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Nucleic Acid Therapeutics 封面图

Nucleic Acid Therapeutics

IF4.7
论文数776
被引数1694
期刊论文 776
发表时间
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Antisense Oligonucleotides that Are Toxic to Prion-Infected Mice Share an Emergent Mechanism反义寡核苷酸对朊病毒感染小鼠具有毒性并共享一种涌现机制
deleteNucleic Acid Therapeutics
IF4.7
delete2026-01-01
delete0
PREAI
deleteHien T. Zhao; Jill O’Moore; Daniel A. Sprague; Juliana E Gentile; Sagar S. Damle; Briana Noble; Taylor L Corridon; Simone Lord; Jason Le; Samantha Graffam; Michael Howard; Kendrick DeSouza-Lenz; Hongda Li; John E. Matson; Susan Li; Stéphanie Klein; Tyler J. Caron; Alissa A. Coffey; Sonia M. Vallabh; Holly B. Kordasiewicz; Andrea Grindeland Panter; Eric Vallabh Minikel
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Applying Synthetic Nucleic Acid Therapeutics to Gene Activation for Haploinsufficient Diseases
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-12-01
delete0
PREAI
deleteTse, Victor; Corey, David R.
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An RNA Aptamer Targeting PAI-1 That Restores tPA Activity, Unexpectedly Suppresses Cancer Cell Progression靶向PAI-1的RNA适配体可恢复tPA活性，意外地抑制了癌细胞进展
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-12-01
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PREAI
deleteHu, Christopher; Schneidler, Austin; Barry, Mamadou; Gimba, Michelle; Zhou, Sihan; Fortenberry, Yolanda M.
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Letter: Correspondence on Damle, SS, et al. (2025) A Workflow for Transcriptome-Wide Assessment of Antisense Oligonucleotide Selectivity. Nucleic Acid Therapeutics信函：关于Damle, SS等人（2025年）《转录组范围反义寡核苷酸选择性评估的工作流程》的通信，《核酸治疗学》
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-12-01
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PREAI
deleteCrooke, Stanley T.
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Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO; siRNA; and Nonvaccine mRNA/LNP Therapies by the IQ Consortium核酸疗法的免疫原性风险评估：IQ Consortium 对 ASO、siRNA 及非疫苗 mRNA/LNP 疗法的综合评估
deletenucleic acid therapeutics
IF4.7
delete2025-11-05
delete0
PREAI
deleteJoanna Grudzinska-Goebel; Manuela Braun; Lin-Zhi Chen; Swati Gupta; Sabine Lohmann; Pedro Morais; Tao Niu; Edit Tarcsa; Sophie Tourdot; Amir S. Youssef; Vibha Jawa
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Unveiling Liver Micro-Distribution: NanoSIMS Imaging Reveals Critical Intracellular Distribution of Chemically Modified Antisense Oligonucleotides揭示肝脏微分布：NanoSIMS成像揭示化学修饰反义寡核苷酸的关键细胞内分布
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-11-01
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PREAI
deleteYasuhara, Hidenori; Kadotsuji, Kenta; Watanabe, Kenichi; Kakutani, Tomomi; Tochitani, Tomoaki; Mise, Izuru; Konishi, Mei; Nakagawa, Tetsuya; Miyawaki, Izuru
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Antisense Oligonucleotide Quantification via Splint-Ligation PCR Assay in Nonhuman Primate Central Nervous System Tissues and Biofluids非人灵长类中枢神经系统组织和生物流体中反义寡核苷酸通过接合链连接PCR法的定量分析
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IF4.7
delete2025-11-01
delete0
PREAI
deleteJepp, Thomas; Christian, Sarah; Dindot, Scott V.
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Class-Specific Adverse Events of Patients Treated with Small Interfering RNA Therapeutics: A Disproportionality Analysis of the United States Food and Drug Administration Adverse Event Reporting System Database Based on the MY FAERS Platform小干扰RNA疗法患者的类特异性不良事件：基于MY FAERS平台对美国食品药品监督管理局不良事件报告系统数据库的不均衡性分析
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-11-01
delete0
PREAI
deleteLi, Ze; Wang, Xiaozhen; Li, Dandan; Sun, Yiqi; Zhang, Lin; Li, Xingang
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A Workflow for Transcriptome-Wide Assessment of Antisense Oligonucleotide Selectivity一种用于全转录组范围评估反义寡核苷酸选择性的工作流程
deletenucleic acid therapeutics
IF4.7
delete2025-09-29
delete0
PREAI
deleteSagar S. Damle; Andy Watt; Steven Kuntz; Amanda Crutchfield; Emma Carlborg; Judy Webb; Clare Quirk; Dorde Relic; Scott Donovan; Christopher E. Hart; Frank Rigo
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Cryopreservation of siRNA-Treated Cells Is FeasiblesiRNA处理细胞的冷冻保存是可行的
deletenucleic acid therapeutics
IF4.7
delete2025-09-23
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deleteOAAI
deleteMelanie Sauer; Xavier Segarra-Visent; Leon Breuer; Vasileios Tzirtziganis; Tatyana Ryaykenen; David A. Cooper; Dimas Echeverria; Anastasia Kremer; Reka A. Haraszti
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Use of a Transgenic Human PNPLA3I148M Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics使用转基因人PNPLA3I148M敲入小鼠进行siRNA疗法转化安全性评估
deletenucleic acid therapeutics
IF4.7
delete2025-09-06
delete0
PREAI
deleteBen Brooks; Artem Shkumatov; Jackson Kalanzi; Kim Henderson Park; Julie M. Lade; Diana Wong; Hui Dou; Jason Long; Ingrid C. Rulifson; Justin K. Murray; Lauren Mihalcik; Tod A. Harper
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Binding and Ligand Activation Driven Enrichment-Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency结合和配体激活驱动的富集-定向进化改善SaCas9 gRNA的基因编辑效率
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-09-01
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PREAI
deleteLlanga, Telmo; Bush, Korie; Sun, Ying; Yan, Amy; Zhou, Jonathan; Gorodkin, Jan; Sullenger, Bruce A.
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Quantification of mRNA Decay Rates in HeLa and SH-SY5Y Cell Lines Reveals Novel Properties of Membrane Protein Coding Transcripts人乳头瘤病毒细胞和SH-SY5Y细胞系中mRNA降解速率的量化揭示了膜蛋白编码转录本的新特性
deleteNUCLEIC ACID THERAPEUTICS
IF4.7
delete2025-09-01
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PREAI
deleteMartinez, Melanie B.; Williamson, Colton J.; Cazares, Tareian; Tang, Chunlao; Debets, Marjoke F.; Gangras, Pooja
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In Vivo Phage Display for the Identification of Muscle Homing Peptides to Improve the Delivery of Phosphorodiamidate Morpholino Oligomers for Duchenne Muscular Dystrophy Therapy体内噬菌体展示技术用于鉴定靶向肌肉的归巢肽，以改善磷酸二酰胺类吗啉寡聚体在杜氏肌营养不良症治疗中的递送。
deletenucleic acid therapeutics
IF4.7
delete2025-08-29
delete0
PREAI
deleteAnne-Fleur E. Schneider; Christa L. Tanganyika-de Winter; Hailiang Mei; Silvana M. G. Jirka; Xuyu Tan; Emily G. Thompson; Kristin Ha; Anindita Mitra; Stephanie Garcia; Marleen Luimes; Ryan Oliver; Kathy Y. Morgan; Vincent Guerlavais; Annemieke Aartsma-Rus
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Cell Type Distribution of Intrathecal Antisense Oligonucleotide Activity in Deep Brain Regions of Non-Human Primates非人灵长类动物深部脑区鞘内反义寡核苷酸活性的细胞类型分布
deletenucleic acid therapeutics
IF4.7
delete2025-08-26
delete0
deleteOAAI
deleteJeannine A. Frei; Juliana E. Gentile; Yuan Lian; Meredith A. Mortberg; Juliana Capitanio; Paymaan Jafar-nejad; Sonia M. Vallabh; Hien T. Zhao; Eric Vallabh Minikel
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Context Matters: The Importance of a Comprehensive Genomic Region When Assessing the Therapeutic Potential of Antisense Oligonucleotides in Splicing Assays上下文很重要：在评估反义寡核苷酸在剪接测定中的治疗潜力时，全面基因组区域的重要性。
deletenucleic acid therapeutics
IF4.7
delete2025-08-25
delete0
PREAI
deleteDyah W. Karjosukarso; Julia F. Kiefmann; Femke Bukkems; Lonneke Duijkers; Rob W.J. Collin
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Rosalind Franklin Society Proudly Announces the 2024 Award Recipient for Nucleic Acid TherapeuticsRosalind Franklin Society自豪地宣布2024年核酸治疗奖获奖者。
deletenucleic acid therapeutics
IF4.7
delete2025-08-07
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PREAI
deleteAurélie Goyenvalle
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Characterizing Antibodies Targeting Antisense Oligonucleotide Phosphorothioate and 2′-O-Methoxyethyl Modifications for Intracellular Trafficking and Biodistribution Studies表征靶向反义寡核苷酸硫代磷酸酯和2′-O-甲氧基乙基修饰的抗体的细胞内转运和生物分布研究
deletenucleic acid therapeutics
IF4.7
delete2025-07-21
delete0
PREAI
deleteInês Fial; Seth A. Farrier; David P. Chimento; Carl A. Ascoli; Xiao Wan; Peter L. Oliver
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Molecular Modeling of Antisense Oligonucleotide Analogs反义寡核苷酸类似物的分子建模
deletenucleic acid therapeutics
IF4.7
delete2025-07-03
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PREAI
deleteRodrigo Galindo-Murillo
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Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides外泌体介导的反义寡核苷酸线粒体递送
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IF4.7
delete2025-06-18
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PREAI
deleteDora von Trentini; Ivan J. Dmochowski
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