Not logged in Functionally Characterizing the Renal Cell Carcinoma Tumor-Immune Microenvironment via Patient-Derived Ex Vivo Models Sirc, Neja; Smolander, Johannes; Kumari, Anita N.; Liu, Jianyin; Lee, Moon Hee; Lahdensuo, Kanerva; Jarvinen, Riikka; Tornberg, Sara V.; Lin, Linh; Laitinen, Hanna K.; Theodoropoulos, Jason; Klievink, Jay; Mirtti, Tuomas; Kreutzman, Anna S.; Haikala, Heidi M.; Jarvinen, Petrus; Mustjoki, Satu; Peltonen, Karita Share Save
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Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses Turpin, Rita; Peltonen, Karita; Rannikko, Jenna H.; Liu, Ruixian; Kumari, Anita N.; Nicorici, Daniel; Lee, Moon Hee; Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo; Mattson, Johanna; Jarvinen, Petrus; Lahdensuo, Kanerva; Jarvinen, Riikka; Tornberg, Sara; Mirtti, Tuomas; Bostrom, Pia; Koskivuo, Ilkka; Thotakura, Anil; Pouwels, Jeroen; Hollmen, Maija; Mustjoki, Satu; Klefstroem, Juha Share Save
Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma Poloske, Daniel; Sorger, Helena; Schoenbichler, Anna; de Araujo, Elvin D.; Neubauer, Heidi A.; Orlova, Anna; Timonen, Sanna H.; Abdallah, Diaaeldin I.; Ianevski, Aleksandr; Kuusanmaki, Heikki; Surbek, Marta; Heyes, Elisabeth; Eder, Thomas; Wagner, Christina; Suske, Tobias; Metzelder, Martin L.; Bergmann, Michael; Dahlhoff, Maik; Grebien, Florian; Fleck, Roman; Pirker, Christine; Berger, Walter; Hadzijusufovic, Emir; Sperr, Wolfgang R.; Kenner, Lukas; Valent, Peter; Aittokallio, Tero; Herling, Marco; Mustjoki, Satu; Gunning, Patrick T.; Moriggl, Richard Share Save
Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response Warfvinge, Rebecca; Ulfsson, Linda Geironson; Dhapola, Parashar; Safi, Fatemeh; Sommarin, Mikael; Soneji, Shamit; Hjorth-Hansen, Henrik; Mustjoki, Satu; Richter, Johan; Thakur, Ram Krishna; Karlsson, Goran Share Save
Computational Cytomorphological Analyses Identifies Bone Marrow Erythroblast Proportion As a Biomarker of Treatment-Free Remission in CML Purhonen, Mikko; Tatun, Mikael; Hung, Kevin; Tafjord, Oda; Adnan-Awad, Shady; Koskenvesa, Perttu; Siitonen, Sanna; Porkka, Kimmo; Mustjoki, Satu; Danielsson, Signe; Hjorth-Hansen, Henrik; Olsson-Stromberg, Ulla; Kumagai, Takashi; Kimura, Shinya; Ross, David M.; Bruck, Oscar E. Share Save
Predicting Antigen-Specific T Cell Immunity Against Wilms Tumor 1 in Hematologic Cancer Jokinen, Emmi; Ford, Brittany; Huuhtanen, Jani; Forsten, Sofia; Klievink, Jay; Antignani, Gabriella; Bruck, Oscar E.; Cerullo, Vincenzo; Peltonen, Karita; Mustjoki, Satu Share Save
Ex vivo modeling of precision immuno-oncology responses in lung cancer Alsaed, Bassel; Smolander, Johannes; Laitinen, Hanna; Lin, Linh; Bobik, Nina; Lahtinen, Lilja; Rasanen, Mikko; Jansouz, Shadi; Peltonen, Karita; Jokinen, Emmi; Klievink, Jay; Ganesh, Keerthana; Ainola, Mari; Sutinen, Eva; Ronty, Mikko; Narvi, Elli; Thotakura, Anil; Saharinen, Pipsa; Mustjoki, Satu; Ilonen, Ilkka; Haikala, Heidi M. Share Save
Phase II study of nivolumab and relatlimab utilizing single cell analysis of circulating T cells reveals immune features associated with response to dual PD-1 and LAG-3 inhibition Dollar, J. J.; Decatur, C.; Salazar, S.; Cetta, N.; Huuhtanen, J.; Estevez, C.; Cruz, A.; Durante, M.; Mustjoki, S.; Correa, Z.; Harbour, J. W.; Lutzky, J. Share Save
Somatic mutations associate with clonal expansion of CD8+ T cells Lundgren, Sofie; Myllymaki, Mikko; Jarvinen, Timo; Keraenen, Mikko A. I.; Theodoropoulos, Jason; Smolander, Johannes; Kim, Daehong; Salmenniemi, Urpu; Walldin, Gunilla; Savola, Paula; Kelkka, Tiina; Rajala, Hanna; Hellstroem-Lindberg, Eva; Itala-Remes, Maija; Kankainen, Matti; Mustjoki, Satu Share Save
Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia Awad, Shady Adnan; Dufva, Olli; Klievink, Jay; Karjalainen, Ella; Ianevski, Aleksandr; Pietarinen, Paavo; Kim, Daehong; Potdar, Swapnil; Wolf, Maija; Lotfi, Kourosh; Aittokallio, Tero; Wennerberg, Krister; Porkka, Kimmo; Mustjoki, Satu Share Save
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia Suske, Tobias; Sorger, Helena; Manhart, Gabriele; Ruge, Frank; Prutsch, Nicole; Zimmerman, Mark W.; Eder, Thomas; Abdallah, Diaaeldin I.; Maurer, Barbara; Wagner, Christina; Schoenefeldt, Susann; Spirk, Katrin; Pichler, Alexander; Pemovska, Tea; Schweicker, Carmen; Poeloeske, Daniel; Hubanic, Emina; Jungherz, Dennis; Mueller, Tony Andreas; Aung, Myint Myat Khine; Orlova, Anna; Pham, Ha Thi Thanh; Zimmel, Kerstin; Krausgruber, Thomas; Bock, Christoph; Mueller, Mathias; Dahlhoff, Maik; Boersma, Auke; Ruelicke, Thomas; Fleck, Roman; Araujo, Elvin Dominic de; Gunning, Patrick Thomas; Aittokallio, Tero; Mustjoki, Satu; Sanda, Takaomi; Hartmann, Sylvia; Grebien, Florian; Hoermann, Gregor; Haferlach, Torsten; Staber, Philipp Bernhard; Neubauer, Heidi Anne; Look, Alfred Thomas; Herling, Marco; Moriggl, Richard Share Save
Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment Turpin, Rita; Liu, Ruixian; Munne, Pauliina M.; Peura, Aino; Rannikko, Jenna H.; Philips, Gino; Boeckx, Bram; Salmelin, Natasha; Hurskainen, Elina; Suleymanova, Ilida; Aung, July; Vuorinen, Elisa M.; Lehtinen, Laura; Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo J.; Mattson, Johanna; Mustjoki, Satu; Saavalainen, Paeivi; Goga, Andrei; Lambrechts, Diether; Pouwels, Jeroen; Hollmen, Maija; Klefstrom, Juha Share Save
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Correction: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial (Jan, 10.1038/s41375-024-02145-6 , 2024) Flygt, Hjalmar; Soederlund, Stina; Richter, Johan; Saussele, Susanne; Koskenvesa, Perttu; Stenke, Leif; Mustjoki, Satu; Dimitrijevic, Andreja; Stentoft, Jesper; Majeed, Waleed; Roy, Lydia; Wolf, Dominik; Dreimane, Arta; Gjertsen, Bjorn Tore; Gedde-Dahl, Tobias; Ahlstrand, Erik; Markevaern, Berit; Hjorth-Hansen, Henrik; Janssen, Jeroen; Olsson-Stroemberg, Ulla Share Save
Tracing back primed resistance in cancer via sister cells Dai, Jun; Zheng, Shuyu; Falco, Matias M.; Bao, Jie; Eriksson, Johanna; Pikkusaari, Sanna; Forsten, Sofia; Jiang, Jing; Wang, Wenyu; Gao, Luping; Perez-Villatoro, Fernando; Dufva, Olli; Saeed, Khalid; Wang, Yinyin; Amiryousefi, Ali; Farkkila, Anniina; Mustjoki, Satu; Kauppi, Liisa; Tang, Jing; Vaharautio, Anna Share Save
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial Flygt, Hjalmar; Soederlund, Stina; Richter, Johan; Saussele, Susanne; Koskenvesa, Perttu; Stenke, Leif; Mustjoki, Satu; Dimitrijevic, Andreja; Stentoft, Jesper; Majeed, Waleed; Roy, Lydia; Wolf, Dominik; Dreimane, Arta; Gjertsen, Bjorn Tore; Gedde-Dahl, Tobias; Ahlstrand, Erik; Markevaern, Berit; Hjorth-Hansen, Henrik; Janssen, Jeroen; Olsson-Stroemberg, Ulla Share Save
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