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Medicinal Chemistry Research 封面图

Medicinal Chemistry Research

IF3.1
论文数271
被引数6962
期刊论文 271
发表时间
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Small-molecule ferroptosis inducers and sensitizers in anticancer drug discovery: medicinal chemistry, structure–activity relationships, and translational perspectives小分子铁死亡诱导剂和增敏剂在抗癌药物发现中的应用：药物化学、构效关系及转化研究展望
deleteMedicinal Chemistry Research
IF3.1
delete2026-10-24
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PREAI
deleteAashik Malik; Md Arif Naseer; Mayank Yadav; Zulphikar Ali; Jai Parkash Kadian
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Azole chroman-4-one, tetralone and chromen-4-one derivatives: synthesis, Mycobacterium tuberculosis CYP121A1 enzyme inhibition and antimycobacterial activity唑-色满-4-酮、四氢萘酮和色烯-4-酮衍生物：合成、分枝杆菌CYP121A1酶抑制和抗分枝杆菌活性
deleteMedicinal Chemistry Research
IF3.1
delete2026-10-23
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deleteJabril M. Abdali; Lama A. Alshabani; Alistair K. Brown; Amit Kumar; Sam Wilcocks; Ahmed Y. G. Alhejaili; Sanjida Y. Kalam; D. Fernando Estrada; Claire Simons
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Structure-based discovery of acridone alkaloids as disruptors of the HEG1–KRIT1 protein–protein interaction in cerebral cavernous malformation signaling基于结构的阿卡利酮类生物碱的发现及其作为脑海绵状血管瘤信号通路中HEG1–KRIT1蛋白–蛋白相互作用干扰剂的作用
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IF3.1
delete2026-10-13
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PREAI
deleteEmadeldin M. Kamel; May Bin-Jumah; Haifa E. Alfassam; Raghad A Alotaibi; Ahmed A. Allam; Fahad M. Alshabrmi; Faris F. Aba Alkhayl; Al Mokhtar Lamsabhi
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Coumarin scaffolds in breast cancer research: derivatives, hybrids, and therapeutic potential香豆素骨架在乳腺癌研究中的应用：衍生物、杂化物及其治疗潜力
deleteMedicinal Chemistry Research
IF3.1
delete2026-10-13
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deleteShagufta; Irshad Ahmad; Isha Khan; Maimonah Al Zubaidi; Aayat Aladhamy
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Special issue of Medicinal Chemistry Research in honor of Dr. Kenneth A. Jacobson为纪念肯尼斯·A·雅各布森博士而出版的《药物化学研究》特刊
deleteMedicinal Chemistry Research
IF3.1
delete2026-10-09
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deleteCarola Gallo-Rodriguez; Juan Bautista Rodriguez; Pnina Fishman
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Bicyclononane-2,8-bis(trifluoromethyl)quinoline hybrids: synthesis, antiplasmodial and antitrypanosomal activity双环壬烷-2,8-双(三氟甲基)喹啉杂化物的合成、抗疟原虫和抗锥虫活性
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IF3.1
delete2026-10-06
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deleteJohanna Dolensky; Werner Seebacher; Eva-Maria Pferschy-Wenzig; Miriam Zehentner; Robert Saf; Pascal Mäser; Monica Cal; Robert Weis
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From danger to resolution: targeting purinergic signaling in CNS diseases从危险到解决：靶向中枢神经系统疾病中的嘌呤能信号
deleteMedicinal Chemistry Research
IF3.1
delete2026-10-05
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deleteCamille Degryse; Kirti Gupta; Luc Buée; Thierry Burnouf; David Blum; Ming-Li Chou
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Vepdegestrant: the first FDA-approved oral PROTAC and a milestone in targeted protein degradationVepdegestrant：首个FDA批准的口服PROTAC，靶向蛋白质降解领域的里程碑
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IF3.1
delete2026-10-01
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deleteJeffrey Yang; Longqin Hu
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Baxdrostat (Baxfendy®), a first-in-class aldosterone synthase inhibitor approved for adults with uncontrolled hypertensionBaxdrostat (Baxfendy®)，一种用于控制成人难治性高血压的第一类醛固酮合成酶抑制剂
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IF3.1
delete2026-09-29
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deleteAhmed R. Ali; Longqin Hu
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Design and biological evaluation of sulfonamide–chalcone hybrids with in vitro tumor-selective cytotoxicity against oral squamous cell carcinoma: SAR, QSAR, and in silico ADME studies磺酰胺-查尔酮杂合物的设计与生物学评价：体外肿瘤选择性细胞毒性对口腔鳞状细胞癌的SAR、QSAR及计算机ADME研究
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IF3.1
delete2026-09-29
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deleteGulsen Ozli; Hiroshi Sakagami; M. Fatih Polat; Cavit Kazaz; Kota Kurosaki; Yoshihiro Uesawa; Kaito Inden; Halise Inci Gul
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Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applicationsGlypican-3靶向生物缀合物用于肝细胞癌：设计、工程与转化应用
deleteMedicinal Chemistry Research
IF3.1
delete2026-09-28
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deleteYi Liu; Jiaying Zhu; Haolei Yu; Chenyu Wang; Yue You; Zixuan Hong; Chenbo Zhang; Chenpengyu Zhang; Zhihao Zhang
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Optimization of a bis-imine scaffold as a glyoxalase I inhibitor: synthesis, SAR, and docking studies双亚胺骨架作为甘油醛酸酶I抑制剂的优化：合成、构效关系和对接研究
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IF3.1
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deleteButhina A. Al-Oudat; Farah B. Al-Omari; Suaad A. Audat; Nizar A. Al-Shar’i; Qosay A. Al-Balas
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Pantoprazole as a potential repurposed drug targeting the adenosinergic system in esophageal cancer泮托拉唑作为靶向食管癌腺苷能系统的潜在再利用药物
deleteMedicinal Chemistry Research
IF3.1
delete2026-09-25
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deleteAdriana Simioni; Rafael D Weimer; Julia B de Souza; Isadora V Citrini; Julia A da Rosa; Kaline Cardoso; Maria E Delawi; Luis FSM Timmers; Fernanda B Morrone
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Peptide-based allosteric modulators of AMPA receptors: design, docking and ligand-receptor interactions基于肽的AMPA受体别构调节剂：设计、对接及配体-受体相互作用
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IF3.1
delete2026-09-24
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deleteTatiana V. Vyunova; Liudmila A. Andreeva; Konstantin V. Shevchenko; Valeriy P. Shevchenko; Igor Y. Nagaev; Andrey A. Butylin; Mstislav I. Lavrov; Vladimir A. Palyulin; Pavel E. Musienko; Nikolay F. Myasoedov
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Repurposing antifolates as G9a methyltransferase inhibitors for potential Alzheimer’s disease therapeutics via 3D QSAR/pharmacophore mapping and experimental validations通过3D QSAR/药效团映射和实验验证，将抗叶酸药物重新定位为G9a甲基转移酶抑制剂，用于潜在阿尔茨海默病治疗
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IF3.1
delete2026-09-24
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deleteAbhisek Jana; Aina Bellver-Sanchis; Koushik Barman; Christian Griñán-Ferré; Deb Ranjan Banerjee
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Effect of pipernonaline from Piper retrofractum on memory disorder in mice and neurite outgrowth activity of PC12 cellsPiper retrofractum中胡椒诺拉明对小鼠记忆障碍的影响及对PC12细胞轴突生长活性的作用
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IF3.1
delete2026-09-24
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deleteRuna Fujimoto; Yuzuki Irie; Tohru Mitsunaga; Kosei Yamauchi
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An updated review of enantioselective syntheses and biological actions of carbanucleosides手性选择性合成和碳核苷类生物活性的最新综述
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IF3.1
delete2026-09-24
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deleteSheila I. de Diego Saadia; Sergio H. Szajnman; Juan B. Rodriguez
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Artificial intelligence–assisted lead optimization in drug discovery: bridging computational advances and translational challenges人工智能辅助的药物发现中的先导化合物优化：连接计算进展与转化挑战
deleteMedicinal Chemistry Research
IF3.1
delete2026-09-17
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deleteFatma AlZahraa A. A. Mohamed; Ahmed Mohsen Kamal El-sagheir
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Probing novel azole–sulfonamide urea/thiourea conjugates as multitarget inhibitors of AChE and hCAs (I and II): synthesis, in vitro, and in silico studies探索新型唑类–磺酰胺脲/硫脲共轭物作为乙酰胆碱酯酶和人碳酸酐酶（I和II）的多靶点抑制剂的合成、体外及计算机模拟研究
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IF3.1
delete2026-09-17
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deleteİrfan Çapan; Çağan Yasa; Yeliz Demir; Metin Güzelcan; Mohammed T. Qaoud; Yusuf Sert; İrfan Koca; İlhami Gülçin
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Unveiling the therapeutic potential of Calotropis procera: from traditional applications to phytochemistry, pharmacology, and safety揭示Calotropis procera的 therapeutic potential：从传统应用到植物化学、药理学和安全性
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IF3.1
delete2026-09-17
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deleteNitish Kumar; Rohit Singh Negi; Jyotirmayee Behera; Manjeet Kumar Sah Gond; Sunil Kumar Mishra
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