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PD3D®models as jacks-of-all-trades for cancer research and therapy response prediction Wedeken, Lena; Forbrig, Samantha; Herrera-Glomm, Katja; Loskutov, Juergen; Pfohl, Ulrike; Piven, Irina; Poehle, Michael; Regenbrecht, Manuela J.; Seller, Barbara; Yapto, Cynthia; Finkler, Sabine; Ruhe, Larissa; Adelmann, Quirin Graf; Reinhard, Christoph; Flechner, Marie; Uhlig, Katja; Kaul, David; Roohani, Siyer; Niethard, Maya; Sauer, Rica; Regenbrecht, Christian R. Share Save
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer Kendzia, Sandra; Franke, Susanne; Kroehler, Tarek; Golob-Schwarzl, Nicole; Schweiger, Caroline; Toeglhofer, Anna M.; Skofler, Christina; Uranitsch, Stefan; El-Heliebi, Amin; Fuchs, Julia; Punschart, Andreas; Stiegler, Philipp; Keil, Marlen; Hoffmann, Jens; Henderson, David; Lehrach, Hans; Yaspo, Marie-Laure; Reinhard, Christoph; Schaefer, Reinhold; Keilholz, Ulrich; Regenbrecht, Christian; Schicho, Rudolf; Fickert, Peter; Lax, Sigurd F.; Erdmann, Frank; Schulz, Marcel H.; Kiemer, Alexandra K.; Haybaeck, Johannes; Kessler, Sonja M. Share Save
Let's get physiological! Impact of media conditions on drug response to targeted therapies in CRC organoids Loskutov, Jurgen; Erdmann, Gerrit; Arndt, Anja; Adelmann, Quirin Graf; Dudys, Przemyslaw; Flechner, Marie; Nadolny, Madeleine; Osman, Katja; Pfohl, Ulrike; Reinhard, Christoph; Templin, Markus; Uhlig, Katja; Wedeken, Lena; Regenbrecht, Christian Share Save
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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (vol 3, 367, 2020) Peille, Anne-Lise; Vuaroqueaux, Vincent; Wong, Swee-Seong; Ting, Jason; Klingner, Kerstin; Zeitouni, Bruno; Landesfeind, Manuel; Kim, Woo Ho; Lee, Hyuk-Joon; Kong, Seong-Ho; Wulur, Isabella; Bray, Steven; Bronsert, Peter; Zanella, Nina; Donoho, Greg; Yang, Han-Kwang; Fiebig, Heinz-Herbert; Reinhard, Christoph; Aggarwal, Amit Share Save
Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma Peille, Anne-Lise; Vuaroqueaux, Vincent; Wong, Swee-Seong; Ting, Jason; Klinger, Kerstin; Zeitouni, Bruno; Landesfeind, Manuel; Kim, Woo Ho; Lee, Hyuk-Joon; Kong, Seong-Ho; Wulur, Isabella; Bray, Steven; Bronsert, Peter; Zanella, Nina; Donoho, Greg; Yang, Han-Kwang; Fiebig, Heinz-Herbert; Reinhard, Christoph; Aggarwal, Amit Share Save
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis Liu, Jiangang; Cho, Yong Beom; Hong, Hye Kyung; Wu, Song; Ebert, Philip J.; Bray, Steven M.; Wong, Swee Seong; Ting, Jason C.; Calley, John N.; Whittington, Catherine F.; Bhagwat, Shripad V.; Reinhard, Christoph; Wild, Robert; Nam, Do-Hyun; Aggarwal, Amit; Lee, Woo Yong; Peng, Sheng-Bin Share Save
Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy Du, Jian; Yan, Lei; Torres, Raquel; Gong, Xueqian; Bian, Huimin; Marugan, Carlos; Boehnke, Karsten; Baquero, Carmen; Hui, Yu-Hua; Chapman, Sonya C.; Yang, Yanzhu; Zeng, Yi; Bogner, Sarah M.; Foreman, Robert T.; Capen, Andrew; Donoho, Gregory P.; Van Horn, Robert D.; Barnard, Darlene S.; Dempsey, Jack A.; Beckmann, Richard P.; Marshall, Mark S.; Chio, Li-Chun; Qian, Yuewei; Webster, Yue W.; Aggarwal, Amit; Chu, Shaoyou; Bhattachar, Shobha; Stancato, Louis F.; Dowless, Michele S.; Iversen, Phillip W.; Manro, Jason R.; Walgren, Jennie L.; Halstead, Bartley W.; Dieter, Matthew Z.; Martinez, Ricardo; Bhagwat, Shripad V.; Kreklau, Emiko L.; Jose Lallena, Maria; Ye, Xiang S.; Patel, Bharvin K. R.; Reinhard, Christoph; Plowman, Gregory D.; Barda, David A.; Henry, James R.; Buchanan, Sean G.; Campbell, Robert M. Share Save
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients Bray, Steven M.; Lee, Jeeyun; Kim, Seung Tae; Hur, Joon Young; Ebert, Philip J.; Calley, John N.; Wulur, Isabella H.; Gopalappa, Thejaswini; Wong, Swee Seong; Qian, Hui-Rong; Ting, Jason C.; Liu, Jiangang; Willard, Melinda D.; Novosiadly, Ruslan D.; Park, Young Suk; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Aggarwal, Amit; Kim, Hee Cheol; Reinhard, Christoph Share Save
The CHK1 kinase inhibitor prexasertib (LY2606368) shows potent single-agent efficacy in in vitro and in vivo models of castrate-resistant prostate cancer McNulty, Ann; Donoho, Greg; Dempsey, Jack; Abel, Adem; Stephens, Jennifer; Martinez, Ricardo; Gerald, Damien; Perruzzi, Carole; O'Mahony, Marguerita; Reinhard, Christoph; Lin, Aimee; Wu, Wenjuan Share Save
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Inhibition of PI3K/AKT/mTOR signaling by a dual PI3K/mTOR inhibitor (LY3023414) potentiates the antitumor efficacy of the Chk1 inhibitor prexasertib (LY2606368) in models of human high-grade serous ovarian cancer (HGSOC) Dempsey, Jack; Donoho, Greg; Iversen, Philip; Stephens, Jennifer; McNulty, Ann; Martinez, Ricardo; Reinhard, Christoph; Stancato, Louis; Lin, Aimee; Wu, Wenjuan Share Save
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene Gong, Xueqian; Du, Jian; Parsons, Stephen H.; Merzoug, Farhana F.; Webster, Yue; Iversen, Philip W.; Chio, Li-Chun; Van Horn, Robert D.; Lin, Xi; Blosser, Wayne; Han, Bomie; Jin, Shaoling; Yao, Sufang; Bian, Huimin; Ficklin, Chris; Fan, Li; Kapoor, Avnish; Antonysamy, Stephen; Mc Nulty, Ann M.; Froning, Karen; Manglicmot, Danalyn; Pustilnik, Anna; Weichert, Kenneth; Wasserman, Stephen R.; Dowless, Michele; Marugan, Carlos; Baquero, Carmen; Jose Lallena, Maria; Eastman, Scott W.; Hui, Yu-Hua; Dieter, Matthew Z.; Doman, Thompson; Chu, Shaoyou; Qian, Hui-Rong; Ye, Xiang S.; Barda, David A.; Plowman, Gregory D.; Reinhard, Christoph; Campbell, Robert M.; Henry, James R.; Buchanan, Sean G. Share Save
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression Gantenbein, Nadine; Bernhart, Eva; Anders, Ines; Golob-Schwarzl, Nicole; Krassnig, Stefanie; Wodlej, Christina; Brcic, Luka; Lindenmann, Joerg; Fink-Neuboeck, Nicole; Gollowitsch, Franz; Stacher-Priehse, Elvira; Asslaber, Martin; Gogg-Kamerer, Margit; Rolff, Jana; Hoffmann, Jens; Silvestri, Alessandra; Regenbrecht, Christian; Reinhard, Christoph; Pehserl, Anna-Maria; Pichler, Martin; Sokolova, Olga; Naumann, Michael; Mitterer, Valentin; Pertschy, Brigitte; Bergler, Helmut; Popper, Helmut; Sattler, Wolfgang; Haybaeck, Johannes Share Save
Combination of an ERK1/2 inhibitor (LY3214996) with VEGFR-2 inhibitor enhances anti-tumor activity in KRAS mutant non-small cell lung cancer Wu, Wenjuan; Bhagwat, Shripad V.; Jones, Bonita D.; Swearingen, Michelle L.; Falcon, Beverly L.; McMillen, William T.; Joseph, Sajan; Buchanan, Sean; Peng, Sheng-Bin; Reinhard, Christoph; Tiu, Ramon V. Share Save
Anti-tumor activity of the Chk1 inhibitor prexasertib (LY2606368) as a single agent in triple negative breast cancer models Wu, Wenjuan; King, Constance; Donoho, Gregory; Iversen, Philip; Capen, Andrew; Castanares, Mark; Stephens, Jennifer; Ding, Yan; Pratt, Susan; Martinez, Ricardo; Buchanan, Sean; Reinhard, Christoph; Beckmann, Richard; Lin, Aimee Share Save
Intrinsic and acquired resistance to cetuximab in colorectal cancer patients Bray, Steven M.; Lee, Jeeyun; Kim, Seung Tae; Ebert, Philip J.; Calley, John N.; Wulur, Isabella H.; Gopalappa, Thejaswini; Wong, Swee Seong; Qian, Hui-Rong; Ting, Jason C.; Liu, Jiangang; Willard, Melinda D.; Aggarwal, Amit; Novosiadly, Ruslan D.; Kim, Hee-Cheol; Reinhard, Christoph Share Save
Combination of a novel ERK1/2 inhibitor (LY3214996) with CDK4 and CDK6 inhibitor (abemaciclib) enhances antitumor efficacy in KRAS mutant non-small cell lung cancer (NSCLC) Wu, Wenjuan; Bhagwat, Shripad V.; King, Constance; Pratt, Susan; Gong, Xueqian; Stewart, Julie; Jones, Bonita; Flack, Robert; Beckman, Richard; Falcon, Beverly; Manro, Jason; McMillen, William T.; Tiu, Ramon V.; Peng, Sheng-Bin; Reinhard, Christoph; Joseph, Sajan; Buchanan, Sean Share Save
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