Not logged in USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer Kumari, Nishi; Wright, Sarah C. E.; Witham, Christopher M.; Monserrat, Laia; Palafox, Marta; Richard, John L. C.; Costa, Carlotta; Elkabets, Moshe; Agostino, Mark; Klemm, Theresa; Eccles, Melissa; Garnham, Alex; Wu, Ting; Nilsson, Jonas A.; Walz, Nikita; Venugopal, Veena; Cerra, Anthony; Vasilevski, Natali; Bridgeman, Stephanie; Bassi, Sona; Saei, Azad; Helal, Moutaz; Neundorf, Philipp; Riedel, Angela; Rosenfeldt, Mathias; Gill, Jespal; Pahor, Nikolett; Hartmann, Oliver; Chung, Jacky; Sidhu, Sachdev S.; Moderau, Nina; Jha, Sudhakar; Rodon, Jordi; Diefenbacher, Markus E.; Komander, David; Serra, Violeta; Eichhorn, Pieter Johan Adam Share Save
Targeting CCR7-PI3K? overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbo, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D.; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G.; Chiono, Valeria; Kamm, Roger D.; Hirsch, Emilio; Koch, Raphael; Weinstock, David M.; Aster, Jon C.; Voena, Claudia; Chiarle, Roberto Share Save
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models Jacob, Sheeba; Turner, Tia H.; Cai, Jinyang; Floros, Konstantinos V.; Yu, Ann K.; Coon, Colin M.; Khatri, Rishabh; Alzubi, Mohammad A.; Jakubik, Charles T.; Bouck, Ynes M.; Puchalapalli, Madhavi; Shende, Mayuri; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Hu, Bin; Harrell, J. Chuck; Benes, Cyril H.; Koblinski, Jennifer E.; Costa, Carlotta; Faber, Anthony C. Share Save
The perivascular niche protects ALK plus lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis Mastini, Cristina; Campisi, Marco; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Peola, Silvia; Martinengo, Cinzia; Patrucco, Enrico; Mota, Ines; Arrigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Chiono, Valeria; Kamm, Roger D.; Hirsch, Emilio; Aster, Jon C.; Voena, Claudia; Chiarle, Roberto Share Save
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms Wang, Ye; Mohseni, Morvarid; Grauel, Angelo; Diez, Javier Estrada; Guan, Wei; Liang, Simon; Choi, Jiyoung Elizabeth; Pu, Minying; Chen, Dongshu; Laszewski, Tyler; Schwartz, Stephanie; Gu, Jane; Mansur, Leandra; Burks, Tyler; Brodeur, Lauren; Velazquez, Roberto; Kovats, Steve; Pant, Bhavesh; Buruzula, Giri; Deng, Emily; Chen, Julie T.; Sari-Sarraf, Farid; Dornelas, Christina; Varadarajan, Malini; Yu, Haiyan; Liu, Chen; Lim, Joanne; Hao, Huai-Xiang; Jiang, Xiaomo; Malamas, Anthony; LaMarche, Matthew J.; Geyer, Felipe Correa; McLaughlin, Margaret; Costa, Carlotta; Wagner, Joel; Ruddy, David; Jayaraman, Pushpa; Kirkpatrick, Nathaniel D.; Zhang, Pu; Iartchouk, Oleg; Aardalen, Kimberly; Cremasco, Viviana; Dranoff, Glenn; Engelman, Jeffrey A.; Silver, Serena; Wang, Hongyun; Hastings, William D.; Goldoni, Silvia Share Save
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ka inhibitors in breast cancer Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan Share Save
Genomic screening reveals UBA1 as a potent and druggable target in diverse models of triple negative breast cancer Jacob, Sheeba; Turner, Tia H.; Yu, Ann K.; Coon, Colin M.; Alzubi, Mohammad A.; Jakubik, Charles T.; Bouck, Ynes; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Koblinski, Jennifer; Harrell, Joshua C.; Benes, Cyril H.; Costa, Carlotta; Faber, Anthony C. Share Save
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James R.; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan Share Save
NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 Dastur, Anahita; Choi, Ahyun; Costa, Carlotta; Yin, Xunqin; Williams, August; McClanaghan, Joseph; Greenberg, Max; Roderick, Justine; Patel, Neha U.; Boisvert, Jessica; McDermott, Ultan; Garnett, Mathew J.; Almenara, Jorge; Grant, Steven; Rizzo, Kathryn; Engelman, Jeffrey A.; Kelliher, Michelle; Faber, Anthony C.; Benes, Cyril H. Share Save
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Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy Floros, Konstantinos V.; Lochmann, Timothy L.; Hu, Bin; Monterrubio, Carles; Hughes, Mark T.; Wells, Jason D.; Bernado Morales, Cristina; Ghotra, Maninderjit S.; Costa, Carlotta; Souers, Andrew J.; Boikos, Sosipatros A.; Leverson, Joel D.; Tan, Ming; Serra, Violeta; Koblinski, Jennifer E.; Arribas, Joaquin; Prat, Aleix; Pare, Laia; Miller, Todd W.; Dozmorov, Mikhail G.; Harada, Hisashi; Windle, Brad E.; Scaltriti, Maurizio; Faber, Anthony C. Share Save
Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression Lochmann, Timothy L.; Floros, Konstantinos V.; Naseri, Mitra; Powell, Krista M.; Cook, Wade; March, Ryan J.; Stein, Giovanna T.; Greninger, Patricia; Maves, Yuki Kato; Saunders, Laura R.; Dylla, Scott J.; Costa, Carlotta; Boikos, Sosipatros A.; Leverson, Joel D.; Souers, Andrew J.; Krystal, Geoffrey W.; Harada, Hisashi; Benes, Cyril H.; Faber, Anthony C. Share Save
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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Ferraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Kodack, David P.; Askoxylakis, Vasileios; Ferraro, Gino B.; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Z. Alexander; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Yongchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina S. F.; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, C. Ryan; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Monica V.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save
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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor Jia, Yong; Juarez, Jose; Li, Jie; Manuia, Mari; Niederst, Matthew J.; Tompkins, Celin; Timple, Noelito; Vaillancourt, Mei-Ting; Pferdekamper, AnneMarie Culazzo; Lockerman, Elizabeth L.; Li, Chun; Anderson, Jennifer; Costa, Carlotta; Liao, Debbie; Murphy, Eric; DiDonato, Michael; Bursulaya, Badry; Lelais, Gerald; Barretina, Jordi; McNeill, Matthew; Epple, Robert; Marsilje, Thomas H.; Pathan, Nuzhat; Engelman, Jeffrey A.; Michellys, Pierre-Yves; McNamara, Peter; Harris, Jennifer; Bender, Steven; Kasibhatla, Shailaja Share Save
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition Hata, Aaron N.; Niederst, Matthew J.; Archibald, Hannah L.; Gomez-Caraballo, Maria; Siddiqui, Faria M.; Mulvey, Hillary E.; Maruvka, Yosef E.; Ji, Fei; Bhang, Hyo-eun C.; Radhakrishna, Viveksagar Krishnamurthy; Siravegna, Giulia; Hu, Haichuan; Raoof, Sana; Lockerman, Elizabeth; Kalsy, Anuj; Lee, Dana; Keating, Celina L.; Ruddy, David A.; Damon, Leah J.; Crystal, Adam S.; Costa, Carlotta; Piotrowska, Zofia; Bardelli, Alberto; Iafrate, Anthony J.; Sadreyev, Ruslan I.; Stegmeier, Frank; Getz, Gad; Sequist, Lecia V.; Faber, Anthony C.; Engelman, Jeffrey A. Share Save
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