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Safety, tolerability, and preliminary efficacy of nadunolimab, an anti-IL-1 receptor accessory protein monoclonal antibody, in combination with pembrolizumab in patients with solid tumors 安全性、耐受性及nadunolimab（一种抗IL-1受体辅助蛋白单克隆抗体）与pembrolizumab联合应用在实体瘤患者中的初步疗效 Cohen, Roger B.; Jimeno, Antonio; Hreno, Jennifer; Sun, Lova; Wallen-Ohman, Marie; Millrud, Camilla Rydberg; Sanfridson, Annika; Garcia-Ribas, Ignacio 分享 收藏
An investigation of extended-interval dosing of atezolizumab in Japanese patients with advanced solid tumors: safety and pharmacokinetics of a dose of 1680 mg every 4 weeks 日本晚期实体瘤患者中阿特珠单抗延长间隔给药方案的研究：每4周一次1680 mg剂量的安全性与药代动力学 Kondo, Shunsuke; Kitano, Shigehisa; Sato, Jun; Katsuya, Yuki; Kogawa, Takahiro; Mizugaki, Hidenori; Miyamoto, Ippei; Iwasawa, Shunichiro; Imaizumi, Tatsuki; Tomita, Hiroaki; Murakami, Chika; Miyake, Takeshi; Yamamoto, Noboru 分享 收藏
Phase 1 study of HP518, a PROTAC AR degrader in patients with mCRPC: results on safety, pharmacokinetics, and anti-tumor activity HP518的I期研究，HP518是一种PROTAC AR降解剂，用于mCRPC患者：安全性、药代动力学和抗肿瘤活性的结果 Azad, Arun A.; Gurney, Howard; Underhill, Craig; Horvath, Lisa; Voskoboynik, Mark; Li, Xinghai; King, Ivan; Shao, Lisa; Dai, Yiyun; Perabo, Frank 分享 收藏
Glasdegib combined with chemotherapy in the treatment of patients with acute myeloid leukemia: a comprehensive meta-analysis glasdegib联合化疗在急性髓系白血病患者治疗中的应用：一项综合荟萃分析 Shaban, Ahmed Yasser; Mohammed, Fatma; Marey, Mohamed Mahmoud; Aldemerdash, Mohamed A.; Abbas, Ahmed W.; Saeed, Omar; Saeed, Abdelrahman; Elhady, Mahmoud M.; Sharabati, Israa; Hamed, Mohamed; Abou-Shanab, Ahmed R. A.; Bahnasy, Ahmed; Abdelgawad, Hussien Ahmed H. 分享 收藏
PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combination with gemcitabine and nab-paclitaxel in non-resectable or metastatic pancreatic cancer PANTAX：一项关于外排泵抑制剂SCO-101联合吉西他滨和nab-紫杉醇治疗不可切除或转移性胰腺癌的Ib期临床试验 Shim, Susy; Reinacher-Schick, Anke; Kraeft, Anna-Lena; Tarpgaard, Line Schmidt; Ettrich, Thomas Jens; Kestler, Angelika; Christensen, Signe; Jandu, Haatisha; Nawabi, Mubeen; Roest, Nicklas Lindland; Damstrup, Lars; Vestlev, Peter Michael; Bruenner, Nils; Stenvang, Jan; Ladekarl, Morten 分享 收藏
The up-regulated expression level of deubiquitinating enzyme USP46 induces the apoptosis of A549 cells by TRAF6 USP46去泛素化酶的上调表达水平通过TRAF6诱导A549细胞凋亡。 Zhao, Xuan; Li, Yanan; Gu, Dandan; Wang, Xiaoru; Han, Guangxin; Yao, Yasen; Ren, Limei; Yao, Qingguo; Li, Xiaobing; Qi, Yonghao 分享 收藏
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