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Toxicological Sciences 封面图

Toxicological Sciences

IF4.1
论文数9296
被引数16031
期刊论文 9296
发表时间
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Loss of LKB1 protects against acetaminophen hepatotoxicity in mice through sex-specific mechanismsLKB1缺失通过性别特异性机制保护小鼠免受对乙酰氨基酚肝毒性影响
deleteToxicological Sciences
IF4.1
delete2026-10-29
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deleteOAAI
deleteDebasree Bhadra, MPharm; Jenna S Caswell, BS; Kathryn L Smith, PhD; Natalie Porat-Shliom, PhD; Mitchell R McGill, PhD
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Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes Ahr-dependent seboatrophy, with elevated expression of infundibular Blimp1单细胞分析显示，2,3,7,8-四氯二苯并对二噁英（TCDD）处理的鼠皮肤中，皮脂腺分化先于Ahr依赖性皮脂萎缩，且漏斗部Blimp1表达升高
deleteToxicological Sciences
IF4.1
delete2026-10-26
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deleteSyeda Mashnia Tasnim; Subhash Solanki; Jyoti Bhuju; Lauren Thompson; Omar Skalli; Elizabeth A Grice; Carrie Hayes Sutter; Thomas R Sutter
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Modernising cosmetic chemical safety assessment: an updated workflow化妆品化学品安全评估现代化：一种更新后的工作流程
deleteToxicological Sciences
IF4.1
delete2026-10-24
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deleteMatthew P Dent; Catherine Mahony; Abdulkarim Najjar; Gladys Ouedraogo; David Allen; Andreea Cuciureanu; Arianna Giusti; Fabrice Nesslany; Andreas Schepky; Harald Streicher; J Gerald Kenna; null
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Maternal PFOS Exposure Impairs β‑Cell Insulin Secretion and Glucose Tolerance in Rats母体PFOS暴露损害大鼠β细胞胰岛素分泌和葡萄糖耐受性
deleteToxicological Sciences
IF4.1
delete2026-10-12
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PREAI
deleteAlissa Hofmann; Pankaj Yadav; Ruolin Song; Sri Vidya Dangudubiyyam; Jay S Mishra; Sathish Kumar
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Lipid Nanoparticle-Formulated Synthetic Messenger RNA Induces Reversible Hematopoietic Bias via Type I Interferon Responses Under Upper-Bound Inflammatory Conditions in Preclinical Animal Models脂质纳米粒递送合成的信使RNA通过I型干扰素反应在预临床动物模型的炎症上限条件下诱导可逆的造血偏向
deleteToxicological Sciences
IF4.1
delete2026-10-09
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PREAI
deleteJae-Hun Ahn; Na-Young Lee; Hee-Jin Bae; Jooil Kim; Jina Kwak; Gahyun Roh; Seo-Hyeon Bae; Jisun Lee; Jae-Hwan Nam; Ji-Eun Kim; Byeong-Cheol Kang
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Friend and foe?: metals as facilitators and disruptors of steroid nuclear receptor signaling朋友还是敌人？：金属作为类固醇核受体信号通路的促进剂和干扰剂
deleteToxicological Sciences
IF4.1
delete2026-10-09
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PREAI
deleteKyle R Siegel; Christopher D Kassotis
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Real-world river water organic pollutant mixture induces ovarian hyperandrogenism via aryl hydrocarbon receptor activation实际河流水体有机污染物混合物通过激活芳基烃受体诱导卵巢高雄激素血症
deleteToxicological Sciences
IF4.1
delete2026-10-07
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PREAI
deleteSamantha L Cheron; Kunlin Ou; Tingjie Zhan; Jiyang Zhang; Congcong Zhang; Hilly Yang; Shichao Liu; Qiang Zhang; Daniel R Millemann; Josephine A Bonventre; Brian Buckley; Shuo Xiao
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A Multiparametric in vitro Strategy for Small Molecule Drug-Induced Liver Injury Risk Mitigation in Early Drug Development一种用于早期药物开发中小分子药物诱导性肝损伤风险缓解的多参数体外策略
deleteToxicological Sciences
IF4.1
delete2026-10-03
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deleteLeah M Norona; Fjodor Melnikov; Tomomi Kiyota; Christopher Lawson; Cyrus Khojasteh; Joyce Liu; Kevin Johnson; Tony Pourmohamad; Lennart T Anger; William R Proctor; Aaron M Fullerton
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Maternal Gestational and Lactational Exposure to Polystyrene Nanoplastics Triggers Vascular Injury and Lipid Deposition in Mouse Offspring母体妊娠期和哺乳期暴露于聚苯乙烯纳米塑料可触发小鼠后代血管损伤和脂质沉积
deleteToxicological Sciences
IF4.1
delete2026-10-01
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PREAI
deleteTan Ma; Yue Zhou; Chenghao Shen; Ruiping Hu; Haibo Jin; Hongliang Li; Jingyan Liang
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Baseline Environmental Contamination Data and Model-based Screening of Children's Exposure-Risk Estimates from Metal(loid)-laden Vegetables and Soils基准环境污染物数据及基于模型筛选的儿童经重金属（类）蔬菜和土壤暴露-风险估算
deleteToxicological Sciences
IF4.1
delete2026-09-29
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PREAI
deleteBrian Turyahabwe; Godswill J Udom; Modinat A Adefisayo; Muyiwa M Orosun; Emmanuel O Ademilusi; Rashid Iqbal; Kamola Zaynalova; Nafisakhon Mamatova; Ibrahim Mahariq; Aseel Smerat
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Endothelial Proteotoxic Stress Drives Inhaled Benzene-Induced Vascular Inflammation in Mice内皮蛋白毒性应激驱动吸入苯诱导的小鼠血管炎症
deleteToxicological Sciences
IF4.1
delete2026-09-29
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PREAI
deleteSamantha A McFall; Marina V Malovichko; Nalinie S Wickramasinghe; Breandon S Taylor; Mohammad T Malik; Daniel J Conklin; Igor N Zelko; Sanjay Srivastava
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The aryl hydrocarbon signaling pathway in the ovary changes throughout reproductive aging and in response to a mixture of phthalates over time in mice小鼠卵巢中的芳烃受体信号通路随繁殖年龄变化，并随时间对邻苯二甲酸酯混合物的反应而改变
deleteToxicological Sciences
IF4.1
delete2026-09-25
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PREAI
deleteAngela E Dean; Ramsés Santacruz-Márquez; Adira M Safar; Mary J Laws; Taylor A Seaton; Estella Miller; Justin Huff; Lydia M Hall; Jodi A Flaws
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Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate alters the aryl hydrocarbon receptor signaling pathway in the ovary throughout reproductive aging in mice暴露于邻苯二甲酸二（2-乙基己基）酯和邻苯二甲酸二异壬酯会改变小鼠整个生殖衰老过程中的卵巢芳烃受体信号通路
deleteToxicological Sciences
IF4.1
delete2026-09-25
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PREAI
deleteAngela E Dean; Ramsés Santacruz-Márquez; Adira M Safar; Mary J Laws; Taylor A Seaton; Estella Miller; Justin Huff; Lydia M Hall; Jodi A Flaws
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Early-gestational binge ethanol exposure induces persistent motor dysfunction associated with cerebellar redox and cytokine dysregulation in rat offspring孕早期暴饮乙醇暴露诱导大鼠子代持续性运动功能障碍，并与小脑氧化还原和细胞因子失调相关
deleteToxicological Sciences
IF4.1
delete2026-09-24
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PREAI
deletePaulo Fernando Santos Mendes; Daiane Claydes Baia-da-Silva; Vinicius Ruan Neves dos Santos; Leonardo de Oliveira Bittencout; Lucas Villar Pedrosa da Silva Pantoja; Luanna de Melo Pereira Fernandes; Rommel Mario Rodríguez Burbano; Cristiane do Socorro Ferraz Maia; Rafael Rodrigues Lima
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Integrated single-cell and epigenomic analysis reveals cellular specificity of CYP2E1 in human alcohol-related liver disease整合单细胞和表观基因组学分析揭示了人类酒精相关肝病中CYP2E1的细胞特异性
deleteToxicological Sciences
IF4.1
delete2026-09-21
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PREAI
deleteLukas Neckermann; Eleusa Karavasili; Anne Dropmann; Seddik Hammad
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Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: Phthalate-heat interactions in the ovary高温和邻苯二甲酸单(2-乙基己基)酯的联合暴露抑制小鼠胃窦卵泡生长和雌二醇合成：卵巢中的邻苯二甲酸酯-热相互作用
deleteToxicological Sciences
IF4.1
delete2026-09-15
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deleteSundus Ghuneim; Madison Wilson; Caroline Harper; Sophia Sherlock; Gretchen Ruschman; Patrick Hannon
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Nonclinical Safety Assessment of SBT777101, a CAR-Engineered Regulatory T Cell Therapy for Autoimmune DiseasesSBT777101的非临床安全性评估，一种用于自身免疫性疾病的CAR-工程化调节性T细胞疗法
deleteToxicological Sciences
IF4.1
delete2026-09-15
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deleteHerve Lebrec; Jonathan M Clingan; Anne-Renee van der Vuurst de Vries; Lauren Mihalcik; Yuchi Honaker; Sara Charmsaz; Seonhwa Dura; Kathryn Hooper; Yuanyuan Xiao; Michelle Blake; Max Fiebiger; Radha Dhayal; Christine Saechao; Alexandre Iannello; Fred Ramsdell; Jeffrey A Bluestone; Josh Beilke
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Human in vitro airway models to assess point-of-contact respiratory toxicity of surfactants and derive human equivalent concentrations after single dose exposure人体体外气道模型用于评估表面活性剂的接触点呼吸道毒性及单次剂量暴露后的人体等效浓度
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IF4.1
delete2026-09-10
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deleteAndreas O Stucki; Monita Sharma; Jessica R Murray; Sandra Verstraelen; Evelien Frijns; Karen Hollanders; An Jacobs; Anthony Luz; Sylvie Remy; Nuria Roldan; Jo Van Laer; Miyoung Yoon; Keith Salazar; Natalia Garcia-Reyero Vinas; Anna B Lowit; Amy J Clippinger
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A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson Disease高通量方法用于计算开发人类候选不良结局路径：以杀虫剂和帕金森病为例的概念验证
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IF4.1
delete2026-09-10
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deleteDorian Rollin; Chenyu Shen; Ksenia Groh; Marissa B Kosnik
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Loss of Vacuole Membrane Protein 1 protects against acetaminophen-induced liver injury by modulating inflammation and hepatocyte proliferationVacuole Membrane Protein 1的缺失通过调节炎症和肝细胞增殖来保护 against 醋氨酚诱导的肝损伤
deleteToxicological Sciences
IF4.1
delete2026-09-09
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deleteKhue Nguyen; Mengwei Niu; Hong-Min Ni
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