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SaveDrug-tolerant persisting polyploid giant cancer cells mediate resistance to HER2-targeting antibody-drug conjugates
Yazdi, Narjes; Pourjamal, Negar; Katainen, Riku; Vaananen, Juho; Dai, Jun; Vaharautio, Anna; Isola, Jorma; Kempas, Minna; Le Joncour, Vadim; Laakkonen, Pirjo; Joensuu, Heikki; Barok, Mark Share Save Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumoursMartin, Samantha; Katainen, Riku; Taira, Aurora; Valimaki, Niko; Ristimaki, Ari; Seppala, Toni; Renkonen-Sinisalo, Laura; Lepisto, Anna; Tahkola, Kyosti; Mattila, Anne; Koskensalo, Selja; Mecklin, Jukka-Pekka; Rajamaki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A. Share Save Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in FinlandNurminen, Riikka; Afyounian, Ebrahim; Paunu, Niina; Katainen, Riku; Isomaki, Mari; Nurminen, Anssi; Scaravilli, Mauro; Tolppanen, Jenni; Fey, Vidal; Kivinen, Anni; Helen, Pauli; Valimaki, Niko; Kesseli, Juha; Aaltonen, Lauri A.; Haapasalo, Hannu; Nykter, Matti; Rautajoki, Kirsi J. Share Save Lower incidence of small intestinal adenocarcinomas may be due to constrained copy number karyotype and increased immune surveillanceNowinski, Salpie; Balarajah, Vickna; Baker, Ann-Marie; Katainen, Riku; Hughes, Christine; Guo, Qingli; Zapata, Luis; Lakatos, Eszter; Kocher, Hemant M.; Graham, Trevor A. Share Save APOBEC mutagenesis is a common process in normal human small intestineWang, Yichen; Robinson, Philip S.; Coorens, Tim H. H.; Moore, Luiza; Lee-Six, Henry; Noorani, Ayesha; Sanders, Mathijs A.; Jung, Hyunchul; Katainen, Riku; Heuschkel, Robert; Brunton-Sim, Roxanne; Weston, Robyn; Read, Debbie; Nobbs, Beverley; Fitzgerald, Rebecca C.; Saeb-Parsy, Kourosh; Martincorena, Inigo; Campbell, Peter J.; Rushbrook, Simon; Zilbauer, Matthias; Buczacki, Simon James Alexander; Stratton, Michael R. Share Save Share Save Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal CancerRajamaki, Kristiina; Taira, Aurora; Katainen, Riku; Valimaki, Niko; Kuosmanen, Anna; Plaketti, Roosa-Maria; Seppala, Toni T.; Ahtiainen, Maarit; Wirta, Erkki-Ville; Vartiainen, Emilia; Sulo, Paivi; Ravantti, Janne; Lehtipuro, Suvi; Granberg, Kirsi J.; Nykter, Matti; Tanskanen, Tomas; Ristimaki, Ari; Koskensalo, Selja; Renkonen-Sinisalo, Laura; Lepisto, Anna; Bohm, Jan; Taipale, Jussi; Mecklin, Jukka-Pekka; Aavikko, Mervi; Palin, Kimmo; Aaltonen, Lauri A. Share Save Share Save WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomasAavikko, Mervi; Kaasinen, Eevi; Andersson, Noora; Pentinmikko, Nalle; Sulo, Paivi; Donner, Iikki; Pihlajamaa, Paivi; Kuosmanen, Anna; Bramante, Simona; Katainen, Riku; Sipila, Lauri J.; Martin, Samantha; Arola, Johanna; Carpen, Olli; Heiskanen, Ilkka; Mecklin, Jukka-Pekka; Taipale, Jussi; Ristimaki, Ari; Lehti, Kaisa; Gucciardo, Erika; Katajisto, Pekka; Schalin-Jantti, Camilla; Vahteristo, Pia; Aaltonen, Lauri A. Share Save No evidence of EMAST in whole genome sequencing data from 248 colorectal cancersKondelin, Johanna; Martin, Samantha; Katainen, Riku; Renkonen-Sinisalo, Laura; Lepisto, Anna; Koskensalo, Selja; Bohm, Jan; Mecklin, Jukka-Pekka; Cajuso, Tatiana; Hanninen, Ulrika A.; Valimaki, Niko; Ravantti, Janne; Rajamaki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A. Share Save Colibactin DNA-damage signature indicates mutational impact in colorectal cancerDziubanska-Kusibab, Paulina J.; Berger, Hilmar; Battistini, Federica; Bouwman, Britta A. M.; Iftekhar, Amina; Katainen, Riku; Cajuso, Tatiana; Crosetto, Nicola; Orozco, Modesto; Aaltonen, Lauri A.; Meyer, Thomas F. Share Save Retrotransposon insertions can initiate colorectal cancer and are associated with poor survivalCajuso, Tatiana; Sulo, Paivi; Tanskanen, Tomas; Katainen, Riku; Taira, Aurora; Hanninen, Ulrika A.; Kondelin, Johanna; Forsstrom, Linda; Valimaki, Niko; Aavikko, Mervi; Kaasinen, Eevi; Ristimaki, Ari; Koskensalo, Selja; Lepisto, Anna; Renkonen-Sinisalo, Laura; Seppala, Toni; Kuopio, Teijo; Bohm, Jan; Mecklin, Jukka-Pekka; Kilpivaara, Outi; Pitkanen, Esa; Palin, Kimmo; Aaltonen, Lauri A. Share Save Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancersHanninen, Ulrika A.; Wirta, Erkki-Ville; Katainen, Riku; Tanskanen, Tomas; Hamberg, Jiri; Taipale, Minna; Bohm, Jan; Renkonen-Sinisalo, Laura; Lepisto, Anna; Forsstrom, Linda M.; Pitkanen, Esa; Palin, Kimmo; Seppala, Toni T.; Makinen, Netta; Mecklin, Jukka-Pekka; Aaltonen, Lauri A. Share Save Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humansKaasinen, Eevi; Kuismin, Outi; Rajamaki, Kristiina; Ristolainen, Heikki; Aavikko, Mervi; Kondelin, Johanna; Saarinen, Silva; Berta, Davide G.; Katainen, Riku; Hirvonen, Elina A. M.; Karhu, Auli; Taira, Aurora; Tanskanen, Tomas; Alkodsi, Amjad; Taipale, Minna; Morgunova, Ekaterina; Franssila, Kaarle; Lehtonen, Rainer; Makinen, Markus; Aittomaki, Kristiina; Palotie, Aarno; Kurki, Mitja, I; Pietilainen, Olli; Hilpert, Morgane; Saarentaus, Elmo; Niinimaki, Jaakko; Junttila, Juhani; Kaikkonen, Kari; Vahteristo, Pia; Skoda, Radek C.; Seppanen, Mikko R. J.; Eklund, Kari K.; Taipale, Jussi; Kilpivaara, Outi; Aaltonen, Lauri A. Share Save Share Save Contribution of allelic imbalance to colorectal cancerPalin, Kimmo; Pitkanen, Esa; Turunen, Mikko; Sahu, Biswajyoti; Pihlajamaa, Paivi; Kivioja, Teemu; Kaasinen, Eevi; Valimaki, Niko; Hanninen, Ulrika A.; Cajuso, Tatiana; Aavikko, Mervi; Tuupanen, Sari; Kilpivaara, Outi; van den Berg, Linda; Kondelin, Johanna; Tanskanen, Tomas; Katainen, Riku; Grau, Marta; Rauanheimo, Heli; Plaketti, Roosa-Maria; Taira, Aurora; Sulo, Paivi; Hartonen, Tuomo; Dave, Kashyap; Schmierer, Bernhard; Botla, Sandeep; Sokolova, Maria; Vaharautio, Anna; Gladysz, Kornelia; Ongen, Halit; Dermitzakis, Emmanouil; Bramsen, Jesper Bertram; Orntoft, Torben Falck; Andersen, Claus Lindbjerg; Ristimaki, Ari; Lepisto, Anna; Renkonen-Sinisalo, Laura; Mecklin, Jukka-Pekka; Taipale, Jussi; Aaltonen, Lauri A. Share Save Identification of predisposing genes for small bowel adenocarcinoma by exome sequencingHanninen, Ulrika A.; Katainen, Riku; Tanskanen, Tomas; Hamberg, Jiri; Ristimaki, Ari; Pukkala, Eero; Taipale, Minna; Mecklin, Jukka-Pekka; Aavikko, Mervi; Forsstrom, Linda M.; Pitkanen, Esa; Makinen, Netta; Aaltonen, Lauri A. Share Save Exome-wide somatic mutation characterization of small bowel adenocarcinomaHanninen, Ulrika A.; Katainen, Riku; Tanskanen, Tomas; Plaketti, Roosa-Maria; Leine, Riku; Hamberg, Jiri; Ristimaki, Ari; Pukkala, Eero; Taipale, Minna; Mecklin, Jukka-Pekka; Forsstrom, Linda M.; Pitkanen, Esa; Palin, Kimmo; Valimaki, Niko; Makinen, Netta; Aaltonen, Lauri A. Share Save Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencingPradhan, Barun; Cajuso, Tatiana; Katainen, Riku; Sulo, Paivi; Tanskanen, Tomas; Kilpivaara, Outi; Pitkanen, Esa; Aaltonen, Lauri A.; Kauppi, Liisa; Palin, Kimmo Share Save 
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