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SaveCryo-EM-guided enhancement of target selectivity of a novel p97 inhibitor for treating multiple myeloma and acute myeloid leukemia
Crawford, Jason; Munuganti, Ravi; Leung, Charles; Singh, Kriti; Gates, Ellen; Zhu, Xing; Bally, Marcel; Dos Santos, Nancy; Sharifiaghdam, Maryam; Nosrati, Zeynab; Axerio-Cilies, Peter; Berezuk, Alison; Cholak, Spencer; Subramaniam, Sriram
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SaveLoss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis
Lebovitz, Chandra; Wretham, Nicole; Osooly, Maryam; Milne, Katy; Dash, Tia; Thornton, Shelby; Tessier-Cloutier, Basile; Sathiyaseelan, Paalini; Bortnik, Svetlana; Go, Nancy Erro; Halvorsen, Elizabeth; Cederberg, Rachel A.; Chow, Norman; Dos Santos, Nancy; Bennewith, Kevin L.; Nelson, Brad H.; Bally, Marcel B.; Lam, Wan L.; Gorski, Sharon M.
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SaveTMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Ennishi, Daisuke; Healy, Shannon; Bashashati, Ali; Saberi, Saeed; Hother, Christoffer; Mottok, Anja; Chan, Fong Chun; Chong, Lauren; Abraham, Libin; Kridel, Robert; Boyle, Merrill; Meissner, Barbara; Aoki, Tomohiro; Takata, Katsuyoshi; Woolcock, Bruce W.; Vigano, Elena; Gold, Michael; Molday, Laurie L.; Molday, Robert S.; Telenius, Adele; Li, Michael Y.; Wretham, Nicole; Dos Santos, Nancy; Wong, Mark; Viller, Natasja N.; Uger, Robert A.; Duns, Gerben; Baticados, Abigail; Madero, Angel; Bristow, Brianna N.; Farinha, Pedro; Slack, Graham W.; Ben-Neriah, Susana; Lai, Daniel; Zhang, Allen W.; Salehi, Sohrab; Shulha, Hennady P.; Chiu, Derek S.; Mostafavi, Sara; Gerrie, Alina S.; Huang, Da Wei; Rushton, Christopher; Villa, Diego; Sehn, Laurie H.; Savage, Kerry J.; Mungall, Andrew J.; Weng, Andrew P.; Bally, Marcel B.; Morin, Ryan D.; Cohen Freue, Gabriela V.; Staudt, Louis M.; Connors, Joseph M.; Marra, Marco A.; Shah, Sohrab P.; Gascoyne, Randy D.; Scott, David W.; Steidl, Christian
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SaveHistone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type
Wang, Yemin; Chen, Shary Yuting; Colborne, Shane; Lambert, Galen; Shin, Chae Young; Dos Santos, Nancy; Orlando, Krystal A.; Lang, Jessica D.; Hendricks, William P. D.; Bally, Marcel B.; Karnezis, Anthony N.; Hass, Ralf; Underhill, T. Michael; Morin, Gregg B.; Trent, Jeffrey M.; Weissman, Bernard E.; Huntsman, David G.
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SaveThe histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type
Wang, Yemin; Chen, Shary Yuting; Karnezis, Anthony N.; Colborne, Shane; Dos Santos, Nancy; Lang, Jessica D.; Hendricks, William P. D.; Orlando, Krystal A.; Yap, Damian; Kommoss, Friedrich; Bally, Marcel B.; Morin, Gregg B.; Trent, Jeffrey M.; Weissman, Bernard E.; Huntsman, David G.
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SaveCX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Xu, Hong; Di Antonio, Marco; McKinney, Steven; Mathew, Veena; Ho, Brandon; O'Neil, Nigel J.; Dos Santos, Nancy; Silvester, Jennifer; Wei, Vivien; Garcia, Jessica; Kabeer, Farhia; Lai, Daniel; Soriano, Priscilla; Banath, Judit; Chiu, Derek S.; Yap, Damian; Le, Daniel D.; Ye, Frank B.; Zhang, Anni; Thu, Kelsie; Soong, John; Lin, Shu-chuan; Tsai, Angela Hsin Chin; Osako, Tomo; Algara, Teresa; Saunders, Darren N.; Wong, Jason; Xian, Jian; Bally, Marcel B.; Brenton, James D.; Brown, Grant W.; Shah, Sohrab P.; Cescon, David; Mak, Tak W.; Caldas, Carlos; Stirling, Peter C.; Hieter, Phil; Balasubramanian, Shankar; Aparicio, Samuel
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SaveDianhydrogalactitol inhibits the growth of glioma stem and non-stem cultures, including temozolomide-resistant cell lines, in vitro and in vivo
Fouse, Shaun D.; Steino, Anne; Butowski, Nicholas; Bacha, Jeffrey A.; Kanekal, Sarath; Dos Santos, Nancy; Brown, Dennis M.; Costello, Joseph F.
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SaveIrinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities
Waterhouse, Dawn N.; Sutherland, Brent W.; Dos Santos, Nancy; Masin, Dana; Osooly, Maryam; Strutt, Dita; Ostlund, Christina; Anantha, Malathi; Harasym, Natashia; Manisali, Irina; Wehbe, Mohamed; Bally, Marcel B.; Webb, Murray S.
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SaveControlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol)
Allen, C; Dos Santos, N; Gallagher, R; Chiu, GNC; Shu, Y; Li, WM; Johnstone, SA; Janoff, AS; Mayer, LD; Webb, MS; Bally, MB
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