未登录Aggregation of monoclonal and bispecific antibodies during pneumatic tube transport of IV bags in a hospital: Mitigation by polysorbate 80, poloxamer 188, and headspace removal医院内气动管道运输IV输液袋过程中单克隆及双特异性抗体的聚集:聚山梨酯80、聚氧乙烯聚氧丙烯共聚物188和顶空去除的缓解作用
Parnian, Parham; Medina, Annette M.; Lopez, Nidia Gonzalez; Flores, Katiria; Lucio, Lakyn; Reist, Lauren; Arnold, Mark A.; Kwok, Stanley C.; Nejadnik, Reza
分享
收藏
分享
收藏
分享
收藏Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design通过突触门控和亲和力调谐的三特异性抗体设计改善T细胞接合剂的双靶向选择性
Zhao, Peng; Schardt, John; Chiang, Chi-, I; Shah, Pooja; Eun, Gee Sung; Martinek, Jan; Cyr, Matthew; Johnson, Yoshimi; Amofah, Bismark; Ye, Xiaoying; Edwards, Samuel; Chen, Xiaoru; Penney, Mark; Liu, Wenhai; Yang, Chunning; Rickert, Keith; Lee, Amber; Payne, Sterling; Zhang, Hanzhi; Kelly, Garrett; Wang, Chunlei; Gerber, Allison; Mulgrew, Kathy; Varma, Rajat; Boyd, Jonathan; Li, Xiuling; Bagert, John D.; Walseng, Even; Mazor, Yariv
分享
收藏Development of production methodologies for scFv-Fc conjugated critical reagents to support CAR-T clinical programs开发用于支持CAR-T临床项目的scFv-Fc偶联关键试剂的生产方法
O'connor, Ellen; Lachacz, Eric; Delmar, Jared; D'souza, Bradley; Edwards, Samuel; Griffin, Christopher; Lin, Rosie; Mody, Neil; Salas, Alicia; Schoch-Lopez, Natalia; Shah, Mitali; Shih, Ai; van Dyk, Dewald; Xu, Yueming
分享
收藏Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in Staphylococcus aureus InfectionClfA002与中和抗体AZD7745复合物的结构,揭示了其在金黄色葡萄球菌感染中的广谱中和机制。
Tkaczyk, Christine; Keren-Kaplan, Tal; Gamson, Adam; Warrener, Paul; Semenova, Elena; Rosenthal, Kim; Barnes, Arnita; Ahani, Bahar; Sellman, Bret R.; Podlaha, Ondrej; Oganesyan, Vaheh
分享
收藏Immune-mediated adverse events in the randomized phase 3 TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer度伐利尤单抗联合吉西他滨和顺铂治疗晚期胆道癌的随机III期TOPAZ-1研究中免疫介导的不良事件
Antonuzzo, Lorenzo; Takahashi, Hidenori; Park, Joon Oh; Sookprasert, Aumkhae; Gillmore, Roopinder; Yang, Sheng-Shun; Cundom, Juan; Petrova, Mila; Vaccaro, Gina; Holmblad, Marielle; Zotkiewicz, Magdalena; Wang, Julie; Rokutanda, Nana; Oh, Do-Youn
分享
收藏Current industry practices on closed system drug-transfer devices for parenteral drug products
de Jong, Isabella; Tan, David Cheng Thiam; Lehermayr, Christian; Daugherty, Mollie; Filipe, Vasco; Winzer, Matthias; Kwok, Stanley C.; Medina, Annette; Guy, Allison; Christian, Twinkle; Singh, Shubhadra N.; Bhattacharya, Soumendu; Jabary, Serene
分享
收藏
分享
收藏Lower Respiratory Tract Infections Following Respiratory Syncytial Virus Monoclonal Antibody Nirsevimab Immunization Versus Placebo: Analysis From a Phase 3 Randomized Clinical Trial (MELODY)呼吸道合胞病毒单克隆抗体Nirsevimab预防接种与安慰剂后的下呼吸道感染: 一项3期随机临床试验 (MELODY) 的分析
Arbetter, Doug; Gopalakrishnan, Vancheswaran; Aksyuk, Anastasia A.; Ahani, Bahar; Chang, Yue; Dagan, Ron; Esser, Mark T.; Hammitt, Laura L.; Mankad, Vaishali S.; Saez-Llorens, Xavier; Shen, David; Leach, Amanda; Kelly, Elizabeth J.; Villafana, Tonya; Wilkins, Deidre
分享
收藏
分享
收藏RSV Neutralizing Antibodies Following Nirsevimab and Palivizumab Dosing
Wilkins, Deidre; Hamren, Ulrika Wahlby; Chang, Yue; Clegg, Lindsay E.; Domachowske, Joseph; Englund, Janet A.; Muller, William J.; Leach, Amanda; Kelly, Elizabeth J.; Villafana, Tonya
分享
收藏Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers
Barrett, Allison M.; Britton, Zachary T.; Carrasco, Rosa A.; Breen, Shannon; Broggi, Maria A. S.; Hatke, Amanda L.; Clark, Benjamin; Yang, Chunning; Phipps, Sandrina; Ortiz, Lorenzo; Janocha, Brianna; Zanvit, Peter; Giraldo, Nicolas A.; Martin, Philip L.; Lapointe, Jean-Martin; Harder, Nathalie; Cornish, Georgina H.; Attili, Bala N. N. R.; Mazor, Yariv; Damschroder, Melissa; Cobbold, Mark; Moody, Gordon; Bosco, Emily E.
分享
收藏Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity基于蛋白质的生物药物的制造后处理对产品质量和以用户为中心的影响
Cappelletto, Elia; Kwok, Stanley C.; Sorret, Lea; Fuentes, Nathalie; Medina, Annette M.; Burleigh, Stephen; Fast, Jonas; Mackenzie, Isla S.; Fureby, Anna Millqvist; Paulsson, Mattias; Wahlgren, Marie; Elofsson, Ulla; Flynn, Angela; Miolo, Giorgia; Nystrom, Lina; De Laureto, Patrizia Polverino; De Paoli, Giorgia
分享
收藏A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis
Long, Merete B.; Gilmour, Amy; Kehl, Margaret; Tabor, David E.; Keller, Ashley E.; Warrener, Paul; Gopalakrishnan, Vancheswaran; Rosengren, Sanna; Crichton, Megan L.; McIntosh, Eve; Giam, Yan Hui; Keir, Holly R.; Brailsford, Wayne; Hughes, Rod; Belvisi, Maria G.; Sellman, Bret R.; DiGiandomenico, Antonio; Chalmers, James D.
分享
收藏Production of native recombinant proteins using a novel split intein affinity technology
Clifford, Robert; Lindman, Susanna; Zhu, Jie; Luo, Ethan; Delmar, Jared; Tao, Yeqing; Ren, Kuishu; Lara, Abigail; Cayatte, Corinne; McTamney, Patrick; O'Connor, Ellen; Ohman, Johan
分享
收藏
分享
收藏
分享
收藏CMC Regulatory Considerations for Antibody-Drug Conjugates抗体-药物偶联物的CMC监管注意事项
Bechtold-Peters, Karoline; Ruggiero, Andrea; Vriezen, Nienke; Ihle, Nathan; Klein, Armin; Morgan, Charles; Schweizer, Daniel; Liu, Dengfeng; Jacobson, Fred; Buecheler, Jakob; Panek, Mark; Duggan, Naomi; Malyala, Padma; Dupraz, Philippe; Desai, Priyanka; Niu, Shufang; Feng, Yiqing; Wang, Xiangyang
分享
收藏