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Science China-Life Sciences 封面图

Science China-Life Sciences

IF9.5
论文数681
被引数9425
期刊论文 681
发表时间
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Myeloid cell-mediated nanoparticle delivery to the CNS via the skull bone marrow-brain axis骨髓细胞介导的纳米颗粒通过颅骨骨髓-脑轴递送至中枢神经系统
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IF9.5
delete2026-10-28
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deleteXinrui Li; Sijia Li; Yihao He; Dandan Zheng; Huitong Ruan
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Incidence of rare cancers in China: trends and insights中国罕见癌种的发病率：趋势与见解
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IF9.5
delete2026-10-27
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deleteYiyi Pan; Jiahui Wang; Yueyu Huang; Wenhui Shen; An Zhao
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Gut microbiota in high-altitude acclimatization and adaptation: microbiota homeostasis, double-edged roles, and gut-X axis-specific microbiota reconstruction高海拔习服与适应中的肠道菌群：菌群稳态、双刃剑作用及肠-X轴特异性菌群重建
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IF9.5
delete2026-10-27
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deleteWangyang Chen; Kun He; Kai Song; Zhen Yu; Daiyu Yang; Hemiao Xu; Shuai Li; Qiming Xiao; Yangjin Ciren; Lingling Zhu; Shizheng Wu; Yuqi Gao; Luobu Gesang; Jinshui Yang; Dong Wu
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The role of microbial enzymes in intervention strategies for metabolic diseases targeting the gut microbiota微生物酶在靶向肠道微生物群的代谢性疾病干预策略中的作用
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deleteYuhua Gao; Xiaoxiang Gao; Kai Wang; Jie Qiao; Changtao Jiang
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PRDM16 attenuates pulmonary fibrosis through NuRD-mediated epigenetic remodeling in lung fibroblastsPRDM16通过NuRD介导的表观遗传重塑减轻肺纤维化
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IF9.5
delete2026-10-22
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deleteJie Wang; Jianfang Li; Bizhi Shang; Xing Feng; Wenjuan Wang; Lu Han; Caizhou Zhong; Xingyue Liu; Yingni Chen; Zheng Wang; Jiafu Long; Jin Su; Zheng Li
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On the archaeological evidence for prehistoric human impacts on Tibetan antelope populations关于史前人类活动对藏羚羊种群影响的考古学证据
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IF9.5
delete2026-10-22
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deleteZhongqiu Li
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A ketamine derivative exerts enhanced antidepressant effects via adenosine signaling氯胺酮衍生物通过腺苷信号发挥增强的抗抑郁作用
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deleteNa Wang; Chenyu Yue; Xiaofeng Fan; Yuan Gao; Huiping Shang; Yali He; Minmin Luo
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Reply to: on the archaeological evidence for prehistoric human impacts on Tibetan antelope populations对史前人类影响藏羚羊种群考古证据的回应
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deleteWeimin Kuang; Li Yu
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MdRAD5B regulates the chromatin accessibility of MdMYB14 under cold by associating with a transcription factor MdLSD1MdRAD5B通过结合转录因子MdLSD1，在低温下调控MdMYB14的染色质可及性
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IF9.5
delete2026-10-20
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deleteYi Song; Ziqing Ma; Jieqiang He; Jiale Wen; Rongxin Zhou; Yuzheng Zhang; Junxing Guo; Ningning Bian; Fengwang Ma; Yinpeng Xie; Qingmei Guan
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Disrupted early molar patterning in syngnathia mouse model在合颚畸形小鼠模型中早期磨牙模式紊乱
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IF9.5
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deleteChensheng Lin; Michaela Prochazkova; Chen Tang; Shunting Chen; Yan Ji; Xinyi Guo; Yiping Chen; Yanding Zhang; Jan Prochazka; Jeremy B. A. Green; Xuefeng Hu
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Tooth organoids: bridging developmental biology and regenerative dentistry牙器官样组织：连接发育生物学与再生牙科
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deleteZiyu Li; Mian Wan; Liwei Zheng
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Polysocial risk score predicts chronic kidney disease incidence and prognosis: mechanistic insights from plasma metabolome, proteome and lifestyle多社会风险评分预测慢性肾脏病发生和预后：来自血浆代谢组、蛋白质组和生活方式的机制见解
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deleteYanjun Zhang; Xiaoqin Gan; Ziliang Ye; Yuanyuan Zhang; Sisi Yang; Hao Xiang; Yu Huang; Yiwei Zhang; Yiting Wu; Sheng Nie; Fan Fan Hou; Xianhui Qin
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Weaning stress reprograms immune translation through GC biased codon usage in piglets with gut microbiota dysbiosis断奶应激通过GC偏向性密码子使用对肠道菌群失调仔猪的免疫翻译进行重编程
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IF9.5
delete2026-10-16
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deleteShiqi Luo; Liang Huang; Erjia Hou; Shuqi Liu; Yige Li; Sai Xiao; Yingkai Wang; Yizhen Wang; Xin Zong
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ATF6α mediates Cr(VI)-induced acute hepatotoxicity via GRP78-dependent mitochondrial dysfunction under oxidative stressATF6α通过GRP78依赖的线粒体功能障碍介导Cr(VI)诱导的氧化应激急性肝毒性
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IF9.5
delete2026-10-14
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deleteYujing Zhang; Mengdan Liu; Shuai Huang; Juan Zhang; Xiaowei Guo; Liuqin He; Sulai Liu
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Rethinking incomplete immune reconstitution in people living with HIV: beyond CD4 metrics toward multi-omics guided precision care重新思考HIV感染者中不完整的免疫重建：超越CD4指标，迈向多组学指导的精准护理
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deleteZhuoya Deng; Xiao-Yan He; Xiuwen Wang; Yong-Tang Zheng; Bin Su; Hong-Yi Zheng
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Current understanding and new promises of umbilical cord blood in emerging clinical applications脐带血在新兴临床应用中的当前理解和新前景
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delete2026-10-12
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deleteXinyu Feng; Yuxuan Liu; Sha Hao; Tao Cheng; Linping Hu
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Awakening cryptic C1 metabolism: engineering de novo formatotrophy in Yarrowia lipolytica unlocks one-carbon biomanufacturing potential唤醒休眠的C1代谢：在解脂耶氏酵母中工程化构建从头甲酸营养性，释放一碳生物制造潜力
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deleteYongjun Wei
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BHLHE40 as a transcriptional rheostat: decoding microenvironmental signals in context-dependent tumor plasticityBHLHE40作为转录调速器：解码依赖微环境信号的肿瘤可塑性
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deleteJie Wang; Fanglin Shao; Rong Zhang; Ruicheng Wu; Dilinaer Wusiman; Koo Han Yoo; Zhouting Tuo; Dengxiong Li; Zhipeng Wang; Dechao Feng
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pH-responsive biomimetic liposomes enhance targeted immunotherapy of bladder cancerpH响应性仿生脂质体增强膀胱癌靶向免疫治疗
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IF9.5
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deleteHaojie Shang; Shuanbao Yu; Zhenzhen Zhou; Dianyu Wang; Yanyang Li; Ke’nan Zhang; Xiaoliang Wu; Ning Wang; Zhaowei Zhu; Shaojin Zhang; Yonghao Zhan; Xuepei Zhang
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DESIGN: a framework for generative AI-enabled crop molecular design-driven breeding设计：一种基于生成式AI驱动的作物分子设计育种框架
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deleteFeng Xu; Ran Fu; Qian Cheng; Shuqin Jiang; Jun Yan; Xiangfeng Wang
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