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Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in PIK3CA-mutant breast cancer Alves, Carla L.; Karimi, Leena; Terp, Mikkel G.; Jakobsen, Mie K.; Zhou, Fiona H.; Policastro, Benedetta; Nissen, Nikoline; Johansen, Lene E.; Ravnsborg, Tina; Eshraghi, Leila; Tamboowala, Sana; Jensen, Ole N.; Lim, Elgene; Ditzel, Henrik J. Share Save
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Targeting P4HA1 promotes CD8+T cell progenitor expansion toward immune memory and systemic anti-tumor immunity Ma, Shijun; Ong, Li-Teng; Jiang, Zemin; Lee, Wee Chyan; Lee, Puay Leng; Yusuf, Mubaraka; Ditzel, Henrik J.; Wang, Yulan; Chen, Qingfeng; Wang, Wenyu; Wu, Xiaojian; Tan, Ern Yu; Yu, Qiang Share Save
RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER plus breast cancer Kindt, Charlotte K.; Ehmsen, Sidse; Traynor, Sofie; Policastro, Benedetta; Nissen, Nikoline; Jakobsen, Mie K.; Hundebol, Monique F.; Johansen, Lene E.; Bak, Martin; Arbajian, Elsa; Staaf, Johan; Ditzel, Henrik J.; Alves, Carla L. Share Save
Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition Jakobsen, Mie K.; Traynor, Sofie; Nielsen, Aaraby Y.; Dahl, Christina; Staehr, Mette; Jakobsen, Simon T.; Madsen, Maria S.; Siersbaek, Rasmus; Terp, Mikkel G.; Jensen, Josefine B.; Pedersen, Christina B.; Shrestha, Anup; Brewer, Jonathan R.; Duijf, Pascal H. G.; Gammelgaard, Odd L.; Ditzel, Henrik J.; Kirkin, Alexei F.; Guldberg, Per; Gjerstorff, Morten F. Share Save
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Gastrin-releasing peptide receptor as theranostic target in estrogen-receptor positive breast cancer: A preclinical study of the theranostic pair [55Co]Co- and [177Lu]Lu-DOTA-RM26 Baun, Christina; Olsen, Birgitte Brinkmann; Alves, Carla Maria Lourenco; Ditzel, Henrik Jorn; Terp, Mikkel; Hildebrandt, Malene Grubbe; Poulsen, Charlotte Aaberg; Ge, Lorraine Gaenaelle; Gammelsrod, Vigga Sand; Orlova, Anna; Dam, Johan Hygum; Thisgaard, Helge Share Save
Association between Geriatric 8 frailty and health-related quality of life in older patients with cancer (PROGNOSIS-G8): a Danish single-centre, prospective cohort study Ditzel, Helena Mogelbjerg; Giger, Ann-Kristine Weber; Lund, Cecilia Margareta; Ditzel, Henrik Jorn; Moeller, Soeren; Pfeiffer, Per; Ryg, Jesper; Ewertz, Marianne; Jorgensen, Trine Lembrecht Share Save
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Genomic alterations associated with resistance and circulating tumor DNA dynamics for early detection of progression on CDK4/6 inhibitor in advanced breast cancer Kindt, Charlotte K.; Alves, Carla L.; Ehmsen, Sidse; Kragh, Amalie; Reinert, Thomas; Vogsen, Marianne; Kodahl, Annette R.; Ronlev, Jeanette D.; Ardik, Dilan; Sorensen, Anna L.; Evald, Kirstine; Clemmensen, Mia L.; Staaf, Johan; Ditzel, Henrik J. Share Save
Single-cell sequencing unveils extensive intratumoral heterogeneity of cancer/testis antigen expression in melanoma and lung cancer Traynor, Sofie; Jakobsen, Mie K.; Green, Tina M.; Komic, Hana; Palarasah, Yaseelan; Pedersen, Christina B.; Ditzel, Henrik J.; Thoren, Fredrik B.; Guldberg, Per; Gjerstorff, Morten F. Share Save
Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with anti-PDL1 therapy effectively inhibits triple-negative breast cancer growth and metastasis Gammelgaard, Odd L.; Terp, Mikkel G.; Kirkin, Alexei F.; Johansen, Simone; Traynor, Sofie; Vever, Henriette; Guldberg, Per; Kodahl, Annette R.; Gjerstorff, Morten F.; Ditzel, Henrik J. Share Save
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BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors Bertran-Alamillo, Jordi; Gimenez-Capitan, Ana; Roman, Ruth; Talbot, Sara; Whiteley, Rebecca; Floc'h, Nicolas; Martinez-Perez, Elizabeth; Martin, Matthew J.; Smith, Paul D.; Sullivan, Ivana; Terp, Mikkel G.; Saeh, Jamal; Marino-Buslje, Cristina; Fabbri, Giulia; Guo, Grace; Xu, Man; Tornador, Cristian; Aguilar-Hernandez, Andres; Reguart, Noemi; Ditzel, Henrik J.; Martinez-Bueno, Alejandro; Nabau-Moreto, Nuria; Gasco, Amaya; Rosell, Rafael; Pease, J. Elizabeth; Polanska, Urszula M.; Travers, Jon; Urosevic, Jelena; Molina-Vila, Miguel A. Share Save
Macrophage CD5L is a target for cancer immunotherapy Sanchez-Moral, Lidia; Paul, Tony; Martori, Clara; Font-Diaz, Joan; Sanjurjo, Lucia; Aran, Gemma; Tellez, Erica; Blanco, Julia; Carrillo, Jorge; Ito, Masaoki; Tuttolomondo, Martina; Ditzel, Henrik J.; Fumagalli, Caterina; Tapia, Gustavo; Sidorova, Julia; Masnou, Helena; Fernandez-Sanmartin, Marco-Antonio; Lozano, Juan-Jose; Vilaplana, Cristina; Rodriguez-Cortes, Alheli; Armengol, Carolina; Valledor, Annabel F.; Kremer, Leonor; Sarriasa, Maria-Rosa Share Save
Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor Karimi, Leena; Alves, Carla L.; Terp, Mikkel G.; Tuttolomondo, Martina; Portman, Neil; Ehmsen, Sidse; Johansen, Lene E.; Bak, Martin; Lim, Elgene; Ditzel, Henrik J. Share Save
DNA methyltransferase inhibition promotes recruitment of myeloid-derived suppressor cells to the tumor microenvironment through induction of tumor cell-intrinsic interleukin-1 Traynor, Sofie; Terp, Mikkel Green; Nielsen, Aaraby Yoheswaran; Guldberg, Per; Jakobsen, Mie; Pedersen, Pernille Gejl; Gammelgaard, Odd Lilleng; Pedersen, Christina Bog; Pedersen, Mathilde Thybo; Rattenborg, Sofie; Ditzel, Henrik Jorn; Gjerstorff, Morten Frier Share Save
Danish translation and validation of the Geriatric 8 and the modified Geriatric 8 screening tools Ditzel, Helena Mogelbjerg; Giger, Ann-Kristine Weber; Olloni, Agon; Brockhattingen, Kristoffer Kittelmann; Lund, Cecilia Margareta; Ditzel, Henrik Jorn; Pfeiffer, Per; Ewertz, Marianne; Ryg, Jesper; Jorgensen, Trine Lembrecht Share Save
Quantitative Phosphoproteomics of the Angiotensin AT2-Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis Peluso, A. Augusto B.; Kempf, Stefan J.; Verano-Braga, Thiago; Rodrigues-Ribeiro, Lucas; Johansen, Lene Egedal; Hansen, Mie Rytz; Kitlen, Gitte; Haugaard, Andreas Houe; Sumners, Colin; Ditzel, Henrik J.; Santos, Robson A.; Bader, Michael; Larsen, Martin R.; Steckelings, U. Muscha Share Save
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