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Drug Metabolism and Disposition 封面图

Drug Metabolism and Disposition

IF4
论文数410
被引数12011
期刊论文 410
发表时间
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Editorial for Virtual Special Section: Endogenous Biomarkers of Drug-Metabolizing Enzymes and Transporters虚拟特刊编辑：药物代谢酶和转运体的内源性生物标志物
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IF4
delete2026-10-28
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PREAI
deleteYurong Lai
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Hepatocyte-Based Models for CYP450 Fraction Metabolized Determination: Recommendations from the Quantitative Fraction Metabolized IQ Consortium Working Group肝细胞基模型用于CYP450分数代谢测定：定量分数代谢IQ联盟工作组建议
deleteDrug Metabolism and Disposition
IF4
delete2026-10-27
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PREAI
deleteAngela C. Doran; Vincent C. Peterkin; Lilian H.J. Richter; Helen Tracey; Ting Wang; Sarah M. Glass; Chuck Locuson; Upendra P. Dahal; Licong Jiang; Dustin M. Smith; Robert L. Walsky; Felix Huth; Birk Poller; Kenichi Umehara; Lawrence Cohen; Niresh Hariparsad
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Investigation of the pharmacokinetics, metabolism, and clearance pathways of a heterobifunctional BRM degrader delivered by a TROP2-targeting antibody探究一种由TROP2靶向抗体递送的杂双功能BRM降解剂的药代动力学、代谢及清除途径
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IF4
delete2026-10-26
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PREAI
deleteJoyce Liu; Shu Chen; Yi-Chen Chen; Yusi Cui; Martine Darwish; Summer Baker Dockrey; Geoffrey Del Rosario; Peter S. Dragovich; Liling Liu; Li Ma; Stephanie Monson; Thomas H. Pillow; Rebecca K. Rowntree; Shang-Fan Yu; Robert L. Yauch; Donglu Zhang
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A Targeted Tandem Mass Spectrometry Based Bottom-Up Proteomic Approach Incorporating Hydrophobicity Matched Internal Standards to Evaluate Brigatinib-Induced Drug Metabolism Enzymes and Transporters Modulation基于靶向串联质谱的底端至上蛋白质组学方法，结合疏水性匹配内标，用于评估布里塔尼布诱导的药物代谢酶和转运体调控
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IF4
delete2026-10-23
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PREAI
deleteNiraj Rajput; Tarang Jadav; Shankha Dey; Pinaki Sengupta
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Cyclical Heat Strain Alters the Function of Hepatic Cytochrome P450 Enzymes in Rats循环热应变改变大鼠肝细胞色素P450酶的功能
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IF4
delete2026-10-21
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PREAI
deletePaxton A. Sample; Dominique O. Farrera; Vivian R. Pirro; Veronica B. Samala; Kulindu Vithanachchi; Alexis B. Cruickshank-Taylor; Xiaohong Zhang; Benjamin J. Renquist; Stephen H. Wright; Nathan J. Cherrington
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Species differences in loxoprofen reductase activities: roles of aldo-keto and carbonyl reductases in humans and rats洛索洛芬还原酶活性中的物种差异：醛酮还原酶和羰基还原酶在人类和鼠类中的作用
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IF4
delete2026-10-19
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PREAI
deleteKohei Suzuki; Tatsuki Fukami; Masataka Nakano; Miki Nakajima
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Systematic Evaluation of Organoid Fidelity for ADME and Toxicity Assessment器官样模型的系统评价及其在药物代谢、分布、排泄和毒性评估中的应用
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IF4
delete2026-10-13
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deleteRuoxuan Xiao; Yuwei Zheng; Shuya Huang; Jianhui Liang; Wenxin Fang; Jing Li; Yan Wang; Lei Chen
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Evaluation of a Long-Term Human Hepatocyte Culture Maintained in PowerHEP Maintenance Medium for Drug Clearance Prediction评估在PowerHEP维持培养基中维持的长期人肝细胞培养物对药物清除率的预测
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IF4
delete2026-10-10
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deleteQianying Yuan; Mitchell Laughlin; Xiaofeng Wu; Sam Zhang; Hannah M. Moulton; Brendon Kapinos; David A. Tess; Manthena V.S. Varma; Thomas Schroeter
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The Relationship Between Age and Endogenous Biomarkers of Organic Anion Transporters 1 and 3 (OAT1/3) in Preterm Neonates: A Cross-sectional Study早产儿年龄与有机阴离子转运蛋白1和3（OAT1/3）内源性生物标志物之间的关系：一项横断面研究
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IF4
delete2026-10-10
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deleteMohamed Y. Abdelgaied; Cheri Gauldin; William Truog; Tamorah Lewis
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Multidimensional Regulation of the Cytochrome P450 Metabolic Network in Pulmonary Arterial Hypertension: Homeostatic Imbalance, Pathological Drivers, and Environmental Interactions肺动脉高压中细胞色素P450代谢网络的多维调控：稳态失衡、病理驱动因子与环境相互作用
deleteDrug Metabolism and Disposition
IF4
delete2026-10-08
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PREAI
deleteFengxue Zhou; Yu Ma; Tao Zhang; Guiqin Liu; Qian Wang; Peng Huang; Yabin Duan; Xiangyang Li; Junbo Zhu
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Absorption, distribution, metabolism, excretion, and pharmacokinetics of remibrutinib, an oral, highly selective, Bruton’s tyrosine kinase inhibitor, in healthy participants at steady state雷米布鲁替尼（remibrutinib）在稳态健康受试者中的吸收、分布、代谢、排泄和药代动力学，雷米布鲁替尼是一种口服、高选择性布鲁顿酪氨酸激酶抑制剂
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IF4
delete2026-10-08
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deleteAlexander David James; Frederic Lozac’h; Melissa Hackling; Marie-Anne Lozac’h; Bharti Shah; Jeanne Hardy; Anton Drollmann; Ad Roffel; Gilbert Lefèvre
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In Vitro-In Vivo Extrapolation of Hepatic Clearance for GalNAc-siRNA Therapeutics Using Rat Liver Tritosomes体外-体内肝清除率外推：使用大鼠肝脏三体膜研究GalNAc-siRNA疗法
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IF4
delete2026-10-07
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deleteHarvey Andersen; Alec Bell; Ryan Hill; Anthony Murphy; Michael Huskin; Michael Mohutsky; Christopher M. Wiethoff
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A Previously Undetected Major Circulating Metabolite of Trazpiroben Revealed by Human Radiolabeled Absorption, Distribution, Metabolism, and Excretion Study特拉匹培南的一种先前未检测到的主要循环代谢物由人体放射性标记的吸收、分布、代谢和排泄研究揭示
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IF4
delete2026-09-29
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deleteSean Xiaochun Zhu; Mitsuhiro Nishihara; Diane Ramsden; Shailly Mehrotra; Kouta Matsumiya; Suresh K. Balani
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Monocarboxylate transporter 6 mediates sex-dependent cisplatin ototoxicity via metabolite uptake单羧酸转运蛋白6通过代谢物摄取介导性别依赖性的顺铂耳毒性
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IF4
delete2026-09-29
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deleteArthur Germakovski; Mengxiao Ye; Vivian Xu; Guang-Di Chen; Li Li; Richard Pasternack; Jason Dey; Lara Karzoun; Jeanine Day; Christian Lopez; Emma R. Evereth; Benjamin D. Kaczynski; Wei Sun; Mark Parker; Bo Hua Hu; Jason A. Sprowl
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EVALUATION OF DEUTERIUM ISOTOPE EFFECTS ON THE METABOLISM OF TEN DRUGS ACROSS MULTIPLE HUMAN CYTOCHROME P450 ENZYMES: CONSIDERATIONS FOR DRUG DESIGN评估10种药物在多种人细胞色素P450酶中的代谢过程中氘同位素效应的评价：药物设计的考虑
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IF4
delete2026-09-29
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PREAI
deleteR. Scott Obach; Matthew A. Cerny
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Impact of Nonspecific Binding to Membrane Vesicles on Unbound IC50 Estimation for P-glycoprotein and BCRP Inhibitors and Implications for DDI Risk Assessment膜泡非特异性结合对P-糖蛋白和BCRP抑制剂游离IC50估算的影响及其对DDI风险评估的启示
deleteDrug Metabolism and Disposition
IF4
delete2026-09-17
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PREAI
deleteRenjie Zhan; Richard Moulton; Scott Tallman; Shelby Hullett; Sangwoo Ryu; Michael Mohutsky; Maria Posada; Bridget Morse; Chester Costales
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Biotransformation and Disposition of Inavolisib, a Selective PI3Kɑ Inhibitor, in Humans伊纳伏利司他（Inavolisib）在人体内的生物转化与分布，该药物是一种选择性PI3Kɑ抑制剂
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IF4
delete2026-09-17
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deleteSungjoon Cho; Sravanthi Cheeti; Ryan Johnson; Jing Wang; Nicky Hwang; Laurent Salphati; S. Cyrus Khojasteh; Shuguang Ma; Donglu Zhang
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Functional Characterization of Rare DPYD Variants Identified in 8,380 Japanese Individuals: Implications for 5-Fluorouracil Metabolism8,380名日本个体中鉴定的稀有DPYD变异的功能表征：对5-氟尿嘧啶代谢的启示
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IF4
delete2026-09-17
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deleteKento Terauchi; Eiji Hishinuma; Akiko Ueda; Shota Nishihara; Sakae Saito; Shu Tadaka; Kengo Kinoshita; Masamitsu Maekawa; Nariyasu Mano; Yuu Miyauchi; Masahiro Hiratsuka
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When microbial drug metabolism becomes a drug disposition variable当微生物药物代谢成为药物处置变量
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delete2026-09-11
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deleteRebecca Lewandowski
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A SYSTEMATIC SURVEY OF COMPUTATIONAL DRUG–DRUG INTERACTION PREDICTION: PROBLEM FORMULATIONS, DATA CHALLENGES, AND SCALABLE ARCHITECTURES计算药物-药物相互作用预测的系统综述：问题表述、数据挑战和可扩展架构
deleteDrug Metabolism and Disposition
IF4
delete2026-09-08
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deleteCanan KOÇ; Fatih ÖZYURT
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