未登录 分享 收藏
Drug Substance and Drug Product Workflows for Quality Risk Management for the Presence of Nitrosamines in Medicines 药品活性成分和药品制剂在药品中存在亚硝胺的质量风险管理工作流程 Dirat, Olivier; Urquhart, Michael W.; Akehurst, Heather; Burns, Michael J.; Dobo, Krista L.; Harvey, James; Kuhl, Nadine; Schlingemann, Joerg; Tomlin, Paula; Wetter, Christian 分享 收藏
In vivo screen of Plasmodium targets for mosquito-based malaria control 基于蚊媒疟疾控制的疟原虫体内靶点筛选 Probst, Alexandra S.; Paton, Douglas G.; Appetecchia, Federico; Bopp, Selina; Adams, Kelsey L.; Rinvee, Tasneem A.; Pou, Sovitj; Winter, Rolf; Du, Esrah W.; Yahiya, Sabrina; Vidoudez, Charles; Singh, Naresh; Rodrigues, Janneth; Castaneda-Casado, Pablo; Tammaro, Chiara; Chen, Daisy; Godinez-Macias, Karla P.; Jaramillo, Jasmine L.; Poce, Giovanna; Rubal, Michael J.; Nilsen, Aaron; Winzeler, Elizabeth A.; Baum, Jake; Burrows, Jeremy N.; Riscoe, Michael K.; Wirth, Dyann F.; Catteruccia, Flaminia 分享 收藏
Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2 炎症和IL-4调控帕金森病和克罗恩病相关激酶LRRK2 Dikovskaya, Dina; Pemberton, Rebecca; Taylor, Matthew; Tasegian, Anna; Bhattacharya, Purbasha; Zeneviciute, Karolina; Sammler, Esther M.; Howden, Andrew J. M.; Alessi, Dario R.; Swamy, Mahima 分享 收藏
分享 收藏
Advancing regulatory dialogue: In silico models for improved vaccine biomanufacturing - an expert meeting report 推进监管对话：用于改进疫苗生物制造的计算机模拟模型——专家会议报告 Meln, Irina; Van Molle, Wim; Velez, Monica Perea; Abrahamsen, Greger; Brusselmans, Koen; Calvosa, Eric; Cardillo, Antonio Gaetano; Clenet, Didier; Forestieri, Caroline; Gernaey, Krist V.; Hoefnagel, Marcel; Jorgensen, John Bagterp; Lebrun, Pierre; Natalis, Laurent; Nilsson, Bernt; Oeppling, Volker; Pollinger, Julius Carl; Rayat, Andrea C. M. E.; Reem, Daniel; Rubbrecht, Michelle; Schmoelder, Johannes; Schofield, Timothy; Smith, Dean; Timmins, Stefanie; von Lieres, Eric; Welin, Mats; Bracewell, Daniel G. 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis 鉴定一类含有五氟苯基结构单元的化合物，该化合物靶向Pks13以抑制结核分枝杆菌的生长。 Green, SR; Harrison, JR; Thompson, S; Murugesan, D; Libardo, MDJ; Engelhart, CA; Meshanni, J; Fletcher, D; Scullion, P; Edwards, D; Epemolu, O; Mutter, N; Shishikura, Y; Riley, J; Ioerger, TR; Guillén, JJR; López, LG; Read, KD; Barry, CE III; Schnappinger, D; Wyatt, PG; Boshoff, HIM; Cleghorn, LAT 分享 收藏
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics 组织特异性STING蛋白的流动和丰度对炎症及靶向治疗药物开发的影响 Angel, Thomas E.; Chen, Zhuo; Moghieb, Ahmed; Ng, Sze-Ling; Beal, Allison M.; Capriotti, Carol; Azzarano, Leonard; Comroe, Debra; Adam, Michael; Moore, Patrick; Hoang, Bao; Blough, Kelly; Kuziw, Joanne; Ramanjulu, Joshi M.; Pesiridis, G. Scott 分享 收藏
分享 收藏
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription mRNA外运因子作为适应性反应，将新生转录本储存在核斑片中，以应对转录的暂时性全局抑制 Williams, Tobias D.; Michalak, Ewa M.; Carey, Kirstyn. T.; Lam, Enid Y. N.; Griesbach, Esther; Chan, Yih-Chih; Papasaikas, Panagiotis; Ngo, Linh; Macpherson, Laura; Gilan, Omer; Rucinski, Amber; Rutkowska-Klute, Anna; Zinn, Nico; Grandi, Paola; Bantscheff, Marcus; Tan, Vicky W. T.; Prinjha, Rab K.; Dawson, Sarah-Jane; Chao, Jeffrey A.; Wickramsinghe, Vihandha O.; Dawson, Mark A. 分享 收藏
分享 收藏
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular 'Direct-to-Biology' Screening Wilders, Harry; Biggs, George; Rowe, Sam M.; Cawood, Emma E.; Riziotis, Ioannis G.; Rendina, Alan R.; Grant, Emma K.; Pettinger, Jonathan; Fallon, David J.; Skehel, Mark; House, David; Tomkinson, Nicholas C. O.; Bush, Jacob T. 分享 收藏
Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors Palisse, Adeline; Cheung, Tony; Blokhuis, Aileen; Cogswell, Thomas; Martins, Bruna S.; Riemens, Rick; Schellekens, Rick; Battocchio, Giovanni; Jansen, Chimed; Cottee, Matthew A.; Ornell, Kimberly; Sacchetto, Claudia; Leon, Leonardo; van Hoek- Emmelot, Maaike; Bostock, Mark; Brauer, Brooke Leann; Beaumont, Kevin; Lucas, Simon C. C.; Ahmed, Samiyah; Blackwell, J. Henry; Boerjesson, Ulf; Gohlke, Andrea; Gramatikov, Iva Monique T.; Hargreaves, David; van Hoeven, Vera; Kantae, Vasudev; Kupcova, Lea; Milbradt, Alexander G.; Seneviratne, Uthpala; Su, Nancy; Vales, John; Wang, Haiyun; White, Michael J.; Kinzel, Olaf 分享 收藏
Effect of a participatory whole-systems approach on mortality in children younger than 5 years in Jigawa state , Nigeria (INSPIRING trial): a community-based, parallel-arm, pragmatic, cluster randomised controlled trial and concurrent mixed-methods process evaluation 参与式全系统方法对尼日利亚吉加瓦州5岁以下儿童死亡率的影响 (INSPIRING试验): 一项基于社区，平行臂，务实，集群随机对照试验和同时混合方法过程评估 King, Carina; Burgess, Rochelle Ann; Bakare, Ayobami A.; Shittu, Funmilayo; Salako, Julius; Bakare, Damola; Uchendu, Obioma C.; Iuliano, Agnese; Djellouli, Nehla; Isah, Adamu; Haruna, Ibrahim; Ahmar, Samy; Ahmed, Tahlil; Valentine, Paula; Olowookere, Temitayo Folorunso; MacCalla, Matthew; Graham, Hamish R.; McCollum, Eric D.; Beard, James; Falade, Adegoke G.; Colbourn, Tim 分享 收藏
分享 收藏
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png)
OAAI
.png){kind=icon}
分享.png){kind=icon}
收藏