linke, Wolfgang A.; Hessel, Anthony L.
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errSave
Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy
errScience
IF45.8
err2025-09-11
err0
PREAI
errRoss C. Bretherton; Isabella M. Reichardt; Kristin A. Zabrecky; Abigail Nagle; Logan R. J. Bailey; Darrian Bugg; Sasha Smolgovsky; Amy L. Gifford; Timothy S. McMillen; Alex J. Goldstein; Kristina B. Kooiker; Galina V. Flint; Amy Martinson; Jagdambika Gunaje; Franziska Koser; Elizabeth Plaster; Wolfgang A. Linke; Michael Regnier; Farid Moussavi-Harami; Nathan J. Sniadecki; Cole A. DeForest; Jennifer Davis
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errSave
NAD+ repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling
errAutophagy
IF14.3
err2025-07-04
err0
PREAI
errMahmoud Abdellatif; Francisco Vasques-Nóvoa; João Pedro Ferreira; Junichi Sadoshima; Abhinav Diwan; Wolfgang A. Linke; Guido Kroemer; Simon Sedej
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errSave
Direction-dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin
errBasic Research in Cardiology
IF8
err2025-06-13
err0
errOAAI
errFelix A. Wagner; Christine M. Loescher; Andreas Unger; Michel Kühn; Annika J. Klotz; Ivan Liashkovich; Dominika Ciechanska; Hermann Schillers; Franziska Koser; Johanna K. Freundt; Anthony L. Hessel; Wolfgang A. Linke
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errSave
Obesity and Comorbidities in HFpEF: A Retrospective Cohort Analysis in a University Hospital Setting
errJOURNAL OF CLINICAL MEDICINE
IF2.9
err2025-05-12
err0
errOAAI
errHobbach, Anastasia Janina; Brix, Tobias Johannes; Weyer-Elberich, Veronika; Varghese, Julian; Reinecke, Holger; Linke, Wolfgang Albrecht
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errSave
Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation
errCIRCULATION
IF38.6
err2024-08-13
err1
errOAAI
errFakuade, Funsho E.; Hubricht, Dominik; Moeller, Vanessa; Sobitov, Izzatullo; Liutkute, Aiste; Doering, Yannic; Seibertz, Fitzwilliam; Gerloff, Marcus; Pronto, Julius Ryan D.; Haghighi, Fereshteh; Brandenburg, Soeren; Alhussini, Khaled; Ignatyeva, Nadezda; Bonhoff, Yara; Kestel, Stefanie; El-Essawi, Aschraf; Jebran, Ahmad Fawad; Grossmann, Marius; Danner, Bernhard C.; Baraki, Hassina; Schmidt, Constanze; Sossalla, Samuel; Kutschka, Ingo; Bening, Constanze; Maack, Christoph; Linke, Wolfgang A.; Heijman, Jordi; Lehnart, Stephan E.; Kensah, George; Ebert, Antje; Mason, Fleur E.; Voigt, Niels
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errSave
Imaging of Existing and Newly Translated Proteins Elucidates Mechanisms of Sarcomere Turnover
errCIRCULATION RESEARCH
IF16.2
err2024-08-02
err1
errOAAI
errDouvdevany, Guy; Erlich, Itai; Haimovich-Caspi, Lilac; Mashiah, Tomer; Prondzynski, Maksymilian; Pricolo, Maria Rosaria; Alegre-Cebollada, Jorge; Linke, Wolfgang A.; Carrier, Lucie; Kehat, Izhak
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errSave
Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function
errEUROPEAN JOURNAL OF HEART FAILURE
IF10.8
err2024-06-04
err2
errOAAI
errFalcao-Pires, Ines; Ferreira, Ana Filipa; Trindade, Fabio; Bertrand, Luc; Ciccarelli, Michele; Visco, Valeria; Dawson, Dana; Hamdani, Nazha; Van Laake, Linda W.; Lezoualc'h, Frank; Linke, Wolfgang A.; Lunde, Ida G.; Rainer, Peter P.; Abdellatif, Mahmoud; van der Velden, Jolanda; Cosentino, Nicola; Paldino, Alessia; Pompilio, Giulio; Zacchigna, Serena; Heymans, Stephane; Thum, Thomas; Tocchetti, Carlo Gabriele
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errSave
Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-05-27
err0
errOAAI
errHessel, Anthony L.; Kuehn, Michel N.; Han, Seong-Won; Ma, Weikang; Irving, Thomas C.; Momb, Brent A.; Song, Taejeong; Sadayappan, Sakthivel; Linke, Wolfgang A.; Palmer, Bradley M.
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errSave
Titin-Based Force Modulates Cardiac Thick and Thin Filaments
errCIRCULATION RESEARCH
IF16.2
err2024-04-12
err0
PREAI
errHessel, Anthony L.; Kuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.
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errSave
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
errANGIOGENESIS
IF9.2
err2024-04-10
err2
errOAAI
errDrost, Carolin Christina; Rovas, Alexandros; Osiaevi, Irina; Schughart, Klaus; Lukasz, Alexander; Linke, Wolfgang A.; Pavenstaedt, Hermann; Kuempers, Philipp
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errSave
BMI-Stratified Exploration of the 'Obesity Paradox': Heart Failure Perspectives from a Large German Insurance Database
errJOURNAL OF CLINICAL MEDICINE
IF2.9
err2024-04-03
err9
errOAAI
errHobbach, Anastasia J.; Feld, Jannik; Linke, Wolfgang A.; Sindermann, Jurgen R.; Droege, Patrik; Ruhnke, Thomas; Guenster, Christian; Reinecke, Holger
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errSave
Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
errNATURE COMMUNICATIONS
IF15.7
err2024-03-23
err3
errOAAI
errHessel, Anthony L.; Engels, Nichlas M.; Kuehn, Michel N.; Nissen, Devin; Sadler, Rachel L.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.; Harris, Samantha P.
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errSave
Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix
errcardiovascular research
IF10.8
err2023-10-26
err9
errOAAI
errLoescher, Christine M.; Freundt, Johanna K.; Unger, Andreas; Hessel, Anthony L.; Kuehn, Michel; Koser, Franziska; Linke, Wolfgang A.
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errSave
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
errCIRCULATION RESEARCH
IF16.2
err2023-07-21
err6
errOAAI
errLi, Jia; Sundnes, Joakim; Hou, Yufeng; Laasmaa, Martin; Ruud, Marianne; Unger, Andreas; Kolstad, Terje R.; Frisk, Michael; Norseng, Per Andreas; Yang, Limin; Setterberg, Ingunn E.; Alves, Estela S.; Kalakoutis, Michaeljohn; Sejersted, Ole M.; Lanner, Johanna T.; Linke, Wolfgang A.; Lunde, Ida G.; de Tombe, Pieter P.; Louch, William E.
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Research Directions

No research directions
Co-authors
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