Not logged inTherapeutic modulation of rock overcomes metabolic adaption to oxphos inhibition and suppresses tumor growth
Blazanin, Nicholas; Liang, Xiaobing; Mahmud, Iqbal; Kim, Eiru; Tan, Lin; Anvar, Nazanin Esmaeili; Chan, Waikin; Ha, Min Jin; Minelli, Rosalba; Peoples, Michael; Lorenzi, Philip; Hart, Travar; Lissanu, Yonathan; Blazanin, Nicholas .png)
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SaveChromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanomaSrinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanomaRose, Johnathon Lynn; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Terranova, Christopher; Gay, Jason; Daniele, Joseph R.; Dmitriy, Loza; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Shah, Parth; Soni, Sanjay; Bristow, Christopher; Wang, Fangyang; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Perelli, Luigi; Wani, Khalida; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save Development of advanced preclinical modeling for a comprehensive characterization of cardiac angiosarcoma biologyMinelli, Rosalba; Perelli, Luigi; Bivona, Benjamin J.; Srinivasan, Sanjana; Catania, Desiree; Amador, Bianca E.; Robinson, Frederick S.; Rose, Johnathon L.; Terranova, Christopher T.; Martinez, Alejandro Hernandez; Deckard, Charles E.; Le, Courtney N.; Hsu, Kuo-Shun; Peoples, Michael; Subramaniam, Aparna; Beird, Hannah C.; Feng, Ningping; Daniele, Joseph R.; Vellano, Christopher; Marszalek, Joseph; Ravi, Vinod; Lazar, Alexander J.; Futreal, Andrew; Heffernan, Timothy P.; Genovese, Giannicola; Giuliani, Virginia Share Save ASCL2+tumor cells modulate the response of colorectal cancer to MAPK targeting therapyVillarreal, Oscar E.; Lee, Hey Min; Ha Tran; Machado, Annette; Alshenaifi, Jumanah; Wong, Chi Wut; Coker, Olu; Minelli, Rosalba; Peoples, Michael; Martinez, Alejandro Hernandez; Fowlkes, Natalie; Kanikarla, Preeti; Lin, Kangyu; Bristow, Christopher; Viale, Andrea; Marszalek, Joseph R.; Shen, John Paul; Kopetz, Scott Share Save Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancerPerelli, Luigi; Carbone, Federica; Zhang, Li; Huang, Justin K. K.; Le, Courtney; Khan, Hania; Citron, Francesca; Del Poggetto, Edoardo; Gutschner, Tony; Tomihara, Hideo; Soeung, Melinda; Minelli, Rosalba; Srinivasan, Sanjana; Peoples, Michael; Lam, Truong Nguyen Anh; Lundgren, Sebastian; Xia, Ruohan; Zhu, Cihui; Mohamed, Alaa M. T.; Zhang, Jianhua; Sircar, Kanishka; Sgambato, Alessandro; Gao, JianJun; Jonasch, Eric; Draetta, Giulio F.; Futreal, Andrew; Bakouny, Ziad; Van Allen, Eliezer M.; Choueiri, Toni; Signoretti, Sabina; Msaouel, Pavlos; Litchfield, Kevin; Turajlic, Samra; Wang, Linghua; Chen, Ying Bei; Di Natale, Renzo G.; Hakimi, A. Ari; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Tannir, Nizar M.; Carugo, Alessandro; Genovese, Giannicola Share Save SMARCB1 regulates the hypoxic stress response in sickle cell traitSoeung, Melinda; Perelli, Luigi; Chen, Ziheng; Dondossola, Eleonora; Ho, -Lin; Carbone, Federica; Zhang, Li; Khan, Hania; Le, Courtney N.; Zhu, Cihui; Peoples, Michael D.; Feng, Ningping; Jiang, Shan; Zacharias, Niki Millward; Minelli, Rosalba; Shapiro, Daniel D.; Deem, Angela K.; Gao, Sisi; Cheng, Emily H.; Lucchetti, Donatella; Walker, Cheryl L.; Carugo, Alessandro; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Tannir, Nizar M.; Draetta, Giulio F.; Msoue, Pavlo; Genovese, Giannicola Share Save Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanomaRose, Johnathon L.; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Daniele, Joseph R.; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Del Poggetto, Edoardo; Zamler, Daniel; Huang, Justin; Perelli, Luigi; Wani, Khalida; Bristow, Christopher; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samplesSrinivasan, Sanjana; Rose, Johnathon; Daniele, Joseph R.; Peoples, Michael; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Wani, Khalida; Perelli, Luigi; Loza, Dmitriy; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Futreal, P. Andrew; Woodman, Scott E.; Lazar, Alexander J.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancerPadhye, Aparna; Konen, Jessica M.; Rodriguez, B. Leticia; Fradette, Jared J.; Ochieng, Joshua K.; Diao, Lixia; Wang, Jing; Lu, Wei; Solis, Luisa S.; Batra, Harsh; Raso, Maria G.; Peoples, Michael D.; Minelli, Rosalba; Carugo, Alessandro; Bristow, Christopher A.; Gibbons, Don L. Share Save Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLLAslan, Burcu; Kismali, Gorkem; Chen, Lisa S.; Iles, LaKesla R.; Mahendra, Mikhila; Peoples, Michael; Gagea, Mihai; Fowlkes, Natalie W.; Zheng, Xiaofeng; Wang, Jing; Vellano, Christopher P.; Marszalek, Joseph R.; Bertilaccio, Maria Teresa Sabrina; Gandhi, Varsha Share Save PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinomaGiuliani, Virginia; Miller, Meredith A.; Liu, Chiu-Yi; Hartono, Stella R.; Class, Caleb A.; Bristow, Christopher A.; Suzuki, Erika; Sanz, Lionel A.; Gao, Guang; Gay, Jason P.; Feng, Ningping; Rose, Johnathon L.; Tomihara, Hideo; Daniele, Joseph R.; Peoples, Michael D.; Bardenhagen, Jennifer P.; Geck Do, Mary K.; Chang, Qing E.; Vangamudi, Bhavatarini; Vellano, Christopher; Ying, Haoqiang; Deem, Angela K.; Do, Kim-Anh; Genovese, Giannicola; Marszalek, Joseph R.; Kovacs, Jeffrey J.; Kim, Michael; Fleming, Jason B.; Guccione, Ernesto; Viale, Andrea; Maitra, Anirban; Emilia Di Francesco, M.; Yap, Timothy A.; Jones, Philip; Draetta, Giulio; Carugo, Alessandro; Chedin, Frederic; Heffernan, Timothy P. Share Save Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal CancerInoue, Akira; Robinson, Frederick S.; Minelli, Rosalba; Tomihara, Hideo; Rizi, Bahar Salimian; Rose, Johnathon L.; Kodama, Takahiro; Srinivasan, Sanjana; Harris, Angela L.; Zuniga, Andy M.; Mullinax, Robert A.; Ma, Xiaoyan; Seth, Sahil; Daniele, Joseph R.; Peoples, Michael D.; Loponte, Sara; Akdemir, Kadir C.; Khor, Tin Oo; Feng, Ningping; Roszik, Jason; Sobieski, Mary M.; Brunell, David; Stephan, Clifford; Giuliani, Virginia; Deem, Angela K.; Shingu, Takashi; Deribe, Yonathan Lissanu; Menter, David G.; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Kopetz, Scott; Draetta, Giulio F.; Genovese, Giannicola; Carugo, Alessandro Share Save Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutationsShariati, Maryam; Evans, Kurt W.; Zheng, Xiaofeng; Bristow, Christopher A.; Ng, Patrick Kwok-Shing; Rizvi, Yasmeen Q.; Tapia, Coya; Yang, Fei; Carugo, Alessandro; Heffernan, Timothy P.; Peoples, Michael D.; Tripathy, Debu; Meric-Bernstam, Funda Share Save Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibSun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save The NEDD8 and EGFR pathways are independent therapeutic targets in colorectal cancerInvrea, Federica; Carugo, Alessandro; Petti, Consalvo; Bristow, Cristopher; Peoples, Michael; Cancelliere, Carlotta; Corrado, Alessia; Bardelli, Alberto; Isella, Claudio; Draetta, Giulio F.; Medico, Enzo Share Save Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistanceSun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save Share Save ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancerManshouri, Roxsan; Coyaud, Etienne; Kundu, Samrat T.; Peng, David H.; Stratton, Sabrina A.; Alton, Kendra; Bajaj, Rakhee; Fradette, Jared J.; Minelli, Rosalba; Peoples, Michael D.; Carugo, Alessandro; Chen, Fengju; Bristow, Christopher; Kovacs, Jeffrey J.; Barton, Michelle C.; Heffernan, Tim; Creighton, Chad J.; Raught, Brian; Gibbons, Don L. Share Save Dissection of clonal heterogeneity unmasks pre-existing chemoresistance and new metabolic vulnerabilities in pancreatic cancerSeth, Sahil; Li, Chieh-Yuan; Loponte, Sara; Ho, I-Lin; Corti, Denise; Sapio, Luigi; Del Poggetto, Edoardo; Peoples, Michael; Karpinets, Tatiana; Robinson, Frederick S.; Jiang, Shan; Dutta, Prasanta; Marszalek, Joseph; Di Francesco, Maria E.; Heffernan, Timothy P.; Giuliani, Virginia; Bhattacharya, Pratip K.; Genovese, Giannicola; Futreal, Andrew; Draetta, Giulio; Viale, Andrea; Carugo, Alessandro Share Save 
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