未登录 返回 期刊详情
期刊论文 108 相关解读 0
First-in-Human Dose Selection and Safety, Tolerability, Pharmacokinetics, and Immunogenicity of the Muscle-Specific Kinase Agonist Adimanebart (ARGX-119) 首次人体剂量选择及安全性、耐受性、药代动力学和免疫原性研究：肌肉特异性激酶激动剂Adimanebart（ARGX-119） van Bragt, Tonke; Kneip, Christa; Priem, Sofie; Leng, Xinghong; Mutch, Rachelle; Patel, Sonya K.; Vanhoenacker, Peter; Vaghi, Cristina; Hoefman, Sven; Shilling, Rebecca; Vanhauwaert, Roeland 分享 收藏
Randomized, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults 随机、安慰剂对照、首次人体研究：新型抗结核药物候选物GSK2556286在健康成人中单次和多次口服给药的安全性、耐受性和药代动力学研究 Ilsley, Emma; Banham-Hall, Edward; Chaychenko, Tetyana; Chinenyeze, Katerina; Maher-Edwards, Gareth; Muya, Catherine; Rolfe, Katie; Sharma, Raman; Tiberi, Simon; Barros-Aguirre, David 分享 收藏
Pharmacokinetics, Safety, and Tolerability of Anti-miR-17 Oligonucleotide RGLS4326 in Healthy Adult Subjects 抗miR-17寡核苷酸RGLS4326在健康成年受试者中的药代动力学、安全性和耐受性 Owen, Tate; Cole, Izaiah; Drygin, Denis; Valencia, Tania; Lee, Edmund C.; Carlson, Morgan; Ruff, Laura; Padgett, Claire; Cremer, Karl; Wright, Timothy M.; Garg, Rekha; Klassen, Preston; Kamel, Amin 分享 收藏
A Phase 1 Oral Mass Balance and Combined Intravenous [14C] Microtracer Study to Characterize the Absorption, Metabolism, Excretion, and Pharmacokinetics of Antitumor Drug E7386 in Humans I期口服质量平衡与联合静脉注射[14C]微示踪剂研究，以表征抗肿瘤药物E7386在人体中的吸收、代谢、排泄和药代动力学 Pathak, Shriram M.; Hayata, Nozomi; Ueno, Takashi; Aluri, Jagadeesh; Wu, Jincao; Brooks, Ashley S.; Laing, Catherine M.; Dutta, Lea; Yasuda, Sanae 分享 收藏
Comments to the Article Wu Y, Völler S, Goulooze SC, et al. A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. J Clin Pharmacol. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303 对文章的评论：Wu Y, Völler S, Goulooze SC等人. 一种用于早产儿、足月新生儿、儿童和成人肝脏清除率的新成熟方程：对对乙酰氨基酚及其代谢物的应用. 临床药理学杂志. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303 Pasanen, Markku; Juvonen, Risto O. 分享 收藏
Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population 戊巴比妥在儿科人群中的群体药代动力学和剂量模拟 Helfer, Victoria Etges; Medina-Aymerich, Lorena; Muller, William J.; Meyer, Marisa; Al-Uzri, Amira; McCulloh, Russell; Hornik, Chi D.; Balevic, Stephen J.; Greenberg, Rachel G.; Benjamin, Daniel K.; Anderson, Sarah G.; Gonzalez, Daniel 分享 收藏
The Effect of Iclepertin on Hematological Parameters: An Overview of Nonclinical Studies and Clinical Trials in Healthy Volunteers and Patients with Cognitive Impairment Associated with Schizophrenia 伊克莱匹汀对血液学参数的影响：非临床研究和健康志愿者及精神分裂症相关认知障碍患者临床试验的概述 Nagy, Peter; Fowler, Justin Corey; Rosenbrock, Holger; Tang, Wenbo; Fu, Eric; Fraser, Annie; Dursema, Holly; Schlichtiger, Julia; Desch, Michael; Gruenenfelder, Fredrik 分享 收藏
In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug-Metabolizing Enzymes 体外和临床评价：Bemnifosbuvir与药物代谢酶的潜在相互作用 Zhou, Xiao-Jian; Vo, Alex; Morelli, Gaetano; Montrond, Maureen; Lynch, Shannan; Pietropaolo, Keith; Belanger, Bruce; Good, Steven; Horga, Arantxa; Agrawal, Nancy; Hammond, Janet 分享 收藏
Evaluation of Relative Bioavailability and Food Effect of a Fixed-Dose Combination Tablet of Islatravir and Lenacapavir 评价伊拉曲韦与伦卡帕韦固定剂量复方片剂的相对生物利用度及食物效应 Niu, Jing; Zhang, Haeyoung; Ling, John; Madera, Sharline; Kwok, Nerissa; West, Steve; Longo, Diane; Gillespie, Gillian; Llamoso, Cyril; Marathe, Dhananjay D. 分享 收藏
Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol 评估洛替格列酮（PF-07081532）与咪达唑仑、奥美拉唑、达比加群、瑞舒伐他汀以及口服避孕药左炔诺孕酮和炔雌醇的药物相互作用潜力 Cronenberger, Carol; Amin, Neeta B.; Le, Vu H.; Carvajal-Gonzalez, Santos; Ashworth, Amy L.; Yi, Ellen C.; Schuster, Tilman; Zhang, Yizhong; Frederich, Robert C.; Friedman, Gary S.; Wang, Ellen Q.; Tsamandouras, Nikolaos 分享 收藏
A Phase 1 Study Evaluating the Pharmacokinetics and Safety of Avacopan in Participants with End-Stage Kidney Disease on Hemodialysis 一项评估接受血液透析的终末期肾病患者中阿伐考潘药代动力学和安全性的1期研究 Mohrmann, Caroline; Oberoi, Rajneet K.; Flach, Stephen D.; Marbury, Thomas C.; Hernandez, Pedro; Gokhale, Manoj; MacElrevey, Celeste R.; Sampson, Caitlin; Amouzadeh, Hamid; Hudson, Krischan; Upreti, Vijay V.; Ward, Jessica A. 分享 收藏
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png)
OAAI
.png)
分享.png)
收藏