logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
返回期刊详情
Journal of Enzyme Inhibition and Medicinal Chemistry 封面图

Journal of Enzyme Inhibition and Medicinal Chemistry

IF5.4
论文数3442
被引数9132
期刊论文 3442
发表时间
delete
Recent advances in the development of tag-targeted protein degradation systems靶向蛋白质降解系统的最新研究进展
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-10-23
delete0
deleteOAAI
deleteBizhi Li; Yang Lu; Jinxin Che; Xiaowu Dong
delete分享
delete收藏
Optimisation and mechanistic characterization of a selective benzoxazine-based MAP4K4 inhibitor in pancreatic cancer cells苯并恶嗪类MAP4K4选择性抑制剂的优化及其在胰腺癌细胞中的机制表征
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-10-16
delete0
deleteOAAI
deleteYi-Wen Wu; Chun-Lin Yang; Yu-Ting Fang-Chin; Yun-Hsuan Yeh; Bor-Jiun Chen; Tzu-Ying Sung; Jung-Chun Chu; Tony Eight Lin; Shih-Chung Yen; Jui-Hua Hsieh; Sing-Han Huang; Cheng-Ying Chu; Kai-Chien Yang; Kai-Cheng Hsu; Shiow-Lin Pan
delete分享
delete收藏
Structure-guided discovery of novel ERα-binding peptides with in vitro antiproliferative activity基于结构的ERα结合肽的发现及其体外抗增殖活性
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-10-01
delete0
deleteOAAI
deleteTing Guo; Yan Zhang; Shudan Yang; Lili Yang; Qisheng Chen; Yuting Wang; Rongrong Dou; Donglan Yuan
delete分享
delete收藏
Identification of benzoxazine scaffold derivatives as novel CDK4 inhibitors for the treatment of cancer苯并恶嗪骨架衍生物作为新型CDK4抑制剂用于癌症治疗
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-30
delete0
deleteOAAI
deleteChao Lin; Shaofeng Sun; Huateng Zhang; Dan Yang; Youyan Wei; Bo Li
delete分享
delete收藏
Integrated computational and experimental identification of a novel ML-IAP-targeting peptide with antiproliferative activity in leukaemia cells整合计算与实验方法鉴定一种靶向ML-IAP的新型抗增殖肽，该肽在白血病细胞中具有抗增殖活性
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-28
delete0
deleteOAAI
deleteYan Wan; Yaozhi Hu; Ye Hong; Yanming Zhang; Na Hu; Jinrong Yao; Wenhui Fu; Xiaotian Yang; Junshuai Yue
delete分享
delete收藏
Identification of Crocin I as a positive modulator of GSTP1 with potential relevance to prostate cancer将藏红花素I鉴定为GSTP1的正向调节剂，可能对前列腺癌具有相关性
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-28
delete0
deleteOAAI
deleteHao Qin; YuanYuan Wang; Yukai Yang; Haihong Fang; Yangbiao Li; Yuxiu Yang; Yinhua Xiong; Lin Zhang
delete分享
delete收藏
Molecular insights into triazole-based compounds for triple-negative breast cancer treatment三氮唑基化合物在治疗三阴性乳腺癌中的分子机制研究
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-28
delete0
deleteOAAI
deleteAhamed Vilangalil; Sindhu Priya E. S.; Sarad Pawar Naik Bukke; Sandhya V.; Nafeesa Meha; Chandrashekar Thalluri; Kasolo Daniel; Allan Amooti Ahikiriza
delete分享
delete收藏
Structure-based analysis reveals a hydrophobic pocket governing P2Y12 receptor agonist potency and selectivity基于结构的分析揭示了一个调控P2Y12受体激动剂效力和选择性的疏水口袋
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-25
delete0
deleteOAAI
deleteMatteo Pavan; Jihyun Lee; John C. Hancock; Paola Oliva; Masaki Terabe; Jinmyoung Joo; Kenneth A. Jacobson
delete分享
delete收藏
Structure-based rational design and biological evaluation of a quinazoline-based EGFR exon 20 insertion inhibitor基于结构的理性设计和对一种喹唑啉类EGFR外显子20插入抑制剂的生物评价
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-25
delete0
deleteOAAI
deleteSooheum Jo; Hyunsoo Jang; Suin Kim; Jaebong Jang
delete分享
delete收藏
Cycloserine inhibits glutamate decarboxylase from Mycobacterium tuberculosis环丝氨酸抑制结核分枝杆菌的谷氨酸脱羧酶
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-21
delete0
deleteOAAI
deleteJan Snášel; Jiří Dostál; Michal Tupec; Ondřej Bulvas; Iva Pichová
delete分享
delete收藏
Exploring novel isatin derivatives as SARS-CoV-2 3CLpro inhibitors探索新型异吲哚酮衍生物作为SARS-CoV-2 3CLpro抑制剂
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-10
delete0
deleteOAAI
deleteJian Song; Cai Shi; Boning Yang; Jingxiang Yang; Caifei Huang; Jiaqi Liu; Shuwen Wu; Shuyuan Mo; Jian Yang
delete分享
delete收藏
Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment基于冷冻电镜结构的依曲韦林作为PRMT5/pICln蛋白-蛋白相互作用特异性抑制剂在前列腺癌治疗中的发现
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-08
delete0
deleteOAAI
deleteZhixia Chi; Xueyong Xu; Zhihang Shen; Xuehong Deng; Bennett D. Elzey; Chenglong Li; Wen Jiang; Chang-Deng Hu
delete分享
delete收藏
Design of aptamer peptides for immunomodulation适配体肽的免疫调节设计
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-09-02
delete0
deleteOAAI
deleteArpan Chowdhury; Prajesh Shrestha; Vivekanandan Subramanian; Venkatesh Mayandi; Mukesh Mahajan; Seetharama D. Jois
delete分享
delete收藏
Exploration of novel hydroxamic acid-based candidates integrating chalcone scaffold cap as multitarget HDAC inhibitors: design, anti-prostatic cancer assessment, in silico docking and molecular dynamic simulation基于羟肟酸的含查尔酮骨架帽的新型候选物作为多靶点HDAC抑制剂的探索：设计、抗前列腺癌评估、计算机对接和分子动力学模拟
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-27
delete0
deleteOAAI
deleteAya I. Abd El-hameed; Ibrahim M. Salem; Rasha M. Allam; Mariem M. Arafat; Hossameldin A. Aziz; Zuhier A. Awan; Tarek S. Ibrahim; Omar Alshazly; Eman A. M. Beshr; Stefan Bräse; Mamdouh F. A. Mohamed
delete分享
delete收藏
Inhibition effects and binding interactions of epigallocatechin and gallocatechin on tyrosinase and their anti-melanogenesis activity表没食子儿茶素和儿茶素对酪氨酸酶的抑制效应与结合作用及其抗黑色素生成活性
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-26
delete0
deleteOAAI
deleteJianjun Zhang; Zheng Shi; Jiang Li; Kaiming Li; Fan Wu; Min Zhao; Rui Xie; Hongbin Luo
delete分享
delete收藏
Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells鉴定候选PRODH别构抑制剂MBTP-15324：对肺癌细胞中脯氨酸代谢物谱和ECM相关基因表达变化的影响
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-24
delete0
deleteOAAI
deleteYuxuan Zhou; Dingyuan Bai; Zhihan Li; Ciqin Li; Chunqiong Li; Mengyao Chen; Cheng Guo; Jun Yan; Yonglong Han; Quanjun Yang
delete分享
delete收藏
Conformationally constrained 6‑aryl‑1‑(3,4,5‑trimethoxyphenyl)-1H-pyrazolo[3,4‑b]pyrazines as novel microtubule destabilizers: design, synthesis, and antitumor evaluation构象限制的6-芳基-1-(3,4,5-三甲氧基苯基)-1H-吡唑并[3,4-b]吡嗪作为新型微管去稳定剂：设计、合成及抗肿瘤评价
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-20
delete0
deleteOAAI
deleteZhu Guo; Yujing Zhang; Ping Zou; Caiyun Sun; Liya Cui; Gang Wang; Chao Wang
delete分享
delete收藏
Novel 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, and biological evaluation as potent tubulin polymerisation inhibitors with anticancer activity新型6-芳基-1-(3,4,5-三甲氧基苯基)-1H-吡唑并[3,4-d]嘧啶衍生物：设计、合成及作为具有抗癌活性的强效微管聚合抑制剂的生物评价
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-13
delete0
deleteOAAI
deleteJiake Gao; Yujing Zhang; Rui Qu; Qianqian Xu; Zhenjuan Sun; Liya Cui; Chao Wang
delete分享
delete收藏
Recent progress in small molecules targeting the acidic tumor microenvironment针对酸性肿瘤微环境的小分子研究新进展
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-04
delete0
deleteOAAI
deleteYinuo Fu; Jiahui Song; Chenyang Yu; Yuxi Guo; Bowei Tang; Guangzhong Yang; Yongsheng Zheng; Qiang Wang
delete分享
delete收藏
Context matters in PROTAC design: navigating the trade-off between degradation and developabilityPROTAC设计中情境的重要性：平衡降解与可开发性之间的权衡
deleteJournal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
delete2026-08-04
delete0
deleteOAAI
deleteBoxin Zhang; Yunfei Zhang; Bingxing Zhang; Jinrong Hu; Changhua Ke; Teng Wu; Meiyan Wei; Juan Xia; Mengzhou Wang; Qianqian Zhao; Lei Tian; Chengyuan Liang
delete分享
delete收藏