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rsc med. chem.

论文数168

被引数

期刊论文 168

发表时间

Exploring the Antimycobacterial Profile of N-Alkyl Imidazoles 探索N-烷基咪唑类化合物的抗分枝杆菌谱

rsc med. chem.

IF0

2026-06-24

PREAI

Alejandro I. Recio-Balsells; Gabriel Di Gresia; Marcelo Luciano Merli; Julia Alejandra Cricco; Hector R. Morbidoni; Guillermo R Labadie

Discovery of Novel SIRT3 Inhibitors with MLLr Leukemia Inhibitory Potency 新型SIRT3抑制剂的发现及其对MLLr白血病的抑制作用

rsc med. chem.

IF0

2026-06-24

PREAI

Shaopeng Chen; Xinyang Wei; Honggang Li; Jiangying Cao; lei zhang

From dual norepinephrine-dopamine reuptake inhibition to selective dopamine reuptake inhibitors: a case of aromatically substituted N; 2-cyclopentylamines 从双重去甲肾上腺素-多巴胺再摄取抑制到选择性多巴胺再摄取抑制剂：一个芳香取代的N;2-环戊基胺的案例

rsc med. chem.

IF0

2026-06-24

OAAI

Majlen A. Dilweg; Willem Jespers; Ameya S Kasture; Rongfang Liu; Tamara A. M. Mocking; Jelle G Van Der Ploeg; M M Baselier; Gerard Van Westen; Thomas Hummel; Sonja Sucic; Adriaan P. IJzerman; Laura H. Heitman; Daan van der Es

Combining β2-AR agonism with butyrylcholinesterase inhibition; a synergistic neuroprotective action against Alzheimer's disease 结合β2-AR激动作用与丁酰胆碱酯酶抑制；对抗阿尔茨海默病的协同神经保护作用

rsc med. chem.

IF0

2026-06-24

PREAI

Alice Wang; Thomas Curel; Sylvie Claeysen; Valentin Travers-Lesage; Marie Elodie Hélène Cadot; Audrey Davis; Jana Sopkova de Oliveira Santos; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Patrick Dallemagne; Marc Since; Christophe Rochais

Synthesis and Bioevaluation of Substituted 2; 11-dihydroimidazo[1′; 5′:1; 2]pyrido-[3; 4-b]indoles as antiplasmodial and antiproliferative agents 取代的2; 11-二氢咪唑并[1′; 5′:1; 2]吡rido-[3; 4-b]吲哚的合成与生物评价：作为抗疟原虫和抗增殖剂的用途

rsc med. chem.

IF0

2026-06-24

PREAI

Adilakshmi Vutla; Akash Pandey; Amanullah Sayeed; Richa Shukla; Ashan Manhas; Niti Kumar; Sanjeev Meena; Dipak Datta; Sanjay Batra

Discovery of Novel Indazole Derivatives with Antineuroinflammatory Activity 发现具有抗神经炎症活性的新型吲唑衍生物

rsc med. chem.

IF0

2026-06-24

PREAI

Qing qing Zhang; Xixi Hou; Xuanwei Zhang; Yimian Wang; Yaquan Cao; Lan Wang; Longfei Mao

Design and synthesis of N-3-substituted quinazolinone derivatives as anticancer agents targeting EGFR N-3-取代喹唑啉酮衍生物的设计与合成及其作为靶向EGFR的抗肿瘤药物

rsc med. chem.

IF0

2026-06-23

PREAI

Pritam Maity; Poonam Yadav; Joydeep Chatterjee; Madhurendra Kumar Katiyar; Umashanker Navik; Raj Kumar

The Many Facets of Sustainability in Medicinal Chemistry: Our Personal Experience 药物化学中可持续性的多面性：我们的个人经验

rsc med. chem.

IF0

2026-06-23

OAAI

Bianca Martinengo; Eleonora Diamanti; Elisa Uliassi; Maria Laura Bolognesi

Targeted Degradation of Pin1 by an Antagonistic Peptide Enhance Gemcitabine Therapy in Pancreatic Cancer 通过拮抗肽靶向降解Pin1可增强吉西他滨在胰腺癌中的治疗效果

rsc med. chem.

IF0

2026-06-23

PREAI

Mengting Chen; Xiangyu Chu; Haipeng Zhao; Lilusi Ma; Jie Meng; Yanlian Yang; Qiaojun Fang; Xiaocui Fang; Chen Wang

Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's disease 基于环境敏感的荧光探针的合理设计及其在监测丁酰胆碱酯酶活性及阿尔茨海默病中的应用

rsc med. chem.

IF0

2026-06-17

PREAI

Ning Guo †; Feng Wang †; Yu Wang; Jiahao Du; Qingwen Zhang; Wenting Cao; Jiongtao Su; Fenqin Zhao; Junfeng Wang; Xiaobin Pang; Yuemin Zhou; Lin Yan

From AlphaFold to site-selective inhibition of DNA methylation in glioblastoma multiforme 从AlphaFold到胶质母细胞瘤中DNA甲基化位点选择性抑制

rsc med. chem.

IF0

2026-06-11

PREAI

Jean-Maxime Besson; Alain Chavanieu; Arulraj Nadaradjane; Pierre-François Cartron; Marie Lopez

New roxadustat amino acid drug conjugation derivatives: molecular docking; molecular dynamics simulation and in vitro assay 新型罗沙司他氨基酸药物缀合衍生物：分子对接、分子动力学模拟及体外实验

rsc med. chem.

IF0

2026-06-11

PREAI

Marjan Samadi; Azizollah Habibi; Leila Karami; Soroush Sardari; Ramin Ebrahimi Kiasari; Ghazaleh Ghavami; Mohammad Shahcheragh

Targeting Hexokinase 2 for Cancer Therapy: Advances; Limitations; and Emerging Opportunities in Inhibitors and Degraders 靶向己糖激酶2用于癌症治疗：抑制剂和降解剂的进展、局限性与新兴机遇

rsc med. chem.

IF0

2026-06-11

PREAI

Xianglong Wang; Baohu Li; Wei-Wei Yao; Jinfei Yang

Discovery of a Potent Dual Target CDK8 and Cyclic C PROTAC Degrader for Treatment of Colorectal Cancer 发现一种高效的靶向CDK8和Cyclic C的双靶点PROTAC降解剂用于结直肠癌治疗

rsc med. chem.

IF0

2026-06-10

PREAI

Xingxing Zhang; Qingsong Chen; Cencen Lei; Da Long Jin; Hao Dong Liu; Yumeng Wang; Chenyu zhao; Liping Zhi; Xinhua Liu

Targeting DNA-PK: medicinal chemistry insights into small-molecule inhibitor discovery and optimisation 靶向DNA-PK：药物化学视角下的小分子抑制剂发现与优化

rsc med. chem.

IF0

2026-06-09

OAAI

Elle Watson; Jack R. R. Hutchinson; Suzannah J. Harnor; Luke Gaughan; Celine Cano

Synthesis; molecular modelling and evaluation of (-)-isopulegolbased 2; 4-diaminopyrimidines as promising Aurora kinase inhibitors 合成；基于(-)-异薄荷醇的2,4-二氨基嘧啶的分子建模与评价，作为有前景的Aurora激酶抑制剂

rsc med. chem.

IF0

2026-06-04

OAAI

Tam Minh Le; Nikoletta Szemerédi; Gabriella Spengler; Minh Canh Nguyen; Huynh Nguyen Khanh Tran; Khac-Minh Thai; Zsolt Szakonyi

Novel Hydroxytyrosol Esters as Potential Anti-Amyloid and Neuroprotective Agents for Alzheimer's Disease 新型羟基酪醇酯作为阿尔茨海默病潜在的抗淀粉样蛋白和神经保护剂

rsc med. chem.

IF0

2026-06-04

OAAI

Ioanna Kalpaktsi; Anthi Panara; Barbara Mavroidi; Garcia Niforos; Amalia D Kalampaliki; Ioanna C Vlachogianni; Eleftheria A Georgiou; Elizabeth Fragopoulou; Anthony Tarbopoulos; AL Skaltsounis; Maria Pelecanou; K Palikaras; Evagelos Gikas; Ioannis K. Kostakis

Novel Urea- and Piperazine-Functionalized Alepterolic Acid Derivatives: Synthesis; Anticancer Activity; and Mechanism of Action 新型脲基和哌嗪基功能化阿勒肽罗酸衍生物：合成；抗肿瘤活性；及作用机制

rsc med. chem.

IF0

2026-06-03

PREAI

Binbin Zhang; Yating Jia; Siyu Qiu; Yanchun Sun; Lian Ma; Peixin Wang; Zixuan Tong; Fengjiao Wang; Guozheng Huang; Jianguo Cao

A Bakuchiol-Linked Tetrazole Exhibits Narrow-spectrum Activity Against Streptococcus pneumoniae bakuchiol-连接的四唑对肺炎链球菌具有窄谱活性

rsc med. chem.

IF0

2026-06-03

PREAI

Neha Sengar; Vidyadhar Pratap; Tuhin Sarkar; Vishnu Kriplani; Astha Gupta; Sanjay Mandal; Prasad V. Bharatam; Dulal Panda; Inder Pal Singh

3-Hydroxypyrimidine-2; 4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors 3-羟基嘧啶-2;4-二酮衍生物作为猴痘病毒消解酶（Mpr）抑制剂

rsc med. chem.

IF0

2026-06-01

PREAI

Muhammad Syafiq Bin Shahari; Jacob P Mahoney; Ziyue Wang; Anil Pant; Ajit Jagtap; Roshan Katekar; Jiashu Xie; Zhilong Yang; Zhengqiang Wang