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Pharmacological Research 封面图

Pharmacological Research

IF10.5
论文数8763
被引数36343
期刊论文 8763
发表时间
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Striatofugal balance and beneficial effects of facilitating nucleus accumbens mGlu4 receptor activity in the Fmr1-/- mouse model of Fragile X Syndrome纹状体离心平衡及促进伏隔核mGlu4受体活性的有益效应在脆性X综合征Fmr1-/-小鼠模型中的作用
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IF10.5
delete2026-10-28
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deleteMathieu Fonteneau; Claire Terrier; Florian Bolot; Fani Pantouli; Agathe Brugoux; Fanny Malhaire; Ingrid Wagnon; Roser Borràs-Tuduri; Paola Rossolillo; Isabelle McCort-Tranchepain; Alexis Bailey; Francine Acher; Amadeu Llebaria; Cyril Goudet; Jérôme A.J. Becker; Julie Le Merrer
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Targeting the Catalytic and ZnF-UBP Domains of HDAC6 Differentially Controls NLRP3 Inflammasome Priming and Assembly in Paclitaxel-Induced Peripheral Neuropathy靶向HDAC6的催化域和ZnF-UBP域差异性地调控紫杉醇诱导的外周神经病中的NLRP3炎症小体预激活和组装
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IF10.5
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deleteHaoran Ying; Ruizhu Yue; Jin Zhang; Xing Guo; Jinsong Li; Wenyu Mo; Yue Hao
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Shugan Xiaozhi Formula Reduces Hepatic Steatosis and Stiffness in MASLD Patients with Elevated ALT: An Exploratory 24-Week Randomized Trial疏肝消脂方降低ALT升高MASLD患者的肝脂肪变性和肝硬度：一项探索性24周随机试验
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IF10.5
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deleteYuxin Sun; Zhiyi Han; Can Li; Die Hu; Fanci Xie; Qingqing Li; Hong Luo; Mianmian Liao; Xiaoling Zhou; Jingbao Hu; Shizao Mo; Nailiang Cai; Xiaojun Ma; Yu Lai; Shijun Zhang; Dan Li; Yufeng Xing; Hua Zhou; Guangdong Tong
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Mitochondrial Transplantation as a Therapeutic Strategy: From Energy Replacement to Metabolic and Immune Reprogramming线粒体移植作为一种治疗策略：从能量替代到代谢和免疫重编程
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IF10.5
delete2026-10-27
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deleteChuli Zhu; Meng Xu; Yanan Ji; Jie Wang; Xinlei Yao; Hualin Sun
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MAMDC2 drives microglia-mediated neuroinflammation via CAND1-dependent IκBα ubiquitination and is targetable by Artemvulactone EMAMDC2通过CAND1依赖的IκBα泛素化驱动小胶质细胞介导的神经炎症，并可被Artemvulactone E靶向
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IF10.5
delete2026-10-26
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deleteTao Liu; Feng Gao; Yiliang Wang; Xiangyu Guo; Zhe Ren; Kai Zheng; Xiaofei Zheng; Yifei Wang
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The dual role of BDNF in epilepsy: insights from calpain-mediated TrkB-FL cleavageBDNF在癫痫中的双重作用：来自钙蛋白酶介导的TrkB-FL切割的见解
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IF10.5
delete2026-10-25
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deleteLeonor Ribeiro-Rodrigues; Inga Griškova-Bulanova; Maria José Diógenes; Sara Xapelli
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GABARAPL1 drives therapeutic differentiation of cancer cells by targeting epigenetic changes regulated by SFPQGABARAPL1通过靶向由SFPQ调控的表观遗传变化来驱动癌细胞的治疗性分化
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IF10.5
delete2026-10-24
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deleteLin Zhou; Jiawen Yang; Di Zhou; Jian Gao; Liwei Wang; Ying Huang; Guoyu Li; Xiaofeng Liu; Xiaoning Wang; Hui Ye; Peipei Xu; Qiang Xu; Yan Shen
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Polyol Pathway Inhibition by Epalrestat Attenuates Pathological Bone Loss through Redox Homeostasis and Sorbitol-Linked Calcium Signaling依帕列斯特通过氧化还原稳态和山梨醇相关的钙信号通路抑制多元醇通路，从而减轻病理性骨丢失
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IF10.5
delete2026-10-24
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deleteChengjun Yao; Zimin Cai; Haixin Song; Qize Xue; Bohan Cai; Wenyao He; Xiangxi Kong; Tao Yang; Jiayan Jin; Jie Li; Binhui Chen; Fengdong Zhao; Jia Chen; Jian Chen; Junhui Liu
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Redox Imbalance and Epigenetic Reprogramming Underlie Polysubstance-Induced Neuronal Dysfunction氧化还原失衡和表观遗传重编程是导致多物质诱导神经元功能障碍的根源
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IF10.5
delete2026-10-23
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deleteKarthick Chennakesavan; Haylee R. Hammond; Nakulan Kalaisejiane; Shyam Devan; Abhinav Karnati; Shainnel O. Eans; Ashai K. Williams; Jay P. McLaughlin; Thangavel Samikkannu
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Comment on "Efficacy of Traditional Chinese Medicine in Managing Gastric Atrophy and Intestinal Metaplasia in Patients with Chronic Atrophic Gastritis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial"对“传统中药在管理慢性萎缩性胃炎患者胃萎缩和肠化生中的疗效：一项多中心、随机、双盲、安慰剂对照试验”的评论
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IF10.5
delete2026-10-22
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deleteYangyuxiao Lu; Mengqi Fang; Xuan Huang
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Decoding voltage-gated sodium channels structure: Molecular mechanisms linking architecture, function, and disease解析电压门控钠通道结构：连接结构、功能和疾病的分子机制
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IF10.5
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deleteJoão Pedro Boazinha; João Carneiro; Nuno M.F.S.A. Cerqueira; Sérgio F. Sousa
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A trifluoromethylated chalcone derivative attenuates Alzheimer disease-related Aβ/Tau pathology by modulating the AMPK-dependent autophagy–proteostasis axis三氟甲基查尔酮衍生物通过调控AMPK依赖的自噬-蛋白质稳态轴来减轻阿尔茨海默病相关的Aβ/Tau病理
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IF10.5
delete2026-10-21
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deleteXing-Yue Zhou; Hui Cai; Lin Chen; Xue-Yan Hu; Xiang-Qian Liu; Ya-Ping Li; Xiang Li; An-Guo Wu; Yu-Fan Fan; Zi-Xiong Chen; Wu Wu; Jian-Ming Wu; Guang-Bo Ge; Xiao-Gang Zhou
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Caffeine attenuates Aβ-induced hippocampal dysfunction alongside changes in adenosine receptor-linked GABA handling and neuronal excitability咖啡因通过改变腺苷受体相关的GABA处理和神经元兴奋性来减轻Aβ诱导的海马功能障碍
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IF10.5
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deleteYing Zhai; Mario A. Acuña; Artur Krzyszkowski; Sara Al-Haj; Natalie E. Nevian; David P. Finn; Thomas Nevian; Andrea Kwakowsky
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Gut Dubosiella newyorkensis alleviates noise-related atherosclerosis by reducing N1-methyl-4-pyridone-3-carboxamide肠道杜氏菌Dubosiella newyorkensis通过减少N1-甲基-4-吡啶酮-3-甲酰胺缓解噪音相关性动脉粥样硬化
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IF10.5
delete2026-10-21
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deleteMengying Chen; Ning Fang; Rui Wang; Zhiqi Wang; Yunlong Gao; Ruoxin Min; Yong Hong; Jingying Wang; Yun Zhang; Yue Li; Yongtai Gong
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Longitudinal Proteomics Integrated with Multi‑Omics Reveal Molecular Drivers of Responses to Neoadjuvant Chemotherapy in Rectal Cancer纵向蛋白质组学整合多组学揭示直肠癌新辅助化疗反应的分子驱动因素
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IF10.5
delete2026-10-20
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deleteLiudan Mai; Chen Shao; Yong Cao; Fenqi Du; Jingyi Liu; Qi Zhang; Lin Sun; Yanlin Dong; Jie Lou; Yuxuan Hou; Yin Ni; Maopeng Yang; Yanlong Liu; Qiuju Zhang
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Pharmacological TRPM8 blockade reprograms patient-derived intestinal fibroblasts and mitigates experimental fibrosis through modulation of myofibroblast activation药理学TRPM8阻断通过调节肌成纤维细胞活化重编程患者来源的肠成纤维细胞并减轻实验性纤维化
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IF10.5
delete2026-10-20
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deleteMaria Francesca Nanì; Maria Michela Rinaldi; Ida Cerqua; Paola De Cicco; Maria Miraglia; Ester Pagano; Fiorentina Roviezzo; Stefano Piazza; Giulia Martinelli; Francesca Paola Tropeano; Gaetano Luglio; Felice Crocetto; Mario Dell’Agli; Raffaele Capasso; Francesca Borrelli; Barbara Romano; Angelo Antonio Izzo
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AI-Guided Identification of a Covalent SMAD3 Regulatory Mechanism of Celastrol in Diabetic Kidney DiseaseAI引导下发现Celastrol在糖尿病肾病中对SMAD3的共价调控机制
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IF10.5
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deletePengchen Chen; Hailong Deng; Wei Wang; Laihong Gao; Guiying Xiang; Jialing Lang; Ying Qin; Zhaodie Geng; Tao Zhang; Xinwen Zhou; Mingjun Shi; Yuanyuan Wang; Ying Xiao; Ran Wei; Lirong Liu; Bing Guo
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Should mitochondrial membrane potential be reconsidered as a criterion of cell death?线粒体膜电位是否应重新考虑作为细胞死亡的标准？
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IF10.5
delete2026-10-19
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deletePetr Mlejnek
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Nifedipine-modulated gut microbiota attenuates hypertensive vascular injury through Bifidobacterium-associated inosine-Adora2b signaling硝苯地平调控的肠道菌群通过双歧杆菌相关的次黄苷-Adora2b信号通路减轻高血压血管损伤
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IF10.5
delete2026-10-17
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deleteXiaoyu Ren; Xuefang Yan; Ping Tang; Jiajia Jin; Zihan Qin; Yun Zhang; Tongxue Zhang; Guixiang Yao; Xianlun Yin; Zhuo Zhao; Zhe Wang; Qunye Zhang
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Low-dose juglone attenuates pressure overload-induced cardiac hypertrophy through Lys207-dependent FoxO1 activation and mitochondrial protection低剂量胡桃醌通过赖氨酸207依赖的FoxO1激活和线粒体保护减轻压力超负荷诱导的心肌肥厚
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IF10.5
delete2026-10-17
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deleteHongyu Chen; Zhihao Yang; Cheng Zhang; Chengxin Ge; Yingliang Zhao; Shaopeng Cheng; Yilin Wang; Hao Chen; Can Xu; Dongjin Wang; Jie Yang
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