Not logged inBotensilimab, an Fc-Enhanced Anti-CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy
Chand, Dhan; Savitsky, David A.; Krishnan, Shanmugarajan; Mednick, Gabriel; Delepine, Chloe; Garcia-Broncano, Pilar; Soh, Kah Teong; Wu, Wei; Wilkens, Margaret K.; Udartseva, Olga; Vincent, Sylvia; Joshi, Bishnu; Keith, Justin G.; Manrique, Mariana; Marques, Marilyn; Tanne, Antoine; Levey, Daniel L.; Han, Haiyong; Ng, Serina; Ridpath, Jackson; Huber, Olivia; Morin, Benjamin; Galand, Claire; Bourdelais, Sean; Gombos, Randi B.; Ward, Rebecca; Qin, Yu; Waight, Jeremy D.; Costa, Matthew R.; Sebastian-Yague, Alvaro; Rudqvist, Nils-Petter; Pupecka-Swider, Malgorzata; Venkatraman, Vignesh; Slee, Andrew; Patel, Jaymin M.; Grossman, Joseph E.; Wilson, Nicholas S.; Von Hoff, Daniel D.; Stebbing, Justin; Curiel, Tyler J.; Buell, Jennifer S.; O'Day, Steven J.; Stein, Robert B. .png)
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SaveMiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastasesKrishnan, Shanmugarajan; Joshi, Bishnu; Keith, Justin; Frazier, Ryan; Kalinowska, Barbara; Choi, Jin San; Sanders, Stephanie; Boi, Shannon; Le Tonqueze, Olivier; Kushner, Nick; Soh, Kah Teong; Stein, Robert; Curiel, Tyler J.; van Dijk, Marc A.; Kim, Enoch; Chantzoura, Eleni; Rudqvist, Nils-Petter; Chand, Dhan Share Save BMS-986442 ( AGEN1777), a novel TIGIT/CD96 bispecific antibody, demonstrates superior monotherapy and combination activity versus conventional anti-TIGIT antibodies in preclinical modelsWard, Rebecca; Ramsay, Nicola; Campbell, Spencer; Patel, Hema; Bushell, Mark; Morin, Benjamin M.; Wensley, Beth; Savitsky, David A.; Garcia-Broncano, Pilar; Joshi, Bishnu; Briend, Emmanuel; Ignatovich, Olga; Jawad, Zahra; Rudqvist, Nils-Petter; Wilson, Nicholas; Chand, Dhan Share Save Share Save Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumorsRudqvist, Nils-Petter; Charpentier, Maud; Lhuillier, Claire; Wennerberg, Erik; Spada, Sheila; Sheridan, Caroline; Zhou, Xi Kathy; Zhang, Tuo; Formenti, Silvia C.; Sims, Jennifer S.; Alonso, Alicia; Demaria, Sandra Share Save A PAN-CANCER MULTI-OMIC IMMUNE SINGLE-CELL ATLAS FOR CANCER IMMUNOTHERAPY: FOCUS ON CD4+T CELLSMok, Lydia; Orlando, Andrea; Lehrer, Julian; Stuart, Joshua; Rudqvist, Nils-Petter; Vincent, Benjamin; Monette, Anne; Senbabaoglu, Yasin; Smith, Kellie; Thomas, Paul; Tschernia, Nicholas; Thorsson, Vesteinn; Zappasodi, Roberta; Jonsson, Vanessa Share Save DISCOVERY OF A PUBLIC HPV16-E6 DIRECTED T CELL RESPONSE THAT IS ASSOCIATED WITH OVERALL AND PROGRESSION FREE SURVIVALSzymonowicz, Klaudia A.; Jiang, Bo; Cheung, Laurene; Xiao, Weihong; Halliday, Alexa J.; Bontekoe, Emily; Akagi, Keiko; Lizee, Gregory; Smith, Kellie; Gillison, Maura; Rudqvist, Nils-Petter Share Save ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancerHsieh, Rodney Cheng-En; Krishnan, Sunil; Wu, Ren-Chin; Boda, Akash R.; Liu, Arthur; Winkler, Michelle; Hsu, Wen-Hao; Lin, Steven Hsesheng; Hung, Mien-Chie; Chan, Li-Chuan; Bhanu, Krithikaa Rajkumar; Srinivasamani, Anupallavi; De Azevedo, Ricardo Alexandre; Chou, Yung-Chih; DePinho, Ronald A.; Gubin, Matthew; Vilar, Eduardo; Chen, Chao Hsien; Slay, Ravaen; Jayaprakash, Priyamvada; Hegde, Shweta Mahendra; Hartley, Genevieve; Lea, Spencer T.; Prasad, Rishika; Morrow, Brittany; Couillault, Coline Agnes; Steiner, Madeline; Wang, Chun-Chieh; Venkatesulu, Bhanu Prasad; Taniguchi, Cullen; Kim, Yon Son Betty; Chen, Junjie; Rudqvist, Nils-Petter; Curran, Michael A. Share Save Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancerWennerberg, Erik; Mukherjee, Sumit; Spada, Sheila; Hung, Clarey; Agrusa, Christopher J.; Chen, Chuang; Valeta-Magara, Amanda; Rudqvist, Nils-Petter; Van Nest, Samantha J.; Kamel, Mohamed K.; Nasar, Abu; Narula, Navneet; Mittal, Vivek; Markowitz, Geoffrey J.; Zhou, Xi Kathy; Adusumilli, Prasad S.; Borczuk, Alain C.; White, Thomas E.; Khan, Abdul G.; Balderes, Paul J.; Lorenz, Ivo C.; Altorki, Nasser; Demaria, Sandra; McGraw, Timothy E.; Stiles, Brendon M. Share Save Share Save T-Cell Receptor Profiling and Prognosis After Stereotactic Body Radiation Therapy For Stage I Non-Small-Cell Lung CancerWu, Lirong; Zhu, Jun; Rudqvist, Nils-Petter; Welsh, James; Lee, Percy; Liao, Zhongxing; Xu, Ting; Jiang, Ming; Zhu, Xiangzhi; Pan, Xuan; Li, Pansong; Zhou, Zhipeng; He, Xia; Yin, Rong; Feng, Jifeng Share Save Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor controlLhuillier, Claire; Rudqvist, Nils-Petter; Yamazaki, Takahiro; Zhang, Tuo; Charpentier, Maud; Galluzzi, Lorenzo; Dephoure, Noah; Clement, Cristina C.; Santambrogio, Laura; Zhou, Xi Kathy; Formenti, Silvia C.; Demaria, Sandra Share Save RADIOTHERAPY AND CTLA-4 BLOCKADE EXPAND ANTITUMOR T CELLS DIFFERENTIATION STATES AND COOPERATE WITH CD40 AGONIST TO INDUCE TUMOR REJECTIONRudqvist, Nils; Lhuillier, Claire; Charpentier, Maud; Wennerberg, Erik; Spada, Sheila; Sheridan, Caroline; Zhou, Xi Kathy; Zhang, Tuo; Sims, Jennifer; Alonso, Alicia; Demaria, Sandra Share Save Share Save CONSTRUCTION OF THE IMMUNE LANDSCAPE OF DURABLE RESPONSE TO CHECKPOINT BLOCKADE THERAPY BY INTEGRATING PUBLICLY AVAILABLE DATASETSRudqvist, Nils-Petter; Zappasodi, Roberta; Wells, Daniel; Thorsson, Vesteinn; Cogdill, Alexandria; Monette, Anne; Najjar, Yana; Sweis, Randy; Wennerberg, Erik; Bommareddy, Praveen; Haymaker, Cara; Khan, Uqba; McGee, Heather; Park, Wungki; Sater, Houssein Abdul; Spencer, Christine; Tschernia, Nicholas; Ascierto, Maria; Barsan, Valentin; Popat, Vinita; Valpione, Sara; Vincent, Benjamin Share Save Share Save Share Save Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude miceSpetz, Johan; Langen, Britta; Rudqvist, Nils-Petter; Parris, Toshima Z.; Shubbar, Emman; Dalmo, Johanna; Waengberg, Bo; Nilsson, Ola; Helou, Khalil; Forssell-Aronsson, Eva Share Save Radiotherapy induces responses of lung cancer to CTLA-4 blockadeFormenti, Silvia C.; Rudqvist, Nils-Petter; Golden, Encouse; Cooper, Benjamin; Wennerberg, Erik; Lhuillier, Claire; Vanpouille-Box, Claire; Friedman, Kent; de Andrade, Lucas Ferrari; Wucherpfennig, Kai W.; Heguy, Adriana; Imai, Naoko; Gnjatic, Sacha; Emerson, Ryan O.; Zhou, Xi Kathy; Zhang, Tuo; Chachoua, Abraham; Demaria, Sandra Share Save Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapySpetz, Johan; Rudqvist, Nils; Langen, Britta; Parris, Toshima Z.; Dalmo, Johanna; Schuller, Emil; Wangberg, Bo; Nilsson, Ola; Helou, Khalil; Forssell-Aronsson, Eva Share Save 
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