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Zachary Gerhart‐Hines

university of copenhagen

36H-index
96Paper Count
1.5WCitation Count
Published Papers 48
Publication Date
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Structurally defining neurokinin selectivity to improve NK2R agonists
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-06-25
err0
errOAAI
errArtem Pavlovskyi; Yinhang Ren; María Gestal-Mato; Ole H. Olsen; Thue W. Schwartz; Zachary Gerhart-Hines; Xiangyu Liu
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Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
errNature
IF48.5
err2026-05-18
err0
errOAAI
errDaniela Liskiewicz; Aaron Novikoff; Ahmed Khalil; Seun Akindehin; Jonathan E. Campbell; Pietra Candela; Russell L. Castelino; Callum Coupland; Maxime Culot; W. Scott Dodson; Jonathan D. Douros; Hannes Embring; Annette Feuchtinger; Brian Finan; Cristina Garcia-Caceres; Xiao-Bing Gao; Fabien Gosselet; Gerald Grandl; Robert M. Gutgesell; Daniel T. Haas; Martin Jastroch; Ezgi Karaoglu; Pamela Kakimoto; Anna Cristina Kaltenbach; Michaela Keuper; Christine M. Kusminski; Danielle C. Leander; Arkadiusz Liskiewicz; Xue Liu; Gandhari Maity-Kumar; Sara Martinez Martinez; Stephanie A. Mowery; Ruben Nogueiras; Marshall Paisley; Diego Perez-Tilve; Patricia S. S. Petersen; Paul T. Pfluger; Sneha Prakash; Sabine Steffens; Alberto Cebrian-Serrano; Monica Tost; Jordan Wean; Christian Weber; Junichi Yoshida; Zachary Gerhart-Hines; Tamas L. Horvath; Philipp E. Scherer; Randy J. Seeley; Richard D. DiMarchi; Matthias H. Tschöp; Natalie Krahmer; Patrick J. Knerr; Timo D. Müller
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GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
errNature
IF48.5
err2026-04-01
err0
PREAI
errLiskiewicz, Daniela; Novikoff, Aaron; Khalil, Ahmed; Akindehin, Seun; Campbell, Jonathan E.; Candela, Pietra; Castelino, Russell L.; Coupland, Callum; Culot, Maxime; Dodson, W. Scott; Douros, Jonathan D.; Embring, Hannes; Feuchtinger, Annette; Finan, Brian; Garcia-Caceres, Cristina; Gao, Xiao-Bing; Gosselet, Fabien; Grandl, Gerald; Gutgesell, Robert M.; Haas, Daniel T.; Jastroch, Martin; Karaoglu, Ezgi; Kakimoto, Pamela; Kaltenbach, Anna Cristina; Keuper, Michaela; Kusminski, Christine M.; Leander, Danielle C.; Liskiewicz, Arkadiusz; Liu, Xue; Maity-Kumar, Gandhari; Martinez, Sara Martinez; Mowery, Stephanie A.; Nogueiras, Ruben; Paisley, Marshall; Perez-Tilve, Diego; Petersen, Patricia S. S.; Pfluger, Paul T.; Prakash, Sneha; Steffens, Sabine; Cebrian-Serrano, Alberto; Tost, Monica; Wean, Jordan; Weber, Christian; Yoshida, Junichi; Gerhart-Hines, Zachary; Horvath, Tamas L.; Scherer, Philipp E.; Seeley, Randy J.; DiMarchi, Richard D.; Tschop, Matthias H.; Krahmer, Natalie; Knerr, Patrick J.; Muller, Timo D.
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Single cell transcriptomics of human weight loss links adipocyte NPY1R to control of lipolysis
errMolecular Metabolism
IF6.6
err2026-02-01
err0
errOAAI
errGrothen, Julius E. R.; Martinez, Jaime M.; Sidiropoulos, Nikos; Massier, Lucas; Zareifi, Danae; Zhong, Jiawei; Davidsen, Ida; Platou, Jette W.; Mandelbaum, Jette; Rothe, Pia; Hvid, Henning; Madsen, Christian Toft; Bruun, Jens M.; Ryden, Mikael; Mejhert, Niklas; Helge, Jorn W.; Gerhart-Hines, Zachary; Pedersen, Thomas A.
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NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
errCell Metabolism
IF30.9
err2025-11-05
err0
PREAI
errSabina Chubanava; Iuliia Karavaeva; Amy M. Ehrlich; Roger M. Justicia; Astrid L. Basse; Ivan Kulik; Emilie Dalbram; Danial Ahwazi; Samuel R. Heaselgrave; Kajetan Trošt; Ben Stocks; Ondřej Hodek; Raissa N. Rodrigues; Jesper F. Havelund; Farina L. Schlabs; Steen Larsen; Caio Y. Yonamine; Carlos Henriquez-Olguín; Daniela Giustarini; Ranieri Rossi; Zachary Gerhart-Hines; Thomas Moritz; Juleen R. Zierath; Kei Sakamoto; Thomas E. Jensen; Nils J. Færgeman; Gareth G. Lavery; Atul S. Deshmukh; Jonas T. Treebak
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The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience
errAGING CELL
IF7.1
err2025-11-01
err0
errOAAI
errJuozaityte, Vaida; Pregnolato, Chiara; Abay-norgaard, Steffen; Rausch, Dylan Matthew; Mcintyre, Rebecca L.; Gerhart-hines, Zachary; Pers, Tune H.; Salcini, Anna Elisabetta; Clemmensen, Christoffer
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Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ
errMolecular Metabolism
IF6.6
err2025-10-30
err0
errOAAI
errOlivia Sveidahl Johansen; Rebecca L. McIntyre; Janane F. Rahbani; Qiaoqiao Zhang; Charlotte Scholtes; Damien Marc Lagarde; Cyrielle Billon; Isabelle Côté; Maria Delgado-Martin; David Tandio; Astrid Linde Basse; Elodie Eury; Anastasia Kralli; Thomas P. Burris; Vincent Giguère; Lawrence Kazak; Zachary Gerhart-Hines
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A consensus guide to preclinical indirect calorimetry experiments
errNature Metabolism
IF20.8
err2025-09-24
err0
PREAI
errAlexander S. Banks; David B. Allison; Thierry Alquier; Ansarullah; Steven N. Austad; Johan Auwerx; Julio E. Ayala; Joseph A. Baur; Stefania Carobbio; Gary A. Churchill; Morten Dall; Rafael de Cabo; Jose Donato; Nathalia R. V. Dragano; Carol F. Elias; Anthony W. Ferrante; Brian N. Finck; Jose E. Galgani; Zachary Gerhart-Hines; Laurie J. Goodyear; Justin L. Grobe; Rana K. Gupta; Kirk M. Habegger; Sean M. Hartig; Andrea L. Hevener; Steven B. Heymsfield; Corey D. Holman; Martin Hrabě de Angelis; David E. James; Lawrence Kazak; Jae Bum Kim; Martin Klingenspor; Xingxing Kong; Sander Kooijman; Louise Lantier; K. C. Kent Lloyd; James C. Lo; Irfan J. Lodhi; Paul S. MacLean; Owen P. McGuinness; Gema Medina-Gómez; Raghavendra G. Mirmira; Christopher D. Morrison; Gregory J. Morton; Timo D. Müller; Yoshihiro Ogawa; David Pajuelo-Reguera; Matthew J. Potthoff; Nathan Qi; Marc L. Reitman; Patrick C. N. Rensen; Jan Rozman; Jennifer M. Rutkowsky; Kei Sakamoto; Philipp E. Scherer; Gary J. Schwartz; Radislav Sedlacek; Mohammed Selloum; Saame Raza Shaikh; Shuai Chen; Gerald I. Shulman; Vojtěch Škop; Alexander A. Soukas; John R. Speakman; Bruce M. Spiegelman; Gregory R. Steinberg; Katrin J. Svensson; John P. Thyfault; Tony Tiganis; Paul M. Titchenell; Nigel Turner; Licio A. Velloso; Antonio Vidal-Puig; Christopher S. Ward; Ashley S. Williams; Christian Wolfrum; Allison W. Xu; Ying Xu; Juleen R. Zierath
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Intracrine FFA4 signaling controls lipolysis at lipid droplets
errNature Chemical Biology
IF13.7
err2025-08-05
err0
errOAAI
errShannon L. O’Brien; Emma Tripp; Natasja Barki; Elodie Blondel-Tepaz; Gabrielle Smith; Adam Boufersaoui; Jennie Roberts; Jeremy A. Pike; Joao Correia; Tamara Miljus; Michel Bouvier; Daniel A. Tennant; Brian D. Hudson; Zachary Gerhart-Hines; Graeme Milligan; Thue W. Schwartz; Davide Calebiro
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Shaping the future of cardiometabolic innovation: advances and opportunities
errNature Metabolism
IF20.8
err2025-07-11
err0
PREAI
errChristoffer Clemmensen; Zachary Gerhart-Hines; Thue W. Schwartz; Juleen R. Zierath; Kei Sakamoto
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Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine
errMOLECULAR METABOLISM
IF6.6
err2025-03-01
err0
errOAAI
errAgueda-Oyarzabal, Marina; Isidor, Marie S.; Plucinska, Kaja; Ingerslev, Lars R.; Dmytriyeva, Oksana; Petersen, Patricia S. S.; Laftih, Sara; Pontoppidan, Axel B.; Henningsen, Jo B.; Rupar, Kaja; Brown, Erin L.; Schwartz, Thue W.; Barres, Romain; Gerhart-Hines, Zachary; Scheele, Camilla C.; Emanuelli, Brice
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Mild Cold Stress at Ambient Temperature Elevates Muscle Calcium Cycling and Exercise Adaptations in Obese Female Mice
errENDOCRINOLOGY
IF3.3
err2024-08-13
err0
PREAI
errRaun, Steffen H.; Braun, Jessica L.; Karavaeva, Iuliia; Henriquez-Olguin, Carlos; Ali, Mona S.; Moller, Lisbeth L., V; Gerhart-Hines, Zachary; Fajardo, Val A.; Richter, Erik A.; Sylow, Lykke
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MCT1 helps brown fat suck up succinate
errNATURE METABOLISM
IF20.8
err2024-02-20
err0
PREAI
errLund, Jens; Isidor, Marie Sophie; Gerhart-Hines, Zachary
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TNIK is a conserved regulator of glucose and lipid metabolism in obesity
errSCIENCE ADVANCES
IF12.5
err2023-08-11
err9
errOAAI
errPham, T. C. Phung; Dollet, Lucile; Ali, Mona S.; Raun, Steffen H.; Moller, Lisbeth L. V.; Jafari, Abbas; Ditzel, Nicholas; Andersen, Nicoline R.; Fritzen, Andreas M.; Gerhart-Hines, Zachary; Kiens, Bente; Suomalainen, Anu; Simpson, Stephen J.; Olsen, Morten Salling; Kieser, Arnd; Schjerling, Peter; Nieminen, Anni I.; Richter, Erik A.; Havula, Essi; Sylow, Lykke
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Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue
errJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
err2023-05-10
err0
PREAI
errChristensen, Ida Bager; Blom, Ida; Dohlmann, Tine Lovso; Finger, Fabian; Helge, Jorn W.; Gerhart-Hines, Zachary; Dela, Flemming; Larsen, Steen
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The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions
errNATURE METABOLISM
IF20.8
err2023-04-13
err30
PREAI
errLund, Jens; Breum, Alberte Wollesen; Gil, Claudia; Falk, Sarah; Sass, Frederike; Isidor, Marie Sophie; Dmytriyeva, Oksana; Ranea-Robles, Pablo; Mathiesen, Cecilie Vad; Basse, Astrid Linde; Johansen, Olivia Sveidahl; Fadahunsi, Nicole; Lund, Camilla; Nicolaisen, Trine Sand; Klein, Anders Bue; Ma, Tao; Emanuelli, Brice; Kleinert, Maximilian; Sorensen, Charlotte Mehlin; Gerhart-Hines, Zachary; Clemmensen, Christoffer
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Overlooked confounding in studies of metabolite salts
errNATURE METABOLISM
IF20.8
err2023-04-13
err1
PREAI
errLund, Jens; Clemmensen, Christoffer; Gerhart-Hines, Zachary
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metabolism in a tissue-specific manner
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-03-30
err13
errOAAI
errBasse, Astrid L.; Nielsen, Karen N.; Karavaeva, Iuliia; Ingerslev, Lars R.; Ma, Tao; Havelund, Jesper F.; Nielsen, Thomas S.; Frost, Mikkel; Peics, Julia; Dalbram, Emilie; Dall, Morten; Zierath, Juleen R.; Barres, Romain; Faergeman, Nils J.; Treebak, Jonas T.; Gerhart-Hines, Zachary
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Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis
errSCIENCE ADVANCES
IF12.5
err2023-02-24
err23
errOAAI
errJohnson, Jordan M.; Peterlin, Alek D.; Balderas, Enrique; Sustarsic, Elahu G.; Maschek, J. Alan; Lang, Marisa J.; Jara-Ramos, Alejandro; Panic, Vanja; Morgan, Jeffrey T.; Villanueva, Claudio J.; Sanchez, Alejandro; Rutter, Jared; Lodhi, Irfan J.; Cox, James E.; Fisher-Wellman, Kelsey H.; Chaudhuri, Dipayan; Gerhart-Hines, Zachary; Funai, Katsuhiko
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Full activation of thermogenesis in brown adipocytes requires Basigin action
errFEBS JOURNAL
IF4.2
err2023-01-14
err4
errOAAI
errRupar, Kaja; Isidor, Marie S.; Argemi-Muntadas, Lidia; Agueda-Oyarzabal, Marina; Plucinska, Kaja; Brown, Erin L.; Mattanovich, Matthias; Bossi, Simone; Tozzi, Marco; Tandio, David; Petersen, Patricia S. S.; Henriksen, Tora I.; Trost, Kajetan; Hansen, Jacob B.; Gerhart-Hines, Zachary; Nielsen, Soren; Moritz, Thomas; Emanuelli, Brice
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Research Directions

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