Not logged in Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers Carroll, Christopher L.; Johnson, Michael G.; Ding, Yanbing; Kang, Zhijun; Vijayan, R. S. K.; Bardenhagen, Jennifer P.; Fang, Cheng; Lapointe, David; Li, Meng; Liu, Chiu-Yi; Lv, Xiaobing; Ma, Xiaoyan; Pang, Jihai; Shepard, Hannah E.; Suarez, Catalina; Yau, Anne Ju; Williams, Christopher C.; Wu, Qi; Heald, Robert A.; Robinson, Helen M. R.; Smith, Graeme C. M.; Cross, Jason B.; Do, Mary K. Geck; Jiang, Yongying; Lively, Sarah; Yap, Timothy A.; Giuliani, Virginia; Heffernan, Timothy; Jones, Philip; Di Francesco, M. Emilia Share Save
Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma Srinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets Zanca, Ciro; Soth, Michael; Gao, Guang; Gay, Jason; Feng, Ningping; Bristow, Christopher; Le, Kang; Xu, Quanyun; Phuong Nguyen; Jiang, Yongying; Perry, Teresa; Mseeh, Faika; Leonard, Paul; Cross, Jason; Giuliani, Virginia; Marszalek, Joe; Jones, Philip; Heffernan, Tim Share Save
Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma Rose, Johnathon Lynn; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Terranova, Christopher; Gay, Jason; Daniele, Joseph R.; Dmitriy, Loza; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Shah, Parth; Soni, Sanjay; Bristow, Christopher; Wang, Fangyang; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Perelli, Luigi; Wani, Khalida; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
Development of advanced preclinical modeling for a comprehensive characterization of cardiac angiosarcoma biology Minelli, Rosalba; Perelli, Luigi; Bivona, Benjamin J.; Srinivasan, Sanjana; Catania, Desiree; Amador, Bianca E.; Robinson, Frederick S.; Rose, Johnathon L.; Terranova, Christopher T.; Martinez, Alejandro Hernandez; Deckard, Charles E.; Le, Courtney N.; Hsu, Kuo-Shun; Peoples, Michael; Subramaniam, Aparna; Beird, Hannah C.; Feng, Ningping; Daniele, Joseph R.; Vellano, Christopher; Marszalek, Joseph; Ravi, Vinod; Lazar, Alexander J.; Futreal, Andrew; Heffernan, Timothy P.; Genovese, Giannicola; Giuliani, Virginia Share Save
Clonal dominance defines metastatic dissemination in pancreatic cancer Ho, I-Lin; Li, Chieh-Yuan; Wang, Fuchenchu; Zhao, Li; Liu, Jingjing; Yen, Er-Yen; Dyke, Charles A.; Shah, Rutvi; Liu, Zhaoliang; Cetin, Ali Osman; Chu, Yanshuo; Citron, Francesca; Attanasio, Sergio; Corti, Denise; Darbaniyan, Faezeh; Del Poggetto, Edoardo; Loponte, Sara; Liu, Jintan; Soeung, Melinda; Chen, Ziheng; Jiang, Shan; Jiang, Hong; Inoue, Akira; Gao, Sisi; Deem, Angela; Feng, Ningping; Ying, Haoqiang; Kim, Michael; Giuliani, Virginia; Genovese, Giannicola; Zhang, Jianhua; Futreal, Andrew; Maitra, Anirban; Heffernan, Timothy; Wang, Linghua; Do, Kim-Anh; Gargiulo, Gaetano; Draetta, Giulio; Carugo, Alessandro; Lin, Ruitao; Viale, Andrea Share Save
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types Pilie, Patrick G.; Giuliani, Virginia; Wang, Wei-Lien; McGrail, Daniel J.; Bristow, Christopher A.; Ngoi, Natalie Y. L.; Kyewalabye, Keith; Wani, Khalida M.; Le, Hung; Campbell, Erick; Sanchez, Nora S.; Yang, Dong; Gheeya, Jinesh S.; Goswamy, Rohit Vivek; Holla, Vijaykumar; Shaw, Kenna Rael; Meric-Bernstam, Funda; Liu, Chiu-Yi; Ma, Xiaoyan; Feng, Ningping; Machado, Annette A.; Bardenhagen, Jennifer P.; Vellano, Christopher P.; Marszalek, Joseph R.; Rajendra, Eeson; Piscitello, Desiree; Johnson, Timothy I.; Likhatcheva, Maria; Elinati, Elias; Majithiya, Jayesh; Neves, Joana; Grinkevich, Vera; Ranzani, Marco; Luzarraga, Marina Roy; Boursier, Marie; Armstrong, Lucy; Geo, Lerin; Lillo, Giorgia; Tse, Wai Yiu; Lazar, Alexander J.; Kopetz, Scott E.; Geck Do, Mary K.; Lively, Sarah; Johnson, Michael G.; Robinson, Helen M. R.; Smith, Graeme C. M.; Carroll, Christopher L.; Di Francesco, M. Emilia; Jones, Philip; Heffernan, Timothy P.; Yap, Timothy A. Share Save
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer Perelli, Luigi; Carbone, Federica; Zhang, Li; Huang, Justin K. K.; Le, Courtney; Khan, Hania; Citron, Francesca; Del Poggetto, Edoardo; Gutschner, Tony; Tomihara, Hideo; Soeung, Melinda; Minelli, Rosalba; Srinivasan, Sanjana; Peoples, Michael; Lam, Truong Nguyen Anh; Lundgren, Sebastian; Xia, Ruohan; Zhu, Cihui; Mohamed, Alaa M. T.; Zhang, Jianhua; Sircar, Kanishka; Sgambato, Alessandro; Gao, JianJun; Jonasch, Eric; Draetta, Giulio F.; Futreal, Andrew; Bakouny, Ziad; Van Allen, Eliezer M.; Choueiri, Toni; Signoretti, Sabina; Msaouel, Pavlos; Litchfield, Kevin; Turajlic, Samra; Wang, Linghua; Chen, Ying Bei; Di Natale, Renzo G.; Hakimi, A. Ari; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Tannir, Nizar M.; Carugo, Alessandro; Genovese, Giannicola Share Save
SMARCB1 regulates the hypoxic stress response in sickle cell trait Soeung, Melinda; Perelli, Luigi; Chen, Ziheng; Dondossola, Eleonora; Ho, -Lin; Carbone, Federica; Zhang, Li; Khan, Hania; Le, Courtney N.; Zhu, Cihui; Peoples, Michael D.; Feng, Ningping; Jiang, Shan; Zacharias, Niki Millward; Minelli, Rosalba; Shapiro, Daniel D.; Deem, Angela K.; Gao, Sisi; Cheng, Emily H.; Lucchetti, Donatella; Walker, Cheryl L.; Carugo, Alessandro; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Tannir, Nizar M.; Draetta, Giulio F.; Msoue, Pavlo; Genovese, Giannicola Share Save
DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma Citron, Francesca; Perelli, Luigi; Chu, Yanshuo; Srinivasan, Sanjana; Ho, I-Lin; Yen, Er-Yen; Shah, Rutvi; Attanasio, Sergio; Montanez, Luis Castillo; Di Pilato, Mauro; Jiang, Shan; Yao, Wantong; Gao, Sisi; Deem, Angela; Genovese, Giannicola; Wang, Linghua; Giuliani, Virginia; Viale, Andrea; Draetta, Giulio F. Share Save
The ATR inhibitor ART0380 shows preclinical efficacy in monotherapy or in combination with gemcitabine, aPD1, PARP inhibitors and topoisomerase 1 poisons Majithiya, Jayesh Bhanabhai; Luzarraga, Marina Roy; Newman, Richard; Costales, Paula; Jones, Philip; Di Francesco, Maria Emilia; Giuliani, Virginia; Caroll, Chris; Do, Mary Geck; Heffernan, Tim; Feng, Ningpeng; Ma, XiaoYan; Lively, Sarah; Johnson, Michael G.; Geo, Lerin; Piscitello, Desiree; Rajendra, Eeson; Grinkevich, Vera; Ranzani, Marco; Stockley, Martin; Langford, Gillian; Heald, Robert; Robinson, Helen M.; Smith, Graeme C. Share Save
Ataxia-telangiectasia mutated loss of function displays variant and tissue specific differences across tumor types Pilie, Patrick G.; Mcgrail, Daniel; Wang, Wei-Lien; Ngoi, Natalie; Kyewalabye, Keith; Wani, Khalida; Le, Hung; Campbell, Erick; Holla, Vijaykumar; Shaw, Kenna R.; Meric-Bernstam, Funda; Lazar, Alexander J.; Giuliani, Virginia; Heffernan, Timothy; Yap, Timothy A. Share Save
Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma Rose, Johnathon L.; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Daniele, Joseph R.; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Del Poggetto, Edoardo; Zamler, Daniel; Huang, Justin; Perelli, Luigi; Wani, Khalida; Bristow, Christopher; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples Srinivasan, Sanjana; Rose, Johnathon; Daniele, Joseph R.; Peoples, Michael; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Wani, Khalida; Perelli, Luigi; Loza, Dmitriy; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Futreal, P. Andrew; Woodman, Scott E.; Lazar, Alexander J.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma Giuliani, Virginia; Miller, Meredith A.; Liu, Chiu-Yi; Hartono, Stella R.; Class, Caleb A.; Bristow, Christopher A.; Suzuki, Erika; Sanz, Lionel A.; Gao, Guang; Gay, Jason P.; Feng, Ningping; Rose, Johnathon L.; Tomihara, Hideo; Daniele, Joseph R.; Peoples, Michael D.; Bardenhagen, Jennifer P.; Geck Do, Mary K.; Chang, Qing E.; Vangamudi, Bhavatarini; Vellano, Christopher; Ying, Haoqiang; Deem, Angela K.; Do, Kim-Anh; Genovese, Giannicola; Marszalek, Joseph R.; Kovacs, Jeffrey J.; Kim, Michael; Fleming, Jason B.; Guccione, Ernesto; Viale, Andrea; Maitra, Anirban; Emilia Di Francesco, M.; Yap, Timothy A.; Jones, Philip; Draetta, Giulio; Carugo, Alessandro; Chedin, Frederic; Heffernan, Timothy P. Share Save
Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer Inoue, Akira; Robinson, Frederick S.; Minelli, Rosalba; Tomihara, Hideo; Rizi, Bahar Salimian; Rose, Johnathon L.; Kodama, Takahiro; Srinivasan, Sanjana; Harris, Angela L.; Zuniga, Andy M.; Mullinax, Robert A.; Ma, Xiaoyan; Seth, Sahil; Daniele, Joseph R.; Peoples, Michael D.; Loponte, Sara; Akdemir, Kadir C.; Khor, Tin Oo; Feng, Ningping; Roszik, Jason; Sobieski, Mary M.; Brunell, David; Stephan, Clifford; Giuliani, Virginia; Deem, Angela K.; Shingu, Takashi; Deribe, Yonathan Lissanu; Menter, David G.; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Kopetz, Scott; Draetta, Giulio F.; Genovese, Giannicola; Carugo, Alessandro Share Save
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Sun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save
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