Not logged in Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations (vol 4, pg 1345, 2023) Miyazaki, Isao; Odintsov, Igor; Ishida, Keiji; Lui, Allan J. W.; Kato, Masanori; Suzuki, Tatsuya; Zhang, Tom; Wakayama, Kentaro; Kurth, Renate I.; Cheng, Ryan; Fujita, Hidenori; Delasos, Lukas; Vojnic, Morana; Khodos, Inna; Yamada, Yukari; Ishizawa, Kota; Mattar, Marissa S.; Funabashi, Kaoru; Chang, Qing; Ohkubo, Shuichi; Yano, Wakako; Terada, Ryuichiro; Giuliano, Claudio; Lu, Yue Christine; Bonifacio, Annalisa; Kunte, Siddharth; Davare, Monika A.; Cheng, Emily H.; de Stanchina, Elisa; Lovati, Emanuela; Iwasawa, Yoshikazu; Ladanyi, Marc; Somwar, Romel Share Save
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations Miyazaki, Isao; Odintsov, Igor; Ishida, Keiji; Lui, Allan J. W.; Kato, Masanori; Suzuki, Tatsuya; Zhang, Tom; Wakayama, Kentaro; Kurth, Renate I.; Cheng, Ryan; Fujita, Hidenori; Delasos, Lukas; Vojnic, Morana; Khodos, Inna; Yamada, Yukari; Ishizawa, Kota; Mattar, Marissa S.; Funabashi, Kaoru; Chang, Qing; Ohkubo, Shuichi; Yano, Wakako; Terada, Ryuichiro; Giuliano, Claudio; Lu, Yue Christine; Bonifacio, Annalisa; Kunte, Siddharth; Davare, Monika A.; Cheng, Emily H.; de Stanchina, Elisa; Lovati, Emanuela; Iwasawa, Yoshikazu; Ladanyi, Marc; Somwar, Romel Share Save
The ectonucleotidase CD39 identifies tumor-reactive CD8+T cells predictive of immune checkpoint blockade efficacy in human lung cancer Chow, Andrew; Uddin, Fathema Z.; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y.; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E.; Quintanal-Villalonga, Alvaro; Chan, Joseph M.; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S.; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L.; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A.; Hellmann, Matthew D.; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D.; Merghoub, Taha; Rudin, Charles M. Share Save
MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression Farnsworth, Dylan A.; Inoue, Yusuke; Johnson, Fraser D.; De Rappard-Yuswack, Georgia; Lu, Daniel; Shi, Rocky; Ma, Lok In Josephine; Mattar, Marissa S.; Somwar, Romel; Ladanyi, Marc; Unni, Arun M.; Lockwood, William W. Share Save
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Timaul, Neilawattie Merna; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S.; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M.; Janne, Pasi A.; McCormick, Frank; Yao, Zhan; Rosen, Neal Share Save
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer Pereira, Patricia M. R.; Mandleywala, Komal; Monette, Sebastien; Lumish, Melissa; Tully, Kathryn M.; Panikar, Sandeep Surendra; Cornejo, Mike; Mauguen, Audrey; Ragupathi, Ashwin; Keltee, Nai C.; Mattar, Marissa; Janjigian, Yelena Y.; Lewis, Jason S. Share Save
MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer Iyer, Sudarshan R.; Odintsov, Igor; Schoenfeld, Adam J.; Siau, Evan; Mattar, Marissa S.; de Stanchina, Elisa; Khodos, Inna; Drilon, Alexander; Riely, Gregory J.; Ladanyi, Marc; Somwar, Romel; Davare, Monika A. Share Save
Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements Schram, Alison M.; Odintsov, Igor; Espinosa-Cotton, Madelyn; Khodos, Inna; Sisso, Whitney J.; Mattar, Marissa S.; Lui, Allan J. W.; Vojnic, Morana; Shameem, Sara H.; Chauhan, Thrusha; Torrisi, Jean; Ford, Jim; O'Connor, Marie N.; Geuijen, Cecile A. W.; Schackmann, Ron C. J.; van Bueren, Jeroen J. Lammerts; Wasserman, Ernesto; de Stanchina, Elisa; O'Reilly, Eileen M.; Ladanyi, Marc; Drilon, Alexander; Somwar, Romel Share Save
Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling Smith, Roger S.; Odintsov, Igor; Liu, Zebing; Lui, Allan Jo-Weng; Hayashi, Takuo; Vojnic, Morana; Suehara, Yoshiyuki; Delasos, Lukas; Mattar, Marissa S.; Hmeljak, Julija; Ramirez, Hillary A.; Shaw, Melissa; Bui, Gabrielle; Hartono, Alifiani B.; Gladstone, Eric; Kunte, Siddharth; Magnan, Heather; Khodos, Inna; De Stanchina, Elisa; La Quaglia, Michael P.; Yao, Jinjuan; Lae, Marick; Lee, Sean B.; Spraggon, Lee; Pratilas, Christine A.; Ladanyi, Marc; Somwar, Romel Share Save
TAS0953/HM06 is effective in preclinical models of diverse tumor types driven by RET alterations Odintsov, Igor; Kurth, Renate I.; Ishizawa, Kota; Delasos, Lukas; Lui, Allan J. W.; Khodos, Inna; Hagen, Connor J.; Chang, Qing; Mattar, Marissa S.; Vojnic, Morana; Kunte, Siddharth; Bonifacio, Annalisa; Giuliano, Claudio; De Stanchina, Elisa; Cheng, Emily; Lovati, Emanuela; Ladanyi, Marc; Somwar, Romel Share Save
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer Joshi, Suhasini; Gomes, Erica DaGama; Wang, Tai; Corben, Adriana; Taldone, Tony; Gandu, Srinivasa; Xu, Chao; Sharma, Sahil; Buddaseth, Salma; Yan, Pengrong; Chan, Lon Yin L.; Gokce, Askan; Rajasekhar, Vinagolu K.; Shrestha, Lisa; Panchal, Palak; Almodovar, Justina; Digwal, Chander S.; Rodina, Anna; Merugu, Swathi; Pillarsetty, NagaVaraKishore; Miclea, Vlad; Peter, Radu I.; Wang, Wanyan; Ginsberg, Stephen D.; Tang, Laura; Mattar, Marissa; de Stanchina, Elisa; Yu, Kenneth H.; Lowery, Maeve; Grbovic-Huezo, Olivera; O'Reilly, Eileen M.; Janjigian, Yelena; Healey, John H.; Jarnagin, William R.; Allen, Peter J.; Sander, Chris; Erdjument-Bromage, Hediye; Neubert, Thomas A.; Leach, Steven D.; Chiosis, Gabriela Share Save
RET inhibition in novel patient-derived models of RET fusion-positive lung adenocarcinoma reveals a role for MYC upregulation Hayashi, Takuo; Odintsov, Igor; Smith, Roger S.; Ishizawa, Kota; Liu, Allan J. W.; Delasos, Lukas; Kurzatkowski, Christopher; Tai, Huichun; Gladstone, Eric; Vojnic, Morana; Kohsaka, Shinji; Suzawa, Ken; Liu, Zebing; Kunte, Siddharth; Mattar, Marissa S.; Khodos, Inna; Davare, Monika A.; Drilon, Alexander; Cheng, Emily; de Stanchina, Elisa; Ladanyi, Marc; Somwar, Romel Share Save
NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors Somwar, Romel; Hofmann, Nicolle E.; Smith, Bryan; Odintsov, Igor; Vojnic, Morana; Linkov, Irina; Tam, Ashley; Khodos, Inna; Mattar, Marissa S.; de Stanchina, Elisa; Flynn, Daniel; Ladanyi, Marc; Drilon, Alexander; Shinde, Ujwal; Davare, Monika A. Share Save
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers Li, Bob T.; Michelini, Flavia; Misale, Sandra; Cocco, Emiliano; Baldino, Laura; Cai, Yanyan; Shifman, Sophie; Tu, Hai-Yan; Myers, Mackenzie L.; Xu, Chongrui; Mattar, Marissa; Khodos, Inna; Little, Megan; Qeriqi, Besnik; Weitsman, Gregory; Wilhem, Clare J.; Lalani, Alshad S.; Diala, Irmina; Freedman, Rachel A.; Lin, Nancy U.; Solit, David B.; Berger, Michael F.; Barber, Paul R.; Ng, Tony; Offin, Michael; Isbell, James M.; Jones, David R.; Yu, Helena A.; Thyparambil, Sheeno; Liao, Wei-Li; Bhalkikar, Anuja; Cecchi, Fabiola; Hyman, David M.; Lewis, Jason S.; Buonocore, Darren J.; Ho, Alan L.; Makker, Vicky; Reis-Filho, Jorge S.; Razavi, Pedram; Arcila, Maria E.; Kris, Mark G.; Poirier, John T.; Shen, Ronglai; Tsurutani, Junji; Ulaner, Gary A.; de Stanchina, Elisa; Rosen, Neal; Rudin, Charles M.; Scaltriti, Maurizio Share Save
Regenerative lineages and immune-mediated pruning in lung cancer metastasis Laughney, Ashley M.; Hu, Jing; Campbell, Nathaniel R.; Bakhoum, Samuel F.; Setty, Manu; Lavallee, Vincent-Philippe; Xie, Yubin; Masilionis, Ignas; Carr, Ambrose J.; Kottapalli, Sanjay; Allaj, Viola; Mattar, Marissa; Rekhtman, Natasha; Xavier, Joao B.; Mazutisz, Linas; Poirier, John T.; Rudin, Charles M.; Pe'er, Dana; Massague, Joan Share Save
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Resistance to TRK inhibition mediated by convergent MAPK pathway activation Cocco, Emiliano; Schram, Alison M.; Kulick, Amanda; Misale, Sandra; Won, Helen H.; Yaeger, Rona; Razavi, Pedram; Ptashkin, Ryan; Hechtman, Jaclyn F.; Toska, Eneda; Cownie, James; Somwar, Romel; Shifman, Sophie; Mattar, Marissa; Selcuklu, S. Duygu; Samoila, Aliaksandra; Guzman, Sean; Tuch, Brian B.; Ebata, Kevin; de Stanchina, Elisa; Nagy, Rebecca J.; Lanman, Richard B.; Houck-Loomis, Brian; Patel, Juber A.; Berger, Michael F.; Ladanyi, Marc; Hyman, David M.; Drilon, Alexander; Scaltriti, Maurizio Share Save
Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation Cocco, Emiliano; Kulick, Amanda; Misale, Sandra; Yaeger, Rona; Razavi, Pedram; Won, Helen H.; Ptashkin, Ryan; Hechtman, Jaclyn F.; Toska, Eneda; Cownie, James; Somwar, Romel; Shifman, Sophie; Mattar, Marissa; Selcuklu, S. Duygu; Samoila, Aliaksandra; Guzman, Sean; Tuch, Brian B.; Ebata, Kevin; de Stanchina, Elisa; Nagy, Rebecca J.; Lanman, Richard B.; Berger, Michael F.; Ladanyi, Marc; Hyman, David M.; Drilon, Alexander; Scaltriti, Maurizio; Schram, Alison M. Share Save
EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer Sanchez-Vega, Francisco; Hechtman, Jaclyn F.; Castel, Pau; Ku, Geoffrey Y.; Tuvy, Yaelle; Won, Helen; Fong, Christopher J.; Bouvier, Nancy; Nanjangud, Gouri J.; Soong, Joanne; Vakiani, Efsevia; Schattner, Mark; Kelsen, David P.; Lefkowitz, Robert A.; Brown, Karen; Lacouture, Mario E.; Capanu, Marinela; Mattar, Marissa; Qeriqi, Besnik; Cecchi, Fabiola; Tian, Yuan; Hembrough, Todd; Nagy, Rebecca J.; Lanman, Richard B.; Larson, Steven M.; Pandit-Taskar, Neeta; Schoder, Heiko; Iacobuzio-Donahue, Christine A.; Ilson, David H.; Weber, Wolfgang A.; Berger, Michael F.; De Stanchina, Elisa; Taylor, Barry S.; Lewis, Jason S.; Solit, David B.; Carrasquillo, Jorge A.; Scaltriti, Maurizio; Schultz, Nikolaus; Janjigian, Yelena Y. Share Save
Oncogenic KRAS mediates resistance to MET targeted therapy in non-small cell lung cancer (NSCLC) with MET mutations that induce exon14 skipping Suzawa, Ken; Offin, Michael D.; Kurzatkowski, Christopher; Liu, Daniel; Vojnic, Morana; Smith, Roger S.; Mattar, Marissa; Khodos, Inna; de Stanchina, Elisa; Sabari, Joshua K.; Lockwood, William W.; Drilon, Alexander E.; Ladanyi, Marc; Somwar, Romel Share Save
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