Van Andel Institute

学者数1.8K

论文数1.1K

被引数16

关联论文 (1057)

发表时间

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial 口服维生素C补充剂在克隆性血细胞减少症未定意义或低风险髓系恶性肿瘤患者中的应用：EVITA一项2期随机、安慰剂对照试验的结果

Cancer

IF5.1

2026-09-21

OAAI

Stine Ulrik Mikkelsen MD, PhD; Ali Al-Mousawi MD; Amalie Bach Puglisi MD; Anders Pommer Vallentin MD; Astrid Østergaard Mortensen BSc; Zachary Madaj MSc; Toshinori Hinoue MSc, PhD; Heidi Naomi Ottesen BSc; Jakob Schmidt Jespersen MSc, PhD; Linn Gillberg MSc, PhD; Morten Tulstrup MD, MSc, PhD; Niels Richard Hansen MSc; Jakob Werner Hansen MD, PhD; Mette Klarskov Andersen MD, DMSc; Stacey Lyn Thomas MSc, PhD; Christine Isaguirre BSc; Ryan Sheldon MSc, PhD; Marie Adams MSc; Ryan Burgos BSc; Stephen Baylin MD; Bo Kok Mortensen MD, PhD; Casey Lee O’Connell MD; Marianne Tang Severinsen MD, PhD; Peter William Laird PhD; Jens Lykkesfeldt PhD, DMSc; Peter Jones PhD, DSc; Kirsten Grønbæk MD, DMSc

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveal that the Oncogenic Y220C Variant is a Loss-of-Function Mutation for Zn2+-Binding at Physiological Temperature 热力学分析揭示野生型与Y220C TP53 DBDs，表明在生理温度下致癌性Y220C变异体是锌离子结合功能的失活突变

Biochemistry

IF3

2026-09-15

PREAI

Jacob I. Stuckey; Valerie Vivat; Bradley M. Dickson; Jeremy W. Setser; Yong Li; Claudia M. Cremers; Jonathan E. Wilson; Daniele Peterle; John R. Engen; Thomas E. Wales; Rainer Wilcken; Erin B. Rohan; Gregg Chenail; James E. Audia; Robert J. Sims III

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35 帕金森病相关D620N突变选择性地改变了VPS35的脑特异性蛋白质相互作用组

Neurobiology of Disease

IF5.6

2026-09-01

OAAI

Erin T. Williams; Maxwell Frye; Xi Chen; Jordan Rowlands; Md. Shariful Islam; Darren J. Moore

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization 硫辛酸的功能分区解耦了细胞丰度与线粒体利用

Journal of Lipid Research

IF4.1

2026-08-20

OAAI

Pieter R. Norden; Riley J. Wedan; Abigail E. Ellis; Madeleine L. Hart; Megan R. Gendjar; Morgan T. Canfield; Ryan D. Sheldon; Sara M. Nowinski

Targeting HDAC and proteostasis to eradicate quiescent cancer cells 靶向HDAC和蛋白质稳态以清除休眠癌细胞

Cancer Gene Therapy

IF5

2026-08-13

OAAI

Qi Jiang; Michelle Ertel; Austin Arrigo; Amjad Hijazzi; Sara Sannino; Jennifer L. Goeckeler-Fried; April Sagan; Ian Beddows; Betsy Ann Varghese; Daniel D. Brown; Wayne Stallaert; Adrian Lee; Amanda M. Clark; Hui Shen; Jeffrey L. Brodsky; Hatice U. Osmanbeyoglu; Ronald J. Buckanovich

Mechanistic diversity of clamp loading at small DNA gaps 小DNA缺口处夹子装载的机制多样性

Journal of Biological Chemistry

IF3.9

2026-08-10

OAAI

Fengwei Zheng; Michael E. O’Donnell; Huilin Li

Career pathways, part 20 职业发展路径，第20部分

Nature Metabolism

IF20.8

2026-08-07

PREAI

Adelheid Lempradl; Lauren V. Albrecht

Distinct amyloid-β filament fold in individuals with APP Flemish mutation 携带APP弗拉芒突变的个体中存在独特的淀粉样蛋白-β原纤维折叠

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2026-08-06

PREAI

Peerzada Shariq Shaheen Khaki; Pablo Adrian Guillen-Poza; Carlton Wong; Chloe Kan; Rakesh Sharma; Rio Sugimura; Andrew C. Robinson; Alejandro Valbuena; Roy Chun-Laam NG; Yang Yang; Ruben Hervas

Deletion of the Wnt regulator Znrf3 alters bone geometry without inducing high bone mass 删除Wnt调控因子Znrf3会改变骨几何结构但不诱导高骨量

Bone

IF3.6

2026-07-28

PREAI

Cassandra R. Diegel; Megan N. Michalski; Gabrielle Foxa Wiartalla; Zhendong A. Zhong; Zachary B. Madaj; Bart O. Williams

Cryo-EM structures of human FANCJ reveal the mechanism of G-quadruplex unwinding and disease-associated mutations 人类FANCJ的冷冻电镜结构揭示了G-四链体解旋及与疾病相关突变的机制

Nature Communications

IF15.7

2026-07-15

OAAI

Qinglong You; Naoko Kakusho; Hiroyuki Sasanuma; Hisao Masai; Huilin Li

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function 小鼠关节炎中的应急髓系生成导致树突状细胞发育和功能的细胞固有性改变

iScience

IF4.1

2026-07-08

OAAI

Lin Tze Tung; Roselyn R. Jiang; Bianca Pozzebon; Mathieu Mancini; Lucie Droin; Mitra Yousefi; Joo Eun (June) Kim; Marwah Mousa; Yue Liang; Connie M. Krawczyk; Ines Colmegna; Danielle Malo; David Langlais; Silvia M. Vidal; Anastasia Nijnik

Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson’s disease: LRRK2-driven systemic depletion of pyrimidine nucleosides G2019S LRRK2与代谢综合征在帕金森病两-hit小鼠模型中的相互作用：LRRK2驱动的嘧啶核苷酸系统性耗竭

npj Parkinsons Disease

IF8.2

2026-07-08

OAAI

Yue Ma; Madalynn L. Erb; Kayla A. Sipple; Alina V. Offerman; Junwei Niu; Zachary B. Madaj; Zhen Fu; Kin H. Lau; Darren J. Moore

Characterization of selection on immune regulatory elements and MHC gene diversity in Holstein cattle 对荷斯坦牛免疫调控元件的选择压力和MHC基因多样性的表征

Journal of Dairy Science

IF4.4

2026-06-12

OAAI

A. Booms; C. Lohr; G.A. Coetzee; S.J. Wells; B.A. Crooker; C. Droscha

Chronic viral infection aggravates white adipose tissue dysfunction and liver pathology in obesity 慢性病毒感染加剧肥胖症中白色脂肪组织功能障碍和肝脏病理学变化

Molecular Metabolism

IF6.6

2026-06-09

OAAI

Katarzyna M. Luda; Marianne Agerholm; Si Brask Sonne; Dipsikha Biswas; Lisa DeCamp; Russell G. Jones; Allan Randrup Thomsen; Benjamin Anderschou Holbeck Jensen; Jan Pravsgaard Christensen; Kei Sakamoto

Enzyme tethering for in situ epigenomics 原位表观基因组学的酶束缚

Nature Reviews Methods Primers

IF56

2026-06-04

PREAI

Kami Ahmad; Sandipan Brahma; Derek H. Janssens; Jop Kind; Nadiya Khyzha; Michael P. Meers; Srinivas Ramachandran; Ye Zheng; Steven Henikoff

Peroxisomes orchestrate metabolic flexibility and longevity via an interorganelle cascade 过氧化物酶体通过细胞器级联协调代谢灵活性和寿命

Nature Aging

IF19.4

2026-05-20

OAAI

Arpit Sharma; Aditi Prabhakar; Miriam Valera-Alberni; Jamie D. Kraft; Abigail E. Ellis; Ryan D. Sheldon; Meeta Mistry; Pallas Yao; Yanshan Liang; Sheng Hui; William B. Mair

An RNF4-Based Tool for Tracking Subcellular Localization of PolySUMOylation During Cellular Stress 基于RNF4的工具用于追踪细胞应激期间多SUMO化的亚细胞定位

Biomolecules

IF4.8

2026-05-20

OAAI

Joseph S. Floramo; Yaguang Zhao; Lorna Cohen; Kristin Gallik; David Brass; Tao Yang

Retrotransposons in Bone and Joint Diseases 转座子在骨与关节疾病中的作用

FASEB BioAdvances

IF2

2026-05-18

OAAI

Liu, Ye; Jang, H. Josh; Yang, Tao