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Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project Coleman, Amanda E.; Creevy, Kate E.; Anderson, Rozalyn; Reed, May J.; Fajt, Virginia R.; Aicher, Kathleen M.; Atiee, Genna; Barnett, Brian G.; Baumwart, Ryan D.; Boudreau, Beth; Cunningham, Suzanne M.; Dunbar, Matthew D.; Ditzler, Bobbie; Ferguson, Anna M.; Forsyth, Kiersten K.; Gambino, Anya N.; Gordon, Sonya G.; Hammond, Hillary K.; Holland, Sydney N.; Iannaccone, Mary K.; Illing, Kate; Kadotani, Saki; Knowles, Shelby A.; Maclean, Evan L.; Maran, Brian A.; Markovic, Lauren E.; Mcgrath, Stephanie; Melvin, Rachel L.; Mueller, Mikaela S.; Nelson, O. Lynne; Olby, Natasha J.; Pancotto, Theresa E.; Parsley, Elizabeth; Potter, Brianna M.; Prescott, Jena O.; Saunders, Ashley B.; Sawyer, Holly M.; Scansen, Brian A.; Schmid, Sarah M.; Smith, Courtney C.; Tjostheim, Sonja S.; Tolbert, M. Katherine; Tropf, Melissa A.; Visser, Lance C.; Ward, Jessica L.; Wesselowski, Sonya R.; Windsor, Rebecca C.; Yang, Vicky K.; Ruple, Audrey; Promislow, Daniel E. L.; Kaeberlein, Matt; Dog Aging Project Consortium, Joshua M. Share Save
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Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice Blank, Heidi M.; Hammer, Staci E.; Boatright, Laurel; Roberts, Courtney; Heyden, Katarina E.; Nagarajan, Aravindh; Tsuchiya, Mitsuhiro; Brun, Marcel; Johnson, Charles; Stover, Patrick J.; Sitcheran, Raquel; Kennedy, Brian K.; Adams, L. Garry; Kaeberlein, Matt; Field, Martha S.; Threadgill, David W.; Andrews-Polymenis, Helene L.; Polymenis, Michael Share Save
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Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age Moliere, Adrian; Park, Ji Young Cecilia; Goyala, Anita; Vayndorf, Elena M.; Zhang, Bruce; Hsiung, Kuei Ching; Jung, Yoonji; Kwon, Sujeong; Statzer, Cyril; Meyer, David; Nguyen, Richard; Chadwick, Joseph; Thompson, Maximilian A.; Schumacher, Bjoern; Lee, Seung-Jae V.; Essmann, Clara L.; Macarthur, Michael R.; Kaeberlein, Matt; David, Della; Gems, David; Ewald, Collin Y. Share Save
Evaluation of off-label rapamycin use on oral health Hudson, Johnny; Kaeberlein, Tammi; Mahal, Akashdeep; Wong, Nelson; Ghorbanifarajzadeh, Mina; Radella, Frank; Isman, Anar; Nyquist, Andy; Zalzala, Sajad; Haddad, George; Kaeberlein, Matt; An, Jonathan Y. Share Save
The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials Harinath, Girish; Zalzala, Sajad; Nyquist, Andy; Wouters, Maartje; Isman, Anar; Moel, Mauricio; Verdin, Eric; Kaeberlein, Matt; Kennedy, Brian; Bischof, Evelyne Share Save
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Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome Bitto, Alessandro; Grillo, Anthony S.; Ito, Takashi K.; Stanaway, Ian B.; Nguyen, Bao M. G.; Ying, Kejun; Tung, Herman; Smith, Kaleb; Tran, Ngoc; Velikanje, Gunnar; Urfer, Silvan R.; Snyder, Jessica M.; Barton, Jacob; Sharma, Ayush; Kayser, Ernst-Bernhard; Wang, Lu; Smith, Daniel L.; Thompson, J. Will; DuBois, Laura; DePaolo, William; Kaeberlein, Matt Share Save
Evaluation of off-label rapamycin use to promote healthspan in 333 adults Kaeberlein, Tammi L.; Green, Alan S.; Haddad, George; Hudson, Johnny; Isman, Anar; Nyquist, Andy; Rosen, Bradley S.; Suh, Yousin; Zalzala, Sajad; Zhang, Xingyu; Blagosklonny, Mikhail V.; An, Jonathan Y.; Kaeberlein, Matt Share Save
Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan Phua, Cheryl Zi Jin; Zhao, Xiaqing; Turcios-Hernandez, Lesly; McKernan, Morrigan; Abyadeh, Morteza; Ma, Siming; Promislow, Daniel; Kaeberlein, Matt; Kaya, Alaattin Share Save
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