Not logged in ORIC-114, a highly selective, brain penetrant EGFR and HER2 inhibitor, demonstrates best-in-class properties against Exon 20 insertions and other atypical EGFR mutations Junttila, M.; Repellin, C. E.; Warne, R.; Long, J. E.; Sambucetti, L.; Ashley, P.; Andreatta, G.; Baik, J.; Salaniwal, S.; Colas, C.; Romero, A.; Soroceanu, L.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. Share Save
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S. Share Save
ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models Daemen, Anneleen; Yuen, Natalie; Wang, Amber; Pankov, Aleksandr; Ulicna, Livia; Chen, Chelsea; Duong, Frank L.; Long, Jason; Marx, Matthew A.; Christensen, James G.; Friedman, Lori S.; Junttila, Melissa R. Share Save
ORIC-613, a potential first- and best-in-class, orally bioavailable, potent and selective PLK4 inhibitor with synthetic lethality in TRIM37 high cancer models Edgar, Kyle A.; McRee, Siobhan; Andretta, Gina; Chen, Chelsea; Colas, Christophe; Fang, Wei; Kong, Wayne; Long, Jason; Liu, Fang; Moore, Jared; Pankov, Aleskandr; Shore, Dan; Tan, Joanne; Warne, Robert; Ulicna, Livia; Vekariya, Rakesh; Daemen, Anneleen; Romero, F.; Junttila, Melissa R.; Friedman, Lori S. Share Save
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities Jiang, Yi-Zhou; Ma, Ding; Jin, Xi; Xiao, Yi; Yu, Ying; Shi, Jinxiu; Zhou, Yi-Fan; Fu, Tong; Lin, Cai-Jin; Dai, Lei-Jie; Liu, Cheng-Lin; Zhao, Shen; Su, Guan-Hua; Hou, Wanwan; Liu, Yaqing; Chen, Qingwang; Yang, Jingcheng; Zhang, Naixin; Zhang, Wen-Juan; Liu, Wei; Ge, Weigang; Yang, Wen-Tao; You, Chao; Gu, Yajia; Kaklamani, Virginia; Bertucci, Francois; Verschraegen, Claire; Daemen, Anneleen; Shah, Nakul M.; Wang, Ting; Guo, Tiannan; Shi, Leming; Perou, Charles M.; Zheng, Yuanting; Huang, Wei; Shao, Zhi-Ming Share Save
A global phase 1b study of ORIC-114, a highly selective, brain penetrant EGFR and HER2 inhibitor, in patients with advanced solid tumors harboring EGFR Exon 20 or HER2 alterations Hong, M. H.; Spira, A. I.; Lee, K. H.; Cho, E. K.; Han, J-Y.; Shim, B. Y.; Lee, J-S.; Kao, S. C-H.; Kim, S-W.; Khattak, A.; Patel, M.; Xu, R.; Wang, J.; Ariazi, E.; Daemen, A.; Maneval, E. Chow; Multani, P. S.; Patel, R.; Ahn, M-J. Share Save
Preclinical activity of ORIC-114, a highly selective, brain penetrant, irreversible kinase inhibitor, against atypical mutations in EGFR Junttila, M. R.; Warne, R.; Repellin, C.; Sambucetti, L.; Chang, J.; Kim, S.; Kim, H. Y.; Shin, D. G.; Park, D. H.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. Share Save
Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not Mcree, Siobhan K.; Chen, Chelsea; Colas, Christophe; Fang, Wie; Kong, Wayne; Liu, Fang; Long, Jason; Moore, Jared; Pankov, Alex; Shore, Dan; Tan, Joanne; Warne, Robert; Vekariya, Rakesh; Young, Amy; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.; Edgar, Kyle A. Share Save
Biomarker strategy for a phase 1 study of ORIC-944, a potent and selective allosteric PRC2 inhibitor, in patients with metastatic prostate cancer Daemen, Anneleen; Yuen, Natalie; Pankov, Aleksandr; Ariazi, Eric A.; Katewa, Subhash D.; Duong, Frank L.; Wang, Amber; Barkund, Shravani; Kaushik, Shelly; Sun, Jessica D.; Friedman, Lori S.; Junttila, Melissa R. Share Save
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer Liang, Jackson; Ingalla, Ellen Rei; Yao, Xiaosai; Wang, Bu-Er; Tai, Lisa; Giltnane, Jennifer; Liang, Yuxin; Daemen, Anneleen; Moore, Heather M.; Aimi, Junko; Chang, Ching -Wei; Gates, Mary R.; Eng-Wong, Jennifer; Tam, Lucinda; Bacarro, Natasha; Roose-Girma, Merone; Bellet, Meritxell; Hafner, Marc; Metcalfe, Ciara Share Save
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer Johnson, Radia M.; Qu, Xueping; Lin, Chu-Fang; Huw, Ling-Yuh; Venkatanarayan, Avinashnarayan; Sokol, Ethan; Ou, Fang-Shu; Ihuegbu, Nnamdi; Zill, Oliver A.; Kabbarah, Omar; Wang, Lisa; Bourgon, Richard; de Sousa e Melo, Felipe; Bolen, Chris; Daemen, Anneleen; Venook, Alan P.; Innocenti, Federico; Lenz, Heinz-Josef; Bais, Carlos Share Save
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation Pribluda, Ariel; Daemen, Anneleen; Lima, Anthony Nelson; Wang, Xi; Hafner, Marc; Poon, Chungkee; Modrusan, Zora; Katakam, Anand Kumar; Foreman, Oded; Eastham, Jefferey; Hung, Jefferey; Haley, Benjamin; Garcia, Julia T.; Jackson, Erica L.; Junttila, Melissa R. Share Save
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Savill, Kristin M. Zimmerman; Lee, Brian B.; Oeh, Jason; Lin, Jie; Lin, Eva; Chung, Wei-Jen; Young, Amy; Chen, Wennie; Mis, Monika; Mesh, Kathryn; Eastham, Jeffrey; Gnad, Florian; Jiang, Zhaoshi; Stawiski, Eric W.; Haley, Benjamin; Daemen, Anneleen; Wang, Xiaojing; Koeppen, Hartmut; Modrusan, Zora; Martin, Scott E.; Sampath, Deepak; Lin, Kui Share Save
Initial results from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with enzalutamide in patients with metastatic prostate cancer Abida, Wassim; Agarwal, Neeraj; Hahn, Andrew W.; Shore, Neal; Sieber, Paul; Dorff, Tanya; Rettig, Mathew; Smith, Mathew; Monk, Paul; Xu, Rongda; Johnson, Ann; Daemen, Anneleen; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Morris, Michael J. Share Save
Biomarker results supporting selection of RP2D from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with enzalutamide in patients with metastatic prostate cancer progressing on enzalutamide Daemen, Anneleen; Barkund, Shravani; Johnson, Ann; Pankov, Aleksandr; Wang, Amber W.; Zhou, Haiying; Multani, Pratik S.; Maneval, Edna Chow; Friedman, Lori S.; Patel, Rupal Share Save
Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer Desbois, Melanie; Udyavar, Akshata R.; Ryner, Lisa; Kozlowski, Cleopatra; Guan, Yinghui; Duerrbaum, Milena; Lu, Shan; Fortin, Jean-Philippe; Koeppen, Hartmut; Ziai, James; Chang, Ching-Wei; Keerthivasan, Shilpa; Plante, Marie; Bourgon, Richard; Bais, Carlos; Hegde, Priti; Daemen, Anneleen; Turley, Shannon; Wang, Yulei Share Save
Development of a gene expression-based prognostic signature for IDH wild-type glioblastoma Johnson, Radia M.; Phillips, Heidi S.; Bais, Carlos; Brennan, Cameron W.; Cloughesy, Timothy F.; Daemen, Anneleen; Herrlinger, Ulrich; Jenkins, Robert B.; Lai, Albert; Mancao, Christoph; Weller, Michael; Wick, Wolfgang; Bourgon, Richard; Garcia, Josep Share Save
ARID1A mutations induce an EGFR-like gene expression signature and confer intrinsic and acquired resistance to cetuximab treatment in first line metastatic CRC Johnson, Radia Marie; Qu, Xueping; Thomas, Joshua; Kschonsak, Yvonne; Huw, Ling-Yuh; Ou, Fang-Shu; Sokol, Ethan; Ihuegbu, Nnamdi; Zill, Oliver; Kabbarah, Omar; Daemen, Anneleen; Bourgon, Richard; Venook, Alan; Innocenti, Federico; Lenz, Heinz-Josef; de Sousa e Melo, Felipe; Bais, Carlos Share Save
ORIC-101 overcomes resistance to diverse chemotherapeutics across cancer types Zhou, Haiying; Barkund, Shravani; Pankov, Aleksandr; Hegde, Ganapati; Kong, Wayne; Narayanan, Padmini; Sun, Jessica D.; Kabbarah, Omar; Friedman, Lori S.; Daemen, Anneleen Share Save
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