Not logged inBreadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
Li, Dapeng; Martinez, David R.; Schafer, Alexandra; Chen, Haiyan; Barr, Maggie; Sutherland, Laura L.; Lee, Esther; Parks, Robert; Mielke, Dieter; Edwards, Whitney; Newman, Amanda; Bock, Kevin W.; Minai, Mahnaz; Nagata, Bianca M.; Gagne, Matthew; Douek, Daniel; DeMarco, C. Todd; Denny, Thomas N.; Oguin, Thomas H., III; Brown, Alecia; Rountree, Wes; Wang, Yunfei; Mansouri, Katayoun; Edwards, Robert J.; Ferrari, Guido; Sempowski, Gregory D.; Eaton, Amanda; Tang, Juanjie; Cain, Derek W.; Santra, Sampa; Pardi, Norbert; Weissman, Drew; Tomai, Mark; Fox, Christopher; Moore, Ian N.; Andersen, Hanne; Lewis, Mark G.; Golding, Hana; Khurana, Surender; Seder, Robert; Baric, Ralph S.; Montefiori, David C.; Saunders, Kevin O.; Haynes, Barton F. .png)
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SaveStabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infectionSaunders, Kevin O.; Edwards, Robert J.; Tilahun, Kedamawit; Manne, Kartik; Lu, Xiaozhi; Cain, Derek W.; Wiehe, Kevin; Williams, Wilton B.; Mansouri, Katayoun; Hernandez, Giovanna E.; Sutherland, Laura; Scearce, Richard; Parks, Robert; Barr, Maggie; DeMarco, Todd; Eater, Chloe M.; Eaton, Amanda; Morton, Georgeanna; Mildenberg, Benjamin; Wang, Yunfei; Rountree, R. Wes; Tomai, Mark A.; Fox, Christopher B.; Moody, M. Anthony; Alam, S. Munir; Santra, Sampa; Lewis, Mark G.; Denny, Thomas N.; Shaw, George M.; Montefiori, David C.; Acharya, Priyamvada; Haynes, Barton F. Share Save Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates (Dec, 10.1038/s41541-02100307-6, 2020)Saunders, Kevin O.; Pardi, Norbert; Parks, Robert; Santra, Sampa; Mu, Zekun; Sutherland, Laura; Scearce, Richard; Barr, Maggie; Eaton, Amanda; Hernandez, Giovanna; Goodman, Derrick; Hogan, Michael J.; Tombacz, Istvan; Gordon, David N.; Rountree, R. Wes; Wang, Yunfei; Lewis, Mark G.; Pierson, Theodore C.; Barbosa, Chris; Tam, Ying; Matyas, Gary R.; Rao, Mangala; Beck, Zoltan; Shen, Xiaoying; Ferrari, Guido; Tomaras, Georgia D.; Montefiori, David C.; Weissman, Drew; Haynes, Barton F. Share Save The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccinationTomalka, Jeffrey Alan; Pelletier, Adam Nicolas; Fourati, Slim; Latif, Muhammad Bilal; Sharma, Ashish; Furr, Kathryn; Carlson, Kevin; Lifton, Michelle; Gonzalez, Ana; Wilkinson, Peter; Franchini, Genoveffa; Parks, Robert; Letvin, Norman; Yates, Nicole; Seaton, Kelly; Tomaras, Georgia; Tartaglia, Jim; Robb, Merlin L.; Michael, Nelson L.; Koup, Richard; Haynes, Barton; Santra, Sampa; Sekaly, Rafick Pierre Share Save Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primatesCai, Fangping; Chen, Wei-Hung; Wu, Weimin; Jones, Julia A.; Choe, Misook; Gohain, Neelakshi; Shen, Xiaoying; LaBranche, Celia; Eaton, Amanda; Sutherland, Laura; Lee, Esther M.; Hernandez, Giovanna E.; Wu, Nelson R.; Scearce, Richard; Seaman, Michael S.; Moody, M. Anthony; Santra, Sampa; Wiehe, Kevin; Tomaras, Georgia D.; Wagh, Kshitij; Korber, Bette; Bonsignori, Mattia; Montefiori, David C.; Haynes, Barton F.; de Val, Natalia; Joyce, M. Gordon; Saunders, Kevin O. Share Save Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primatesSaunders, Kevin O.; Pardi, Norbert; Parks, Robert; Santra, Sampa; Mu, Zekun; Sutherland, Laura; Scearce, Richard; Barr, Maggie; Eaton, Amanda; Hernandez, Giovanna; Goodman, Derrick; Hogan, Michael J.; Tombacz, Istvan; Gordon, David N.; Rountree, R. Wes; Wang, Yunfei; Lewis, Mark G.; Pierson, Theodore C.; Barbosa, Chris; Tam, Ying; Shen, Xiaoying; Ferrari, Guido; Tomaras, Georgia D.; Montefiori, David C.; Weissman, Drew; Haynes, Barton F. Share Save Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal centerEslamizar, Leila; Petrovas, Constantinos; Leggat, David J.; Furr, Kathryn; Lifton, Michelle L.; Levine, Gail; Ma, Steven; Fletez-Brant, Christopher; Hoyland, Wesley; Prabhakaran, Madhu; Narpala, Sandeep; Boswell, Kristin; Yamamoto, Takuya; Liao, Hua-Xin; Pickup, David; Ramsburg, Elizabeth; Sutherland, Laura; McDermott, Adrian; Roederer, Mario; Montefiori, David; Koup, Richard A.; Haynes, Barton F.; Letvin, Norman L.; Santra, Sampa Share Save Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency VirusesBerendam, Stella J.; Styles, Tiffany M.; Morgan-Asiedu, Papa K.; Tenney, DeAnna; Kumar, Amit; Obregon-Perko, Veronica; Bar, Katharine J.; Saunders, Kevin O.; Santra, Sampa; De Paris, Kristina; Tomaras, Georgia D.; Chahroudi, Ann; Permar, Sallie R.; Amara, Rama R.; Fouda, Genevieve G. Share Save Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 EnvsBlasi, Maria; Negri, Donatella; Saunders, Kevin O.; Baker, Erich J.; Stadtler, Hannah; LaBranche, Celia; Mildenberg, Benjamin; Morton, Georgeanna; Ciarla, Andrew; Shen, Xiaoying; Wang, Yunfei; Rountree, Wes; Balakumaran, Bala; Santra, Sampa; Haynes, Barton F.; Moody, Anthony M.; Cara, Andrea; Klotman, Mary E. Share Save Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaquesBlasi, Maria; Wescott, Elizabeth C.; Baker, Erich J.; Mildenberg, Benjamin; LaBranche, Celia; Rountree, Wes; Haynes, Barton F.; Saunders, Kevin O.; Moody, M. Anthony; Negri, Donatella; Santra, Sampa; Cara, Andrea; Klotman, Mary E. Share Save Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisitionGorini, Giacomo; Fourati, Slim; Vaccari, Monica; Rahman, Mohammad Arif; Gordon, Shari N.; Brown, Dallas R.; Law, Lynn; Chang, Jean; Green, Richard; Barrenas, Fredrik; Liyanage, Namal P. M.; Doster, Melvin N.; Schifanella, Luca; Bissa, Massimiliano; de Castro, Isabela Silva; Washington-Parks, Robyn; Galli, Veronica; Fuller, Deborah H.; Santra, Sampa; Agy, Michael; Pal, Ranajit; Palermo, Robert E.; Tomaras, Georgia D.; Shen, Xiaoying; LaBranche, Celia C.; Montefiori, David C.; Venzon, David J.; Trinh, Hung, V; Rao, Mangala; Gale, Michael, Jr.; Sekaly, Rafick P.; Franchini, Genoveffa Share Save Immune checkpoint modulation enhances HIV-1 antibody inductionBradley, Todd; Kuraoka, Masayuki; Yeh, Chen-Hao; Tian, Ming; Chen, Huan; Cain, Derek W.; Chen, Xuejun; Cheng, Cheng; Ellebedy, Ali H.; Parks, Robert; Barr, Maggie; Sutherland, Laura L.; Scearce, Richard M.; Bowman, Cindy M.; Bouton-Verville, Hilary; Santra, Sampa; Wiehe, Kevin; Lewis, Mark G.; Ogbe, Ane; Borrow, Persephone; Montefiori, David; Bonsignori, Mattia; Moody, M. Anthony; Verkoczy, Laurent; Saunders, Kevin O.; Ahmed, Rafi; Mascola, John R.; Kelsoe, Garnett; Alt, Frederick W.; Haynes, Barton F. Share Save Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope ImmunizationHan, Qifeng; Bradley, Todd; Williams, Wilton B.; Cain, Derek W.; Montefiori, David C.; Saunders, Kevin O.; Parks, Robert J.; Edwards, Regina W.; Ferrari, Guido; Mueller, Olaf; Shen, Xiaoying; Wiehe, Kevin J.; Reed, Steven; Fox, Christopher B.; Rountree, Wes; Vandergrift, Nathan A.; Wang, Yunfei; Sutherland, Laura L.; Santra, Sampa; Moody, M. Anthony; Permar, Sallie R.; Tomaras, Georgia D.; Lewis, Mark G.; Van Rompay, Koen K. A.; Haynes, Barton F. Share Save Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacyChamcha, Venkateswarlu; Reddy, Pradeep B. J.; Kannanganat, Sunil; Wilkins, Courtney; Gangadhara, Sailaja; Velu, Vijayakumar; Green, Richard; Law, G. Lynn; Chang, Jean; Bowen, James R.; Kozlowski, Pamela A.; Lifton, Michelle; Santra, Sampa; Legere, Traci; Chea, Lynette S.; Chennareddi, Lakshmi; Yu, Tianwei; Suthar, Mehul S.; Silvestri, Guido; Derdeyn, Cynthia A.; Gale, Michael, Jr.; Villinger, Francois; Hunter, Eric; Amara, Rama Rao Share Save IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cellsBlasi, Maria; Negri, Donatella; LaBranche, Celia; Alam, S. Munir; Baker, Erich J.; Brunner, Elizabeth C.; Gladden, Morgan A.; Michelini, Zuleika; Vandergrift, Nathan A.; Wiehe, Kevin J.; Parks, Robert; Shen, Xiaoying; Bonsignori, Mattia; Tomaras, Georgia D.; Ferrari, Guido; Montefiori, David C.; Santra, Sampa; Haynes, Barton F.; Moody, Michael A.; Cara, Andrea; Klotman, Mary E. Share Save A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challengeMadani, Navid; Princiotto, Amy M.; Linh Mach; Ding, Shilei; Prevost, Jeremie; Richard, Jonathan; Hora, Bhavna; Sutherland, Laura; Zhao, Connie A.; Conn, Brandon P.; Bradley, Todd; Moody, M. Anthony; Melillo, Bruno; Finzi, Andres; Haynes, Barton F.; Smith, Amos B., III; Santra, Sampa; Sodroski, Joseph Share Save Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman PrimatesSaunders, Kevin O.; Santra, Sampa; Parks, Robert; Yates, Nicole L.; Sutherland, Laura L.; Scearce, Richard M.; Balachandran, Harikrishnan; Bradley, Todd; Goodman, Derrick; Eaton, Amanda; Stanfield-Oakley, Sherry A.; Tartaglia, James; Phogat, Sanjay; Pantaleo, Giuseppe; Esteban, Mariano; Gomez, Carmen E.; Perdiguero, Beatriz; Jacobs, Bertram; Kibler, Karen; Korber, Bette; Montefiori, David C.; Ferrari, Guido; Vandergrift, Nathan; Liao, Hua-Xin; Tomaras, Georgia D.; Haynes, Barton F. Share Save Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal ModelsSaunders, Kevin O.; Verkoczy, Laurent K.; Jiang, Chuancang; Zhang, Jinsong; Parks, Robert; Chen, Haiyan; Housman, Max; Bouton-Verville, Hilary; Shen, Xiaoying; Trama, Ashley M.; Scearce, Richard; Sutherland, Laura; Santra, Sampa; Newman, Amanda; Eaton, Amanda; Xu, Kai; Georgiev, Ivelin S.; Joyce, M. Gordon; Tomaras, Georgia D.; Bonsignori, Mattia; Reed, Steven G.; Salazar, Andres; Mascola, John R.; Moody, M. Anthony; Cain, Derek W.; Centlivre, Mireille; Zurawski, Sandra; Zurawski, Gerard; Erickson, Harold P.; Kwong, Peter D.; Alam, S. Munir; Levy, Yves; Montefiori, David C.; Haynes, Barton F. Share Save Initiation of HIV neutralizing B cell lineages with sequential envelope immunizationsWilliams, Wilton B.; Zhang, Jinsong; Jiang, Chuancang; Nicely, Nathan I.; Fera, Daniela; Luo, Kan; Moody, M. Anthony; Liao, Hua-Xin; Alam, S. Munir; Kepler, Thomas B.; Ramesh, Akshaya; Wiehe, Kevin; Holland, James A.; Bradley, Todd; Vandergrift, Nathan; Saunders, Kevin O.; Parks, Robert; Foulger, Andrew; Xia, Shi-Mao; Bonsignori, Mattia; Montefiori, David C.; Louder, Mark; Eaton, Amanda; Santra, Sampa; Scearce, Richard; Sutherland, Laura; Newman, Amanda; Bouton-Verville, Hilary; Bowman, Cindy; Bomze, Howard; Gao, Feng; Marshall, Dawn J.; Whitesides, John F.; Nie, Xiaoyan; Kelsoe, Garnett; Reed, Steven G.; Fox, Christopher B.; Clary, Kim; Koutsoukos, Marguerite; Franco, David; Mascola, John R.; Harrison, Stephen C.; Haynes, Barton F.; Verkoczy, Laurent Share Save Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challengeBradley, Todd; Pollara, Justin; Santra, Sampa; Vandergrift, Nathan; Pittala, Srivamshi; Bailey-Kellogg, Chris; Shen, Xiaoying; Parks, Robert; Goodman, Derrick; Eaton, Amanda; Balachandran, Harikrishnan; Mach, Linh V.; Saunders, Kevin O.; Weiner, Joshua A.; Scearce, Richard; Sutherland, Laura L.; Phogat, Sanjay; Tartaglia, Jim; Reed, Steven G.; Hu, Shiu-Lok; Theis, James F.; Pinter, Abraham; Montefiori, David C.; Kepler, Thomas B.; Peachman, Kristina K.; Rao, Mangala; Michael, Nelson L.; Suscovich, Todd J.; Alter, Galit; Ackerman, Margaret E.; Moody, M. Anthony; Liao, Hua-Xin; Tomaras, Georgia; Ferrari, Guido; Korber, Bette T.; Haynes, Barton F. Share Save 
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