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G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1 Exposito, Francisco; Redrado, Miriam; Serrano, Diego; Calabuig-Farinas, Silvia; Bao-Caamano, Aida; Gallach, Sandra; Jantus-Lewintre, Eloisa; Diaz-Lagares, Angel; Rodriguez-Casanova, Aitor; Sandoval, Juan; San Jose-Eneriz, Edurne; Garcia, Javier; Redin, Esther; Senent, Yaiza; Leon, Sergio; Pio, Ruben; Lopez, Rafael; Oyarzabal, Julen; Pineda-Lucena, Antonio; Agirre, Xabier; Montuenga, Luis M.; Prosper, Felipe; Calvo, Alfonso Share Save
BET inhibitors downregulate the expression of the essentiallncRNA SMILO in multiple myeloma through regulation of the transcription factor FLI1 Gomez-Echarte, Nahia; San Jose-Eneriz, Edurne; Carrasco-Leon, Arantxa; Barrena, Naroa; Miranda, Estibaliz; Garate, Leire; Garcia-Torre, Beatriz; Alonso-Moreno, Sandra; Gimenez-Camino, Naroa; Urizar-Compains, Estibaliz; Olaverri-Mendizabal, Danel; Aguirre-Ruiz, Paula; Ariceta, Benat; Tamariz-Amador, Luis-Esteban; Rodriguez-Otero, Paula; Planes, Francisco J.; Belver, Laura; Martin-Subero, Jose Ignacio; Prosper, Felipe; Agirre, Xabier Share Save
Epigenetic-based differentiation therapy for Acute Myeloid Leukemia San Jose-Eneriz, Edurne; Gimenez-Camino, Naroa; Rabal, Obdulia; Garate, Leire; Miranda, Estibaliz; Gomez-Echarte, Nahia; Garcia, Fernando; Charalampopoulou, Stella; Saez, Elena; Vilas-Zornoza, Amaia; San Martin-Uriz, Patxi; Valcarcel, Luis V.; Barrena, Naroa; Alignani, Diego; Tamariz-Amador, Luis Esteban; Perez-Ruiz, Ana; Hilscher, Sebastian; Schutkowski, Mike; Alfonso-Pierola, Ana; Martinez-Calle, Nicolas; Larrayoz, Maria Jose; Paiva, Bruno; Calasanz, Maria Jose; Munoz, Javier; Isasa, Marta; Martin-Subero, Jose Ignacio; Pineda-Lucena, Antonio; Oyarzabal, Julen; Agirre, Xabier; Prosper, Felipe Share Save
Modulation of tumor microenvironment by targeting histone acetylation in bladder cancer Nunes, Sandra P.; Morales, Lucia; Rubio, Carolina; Munera-Maravilla, Ester; Lodewijk, Iris; Suarez-Cabrera, Cristian; Martinez, Victor G.; Perez-Escavy, Mercedes; Perez-Crespo, Miriam; Sanchez, Miguel Alonso; Montesinos, Esther; San Jose-Eneriz, Edurne; Agirre, Xabier; Prosper, Felipe; Pineda-Lucena, Antonio; Henrique, Rui; Duenas, Marta; Correia, Margareta P.; Jeronimo, Carmen; Paramio, Jesus M. Share Save
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Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma De Beck, Lien; Awad, Robin Maximilian; Basso, Veronica; Casares, Noelia; De Ridder, Kirsten; De Vlaeminck, Yannick; Gnata, Alessandra; Goyvaerts, Cleo; Lecocq, Quentin; San Jose-Eneriz, Edurne; Verhulst, Stefaan; Maes, Ken; Vanderkerken, Karin; Agirre, Xabier; Prosper, Felipe; Lasarte, Juan Jose; Mondino, Anna; Breckpot, Karine Share Save
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma Rabal, Obdulia; San Jose-Eneriz, Edurne; Agirre, Xabier; Antonio Sanchez-Arias, Juan; de Miguel, Irene; Ordonez, Raquel; Garate, Leire; Miranda, Estibaliz; Saez, Elena; Vilas-Zornoza, Amaia; Pineda-Lucena, Antonio; Estella, Ander; Zhang, Feifei; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease Garcia-Gomez, Antonio; Li, Tianlu; de la Calle-Fabregat, Carlos; Rodriguez-Ubreva, Javier; Ciudad, Laura; Catala-Moll, Francesc; Godoy-Tena, Gerard; Martin-Sanchez, Montserrat; San-Segundo, Laura; Muntion, Sandra; Morales, Xabier; Ortiz-de-Solorzano, Carlos; Oyarzabal, Julen; San Jose-Eneriz, Edurne; Esteller, Manel; Agirre, Xabier; Prosper, Felipe; Garayoa, Mercedes; Ballestar, Esteban Share Save
Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma Ordonez, Raquel; Kulis, Marta; Russinol, Nuria; Chapaprieta, Vicente; Carrasco-Leon, Arantxa; Garcia-Torre, Beatriz; Charalampopoulou, Stella; Clot, Guillem; Beekman, Renee; Meydan, Cem; Duran-Ferrer, Marti; Verdaguer-Dot, Nuria; Vilarrasa-Blasi, Roser; Soler-Vila, Paula; Garate, Leire; Miranda, Estibaliz; San Jose-Eneriz, Edurne; Rodriguez-Madoz, Juan R.; Ezponda, Teresa; Martinez-Turrilas, Rebeca; Vilas-Zornoza, Amaia; Lara-Astiaso, David; Dupere-Richer, Daphne; Martens, Joost H. A.; El-Omri, Halima; Taha, Ruba Y.; Calasanz, Maria J.; Paiva, Bruno; San Miguel, Jesus; Flicek, Paul; Gut, Ivo; Melnick, Ari; Mitsiades, Constantine S.; Licht, Jonathan D.; Campo, Elias; Stunnenberg, Hendrik G.; Agirre, Xabier; Prosper, Felipe; Martin-Subero, Jose, I Share Save
Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression Segovia, Cristina; San Jose-Eneriz, Edurne; Munera-Maravilla, Ester; Martinez-Fernandez, Monica; Garate, Leire; Miranda, Estibaliz; Vilas-Zornoza, Amaia; Lodewijk, Iris; Rubio, Carolina; Segrelles, Carmen; Vitores Valcarcel, Luis; Rabal, Obdulia; Casares, Noelia; Bernardini, Alejandra; Suarez-Cabrera, Cristian; Lopez-Calderon, Fernando F.; Fortes, Puri; Casado, Jose A.; Duenas, Marta; Villacampa, Felipe; Jose Lasarte, Juan; Guerrero-Ramos, Felix; de Velasco, Guillermo; Oyarzabal, Julen; Castellano, Daniel; Agirre, Xabier; Prosper, Felipe; Paramio, Jesus M. Share Save
Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma Barcena-Varela, Marina; Caruso, Stefano; Llerena, Susana; Alvarez-Sola, Gloria; Uriarte, Iker; Latasa, M. Ujue; Urtasun, Raquel; Rebouissou, Sandra; Alvarez, Laura; Jimenez, Maddalen; Santamaria, Eva; Rodriguez-Ortigosa, Carlos; Mazza, Giuseppe; Rombouts, Krista; San Jose-Eneriz, Edurne; Rabal, Obdulia; Agirre, Xabier; Iraburu, Maria; Santos-Laso, Alvaro; Banales, Jesus M.; Zucman-Rossi, Jessica; Prosper, Felipe; Oyarzabal, Julen; Berasain, Carmen; Avila, Matias A.; Fernandez-Barrena, Maite G. Share Save
Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy Rabal, Obdulia; San Jose-Eneriz, Edurne; Agirre, Xabier; Antonio Sanchez-Arias, Juan; Vilas-Zornoza, Amaia; Ugarte, Ana; de Miguel, Irene; Miranda, Estibaliz; Garate, Leire; Fraga, Mario; Santamarina, Pablo; Fernandez Perez, Raul; Ordonez, Raquel; Saez, Elena; Roa, Sergio; Jose Garcia-Barchino, Maria; Angel Martinez-Climent, Jose; Liu, Yingying; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces Rabal, Obdulia; Antonio Sanchez-Arias, Juan; San Jose-Eneriz, Edurne; Agirre, Xabier; de Miguel, Irene; Garate, Leire; Miranda, Estibaliz; Saez, Elena; Roa, Sergio; Angel Martinez-Climent, Jose; Liu, Yingying; Wu, Wei; Xu, Musheng; Prosper, Felipe; Oyarzabal, Julen Share Save
In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer Pey, Jon; San Jose-Eneriz, Edurne; Carmen Ochoa, Maria; Apaolaza, Inigo; de Atauri, Pedro; Rubio, Angel; Cendoya, Xabier; Miranda, Estibaliz; Garate, Leire; Cascante, Marta; Carracedo, Arkaitz; Agirre, Xabier; Prosper, Felipe; Planes, Francisco J. Share Save
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Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies San Jose-Eneriz, Edurne; Agirre, Xabier; Rabal, Obdulia; Vilas-Zornoza, Amaia; Sanchez-Arias, Juan A.; Miranda, Estibaliz; Ugarte, Ana; Roa, Sergio; Paiva, Bruno; Estella-Hermoso de Mendoza, Ander; Maria Alvarez, Rosa; Casares, Noelia; Segura, Victor; Martin-Subero, Jose I.; Ogi, Francois-Xavier; Soule, Pierre; Santiveri, Clara M.; Campos-Olivas, Ramon; Castellano, Giancarlo; Fernandez de Barrena, Maite Garcia; Roberto Rodriguez-Madoz, Juan; Jose Garcia-Barchino, Maria; Jose Lasarte, Juan; Avila, Matias A.; Angel Martinez-Climent, Jose; Oyarzabal, Julen; Prosper, Felipe Share Save
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers Agirre, Xabier; Castellano, Giancarlo; Pascual, Marien; Heath, Simon; Kulis, Marta; Segura, Victor; Bergmann, Anke; Esteve, Anna; Merkel, Angelika; Raineri, Emanuele; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Russinol, Nuria; Queiros, Ana C.; Beekman, Renee; Rodriguez-Madoz, Juan R.; San Jose-Eneriz, Edurne; Fang, Fang; Gutierrez, Norma C.; Garcia-Verdugo, Jose M.; Robson, Michael I.; Schirmer, Eric C.; Guruceaga, Elisabeth; Martens, Joost H. A.; Gut, Marta; Calasanz, Maria J.; Flicek, Paul; Siebert, Reiner; Campo, Elias; San Miguel, Jesus F.; Melnick, Ari; Stunnenberg, Hendrik G.; Gut, Ivo G.; Prosper, Felipe; Martin-Subero, Jose I. Share Save
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