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S

Stephen F. Traynelis

Emory University

85H-index
336Paper Count
3.0WCitation Count
Published Papers 160
Publication Date
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A Subunit-Selective Negative Allosteric Modulator of GluN1/GluN3A Glycine-Activated Receptor
errMolecular Pharmacology
IF3
err2026-01-29
err0
errOAAI
errLeon Jacobs; TrangKimberly T. Nguyen; Adam McCallum; Matt P. Epplin; Riley E. Perszyk; Scott J. Myers; Ken Liu; Yanli Yang; Aletta E. Van der Westhuyzen; Kelsey A. Nocilla; James Allen; Elijah Z. Ullman; Ding Liu; Yufei Du; Hongjie Yuan; Dennis C. Liotta; Stephen F. Traynelis
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Correction: GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy
errMolecular Psychiatry
IF10.1
err2026-01-07
err0
errOAAI
errJohannes R. Lemke; Andrea Eoli; Ilona Krey; Bernt Popp; Vincent Strehlow; Dirk A. Wittekind; Anna-Leena Vuorinen; Hesham M. Aldhalaan; Sarah Baer; Anne de Saint Martin; Trine B. Hammer; Isabella Herman; Frauke Hornemann; Trine Ingebrigtsen; Damien Lederer; Gaetan Lesca; Dana Marafie; Mikael Mathot; Jill A. Rosenfeld; Rikke S. Møller; Helenius J. Schelhaas; Chelsey Stillman; Alessandro Orsini; Anup D. Patel; Juliette Piard; Pierangelo Veggiotti; Danique R. M. Vlaskamp; Sarah Weckhuysen; Stephen F. Traynelis; Tim A. Benke; Henrike O. Heyne; Steffen Syrbe
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errSave
Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency
errEpilepsia
IF6.6
err2026-01-01
err0
errOAAI
errKarnstedt, Maike; Perszyk, Riley E.; Myers, Scott J.; Mcdaniels, Ellington; Somorai, Marta; Borggraefe, Ingo; Veenma, Danielle C. M.; Schoonjans, An-sofie; Striano, Pasquale; Fantaneanu, Tadeu A.; Syrbe, Steffen; Park, Kristen; Chen, Wenjuan; Yuan, Hongjie; Traynelis, Stephen F.; Benke, Timothy A.; Lemke, Johannes R.; Krey, Ilona
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errSave
Mechanism of conductance control and neurosteroid binding in NMDA receptors
errNature
IF48.5
err2025-10-29
err0
PREAI
errHyunook Kang; Ruben Steigerwald; Elijah Z. Ullman; Max Epstein; Srinu Paladugu; Dennis C. Liotta; Stephen F. Traynelis; Hiro Furukawa
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errSave
GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy
errMolecular Psychiatry
IF10.1
err2025-10-14
err0
errOAAI
errJohannes R. Lemke; Andrea Eoli; Ilona Krey; Bernt Popp; Vincent Strehlow; Dirk A. Wittekind; Anna-Leena Vuorinen; Hesham M. Aldhalaan; Sarah Baer; Anne de Saint Martin; Trine B. Hammer; Isabella Herman; Frauke Hornemann; Trine Ingebrigtsen; Damien Lederer; Gaetan Lesca; Dana Marafie; Mikael Mathot; Jill A. Rosenfeld; Rikke S. Møller; Helenius J. Schelhaas; Chelsey Stillman; Alessandro Orsini; Anup D. Patel; Juliette Piard; Pierangelo Veggiotti; Danique R. M. Vlaskamp; Sarah Weckhuysen; Stephen F. Traynelis; Tim A. Benke; Henrike O. Heyne; Steffen Syrbe
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errSave
Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation
errThe Journal of Physiology
IF0
err2025-10-06
err0
errOAAI
errHao Xing; Tue G. Banke; Lu Zhang; Kuai Yu; Chad R. Camp; Russell G. Fritzemeier; Nicholas S. Akins; Srinu Paladugu; Paul J. Arcoria; Brian R. Brady; Olga Prikhodko; Matthew J. Kennedy; Dennis C. Liotta; Hongjie Yuan; Stephen F. Traynelis
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errSave
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil
errBrain
IF11.7
err2025-09-25
err0
errOAAI
errTue G Banke; Michael C Regan; Riley E Perszyk; Lu Zhang; Hao Xing; Jiahui Chen; Sehoon Won; Noriko Simorowski; Eva S Diaz; Sukhan Kim; Rui Song; Jian Rong; Xin Zhou; Ahmad F Chaudhary; Jing Zhang; John F Traynelis; Ellington D McDaniels; Karolina Nitsche; Steve Roache; Christopher S Raymond; Chian-Ming Low; Scott J Myers; Katherine W Roche; Steven H Liang; Stephen F Traynelis; Hiro Furukawa; Hongjie Yuan
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errSave
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy
errBRAIN
IF11.7
err2025-09-01
err1
PREAI
errTeoh, Jiajie; Simko, Jane; Camp, Chad R.; Liu, Christine J.; Wang, Wanqi; Williams, Damian J.; Ma, Liang; Soundararajan, Divyalakshmi; Martin, Caryn; Taylor, Noah K.; Francois, Ekniel; Petri, Sabrina; Kanber, Ayla; Ravichandra, Aishwarya; Pero, Maria Elena; Bartolini, Francesca; Swayne, Theresa C.; Lutz, Cathleen M.; Zuberi, Aamir; Rubinstein, Moran; Hausman-Kedem, Moran; Yuan, Hongjie; Gelinas, Jennifer N.; Sands, Tristan T.; Harper, Scott Q.; Traynelis, Stephen F.; Makinson, Christopher D.; Frankel, Wayne N.
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errSave
Striatal GluN2A gene suppression reduces L-DOPA-induced abnormal involuntary movements in parkinsonian rats.
errNeuropharmacology
IF4.6
err2025-07-29
err0
PREAI
errTaiki Yabumoto; Brik A. Kochoian; Stefano Coletta; Oskar Laur; Xinping Huang; Cassandra A. Bure; Christopher Ware; Peng Jin; Stephen F. Traynelis; Stella M. Papa
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errSave
The thrombin receptor PAR1 orchestrates changes in lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury
errcardiovascular research
IF10.8
err2025-07-17
err0
errOAAI
errChou Chou; Camila Ceballos Paredes; Barbara Summers; Jade Palmer-Johnson; Anjali Trivedi; Aneel Bhagwani; Kasper B. Hansen; Anders S. Kristensen; Stefka Gyoneva; Sharon A. Swanger; Stephen F. Traynelis; Hasina Outtz Reed
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Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl-d-Aspartate Receptor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-21
err0
PREAI
errFritzemeier, Russell G.; Akins, Nicholas S.; Arcoria, Paul J.; Paladugu, Srinu; Ullman, Elijah Z.; Allen, James; Sheikh, Rehan; Nocilla, Kelsey A.; McDaniels, Ellington D.; Coleman, Emanuel M.; Antonoudiou, Pantelis; D'Erasmo, Michael P.; Bartsch, Perry; Sharma, Savita K.; Maguire, Jamie; Traynelis, Stephen F.; Liotta, Dennis C.
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errSave
Clinical development of the GluN2B-selective NMDA receptor inhibitor NP10679 for the treatment of neurologic deficit after subarachnoid hemorrhage
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-01-01
err0
PREAI
errWang, Haichen; Dingledine, Raymond J.; Myers, Scott J.; Traynelis, Stephen F.; Fang, Chuan; Tan, Yanli; Koszalka, George W.; Laskowitz, Daniel T.
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errSave
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA ReceptorS
errMOLECULAR PHARMACOLOGY
IF3
err2024-12-01
err0
PREAI
errUllman, Elijah Z.; Perszyk, Riley E.; Paladugu, Srinu; Fritzemeier, Russell G.; Akins, Nicholas S.; Jacobs, Leon; Liotta, Dennis C.; Traynelis, Stephen F.
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Ligand distances as key predictors of pathogenicity and function in NMDA receptors
errHUMAN MOLECULAR GENETICS
IF3.2
err2024-11-13
err0
errOAAI
errMontanucci, Ludovica; Bruenger, Tobias; Bhattarai, Nisha; Bosselmann, Christian M.; Kim, Sukhan; Allen, James P.; Zhang, Jing; Kloeckner, Chiara; Krey, Ilona; Fariselli, Piero; May, Patrick; Lemke, Johannes R.; Myers, Scott J.; Yuan, Hongjie; Traynelis, Stephen F.; Lal, Dennis
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De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2024-03-28
err3
errOAAI
errXu, Yuchen; Song, Rui; Perszyk, Riley E.; Chen, Wenjuan; Kim, Sukhan; Park, Kristen L.; Allen, James P.; Nocilla, Kelsey A.; Zhang, Jing; Xiangwei, Wenshu; Tankovic, Anel; McDaniels, Ellington D.; Sheikh, Rehan; Mizu, Ruth K.; Karamchandani, Manish M.; Hu, Chun; Kusumoto, Hirofumi; Pecha, Joseph; Cappuccio, Gerarda; Gaitanis, John; Sullivan, Jennifer; Shashi, Vandana; Petrovski, Slave; Jauss, Robin-Tobias; Lee, Hyun Kyung; Bozarth, Xiuhua; Lynch, David R.; Helbig, Ingo; Pierson, Tyler Mark; Boerkoel, Cornelius F.; Myers, Scott J.; Lemke, Johannes R.; Benke, Timothy A.; Yuan, Hongjie; Traynelis, Stephen F.
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Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants
errHUMAN MOLECULAR GENETICS
IF3.2
err2023-11-07
err5
errOAAI
errAllen, James P.; Garber, Kathryn B.; Perszyk, Riley; Khayat, Cara T.; Kell, Steven A.; Kaneko, Maki; Quindipan, Catherine; Saitta, Sulagna; Ladda, Roger L.; Hewson, Stacy; Inbar-Feigenberg, Michal; Prasad, Chitra; Prasad, Asuri N.; Olewiler, Leah; Mu, Weiyu; Rosenthal, Liana S.; Scala, Marcello; Striano, Pasquale; Zara, Federico; McCullock, Tyler W.; Jauss, Robin-Tobias; Lemke, Johannes R.; MacLean, David M.; Zhu, Cheng; Yuan, Hongjie; Myers, Scott J.; Traynelis, Stephen F.
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Clinical and functional consequences of GRIA variants in patients with neurological diseases
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2023-11-03
err1
errOAAI
errXiangWei, Wenshu; Perszyk, Riley E.; Liu, Nana; Xu, Yuchen; Bhattacharya, Subhrajit; Shaulsky, Gil H.; Smith-Hicks, Constance; Fatemi, Ali; Fry, Andrew E.; Chandler, Kate; Wang, Tao; Vogt, Julie; Cohen, Julie S.; Paciorkowski, Alex R.; Poduri, Annapurna; Zhang, Yuehua; Wang, Shuang; Wang, Yuping; Zhai, Qiongxiang; Fang, Fang; Leng, Jie; Garber, Kathryn; Myers, Scott J.; Jauss, Robin-Tobias; Park, Kristen L.; Benke, Timothy A.; Lemke, Johannes R.; Yuan, Hongjie; Jiang, Yuwu; Traynelis, Stephen F.
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errSave
Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-09-19
err9
errOAAI
errCamp, Chad R.; Vlachos, Anna; Kloeckner, Chiara; Krey, Ilona; Banke, Tue G.; Shariatzadeh, Nima; Ruggiero, Sarah M.; Galer, Peter; Park, Kristen L.; Caccavano, Adam; Kimmel, Sarah; Yuan, Xiaoqing; Yuan, Hongjie; Helbig, Ingo; Benke, Tim A.; Lemke, Johannes R.; Pelkey, Kenneth A.; McBain, Chris J.; Traynelis, Stephen F.
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errSave
De novo CLPTM1 variants with reduced GABAAR current response in patients with epilepsy
errEPILEPSIA
IF6.6
err2023-08-30
err1
errOAAI
errLiu, Nana; Li, Jinliang; Gao, Kai; Perszyk, Riley E.; Zhang, Jing; Wang, Jingmin; Wu, Ye; Jenkins, Andrew; Yuan, Hongjie; Traynelis, Stephen F.; Jiang, Yuwu
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errSave
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2023-08-11
err1
errOAAI
errD'Erasmo, Michael P.; Akins, Nicholas S.; Ma, Peipei; Jing, Yao; Swanger, Sharon A.; Sharma, Savita K.; Bartsch, Perry W.; Menaldino, David S.; Arcoria, Paul J.; Bui, Thi-Thien; Pons-Bennaceur, Alexandre; Le, Phuong; Allen, James P.; Ullman, Elijah Z.; Nocilla, Kelsey A.; Zhang, Jing; Perszyk, Riley E.; Kim, Sukhan; Acker, Timothy M.; Taz, Azmain; Burton, Samantha L.; Coe, Kevin; Fritzemeier, Russell G.; Burnashev, Nail; Yuan, Hongjie; Liotta, Dennis C.; Traynelis, Stephen F.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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H-index: 162 · Papers: 652
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Richard L. Huganir
H-index: 145 · Papers: 490
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