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Drug Metabolism and Pharmacokinetics 封面图

Drug Metabolism and Pharmacokinetics

IF2.2
论文数90
被引数1949
期刊论文 90
发表时间
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ADARs regulate hepatic UGT1A6 expression via HNF1αADARs通过HNF1α调节肝细胞UGT1A6表达
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-10-26
delete0
PREAI
deleteShuji Takeuchi; Masataka Nakano; Tatsuki Fukami; Miki Nakajima
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UGT1A1 isoform-selective allosteric inhibition by dirithromycin地红霉素对UGT1A1异构体选择性别构抑制
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-10-21
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PREAI
deleteTing Wang; Tom S. Chan; Mitchell E. Taub
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Theoretical Analysis of Developmental Changes in Adenosine A2A Receptor Occupancy in Premature Infants Under Caffeine Therapy咖啡因治疗下早产儿腺苷A2A受体占有率发育变化的理论分析
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-10-09
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deleteOAAI
deleteHaruka Ide; Akane Hara; Ryosuke Fujihara; Kokoro Fukuzawa; Masato Taguchi
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Microsomal and Hepatocyte Binding in Drug Discovery: Method Suitability and Lipophilicity-Based Predictions药物发现中的微粒体和肝细胞结合：方法适用性与脂溶性预测
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-10-06
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PREAI
deleteLeonel Torrão; Gaëlle Chenal; Stephane Rodde; Birk Poller; Sujal V. Deshmukh; Julia Riede
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Evaluation of Food Effects on Oral Absorption from Lipid-Based Formulations Using an In Vitro Digestion–In Situ Absorption Model with a Physiologically Relevant Surface Area to Volume Ratio利用具有生理相关表面积与体积比的体外消化-体内吸收模型评估食物对脂质基制剂口服吸收的影响
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-10-03
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PREAI
deleteYusuke Tanaka; Shogo Sasaki; Hiroto Nishiura; Ko Imai; Haruya Yagi; Shinji Sakuma
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Translational limitations of a rat-derived hybrid pharmacokinetic–toxicodynamic model for chemotherapy-induced hematologic toxicity in humans源自大鼠的杂交药代动力学–毒效动力学模型在化疗诱导的人类血液毒性中的转化局限性
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-09-28
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PREAI
deleteShinji Kobuchi; Kenji Ikemura; Akihide Kobayashi; Masahiro Okuda; Yukako Ito
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Beyond Km and Vmax: a geometric framework for characterising enzyme modulation and validating kinetic data超越Km和Vmax：表征酶调控和验证动力学数据的几何框架
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-09-28
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PREAI
deleteJonathan Salerno
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Assessment of Infliximab Biotransformation in Patient Serum by Comparing Mass-Spectrometry and Ligand-Binding Assay Quantification通过比较质谱和配体结合分析定量评估患者血清中英夫利昔单抗的生物转化
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-09-15
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deleteOAAI
deleteSho Masui; Aoto Nakajima; Kodai Yajima; Takashi Shimada; Akira Onishi; Makoto Okabe; Shuji Yamamoto; Tomohiro Terada; Atsushi Yonezawa
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Characterization of unusual pyrazole ring-rearranged metabolites of DS-1971a specific to monkeysDS-1971a在猴子中特有且吡唑环发生异常重排的代谢物表征
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-08-01
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PREAI
deleteAsano, Daigo; Michiba, Kazuyoshi; Masuda, Kayoko; Ohnuki, Takashi; Suzuki, Makoto; Suzuki, Tetsuya; Shiozawa, Hideyuki; Shinozuka, Tsuyoshi; Takatsu, Toshio; Nakai, Daisuke
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Development of a Method for Vancomycin Monitoring in Interstitial Fluid Using a Novel Porous Microneedle Array Patch一种用于检测间质液中万古霉素的新型多孔微针阵列贴片的开发方法
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-06-30
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deleteJo Terauchi; Taisei Kawamura; Jongho Park; Kiyomi Saito; Masataka Tajima; Hitoshi Sato; Beomjoon Kim; Erika Sugiyama
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β-Cyclodextrin as a Negative Allosteric Modulator of Mammea A/AA Binding to Serum Albumin: A Spectroscopic and Molecular Dynamics Studyβ-环糊精作为Mammea A/AA与血清白蛋白结合的负向别构调节剂：一项光谱学和分子动力学研究
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-06-29
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PREAI
deleteAteba A. Baruch; Mathieu J.M. Tjegbe; Loveline T. Bamou; Hans M.T. Fofack; Maraf M. Bake; Luc M. Mbaze
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Development and validation of LC–MS-based bioanalytical methods for oligonucleotide therapeutics: points to considerLC–MS为基础的寡核苷酸治疗药物生物分析方法的发展与验证：需考虑的问题
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-06-19
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PREAI
deleteYuchen Sun; Kosuke Saito; Shin-ichiro Nitta; Ryoya Goda; Yuki Kishino; Hisashi Fujita; Masaaki Kakehi; Yoshiharu Hayashi; Satoshi Ito; Tomomi Ishida; Kiyomi Kikuchi; Kazuko Inoue; Kazutaka Shimbo; Takeru Yamaguchi; Fumihiro Jinno; Kaori Murakoshi; Chie Murata; Kentaro Takahara; Mitsuhiko Kawabata; Ruri Kikura-Hanajiri
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A Permeability Assay Adapted for the Assessment of Very Poorly Permeable Compounds in the bRo5 Space.一种适用于评估bRo5空间内极低渗透性化合物的渗透性测定方法
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-06-02
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PREAI
deletePaulina Page; Dallas Bednarczyk
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Tyrosine kinase inhibitors suppress cytochrome P450 2C8 and 2J2 functions and their expression in renal cell carcinoma酪氨酸激酶抑制剂抑制肾细胞癌中细胞色素P450 2C8和2J2的功能及其表达
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-05-29
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PREAI
deleteAyaka Kojima; Masayuki Nadai; Hiroshi Yamazaki; Miki Katoh
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A novel scaling approach for human pharmacokinetic prediction of antibody-drug conjugates using minimal nonclinical data: Integration of monkey PK and in vitro data利用最小非临床数据预测抗体偶联物人体药代动力学的一种新型缩放方法：猴药代动力学与体外数据的整合
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-05-28
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PREAI
deleteSatoshi Nakayama; Nao Torimoto; Toshiyuki Kudo; Kiyomi Ito
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K2-EDTA Anticoagulant Suppresses Calcium-Dependent Paraoxonase 1-Mediated Hydrolysis in Human Plasma Stability AssaysK2-EDTA抗凝剂抑制钙离子依赖的PON1介导的水解在人类血浆稳定性测定中
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-04-21
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PREAI
deleteLloyd Wei Tat Tang
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Role of the arachnoid mater organic anion and cation transporters in the clearance of prostaglandin D2 and metformin from the cerebrospinal fluid in rats蛛网膜有机阴离子和阳离子转运体在清除大鼠脑脊液中前列腺素D2和二甲双胍中的作用
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-04-17
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PREAI
deleteYuka Yaguchi; Kazunari Sasaki; Mai Inagaki; Tetsuya Terasaki; Masanori Tachikawa
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Differences in reactive metabolite formation and cytochrome P450 binding between acetaminophen and its bicyclo[1.1.1]pentane bioisostere乙酰氨基酚及其双环[1.1.1]戊烷生物电子等排体的反应性代谢物形成和细胞色素P450结合差异
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-04-15
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PREAI
deleteMinami Shibata; Ayato Mizuno; Tomoki Nakayoshi; Akifumi Oda; Masaya Nakajima; Masanobu Uchiyama; Masahiro Hiratsuka; Yoshihiro Yamanishi; Kouichi Yoshinari
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Microfluidic post-insertion preparation and evaluation of RGD- and PEG-modified macrophage-derived small extracellular vesicles微流控后插入制备与评估RGD-和PEG修饰的巨噬细胞来源小细胞外囊泡
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-04-02
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deleteOAAI
deleteMizuki Umino; Longjian Geng; Yusuke Ushiroda; Makoto Matsumoto; Hidefumi Mukai; Shigeru Kawakami
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Physiologically-Based Pharmacokinetic Modeling of Coproporphyrin I, an Endogenous OATP1B Substrate, in Cynomolgus Monkeys: Bridging the Inhibitory Effect of Rifampicin to Humans基于生理的药代动力学模型研究——以恒河猴为对象，探讨内源性OATP1B底物粪卟啉I及利福平抑制效应向人类的转化
deleteDrug Metabolism and Pharmacokinetics
IF2.2
delete2026-04-02
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PREAI
deleteTakashi Yoshikado; Yukana Tomoda; Kouki Kasai; Reiki Toda; Satofumi Iida; Koji Chiba
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