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李大力 (Dali Li)

east china normal university

60H-index
273Paper Count
1.1WCitation Count
Published Papers 147
Publication Date
Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2
err2026-08-11
err0
errOAAI
errTingting Cong; Runda Xu; Xuancheng Chen; Junsong Yuan; Zuomiao Lin; Wenqin Yang; Anji Ju; Liren Wang; Qingcan Wang; Jiqin Zhang; Yinqing Li; Dali Li; Ming Zhu
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High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing
err2026-07-27
err0
errOAAI
errMengjia Hong; Changming Luan; Meng Yuan; Hao Huang; Xinyuan Guo; Dihao Meng; Molin Huang; Ye Xu; Shanghui Zhao; Ke Chen; Jiao Chen; Dali Li; Liang Chen
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Precise DNA base editing using AlphaFold3-based contact modelling
errNature
IF48.5
err2026-07-22
err0
PREAI
errHaowei Meng; Zhixin Lei; Yongchang Yan; Liren Wang; Sihan Zhang; Xichen Rao; Chuyun Shao; Xiaoting Zhang; Ke Chen; Lei Yang; Rongrong Liu; Gaohui Yang; Ruoyu Shen; Ruichu Gu; Xinyan Wang; Yiya Wang; Suiru Lu; Zhicong Lv; Bo He; Han Wen; Dali Li; Chengqi Yi
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Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain
err2026-06-17
err0
PREAI
errXiaohui Zhang; Liang Chen; Biyun Zhu; Liren Wang; Caiyu Chen; Mengjia Hong; Yifan Huang; Huiying Li; Honghui Han; Bailian Cai; Weishi Yu; Shuming Yin; Lei Yang; Zuozhen Yang; Meizhen Liu; Ying Zhang; Zhiyong Mao; Yuxuan Wu; Mingyao Liu; Dali Li
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Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid
err2026-05-14
err0
errOAAI
errFengbo Zhong; Xingyu Huang; Huiru Sun; Mengxuan Wang; Qi Qi; Xinlin Song; Kai Lin; Zhuozhuo Li; Jiayun Shen; Qiuyu Lu; Miaomiao Li; Jiaqi Zhang; Ling Yuan; Jia Lv; Xin Wang; Yiyun Cheng; Qihui Wu; Shaohua Fan; Shougang Zhuang; Jia Rao; Dali Li; Yuting Guan
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Chidamide synergizes with cisplatin-etoposide to trigger pyroptosis and anti-tumor immunity in diffuse large B-cell lymphoma
err2026-04-21
err0
errOAAI
errJianbo Wu; Yingying Ye; Danyang Ran; Xing Wang; Hanwen Zhu; Hanmei Zhang; Fuqing Meng; Yalong Song; Zhiwei Li; Lan Mi; Xiaoyuan Zhang; Yixin Qian; Hanrong Li; Xiaowei Tong; Peihuang Wu; Bowen Sun; Xinya Li; Weimin Zhang; Dali Li; Huajun Wu; Yingjie Yu; Yunkun Dang; Fan Lai; Lijuan Deng; Yuqin Song; Jun Zhu; Yan Xie; Mi Deng
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Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope
err2026-02-19
err0
errOAAI
errYanan Huo; Jiale Mei; Dan Zhang; Bing Yan; Dexin Zhang; Chao Dong; Shuming Yin; Meizhen Liu; Xinyan Wang; Dan Chen; Yuting Guan; Gaojie Song; Bing Du; Yongming Wang; Zongli Zheng; Hong Liu; Dali Li; Lei Yang; Liren Wang
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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
err2025-08-07
err0
errOAAI
errJuanjuan Feng; Xuanzheng Xiao; Xinting Xia; Jian Min; Weiying Tang; Xinyi Shi; Ke Xu; Guizhen Zhou; Kangkang Li; Panpan Shen; Rujuan Bao; Shuyao Wu; Mengjia Lin; Kun Yuan; Zhengke Lian; Longmiao Hu; Na Li; Zhengzhen Wu; Xiaotong Zhai; Xiaogu Liu; Kewen Hu; Jun Wu; Chunyong Ding; Huixin Zhao; Xinqi Gong; Sulin Zhang; Jianping Jin; Dali Li; Mingyao Liu; Youqiong Ye; Buyong Ma; Rey-Ting Guo; Ao Zhang; Xiufeng Pang
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PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases
err2025-03-21
err0
errOAAI
errFang, Xiaoliang; Zhong, Yi; Zheng, Rui; Wu, Qihui; Liu, Yu; Zhang, Dexin; Wang, Yuwei; Ding, Wubing; Wang, Kaiyuan; Zhong, Fengbo; Lin, Kai; Yao, Xiaohui; Hu, Qingxun; Li, Xiaofei; Xu, Guofeng; Liu, Na; Nie, Jing; Li, Dali
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BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
err2025-02-28
err2
errOAAI
errMingwei Guo; Fei Shen; Xiaozhen Guo; Jun Zhang; Ying Ma; Xia Wu; Hui Zuo; Jing Yao; Yepeng Hu; Dongmei Wang; Yu Li; Jin Li; Jin Qiu; Jian Yu; Meiyao Meng; Ying Zheng; Xin Chen; Mingkai Gong; Kailin Liu; Ling Jin; Xiangyu Ren; Qiang Zhang; Yu Zhao; Xuejiang Gu; Feixia Shen; Dali Li; Liangcai Gao; Chang Liu; Fei Zhou; Mian Li; Jiqiu Wang; Shuzhe Ding; Xinran Ma; Jian Lu; Cen Xie; Junjie Xiao; Lingyan Xu
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Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model
err2025-01-01
err1
PREAI
errYin, Shuming; Gao, Liangcai; Sun, Xiaoyue; Zhang, Mei; Gao, Hongyi; Chen, Xiaoqing; Zhang, Dan; Ming, Xinyu; Yang, Lei; Hu, Yaqiang; Chen, Xi; Liu, Meizhen; Zhan, Xia; Guan, Yuting; Wang, Liren; Han, Lianshu; Zhu, Ping; Li, Dali
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Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9
err2024-08-16
err0
errOAAI
errZhang, Chen; Nie, Yongqiang; Xu, Bufang; Mu, Chunlan; Tian, Geng G.; Li, Xiaoyong; Cheng, Weiwei; Zhang, Aijun; Li, Dali; Wu, Ji
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Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos
err2024-08-01
err2
PREAI
errXue, Niannian; Hong, Dishan; Zhang, Dan; Wang, Qian; Zhang, Shun; Yang, Lei; Chen, Xi; Li, Yongmei; Han, Honghui; Hu, Chunyi; Liu, Mingyao; Song, Gaojie; Guan, Yuting; Wang, Liren; Zhu, Yifan; Li, Dali
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Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases
err2024-08-01
err2
errOAAI
errZhang, Kun; Wan, Ping; Wang, Liren; Wang, Zhen; Tan, Fangzhi; Li, Jie; Ma, Xiaolong; Cen, Jin; Yuan, Xiang; Liu, Yang; Sun, Zhen; Cheng, Xi; Liu, Yuanhua; Liu, Xuhao; Hu, Jiazhi; Zhong, Guisheng; Li, Dali; Xia, Qiang; Hui, Lijian
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Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy
err2024-07-23
err2
errOAAI
errYang, Ping; Lou, Yingmei; Geng, Zilong; Guo, Zhizhao; Wu, Shuo; Li, Yige; Song, Kaiyuan; Shi, Ting; Zhang, Shasha; Xiong, Junhao; Chen, Alex F.; Li, Dali; Pu, William T.; Da, Lintai; Zhang, Yan; Sun, Kun; Zhang, Bing
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Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing (vol 41, pg 663, 2023)
err2024-04-24
err0
PREAI
errChen, Liang; Zhu, Biyun; Ru, Gaomeng; Meng, Haowei; Yan, Yongchang; Hong, Mengjia; Zhang, Dan; Luan, Changming; Zhang, Shun; Wu, Hao; Gao, Hongyi; Bai, Sijia; Li, Changqing; Ding, Ruoyi; Xue, Niannian; Lei, Zhixin; Chen, Yuting; Guan, Yuting; Siwko, Stefan; Cheng, Yiyun; Song, Gaojie; Wang, Liren; Yi, Chengqi; Liu, Mingyao; Li, Dali
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Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos (vol 42, pg pages638, 2024)
err2024-04-24
err0
PREAI
errChen, Liang; Hong, Mengjia; Luan, Changming; Gao, Hongyi; Ru, Gaomeng; Guo, Xinyuan; Zhang, Dujuan; Zhang, Shun; Li, Changwei; Wu, Jun; Randolph, Peyton B.; Sousa, Alexander A.; Qu, Chao; Zhu, Yifan; Guan, Yuting; Wang, Liren; Liu, Mingyao; Feng, Bo; Song, Gaojie; Liu, David R.; Li, Dali
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Author Correction: Engineering a precise adenine base editor with minimal bystander editing(vol 19, pg 101, 2024)
err2024-04-22
err0
errOAAI
errChen, Liang; Zhang, Shun; Xue, Niannian; Hong, Mengjia; Zhang, Xiaohui; Zhang, Dan; Yang, Jing; Bai, Sijia; Huang, Yifan; Meng, Haowei; Wu, Hao; Luan, Changming; Zhu, Biyun; Ru, Gaomeng; Gao, Hongyi; Zhong, Liping; Liu, Meizhen; Liu, Mingyao; Cheng, Yiyun; Yi, Chengqi; Wang, Liren; Zhao, Yongxiang; Song, Gaojie; Li, Dali
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Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders
err2024-04-19
err7
errOAAI
errTan, Echuan; Wan, Tao; Pan, Qi; Duan, Jianan; Zhang, Song; Wang, Ruijue; Gao, Peng; Lv, Jia; Wang, Hui; Li, Dali; Ping, Yuan; Cheng, Yiyun
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Engineering APOBEC3A deaminase for highly accurate and efficient base editing
err2024-03-29
err4
PREAI
errYang, Lei; Huo, Yanan; Wang, Man; Zhang, Dan; Zhang, Tianai; Wu, Hao; Rao, Xichen; Meng, Haowei; Yin, Shuming; Mei, Jiale; Zhang, Dexin; Chen, Xi; Lv, Jia; Liu, Meizhen; Cheng, Yiyun; Guan, Yuting; Feng, Bo; Song, Gaojie; Yi, Chengqi; Liu, Mingyao; Zeng, Fanyi; Wang, Liren; Li, Dali
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Research Directions

基因治疗整合型载体非整合型载体会随时间而丢失,长期疗效无法保证基因编辑技术遗传疾病动物模型建立农业育种基因编辑技术体系优化与创新基因治疗策略开发与可行性研究微生物产品药物研发遗传改造