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Bioorganic and Medicinal Chemistry Letters

IF2.2
论文数310
被引数33083
期刊论文 310
发表时间
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Development of the fluorescence polarization-based competition assay for the E3 ligase GID4基于荧光偏振法的E3连接酶GID4竞争性分析的开发
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-27
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PREAI
deleteMeiling Zhang; Shijia Xiao; Kexin Yan; Jiyue Sun; Chen Xi; Yuhong Qin; Cheng Dong; Dongxing Chen
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Design, synthesis, and antiviral activity evaluation of the bis-ester prodrug of N4-hydroxycytidine phosphateN4-羟基胞嘧啶磷酸的双酯前药的制备、合成及其抗病毒活性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-25
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PREAI
deleteHao Sun; Xu Yan; Chunhuan Mo; Jia Chen; Yan Liu; Yaohui Liu; Xia Han; Jianqin Gao; Lehua Yin; Jinghua Xu; Yuan Chen; Xinhua He
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Design, synthesis, and biological evaluation of novel 4-aminoquinoline derivatives as potent membrane-targeting antifungal agents设计、合成及生物评价新型4-氨基喹啉衍生物作为强效膜靶向抗真菌剂
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-23
delete0
PREAI
deleteJing Du; Wei Wang; Yanni Ma; Chaoyong Cui; Yuwan Zhang; Jian Yang; Rui Yang
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Alternariol from the endophytic fungus Alternaria sp. S4 acts as a membrane-targeting bactericidal agent against Staphylococcus aureusAlternariol 从内生真菌 Alternaria sp. S4 中分离得到，可作为膜靶向杀菌剂对抗金黄色葡萄球菌。
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-23
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PREAI
deleteYanlin He; Yuwan Zhang; Wei Wang; Chaoyong Cui; Qianyun Hao; Hongguan Xie; Rui Yang
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Identification of a novel Songorine derivative as a potent NLRP3 inflammasome inhibitor鉴定一种新型Songorine衍生物作为强效NLRP3炎症小体抑制剂
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-19
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PREAI
deleteRunqin Liu; Qiang Zhang; Miao Xian; Qifeng Chen
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Discovery and optimization of 2,3-Dihydroindole derivatives as STING receptor allosteric agonists2,3-二氢吲哚衍生物作为STING受体别构激动剂的发现与优化
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-16
delete0
PREAI
deleteYing Liu; Jing Wu; Ni Gao; Lin Zheng; Wenbo Zhang; Fabao Zhao; Bairu Meng; Xinyong Liu; Lanyu Liu; Huajun Zhao; Dongwei Kang
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N-[3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl]-heteroaromatic carboxamide as selective α1A/1D-adrenoceptor antagonists: SAR study and metabolic stability evaluationN-[3-(4-(2-甲氧基苯基)哌嗪-1-基)丙基]-杂芳基羧酰胺作为选择性α1A/1D-肾上腺素能受体拮抗剂：构效关系研究及代谢稳定性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-13
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PREAI
deleteRuxia Duan; Linxin Zhou; Ran Chen; Yajian Huang; Dan Wu; Tomohiko Ohwada; Wei Yi; Junjun Huang
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Design, synthesis, and antibacterial activity evaluation of tryptanthrin derivatives靛红衍生物的设计、合成及其抗菌活性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-11
delete0
PREAI
deleteBing-Yuan Yan; Ran-Qi Feng; Chen Qu; Xu-Wen Li
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Design, synthesis and biological evaluation of ALK/HDAC dual-targeting agentsALK/HDAC双靶点靶向药物的设计、合成与生物活性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-11
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PREAI
deleteYe Kong; Shunda Li; Xintong Xue; Huiping Liu; Ruiwei Fu; Yan Gao; Yingjie Zhang; Xia Xue
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Design, synthesis and biological evaluation of coumarin-based HDAC6 inhibitors for the treatment of ulcerative colitis基于香豆素的HDAC6抑制剂的抗溃疡性结肠炎治疗的设计、合成与生物活性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-10
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PREAI
deleteXiang Qiu; Lingling Dong; Hongzhen Shu; Guangxing Yu; Yuling Tong; Hengfan Ni; Shunjie Zhang
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Identification of flavonoid-based small molecule inhibitors with dual-targeting capability against RdRp and Mpro of SARS-CoV-2鉴定具有双靶点能力的黄酮类小分子抑制剂，针对SARS-CoV-2的RdRp和Mpro
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-08
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PREAI
deleteYanlei Su; Yujia Wang; Jianyuan Zhao; Keyu Guo; Xuhong Duan; Honghai Wu; Dianxing Sun; Jing Zhang; Shan Cen
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A self-assembling peptide platform enables plasma membrane protein degradation一种自组装肽平台能够实现质膜蛋白的降解
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-08
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PREAI
deleteWenjie Zhou; Yanyan Li; Wenli Shi; Binghua Cheng; Jiaming Liang; Zeyu Zhou; Hui Tian; Ximing Shao; Hongchang Li; Lijing Fang; Ke Liu
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A potent and selective RORγ inhibitor for the treatment of autoimmune diseases一种强效且选择性的RORγ抑制剂，用于治疗自身免疫性疾病
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-08
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PREAI
deleteTaku Ikenogami; Masahiro Yokota; Shingo Fujioka; Naoki Ogawa; Masato Noguchi; Akihiro Nomura; Tsuyoshi Adachi; Yoshiaki Katsuda; Kojo Arita; Naoki Miyagawa; Yusuke Aratsu; Kota Asahina; Paul Crowe; Haiyan Tao; Scott Thacher; Makoto Shiozaki
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Synthesis and antitumor activity of derivatives of SKF-83566SKF-83566衍生物的合成与抗肿瘤活性
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-08
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PREAI
deleteXiu-Jun Wang; Meng-Xin Lu; Qiu-yue Jin; Zi-Yan Lang; Ming-Li Yang; Jing Ji
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Bicyclic peptide-based CPPTACs for extracellular and cell membrane protein degradation基于双环肽的CPPTACs用于细胞外和细胞膜蛋白降解
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-08
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PREAI
deleteJinyu Bai; Huaihuai Shi; Jitun Chen; Hui Tian; Jiaxin Liang; Bichun Chen; Jiazhong Li; Lijing Fang
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Design, synthesis, antifungal activity, and molecular docking studies of benzothiazole, S-benzyl-2,4-isodithiobiuret, and thiourea derivatives of 1-hepta-O-benzoyl-β-d-maltose nanoparticles苯并噻唑、S-苄基-2,4-异二硫代缩脲以及1-七-O-苯甲酰基-β-D-麦芽糖基硫脲衍生物的设计、合成、抗真菌活性及分子对接研究
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-07
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PREAI
deleteShankesh C. Zyate; Nikita V. Awajare; Sanjay S. Gaikwad; Kunal Raut; Vikas Jha; Amardeep R. Jadhao; Poonam T. Agrawal
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Discovery of novel imidazo[4,5-b]pyridine derivatives as noncovalent reversible Bruton’s tyrosine kinase inhibitors新型咪唑[4,5-b]吡啶衍生物作为非共价可逆性BTK抑制剂的发现
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-05
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PREAI
deleteYeojeong Kim; Jingyang Sun; Kyoungyim Lee; Soobin Kim; Danbi Lee; Bomi Park; Yeji Lee; Inah Hwang; Jae-Sang Ryu
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Synthesis of new Pyridazinone derivatives and their dual inhibitory activity on aldose reductase and α-glucosidase新型吡啶二酮衍生物的合成及其对醛糖还原酶和α-葡萄糖苷酶的双重抑制活性
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-12-05
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PREAI
deleteMevlüt Akdağ; Merve Güneş Çam; Derya Ergen; Yeliz Demir; Şükrü Beydemir; Azime Berna Özçelik
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Exploring the therapeutic potential of deuterated PPARγ agonists for NASH探索氘代PPARγ激动剂在NASH中的治疗潜力
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-11-28
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PREAI
deleteXudong Pang; Dawei Cui; Ruifeng Liu; Binhua Lv; Cheng-Yun Wang
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Design, synthesis, and activity evaluation of alpinetin derivatives as potential anti-liver cancer drugs阿尔皮宁衍生物的设计、合成及其作为潜在抗肝癌药物的活性评价
deleteBioorganic & Medicinal Chemistry Letters
IF2.2
delete2025-11-27
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PREAI
deleteYanhui Yi; Yupei Sun; Xiangyang Zhang; Jianzeng Xin; Feng Zhao; Wei Zhu; Sheng Liu
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