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Shigeki Higashiyama

Osaka International Cancer Institute

70H-index
362Paper Count
1.9WCitation Count
Published Papers 135
Publication Date
A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING
err2026-05-27
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errTsumugi Shoji; Ayumi Shinojima; Takuma Kishimoto; Kanako Sato; Nana Ikegami; Eisuke Yumoto; Ruri Shindo; Yasunori Uchida; Satoshi Kusumi; Daisuke Koga; Eiji Yamamoto; Yoshinori Hirano; Ryo Ogino; Hirofumi Shibata; Kazushi Izawa; Takahiro Yasumi; Ryota Sato; Jun Nakayama; Shigeki Higashiyama; Junya Hasegawa; Hiroaki Kajiho; Takehiko Sasaki; Yoshihiko Kuchitsu; Tomohiko Taguchi
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KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death
err2025-07-01
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errOAAI
errKyosuke Habu; Yosuke Matsuoka; Hiromi Hiyoshi; Jun Nakayama; Katsuya Watanabe; Sota Tate; Tomohisa Sakaue; Junko Murai; Konomu Uno; Hirotada Nishie; Eiji Kubota; Hiromi Kataoka; Takashi Joh; Yuji Watanabe; Taro Oshikiri; Shigeki Higashiyama
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Implication of KLHL Gene Family Member KLHL5 in Colorectal Cancer Progression and Prognosis
err2025-06-12
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errOAAI
errKonomu Uno; Hirotada Nishie; Hiromi Hiyoshi; Kyosuke Habu; Jun Nakayama; Sota Tate; Tomohisa Sakaue; Eiji Kubota; Mamoru Tanaka; Takaya Shimura; Hiromi Kataoka; Takashi Joh; Shigeki Higashiyama
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Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2
err2025-03-03
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errOAAI
errNakayama, Hironao; Murakami, Akari; Nishida-Fukuda, Hisayo; Fukuda, Shinji; Matsugi, Erina; Nakahara, Masako; Kusumoto, Chiaki; Kamei, Yoshiaki; Higashiyama, Shigeki
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Vesicles Secreted by Renal Cell Carcinoma Cells Cause Vascular Endothelial Cells to Express PSMA and Drive Tumor Progression
errCELLS
IF5.2
err2025-01-22
err0
errOAAI
errWatanabe, Ryuta; Kagimoto, Keito; Chosei, Mami; Sakaue, Tomohisa; Kurata, Mie; Miura, Noriyoshi; Kitazawa, Riko; Kikugawa, Tadahiko; Higashiyama, Shigeki; Saika, Takashi
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MS4A3 Serves As a Biomarker Reflecting the Lineage Differentiation and Metabolic Status of Human Acute Myeloid Leukemia Cells
errBLOOD
IF23.1
err2024-11-05
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PREAI
errKasahara, Hidenori; Yokota, Takafumi; Nakayama, Jun; Shi, Henyun; Imagawa, Yusuke; Hiratsuka, Toru; Takano, Keiko; Shingai, Yasuhiro; Higashiyama, Shigeki
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Naked mole-rat TMEM2 lacks physiological hyaluronan-degrading activity
err2024-09-01
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errOAAI
errSato, Shinya; Mizutani, Yukiko; Abe, Minori; Fukuda, Shinji; Higashiyama, Shigeki; Inoue, Shintaro
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Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
err2024-07-03
err2
errOAAI
errOnji, Hiroshi; Tate, Sota; Sakaue, Tomohisa; Fujiwara, Kohei; Nakano, Shiho; Kawaida, Miho; Onishi, Nobuyuki; Matsumoto, Takashi; Yamagami, Wataru; Sugiyama, Takashi; Higashiyama, Shigeki; Pommier, Yves; Kobayashi, Yusuke; Murai, Junko
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Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
err2023-07-18
err6
errOAAI
errHarada, Yoichiro; Mizote, Yu; Suzuki, Takehiro; Hirayama, Akiyoshi; Ikeda, Satsuki; Nishida, Mikako; Hiratsuka, Toru; Ueda, Ayaka; Imagawa, Yusuke; Maeda, Kento; Ohkawa, Yuki; Murai, Junko; Freeze, Hudson H.; Miyoshi, Eiji; Higashiyama, Shigeki; Udono, Heiichiro; Dohmae, Naoshi; Tahara, Hideaki; Taniguchi, Naoyuki
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Bioprosthetic Valve Deterioration Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium
err2023-07-01
err7
errOAAI
errSakaue, Tomohisa; Koyama, Tadaaki; Nakamura, Yoshitsugu; Okamoto, Keitaro; Kawashima, Takayuki; Umeno, Tadashi; Nakayama, Yasuhide; Miyamoto, Shinji; Shikata, Fumiaki; Hamaguchi, Mika; Aono, Jun; Kurata, Mie; Namiguchi, Kenji; Uchita, Shunji; Masumoto, Junya; Yamaguchi, Osamu; Higashiyama, Shigeki; Izutani, Hironori
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BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing
err2023-06-01
err3
errOAAI
errTanaka, Miruto; Nakamura, Shinsuke; Sakaue, Tomohisa; Yamamoto, Takumi; Maekawa, Masashi; Nishinaka, Anri; Yasuda, Hiroto; Yunoki, Kaori; Sato, Yuji; Sawa, Masaaki; Yoshino, Kohichiro; Shimazawa, Masamitsu; Hatano, Masahiko; Tokuhisa, Takeshi; Higashiyama, Shigeki; Hara, Hideaki
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Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/ CEMIP) and HAS2 expression
err2023-06-01
err9
errOAAI
errSato, Shinya; Miyazaki, Megumi; Fukuda, Shinji; Mizutani, Yukiko; Mizukami, Yoichi; Higashiyama, Shigeki; Inoue, Shintaro
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Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer
err2023-04-01
err2
errOAAI
errHayashi, Yusuke; Nakayama, Jun; Yamamoto, Mizuki; Maekawa, Masashi; Watanabe, Shinya; Higashiyama, Shigeki; Inoue, Jun-ichiro; Yamamoto, Yusuke; Semba, Kentaro
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Phenotypic analysis of Meltrin α (ADAM12)-deficient mice:: Involvement of Meltrin α in adipogenesis and myogenesis
err2023-03-27
err142
errOAAI
errKurisaki, T; Masuda, A; Sudo, K; Sakagami, J; Higashiyama, S; Matsuda, Y; Nagabukuro, A; Tsuji, A; Nabeshima, Y; Asano, M; Iwakura, Y; Sehara-Fujisawa, A
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Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
err2023-01-06
err13
errOAAI
errMuto, Jun; Fukuda, Shinji; Watanabe, Kenji; Dai, Xiuju; Tsuda, Teruko; Kiyoi, Takeshi; Kameda, Kenji; Kawakami, Ryosuke; Mori, Hideki; Shiraishi, Ken; Murakami, Masamoto; Imamura, Takeshi; Higashiyama, Shigeki; Fujisawa, Yasuhiro; Mizukami, Yoichi; Sayama, Koji
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Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma
err2022-09-05
err6
errOAAI
errSeefried, Felix; Haller, Lucia; Fukuda, Shinji; Thongmao, Aranya; Schneider, Nadja; Utikal, Jochen; Higashiyama, Shigeki; Bosserhoff, Anja Katrin; Kuphal, Silke
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A novel mechanism of phosphatase activation for EGFR by Cullin-3/KCTD10 ubiquitin E3 complex in HER2-positive breast cancer cells
err2022-02-15
err0
PREAI
errNishiyama, Kanako; Maekawa, Masashi; Murakami, Akari; Utsunomiya, Kaho; Takemoto, Kana; Kusakabe, Erina; Noda, Haruna; Aoki, Reina; Taguchi, Kana; Yamashita, Michiko; Nakagita, Tomoya; Nakayama, Jun; Chosei, Mami; Kiyoi, Takeshi; Kamei, Yoshiaki; Takeda, Hiroyuki; Takada, Yasutsugu; Higashiyama, Shigeki
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CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP
err2021-06-29
err10
errOAAI
errNishiyama, Kanako; Maekawa, Masashi; Nakagita, Tomoya; Nakayama, Jun; Kiyoi, Takeshi; Chosei, Mami; Murakami, Akari; Kamei, Yoshiaki; Takeda, Hiroyuki; Takada, Yasutsugu; Higashiyama, Shigeki
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Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices
err2021-05-18
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errOAAI
errSuzuki, Tatsuo; Terada, Nobuo; Higashiyama, Shigeki; Kametani, Kiyokazu; Shirai, Yoshinori; Honda, Mamoru; Kai, Tsutomu; Li, Weidong; Tabuchi, Katsuhiko
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