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The AAPS Journal

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论文数137
被引数
期刊论文 137
发表时间
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Updated Recommendations for the Bioanalysis of Antibody–Drug Conjugates (ADC) from the ADC working group of the AAPS Bioanalytical Community美国药典协会生物分析社区抗体药物偶联物(ADC)工作组对抗体药物偶联物生物分析的更新建议
deleteThe AAPS Journal
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delete2026-07-01
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deleteJim X. Shen; Robert Dodge; Shoshana Oberstein; Jennifer Cunliffe; Varun Ramani; Soumya Mohana Sundaram; Ines C. Santos; Chongwoo Yu; Sanjay L. Dholakiya; Seema Kumar; Xiaohui Sophia Xu; Sasha Fraser; Zeinab Mokhtari; Feng Yin; David G. Rizzo; Omar S. Barnaby; Honglue Shen; Dominic E. Warrino; Shivangi Awasthi; Krista Burke; Stephanie Schaffer; Alok Rathi
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In vivo Predictive Dissolution Test Using Biorelevant Bicarbonate Buffer for High-dose Free Acid Drug使用生物相关碳酸氢盐缓冲液的体内预测溶出测试用于高剂量游离酸药物
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delete2026-06-30
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deleteYuki Tarumi; Kiyohiko Sugano
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Simple Hydrodynamic Molecular Weight Model for Rapid Assessment of Therapeutic Protein Oligomerization States in Formulation制剂中快速评估治疗蛋白寡聚化状态的简单流体动力学分子量模型
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delete2026-06-29
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deleteJiaqi Lu; Kang Chen
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Whole-Body Pharmacokinetics of Ionizable Lipid, mRNA, and the Expressed Antibody following Intravenous Administration of mRNA-Loaded Lipid Nanoparticles静脉注射mRNA负载脂质纳米颗粒后，可电离脂质、mRNA及其表达的抗体的全身药代动力学
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delete2026-06-29
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deleteShrusti Tiwari; Mokshada Kumar; Shengjia Wu; Rutuja Kulkarni; Dhaval K. Shah
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Correction: Nanotechnology-enhanced Natural Products for Cancer Chemoprevention: Molecular Mechanisms and Clinical Translation更正：纳米技术增强型天然产物用于癌症化学预防：分子机制与临床转化
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delete2026-06-08
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deleteRajat Nath; Sibashish Kityania; Deepa Nath; Jayanta Kumar Patra; Emran Habibi; Satyajit D. Sarker; Anupam Das Talukdar; Lutfun Nahar
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Guiding the Molnupiravir Tablet Formulation Using Physiologically Based Biopharmaceutics Modeling and Successfully Establishing Dissolution Safe Space基于生理基础的生物药剂学建模指导莫纳皮拉韦片剂处方并成功建立溶出安全空间
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deleteThomas Morrow; Nicole Jarvi; Madeline Halota; Cheng Sun; Prapti Kafle; Rachel King; Grace Okoh; Sanjaykumar Patel; Tycho Heimbach
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Quantitative Estimation of Clinical Intrasubject Variability of a Pharmacokinetic Parameter定量评估某一药代动力学参数的临床受试者内变异性
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delete2026-06-05
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deleteHao-Jui Hsu; Katrina Casteel; Samuel Yang; Vivek Purohit; Vu Le; Kazuko Sagawa
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Targeting Pyruvate Kinase M2: Signal Transduction Pathways and Exploration of Cancer Therapeutic Strategies靶向丙酮酸激酶M2：信号转导通路与癌症治疗策略的探索
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delete2026-06-02
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deleteJiaxing Wang; Wenyu Zhang; Nana Shen; Pan Li; Wentao Xie; Shuya Wang; Ye Cheng; Lin Zhao; Yang Yang; Huadong Zhao
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Context-of-use–Guided Development and Validation of a Transthyretin Immunoassay: A Framework for Biomarker Assay Design使用情境指导下的甲状腺素转运蛋白免疫分析的开发与验证：一种生物标志物分析设计框架
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delete2026-06-01
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deleteTanya Watanabe; John Canfield; Erin Anderson; Leighla Tayefeh; John L. Allinson; Nicholas J. Viney; Joel A. Mathews
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New Frontiers of Drug Development Through the Use of New Approach Methodologies通过新方法学在药物开发中的使用实现新前沿
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deleteM. N. Martinez; J. P. Mochel; K. Allenspach; C. Zdyrski; S. Krishna; I. Rusyn
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Correction to: Considerations in Kp,uu,brain-based Strategy for Selecting CNS-targeted Drug Candidates with Sufficient Target Coverage and Substantial Pharmacodynamic EffectKp,uu,brain-based策略在筛选具有足够靶点覆盖和显著药效作用的CNS靶向药物候选物时的考量修正
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delete2026-05-28
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deleteLing Zou; Huan-Chieh Chien; Devendra Pade; Yanfei Li; Minhkhoi Nguyen; Ravi Kanth Bhamidipati; Zhe Wang; Osatohanmwen Jessica Enogieru; Jan Wahlstrom
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Development and Implementation of a Hinderance-based In Vitro Model for Porous Membranes基于阻碍效应的体外多孔膜模型开发与实现
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delete2026-05-27
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deleteDaniel A. Paterson; Lucy Coleman; Yuri Dancik; Kanika Thakur; Yanling Zhang; Alice Maciel Tabosa; Sebastian Polak; James F. Clarke
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A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance整合肾脏QSP-PK-PD与机器学习的基线信息指导的利尿剂抵抗分层机制框架
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delete2026-05-23
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deleteJialiang Zhou; Vingyou Lou; Yixin Zhao; Linxiu Tang; Zihan Hu; Jiaqi Sun; Jun Chen; Peng Cheng; Yu Cheng; Hua He
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Exploration of Colonic Mucus as A Dissolution Compartment for Orally Administered Drugs结肠黏液作为口服给药药物的溶解腔室的探索
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deleteMingjun Wu; Eva M. Karlsson; Christel A. S. Bergström
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HLA Class II Alleles DRB1*11:01 and DQB1*03:01 Unmask Immunogenetic Susceptibility to Anti-Nivolumab Antibodies in Combination with IpilimumabHLA II类等位基因DRB1*11:01和DQB1*03:01揭示抗纳武利尤单抗抗体联合伊匹木单抗治疗的免疫遗传易感性
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delete2026-05-21
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deleteSurendran Rajendran; Andres H. Gutierrez; Ming-Shan Chien; Tracy Tang; Jochem Gokemeijer; Daron Forman; Anne S. De Groot; Vibha Jawa; Lora Hamuro
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Immunogenicity Assessment for siRNA Therapeutics: A Risk-Based Proposal for Event-Driven TestingsiRNA疗法免疫原性评估：基于风险的偶发事件驱动测试方案
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delete2026-05-19
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deleteAn Zhao; Sarah Bond; Valerie Clausen; Mu Chen; Ching-Ha Lai; Joshua Zylstra; Christine Grimaldi; Michael A. Partridge
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Nanotechnology-enhanced Natural Products for Cancer Chemoprevention: Molecular Mechanisms and Clinical Translation纳米技术增强型天然产物用于癌症化学预防：分子机制与临床转化
deleteThe AAPS Journal
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delete2026-05-13
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deleteRajat Nath; Sibashish Kityania; Deepa Nath; Jayanta Kumar Patra; Emran Habibi; Satyajit D. Sarker; Anupam Das Talukdar; Lutfun Nahar
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Applications of Thermoresponsive Hydrogels for Sustained Drug Release in Ocular and Intravitreal Formulations Treating Visual Impairments温敏水凝胶在治疗视觉障碍的眼用和玻璃体内制剂中用于长效药物释放的应用
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delete2026-05-11
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deleteBayan Alshahrouri; Benjamin E. Blass; Thomas Dürig; Reza Fassihi
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In-depth Characterization of Photo-Stressed Antibody–Drug Conjugates by Mass Spectrometry通过质谱法对光应激抗体偶联药物进行深入表征
deleteThe AAPS Journal
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delete2026-05-11
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deleteXiao Pan; Yimeng Zhao; Shukun Luo; Joshua Bulos; Jieqiang Zhong; Yuetian Yan; Zhijie Wu; Yue Su; Sisi Zhang; Shunhai Wang; Hui Xiao; Wenhua Wang; Dingjiang Liu; Ning Li; Haibo Qiu
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Estimating Intragastric Disintegration Times of Immediate Release Dose Units Administered After a High-Calorie, High-Fat Meal Using Standardized, Commercially Available Equipment and Materials使用标准化、商业可用设备和材料估算高热量、高脂肪餐后立即释放剂量单元的胃内崩解时间
deleteThe AAPS Journal
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delete2026-05-07
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deleteMaria Vertzoni; Erato Androulaki; Shirin Dietrich; Marianna Gereoudaki; Paraskevi Karpasiti; Zoi Margiori; Ioannis Papazoglou; Ioanna Stavrinoudi; Christos Reppas
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