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RSC Medicinal Chemistry 封面图

RSC Medicinal Chemistry

IF3.6
论文数1343
被引数2906
期刊论文 1343
发表时间
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Integrated platform for accelerating therapeutic macrocyclic peptide purification in high-throughput medicinal chemistry用于加速高通量药物化学中治疗性大环肽纯化的集成平台
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IF3.6
delete2026-08-19
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PREAI
deleteJun Wang; Faben Cruz; Lingfei Wang; Angel Ho; May Kong; Michael Hayes; Thomas J. Greshock; Kanaka Hettiarachchi Corresponding Author
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Research progress regarding iminosugars for glycosidase inhibition and hypoglycemic activity关于氮杂糖对糖苷酶抑制和降血糖活性的研究进展
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IF3.6
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deleteChao-Na An; Mei-Qi Yang; Xin-Ran Song; Hai-Shan Zhao; Fangqian Yin; Meng-Yue Li; Ke-Rang Wang Corresponding Author
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Drug repurposing of fluvastatin as a DP2 antagonist: an ensemble learning strategy with in vitro cellular functional validation氟伐他汀作为DP2拮抗剂的药物重定位：基于体外细胞功能验证的集成学习策略
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IF3.6
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deleteGuoHui Wei Corresponding Author; Zhuo Sun; YuanXu Gao; Jia Heng; WenYang Lu; ZiXing Zou
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Probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays通过分子建模和生物实验研究吡唑嘧啶类化合物作为SIRT2抑制剂的探针
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IF3.6
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deleteFrancesca Musumeci; Cecilia Astigiano; Naomi Scarano; Marta Falesiedi; Giorgia Guccione; Jade Calamano; Annalisa Salis; Caterina Miro; Chiara Brullo; Monica Dentice; Elena Cichero Corresponding Author; Santina Bruzzone; Silvia Schenone
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Design; synthesis; and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands设计、合成及X射线结构研究含有四氢异喹啉-3-甲酰胺作为P2配体的强效SARS-CoV-2 Mpro抑制剂
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IF3.6
delete2026-07-24
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deleteArun K. Ghosh Corresponding Author; Ashish Sharma; Satyanarayana Iddum; Sydney N. Bogan; Uttara Jayashankar; Emma K. Lendy; Shin-ichiro Hattori; Nobuyo Higashi-Kuwata; Hiroaki Mitsuya; Andrew D. Mesecar
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Structure–activity relationship for calanthoside; a potential hair-growth stimulant with an indole 2-S-; 3-O-bis-glucoside structure. Part 1: role of two glucoside moieties in promoting HFDPC proliferation咔兰苷的结构-活性关系；一种具有吲哚2-S-；3-O-双葡萄糖苷结构的潜在生发刺激剂。第一部分：两个葡萄糖苷基团在促进HFDPC增殖中的作用
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IF3.6
delete2026-07-24
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deleteRiko Suzuki; Katsuki Takashima; Yoshiaki Manse; Haruto Nishikawa; Mina Ashidate; Shinsuke Marumoto; Fumihiro Ishikawa; Toshio Morikawa Corresponding Author; Genzoh Tanabe Corresponding Author
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Polypharmacology in multi-drug-resistant tuberculosis: current scenario and future promise多药耐药结核病中的多靶点药物作用：现状与未来前景
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IF3.6
delete2026-06-01
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deleteFarooq, Itibaw; Kantroo, Hadiya Amin; Banday, Mohammad Iqbal; Ahmad, Zahoor
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Inhibition effects and binding behavior of alginate oligosaccharides on tyrosinase and elastase: multi-spectroscopic approaches and zebrafish evaluation褐藻寡糖对酪氨酸酶和弹性蛋白酶的抑制效应与结合行为：多光谱法与斑马鱼评价
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IF3.6
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deleteLi, Hangen; Liang, Shuyi; Cen, Yuanyi; Liang, Yan; Xu, Xuetao
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Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications钌(II)多吡啶配合物与DNA损伤应答：机制和治疗意义
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IF3.6
delete2026-05-01
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deleteGill, Martin R.
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Design, synthesis, and biological evaluation of novel SN38-sulfonamide conjugates as Topo I/CA IX dual inhibitors inducing ferroptosis in colorectal cancer新型SN38-磺酰胺偶联物的设计、合成及其作为诱导结肠癌铁死亡拓扑异构酶I/碳酸酐酶IX双抑制剂的生物评价
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IF3.6
delete2026-05-01
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deleteZhao, Xinyu; Ye, Anna; Wang, Yujie; Qiu, Yeying; Liu, Shiyan; Wei, Liyu; Qin, Feng; Zhang, Ye; Huang, Rizhen
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Twenty years of quinazolines as tubulin polymerisation inhibitors二十年来作为微管聚合抑制剂的喹唑啉类化合物
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IF3.6
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deleteO'Brien, Nicholas S.; McCluskey, Adam
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Diverse ring architectures of cyclic peptidomimetics targeting melanocortin receptors靶向黑色素皮质素受体的环状肽类模拟物多样性环状结构
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IF3.6
delete2026-04-01
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deleteYue, Wenxiao K.; Barlow, Nicholas; Thompson, Philip E.
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Lead optimization of 5jc21 (CG13250), a quinolin-2(1H)-one-based inhibitor of the BRD4 member of the bromodomain and extraterminal (BET) family of proteins以喹啉-2(1H)-酮为基础的BRD4抑制剂5jc21(CG13250)的先导化合物优化
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IF3.6
delete2026-04-01
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deleteChauhan, Jay; Pogash, Sarah; Yoshioka, Makoto; Raje, Mithun; Van Eker, Daniel; Strovel, Jeffrey W.; Fletcher, Steven
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Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis苯甲酰肼衍生物的设计、合成及其作为诱导ROS相关线粒体凋亡的抗肿瘤剂的生物评价
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delete2026-03-01
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deleteWei, Rongbin; Wang, Xin; Ding, Yamin; Zhu, Suting; Asiedu, Richmond Kwame Frimpong; Li, Muzi; Qian, Haitao; Gu, Yifei; Jiang, Bailing
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d-Galactose-conjugated pyrimidine thioureas as potent antimicrobial agents: rapid green synthesis, structure-activity relationships and molecular modellingd-半乳糖共轭嘧啶硫脲作为高效抗菌剂：快速绿色合成、构效关系和分子模拟
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deleteThanh, Nguyen Dinh; Toan, Vu Ngoc; Thu, Ngo Hong Anh; Tri, Nguyen Minh; Toan, Duong Ngoc; Van, Hoang Thi Kim
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The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles生物电子等排体取代对超分子自组装两亲物抗菌性和物理化学性质的影响
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deleteNaicker, Pinky K.; Yacoub, Mariam; White, Lisa J.; Balderston, Dominick E.; Hailey, Perry A.; Sutton, J. Mark; Hind, Charlotte K.; Hiscock, Jennifer R.
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The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin一种诺倍半萜-三唑衍生物通过激活Nrf2/HO-1信号通路和与血凝素相互作用对流感A病毒的两种功能
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IF3.6
delete2026-02-01
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deleteZhou, Shaofen; Wei, Jingyan; Li, Shixin; Qiu, Jingnan; Ma, Shuaiqi; He, Jian
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PROTAC-mediated multi-target protein degradation in Alzheimer's disease: mechanistic insights, therapeutic applications, and translational challengesPROTAC介导的多靶点蛋白质降解在阿尔茨海默病中的机制洞察、治疗应用和转化挑战
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deleteWang, Bin; Li, Yunan; Yao, Tingting; Shen, Xinai; Li, Huan; Jiang, Wei; Li, Xinuo; Zhu, Zheying
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, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's disease, 一种新型DYRK1A抑制剂，可减轻脂多糖诱导的小鼠神经炎症和认知障碍：阿尔茨海默病的潜在策略
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deleteRen, Mengyu; Chen, Huanhua; Li, Zhenshu; Zhuang, Jiacheng; Yang, Aizhu; Li, Xiangdong; Li, Xinyu; Wang, Xinpeng; Xu, Zonghe; Liu, Xianghuan; Song, Jiawen; Jiang, Tianhao; Xu, Zihua; Gao, Xudong; Zhao, Qingchun
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Integrating green synthesis and liquid-liquid extraction of lidocaine in deep eutectic solvents在深共熔溶剂中集成利多卡因的绿色合成与液-液萃取
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deletePerri, Assunta; Parrotta, Leonardo C.; Gencarelli, Stefania; Sole, Roberta; Dragostin, Oana M.; Guillena, Gabriela; Di Gioia, Maria L.
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