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AAPS Journal 封面图

AAPS Journal

IF3.7
论文数2371
被引数7462
期刊论文 2371
发表时间
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Predictive Performance of pyDarwin-Selected Versus Expert-Developed Paediatric Tobramycin Population Pharmacokinetic Models for Model-Informed Precision Dosing基于模型指导精准给药的pyDarwin筛选与专家构建儿科托布拉霉素群体药代动力学模型的预测性能比较
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IF3.7
delete2026-10-19
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PREAI
deleteJinglei Wang; Kiera Harwood; Wenyu Yang; Alice Lei; Tony Lai; Keith Nieforth; Stephen Duffull; Mark Sale; Amanda Gwee; Xiao Zhu
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The Patient-Centric Formulation Compass: A Proposed Bottom-Up Framework to Translate Population Insights into Product Design以患者为中心的配方指南：一种将人群见解转化为产品设计并自下而上的框架
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IF3.7
delete2026-10-15
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deleteDomagoj Segregur; Pascal Somville; Jérôme Mantanus; Talia Flanagan
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Liquid Chromatography/tandem Mass Spectrometry-based Target Engagement of Lysine-specific Demethylase 1 Inhibitor TAK-418 Through Detecting Covalent Adducts in the Brain基于液相色谱-串联质谱检测共价加合物，通过靶向结合赖氨酸特异性去甲基化酶1抑制剂TAK-418在脑内的作用机制
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IF3.7
delete2026-10-12
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deleteKota Matsumiya; Shinji Iwasaki; Satoru Matsuda; Yohei Kosugi; Hisao Shimizu; Masaaki Kakehi; Rina Baba; Nobuyuki Amano; Atsushi Nakatani; Haruhide Kimura; Hideki Hirabayashi
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Physiologically based Biopharmaceutics Modeling (PBBM) Reveals a Low Dissolution-related Bioequivalence Risk for Immediate-Release Amlodipine Tablets基于生理学的生物药剂学建模（PBBM）揭示速释氨氯地平片存在低溶解相关性生物等效性风险
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IF3.7
delete2026-10-12
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deletePorfirio de la Cruz Cruz; Larissa Lopes Rodrigues Gomide; Gabriela Moraes do Nascimento; José Trinidad Pérez Urizar; Alberto Martínez Muñoz; Ángel Antonio Vértiz Hernández; Amaury de Jesús Pozos Guillén; Héctor Eduardo Flores Reyes; Ricardo Zamora Ramírez; Luis Manuel Romero Cruz; Marcelino García Sánchez; Mauricio A. García; Michele Georges Issa; Marcelo Dutra Duque
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Nanocarrier-Enabled Delivery of Glucosinolates for Skin Cancer Prevention and Therapy纳米载体介导的芥子油苷递送用于皮肤癌的预防和治疗
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IF3.7
delete2026-10-07
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deleteChandrika Chaturvedi; Carman Giacomantonio; H. P. Vasantha Rupasinghe
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Insights into Drug Absorption Impairment Mechanisms in Hepatic Impairment using Physiologically-based Pharmacokinetic Modelling: A Case Study with Nilotinib利用生理药代动力学模型探讨肝损伤中药物吸收受损机制的案例研究：以尼洛替尼为例
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IF3.7
delete2026-10-07
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deleteLaura G. Al-Amiry Santos; Chara Litou; Karen Rowland Yeo
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Statistical Tools for Biosimilarity Assessment: A Perspective Based on WHO-recommended Approaches基于WHO推荐方法评估生物相似性的统计工具：一种观点
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IF3.7
delete2026-10-07
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deleteAnurag S. Rathore; Anuj Shrivastava
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Utilization of Brain Physiologically Based Pharmacokinetic Modeling in Support of CNS Drug Development: Case Example of Fenebrutinib基于生理药代动力学模型的脑部利用在支持中枢神经系统药物开发中的应用：Fenebrutinib案例示例
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IF3.7
delete2026-10-05
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deleteChristine M. Bowman; Fang Ma; Yan Xu; Denison Kuruvilla; Lin Pan; Matthew R. Durk; Yuan Chen
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Population Pharmacokinetics and Exposure–response Analysis of Durvalumab in Patients with Limited-stage Small-cell Lung Cancer in the Phase 3 ADRIATIC Study度伐利尤单抗在ADRIATIC III期研究中对局限性小细胞肺癌患者的群体药代动力学和暴露-反应分析
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IF3.7
delete2026-09-28
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deleteHong Su; Becky Jiajia Zhao; Yu Fu; Yan-Yan Zhang; Priti Chugh; Ed Casson; KyoungSoo Lim; Song Ren; Diansong Zhou; Peiming Ma; Chunling Fan
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NCA Assistant: An Open-source R/Shiny Interface for Non-compartmental Pharmacokinetic Analysis, Bioequivalence Testing and Study PlanningNCA Assistant：一个用于非房室药代动力学分析、生物等效性测试和研究规划的开放源码R/Shiny界面
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IF3.7
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deleteRob ter Heine
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Challenges in the Quantification of Free TFPI in Human Plasma Following Marstacimab Treatment马斯塔西马单抗治疗后人体血浆中游离TFPI定量分析的挑战
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IF3.7
delete2026-09-22
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deleteKatherine Wright; Kerry Kelleher; Parya Nouri; Lindsay King; Hendrik Neubert
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Synonymous Gene Recoding Affects the Accuracy of Protein Quantification Measurements同义基因重编码影响蛋白质定量测量的准确性
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IF3.7
delete2026-09-21
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deleteNayiri M. Kaissarian; Nigam Padhiar; Nathan Clement; Wells W. Wu; Upendra Katneni; Anton A. Komar; Chava Kimchi-Sarfaty
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Immunogenicity Profile of Lonapegsomatropin During Long-Term Treatment in Children With Growth Hormone Deficiency长效左卡尼汀生长激素在儿童生长激素缺乏症长期治疗中的免疫原性特征
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IF3.7
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deletePer Holse Mygind; Amiee Weiser; Camilla Melin Fürst; Allison S. Komirenko; Meng Mao; Aimee D. Shu; Vibeke Miller Breinholt
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Benchmarking Automated Mass Photometry against SEC-MALS and AUC for Quantifying Cross-Linked Monoclonal Antibody Aggregates将自动化质量光度法与SEC-MALS和AUC进行比对，以量化交联单克隆抗体聚集物
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IF3.7
delete2026-09-21
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deleteMingyue Li; Sharon Polleck; Cliff Entrican; Cassandra Larkin; Brenda Watt; Elizabeth McCoy
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Minimum Significant Ratio for Defining Treatment-Boosted ADA Responses Using Signal-to-Noise as an Alternative to Titer基于信噪比定义治疗增强ADA反应的最小显著比，以替代滴度
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IF3.7
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deleteLili Guo; Kenneth Goldberg; Yong Jiang; Christopher Ehlinger
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Quantitative Characterization of Innate and Adaptive Pharmacology of Allogeneic anti-CD20 Chimeric Antigen Receptor (CAR) Vδ1 γδ T cells using Multiscale Mechanistic Modeling利用多尺度机制建模对异基因抗CD20嵌合抗原受体（CAR）Vδ1 γδ T细胞固有和适应性药理学的定量表征
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IF3.7
delete2026-09-18
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deleteDevam A. Desai; Omar Elashkar; Rodrigo Cristofoletti; Ganesh Mugundu; Aman P. Singh
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Impact of Extraction Recovery and Matrix Effect on qPCR-based Biodistribution Analysis in Gene Therapy: Strategies for Mitigation提取回收率和基质效应对基于qPCR的基因治疗生物分布分析的影响：缓解策略
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IF3.7
delete2026-09-18
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deleteTing Jiang; Zhaomeng Feng; Long Yuan
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Investigating the Role of Phenolic Acid Coformers in Enhancing the Physicochemical Properties of Enzalutamide Coamorphous Systems探究酚酸共形成物在增强恩扎卢替胺共无定形体系物理化学性质中的作用
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IF3.7
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deleteVenkata Krishna Rao Balaga; Argyro Chatziadi; Luděk Ridvan; Miroslav Šoóš
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A Proposal for the Use of an Innovative Two-Stage PK-Clinical Adaptive Trial in Biosimilar Product Development针对生物类似药产品开发中采用创新的两阶段PK-临床适应性试验的提议
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IF3.7
delete2026-09-18
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deleteWeijia Mai; Shein-Chung Chow
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Artificial Intelligence in Pharmaceutical Regulatory Science: Opportunities, Challenges, and Emerging Frameworks人工智能在药物监管科学中的应用：机遇、挑战与新兴框架
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deleteInês Lucas; João Sousa; Carla Vitorino
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