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Clinical and Translational Science 封面图

Clinical and Translational Science

IF2.8
论文数2711
被引数5065
期刊论文 2711
发表时间
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A Multipart Phase 1 Study to Assess Safety and Pharmacokinetics of Ibuzatrelvir in Healthy Participants and Dose Selection for a Dose-Ranging Study一项多部分I期研究，以评估伊布扎特雷韦尔在健康受试者中的安全性和药代动力学，并为剂量探索研究选择剂量
deleteClinical and Translational Science
IF2.8
delete2026-07-11
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deleteRavi Shankar P. Singh; Sima S. Toussi; Frances Hackman; Mona Shahbazi; John Prybylski; Siddhee A. Sahasrabudhe; Penelope Crownover; Eugene P. Kadar; Billy T. George; Negar Niki Alami; Arthur Bergman
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Machine Learning With Genetic and Clinical Data to Predict Ischemic Outcomes After PCI结合遗传和临床数据，利用机器学习预测PCI术后缺血性结局
deleteClinical and Translational Science
IF2.8
delete2026-07-09
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deleteCaroline W. Grant; Brenden S. Ingraham; Ryan J. Lennon; Anvi Raina; Shulan Tian; Gurukripa Kowlgi; Larisa H. Cavallari; Craig R. Lee; Amber Beitelshees; Dominick J. Angiolillo; Francesco Franchi; Julio D. Duarte; Joseph S. Rossi; George A. Stouffer; Eric Klee; Rajiv Gulati; Charanjit Rihal; Michael Farkouh; Arjun P. Athreya; Naveen L. Pereira
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Advancing PEGylated Drug Evaluation: A Novel Approach to Pegfilgrastim Pharmacokinetic Assessment推进聚乙二醇化药物评估：一种新型培非格拉斯他敏药代动力学评估方法
deleteClinical and Translational Science
IF2.8
delete2026-07-08
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deleteElizaveta Svyatova; Da Shi; Ankit Shah; Kristina E. Howard
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Circulating M-MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study治疗期间循环M-MDSC扩增与多发性骨髓瘤治疗反应相关：一项纵向观察性研究
deleteClinical and Translational Science
IF2.8
delete2026-06-29
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deleteQi Yan; Bin Chu; Mengru Liu; Na Ji; Shan Gao; Minqiu Lu; Lei Shi; Lijuan Fang; Qiuqing Xiang; Yuan Chen; Mengzhen Wang; Li Bao
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Development of a Biphasic Modified-Release Ibuprofen Tablet Formulation: Single-Dose and Multiple-Dose Pharmacokinetics and Food-Effect Studies双相缓释布洛芬片剂制剂的开发：单次剂量和多次剂量药代动力学及食物效应研究
deleteClinical and Translational Science
IF2.8
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deleteLudmila Kvapilová; Jiří Hofmann; Josef Černý; Tomáš Hauser; Mohammed Bouhajib; Martin Šíma; Ondřej Slanař
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PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of SiponimodPBPK建模和临床数据揭示CYP3A4和CYP2C9抑制剂对司伏尼莫消除的减弱影响
deleteClinical and Translational Science
IF2.8
delete2026-06-27
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deleteFelix Huth; Kasra Shakeri-Nejad; Anne Gardin; Bharti Shah; Oliver Pohl; Nicole Pezous; Thomas Faller
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Drug Interactions of Vebreltinib, a Novel Type I c-Met Inhibitor, Coadministration With Rifampin or Itraconazole in Healthy Participants维布雷林抑制剂（一种新型I型c-Met抑制剂）与利福平或伊曲康唑联合给药在健康受试者中的药物相互作用
deleteClinical and Translational Science
IF2.8
delete2026-06-25
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deleteJingcheng Chen; Jingxuan Wu; Yuqin Song; Jiangshuo Li; Linna li; Lijun Li; Yanhong Kong; Xiaofang Wu; Hang Yin; Mengyu Hou; Bingyan Wang; Qiannan Gao; Ran Li; Le Wu; Weizhe Xue; Ruihua Dong
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Model-Informed Development of a Subcutaneous Formulation of Tislelizumab: Phase 1 Pharmacokinetics in Patients With Cancer基于模型的替雷利珠单抗皮下制剂开发：癌症患者的1期药代动力学研究
deleteClinical and Translational Science
IF2.8
delete2026-06-23
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deleteXiangyu Liu; Ye Guan; Yixi Liu; Tian Yu; Ramil Abdrashitov; Ziru Niu; Xiao Lin; Xiaohan Ye; Yutong Wang; Srikumar Sahasranaman; William D. Hanley; Nageshwar Budha
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EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi-Omics and Experimental StudyEPHX2调控溃疡性结肠炎中肠道上皮屏障的修复：一项整合多组学与实验研究
deleteClinical and Translational Science
IF2.8
delete2026-06-23
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deleteTian Dai; Siyu Han; Xiaoping Hu; Jiakuo Gu; Dongmei Liu; Jiale Wu; Juyan Zheng; Shiqin Hong; Yiwen Zhang
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A Phase 1, Open-Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy ParticipantsI期开放标签随机研究，探讨健康受试者多次剂量鼻内纳洛酮的药代动力学和安全性
deleteClinical and Translational Science
IF2.8
delete2026-06-22
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deleteDavid Cassie; Bob Warnock; Faisal Akhtar; Duncan McCloskey; David Wyatt
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Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real-World Data Screening and in Vitro Validation别嘌醇作为预防阿尔茨海默病的候选药物：来自真实世界数据筛选和体外验证的证据
deleteClinical and Translational Science
IF2.8
delete2026-06-21
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deleteSho Sakagami; Yuya Yoshida; Shota Uemura; Taisei Kumamoto; Ryotaro Tsukamoto; Takumi Nishi; Shimpei Kawano; Kohei Fukuoka; Hanami Ino; Kengo Hamamura; Shigehiro Ohdo; Naoya Matsunaga
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From Pharmacodynamic Biomarker to Evaluating Treatment Response: Biomarkers in Primary Mitochondrial Diseases从药效学生物标志物到评估治疗效果：原发线粒体疾病的生物标志物
deleteClinical and Translational Science
IF2.8
delete2026-06-19
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deleteSydney Stern; Karryn Crisamore; John Patton; Robert Schuck; Michael Pacanowski
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When Science Outpaces Infrastructure: People, Process, and Technology Challenges for Precision Dosing in Children当科学超越基础设施：儿童精准用药中的人员、流程和技术挑战
deleteClinical and Translational Science
IF2.8
delete2026-06-19
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deleteTamorah Lewis; Karim Jessa; Vijay Ivaturi; Andreas Noack; Dilum P. Aluthge; David Müller-Widmann; Kathryn Capello; Matthew Fong; Ashleigh Miatello; Melanie Barwick
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European Network on Optimizing Treatment With Therapeutic Antibodies in Chronic Inflammatory Diseases: Overview, Progress and Perspectives欧洲优化慢性炎症性疾病治疗性抗体治疗的网络：概述、进展和展望
deleteClinical and Translational Science
IF2.8
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deleteKonstantin Tachkov; Merita Rumano; James Bluett; Nataša Bogavac-Stanojević; Erwin Dreesen; Mehmet Itik; Georgios Kararigas; Paweł Kawalec; Marlene Santos; Silje Skrede; Guenka Petrova; Denis Mulleman
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Predictive Factors for Relapse in Still's Disease: A Retrospective Cohort Study of Clinical and Laboratory Biomarkers斯蒂尔病复发的预测因素：临床和实验室生物标志物的回顾性队列研究
deleteClinical and Translational Science
IF2.8
delete2026-06-19
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deleteİbrahim Yahya Çakır; Abdulsamet Erden; Yeter Mahmutoğlu; Rıza Can Kardaş; Emine Uslu; Ertuğrul Çağrı Bölek; Serdar Sezer; Müçteba Enes Yayla; Hamit Küçük; Abdurrahman Tufan; Aşkın Ateş; Murat Turgay; Mehmet Akif Öztürk
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Challenges in Implementing Revocation of Oncology Drugs Under Conditional Early Approval in Japan: Regulatory Insights From Comparisons With FDA/EMA在日本对获得条件性早期批准的肿瘤药物实施撤销所面临的挑战：与FDA/EMA比较的监管见解
deleteClinical and Translational Science
IF2.8
delete2026-06-18
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deleteTakahiro Handa; Arata Tanaka; Mayumi Shikano; Rika Wakao
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Transcriptomic Profiling of Cutaneous Melanoma Metastases Treated With Microwave Ablation—Pilot Study微波消融治疗的皮肤黑色素瘤转移灶转录组分析—初步研究
deleteClinical and Translational Science
IF2.8
delete2026-06-18
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deletePurevsuren Losol; Daniel O'Driscoll; Andres Vallejo Pulido; Adrian von Witzleben; Konstantinos Boukas; Matthew Sommerlad; Christian Ottensmeier; Michael R. Ardern-Jones
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A Generative AI Framework for Pharmacokinetic Clinical Study Report Authoring生成式人工智能框架用于药代动力学临床研究报告撰写
deleteClinical and Translational Science
IF2.8
delete2026-06-15
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deleteJohn Samuelsson; Samuel Blakeman; Ezra Alexander; Srividya Neelakantan; Ravi Shankar Prasad Singh; May Garrett; Allison Murphy; Jing Zhu; Subha Madhavan; Sheraz Khan
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Utilization of Healthy Volunteers in Oncology Drug Development in Japan: A 10-Year Analysis of Approved Anticancer Agents (2014–2024)日本肿瘤药物开发中健康志愿者的利用：2014-2024年批准的抗肿瘤药物10年分析
deleteClinical and Translational Science
IF2.8
delete2026-06-15
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deleteKana Morihisa; Hiroyuki Yoshitsugu; Hirokazu Wakuda; Naoto Uemura
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Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials早期临床药理学试验中化学、血液学和凝血实验室结果的解释；基于随机对照试验安慰剂组的回顾性分析
deleteClinical and Translational Science
IF2.8
delete2026-06-13
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deleteJannik Rousel; Tessa Niemeyer-van der Kolk; Matthijs Moerland; Robert Rissmann; Naomi B. Klarenbeek; Maurits F. J. M. Vissers; Jacobus Burggraaf
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