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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IF2.2
论文数194
被引数
期刊论文 194
发表时间
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In vitro activity of tizoxanide derivatives on Trypanosoma cruzi bloodstream trypomastigotes体外tizoxanide衍生物对克氏锥虫血液锥鞭毛虫的活性
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-27
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deleteOAAI
deleteAna Luiza B.G. Cavalcante; Renata G. Almeida; Joshua Taujanskas; Sophie Pate; Guilherme A.M. Jardim; Eufrânio N. da Silva Júnior; John F. Bower; Paul M. O'Neill; Rubem F.S. Menna-Barreto; Andrew V. Stachulski
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The aminated pyrimidinyl hydrazones: improved acidic partitioning results in broad anti-cancer cytotoxic action氨化嘧啶基腙：改善酸性分配性能导致广泛的抗肿瘤细胞毒性作用
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-22
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deleteRohina Alim; Scott D. Andrew; Richard K. Haynes; Ho Ning Wong; Christopher J. Parkinson
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Synthesis and biological evaluation of 2-substituted heterocyclic quinolones as inhibitors of Vibrio cholerae sodium pumping NADH-ubiquinone oxidoreductase (NQR)2-取代杂环喹诺酮的合成及其作为Vibrio cholerae钠泵NADH-泛醌氧化还原酶（NQR）抑制剂的生物评价
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-17
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PREAI
deleteChristian Quinto; Daniela Angarita; Jennifer M. Sorescu; Karina Tuz; Oscar X. Juárez; Daniel P. Becker
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Discovery of potent azabenzothiazoloquinoxalines as protease-activated receptor 4 (PAR4) antagonists作为蛋白酶激活受体4（PAR4）拮抗剂的强效氮杂苯并噻唑喹诺啉类化合物的发现
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-17
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PREAI
deleteJ. Alex Bates; Jeremy M. Richter; Xiaojun Zhang; Wen Jiang; Samuel K. Reznik; O. Scott Halpern; Shana L. Posy; Chi Sum; Ji Hua; Jing Yang; Victor R. Guarino; David A. Gordon; Ruth R. Wexler; E. Scott Priestley
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Drug repurposing-inspired design of miconazole-based 1,2,3-triazoles as antichagasic agents基于药物重定位思路的硝酸咪康唑基1,2,3-三氮唑作为抗锥虫病药物的设计
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-10
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PREAI
deleteMariana Araújo Marques; Augusto Vieira Pontes Silva; Rúbia Castro Fernandes Melo Reis; Luiz Felipe de Andrade Santana; Susana Johann; Elda Gonçalves Souza e Leite; Abner Vinicius Gonçalves dos Santos; Larissa Leite Haussman; Rômulo Dias Novaes; Ivo Santana Caldas; Saulo Fehelberg Pinto Braga; Thiago Belarmino de Souza
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Benzothiazoloquinolines as protease-activated receptor 4 (PAR4) antagonists with excellent rat pharmacokinetic properties苯并噻唑喹啉作为具有优异大鼠药代动力学特性的蛋白酶激活受体4（PAR4）拮抗剂
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-10
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PREAI
deleteJeremy M. Richter; J. Alex Bates; Xiaojun Zhang; Wen Jiang; Samuel K. Reznik; O. Scott Halpern; Qinghong Fu; Shana L. Posy; Chi Sum; Ji Hua; Jing Yang; Victor R. Guarino; David A. Gordon; Ruth R. Wexler; E. Scott Priestley
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Design, synthesis, and biological evaluation of 4H-pyran-4-one-based CYP11A1 inhibitors基于4H-吡喃-4-酮的CYP11A1抑制剂的分子设计、合成及生物活性评价
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-09
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PREAI
deleteJingyi Yuan; Dongyu Wang; Yipeng Sun; Xu Luo; Weizheng Fan; Chunlei Tang
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Structure activity relationship studies of alkynyl 6-nitroquinoxalines as potential anti-tuberculosis agents含炔基6-硝基喹喔啉类化合物的构效关系研究及其作为潜在抗结核药物的应用
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-07
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deleteBlesant K. Maluleke; Emmanuel N. Agbo; Ogunyemi O. Oderinlo; Winston. Nxumalo
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Design, synthesis, and preliminary in vitro screening of novel tolmetin hydrazones against colon cancer新型托美丁腙的设计、合成及其对结肠癌的初步体外筛选
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-02
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PREAI
deleteEcem Gökoğlan; İrem Atlihan; Alimet Sema Özen; Pinar Mega Tiber; Özgür Yilmaz; Ş. Güniz Küçükgüzel
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Discovery and characterization of potent and efficacious small-molecule parathyroid hormone Receptor-1 (PTH1R) antagonists for the treatment of hypercalcemia发现和表征用于治疗高钙血症的强效且高效的小分子甲状旁腺激素受体-1（PTH1R）拮抗剂
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-10-01
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PREAI
deleteJoseph Pontillo; Shimiao Wang; Yunfei Zhu; Elizabeth Rico-Bautista; Jonathan Shintaku; Sameer Urgaonkar; Agnes Antwan; Stephen F. Betz
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Uncovering the importance of lipofection for aptamer-mediated therapeutic oligonucleotide delivery in a HER2+ SKBR3 breast cancer cell line揭示脂质转染在HER2+ SKBR3乳腺癌细胞系中适体介导的治疗性寡核苷酸递送中的重要性
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-30
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deleteJoshua O'Grady; Filiz K. Collak; Matthew Reynolds; Bruce C. McKay; William G. Willmore; Maria C. DeRosa; David Sabatino
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Synthesis and pharmacological evaluation of a series of fluoro-substituted 3-phenoxy-azetidines as cortical enhancers for the treatment of apathy氟取代3-苯氧基-氮杂环丁烷系列化合物的合成及其作为皮质增强剂治疗冷漠症的药理学评价
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IF2.2
delete2026-09-30
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PREAI
deleteClas Sonesson; Sverker von Unge; Maria Gullme; Li Rousk; Anne Fagerberg; Therése Knubbe; Boel Svanberg; Elisabeth Ljung; Angelica Johansson; Stephan Hjorth
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Design, synthesis and biological evaluation of novel CDK8/BRD4 dual inhibitors新型CDK8/BRD4双抑制剂的设计、合成与生物活性评价
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-29
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PREAI
deleteLiang, Guoao; Zhang, Xiaochu; Zhu, Jiayi; Wang, Xinren; Huang, Jianhang
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Discovery of potent GPR120 activators with fatty orosensation enhancement activity发现具有增强脂肪酸味觉感受活性的强效GPR120激动剂
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-28
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PREAI
deleteYayoi Kawato; Kazuhiro Sakamoto; Kotoe Nakasha; Seiichi Sato
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Discovery of Fisetin as a potent and cell-active ACVR2A inhibitor发现Fisetin是一种强效且具有细胞活性的ACVR2A抑制剂
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-27
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PREAI
deleteXiaohan Bu; Mengzhe Dai; Zhen Fang; Jun Zou; Shengyong Yang
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Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors以吲唑为基础的衍生物作为Spns2依赖性S1P释放抑制剂的构效关系研究
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-26
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PREAI
deleteMario Hernandez; Deija J. Hawkins; Yugesh Kharel; Tao Huang; Audrey D. Prendergast; Anne M. Brown; Kevin R. Lynch; Webster L. Santos
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Synthesis and discovery of polyisopentenylated acylphloroglucinols with selective antiproliferative activity against breast cancer cells聚异戊烯酰基黄烷醇的合成与发现：具有选择性抑制乳腺癌细胞增殖活性的化合物
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-26
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PREAI
deleteHong-Yuan Wang; Yong Li; Jie Wei; Hong-Yan Han; Chen Yang; Li-Dong Shao; Xing-Ren Li; Gang Xu
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Photocaging of a GPR52 agonist enables light-dependent receptor activation in cellsGPR52激动剂的的光笼蔽实现细胞内光依赖性受体激活
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-24
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PREAI
deleteWen Ren; Yuexin Liu; Xiaoyan Dai; Qi Wang; Bo Zhang; Bichu Cheng
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The antiproliferative and pro-apoptotic effects of 3-deoxy-3α-fluoro-chenodeoxycholic acid and 12β-methyl-3,7-dioxo-17-epi-25-homo-18-nor-5β-cholan-25-oic acid on human breast cancer cell lines3-脱氧-3α-氟-鹅去氧胆酸和12β-甲基-3,7-二氧代-17-epi-25-homo-18-nor-5β-胆烷-25-羧酸对人乳腺癌细胞系的抗增殖和促凋亡作用
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-19
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deleteDivyashree Ravishankar; Joseph M. Watts; Andreas Luxenburger; Lawrence D. Harris; Wanting Jiao; Thibaut Dispa; Alex Weymouth-Wilson; Richard H. Furneaux; Bruno Linclau; Francesca Greco; Helen M.I. Osborn
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Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells发现具有强效、选择性且口服生物利用度的单环吡啶类PKMYT1抑制剂，该抑制剂与CHK1抑制在复制应激癌细胞中具有协同作用
deleteBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
delete2026-09-17
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PREAI
deleteYing Sun; Hongzhu Chu; Yonggang Wei; Xinying Qian; Fei Ye; Hongchuan Zhao; Xinying Zhu; Jing Zhang; Song Huang; Mingyou Hu
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