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收藏分享 收藏 分享 收藏 Population-scale repeat expansions elucidate disease risk and brain atrophy人群规模重复序列扩展阐明疾病风险和脑萎缩
Pounraja, Vijay Kumar; Sul, Jae Hoon; Herman, Joseph; O'Keeffe, Sean; Rajagopal, Veera; Bai, Xiaodong; Kessler, Michael D.; Parikshak, Neelroop; Landheer, Karl; Zhang, Xingmin; Yu, Sean; Zhang, Lance; LeBlanc, Michelle G.; Rico-Varela, Jennifer; Grau, Frederic; Wolf, Sarah; Sundaramoorthy, Sriramkumar; Sepehrband, Farshid; Stahl, Eli A.; Huo, Yuda; Ahmed, Mohsin; Croll, Susan; Salerno, William; Overton, John D.; Marchini, Jonathan; Reid, Jeffrey; Lotta, Luca A.; Baras, Aris; Abecasis, Goncalo R.; Coppola, Giovanni; Gelfman, Sahar 分享 收藏 Effectiveness of linvoseltamab versus real-world standard-of-care in triple-class-exposed relapsed/refractory multiple myeloma in the United States在美国三药类暴露的复发/难治性多发性骨髓瘤中，林洛塞坦单抗相较于真实世界标准疗法的有效性Kumar, Shaji; Weisel, Katja C.; Spin, Paul; Bonar, Nicolle; Siddiqui, Muhaimen; Shokoohi, Mostafa; Wang, Di; Hou, Kevin; West, Michael E. D.; Hampp, Christian; Green, Jeannette; Harnett, James; Humblet, Olivier; Breskin, Alexander; Ge, Wenzhen; Jalbert, Jessica J.; Sobel, Rachel E.; Kroog, Glenn S.; Lorenc, Karen Rodriguez; Ma, Qiufei; Jagannath, Sundar 分享 收藏 Real-world, long-term effectiveness of dupilumab treatment in patients with severe asthma: 2 years of the ProVENT study严重哮喘患者中dupilumab治疗的现实世界长期有效性：ProVENT研究2年结果Lommatzsch, Marek; Schmidt, Olaf; Timmermann, Hartmut; Gappa, Monika; Watz, Henrik; Kwah, Jason; Ledanois, Olivier; Nischan, Nicole; Hahn, Matthias; Heimann, Andreas; Korn, Stephanie 分享 收藏 The Impact and Reliability of Tissue Segmentation on In Vivo Magnetic Resonance Spectroscopy Metabolite Quantification组织分割对活体磁共振波谱代谢物定量分析的影响与可靠性Archibald, Jessica; Igwe, Kay Chioma; Kaiser, Antonia; Landheer, Karl; Lee, Jaimie; Kramer, John L. K.; Gudmundson, Aaron T.; Zollner, Helge J.; Oeltzschner, Georg; Fleischer, Candace C.; Zolch, Niklaus; Near, Jamie; Mikkelsen, Mark 分享 收藏 分享 收藏 Dupilumab Versus Omalizumab: Greater Lung Function Improvements in Patients With Chronic Rhinosinusitis With Nasal Polyps and Uncontrolled Asthma (EVEREST) With Dupilumab度普利尤单抗与奥马珠单抗比较：对于伴有鼻息肉且哮喘未控制的患者，度普利尤单抗可带来更大的肺功能改善（EVEREST研究）Oppenheimer, J.; Wagenmann, M.; Canonica, G. W.; Peters, A. T.; Lipworth, B. J.; Zhang, M.; Corbett, M.; Nash, S.; Gall, R.; Moraco, A.; Heffler, E. 分享 收藏 分享 收藏 Dupilumab Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD) with Type 2 Inflammation across Baseline Eosinophil CountsDupilumab在具有2型炎症的慢性阻塞性肺疾病（COPD）患者中的疗效及基线嗜酸性粒细胞计数的影响Christenson, S.; Sciurba, F.; Vogelmeier, C.; Miravitlles, M.; Hurst, J. R.; Wen, F.; Martinez, F. J.; Saha-Chaudhuri, P.; Soliman, M.; Heble, J. 分享 收藏 2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide & Bicycle Drug Conjugates (PART 1A-Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing & Reporting PART 1B-Regulatory Agencies' Input on Regulated Bioanalysis/BMV)2025年生物分析热点问题白皮书：生物分析实验室信息管理系统（LIMS）的未来是什么？人工智能/机器学习在生物分析中的应用；泪液样本采集；放射性标记质量平衡研究；手性分析；抗体-寡核苷酸与自行车药物偶联物的生物分析（第一部分A：关于质谱分析、色谱法、样品制备和受监管生物分析的采样、验证、分析与报告的建议；第一部分B：监管机构对受监管生物分析/桥接方法验证的反馈）Wojcik, John; Qian, Mark; Rosenbaum, Anton I.; Maes, Estelle; Xue, Yongjun; Kochansky, Christopher; Boer, Jason; Chen, Linzhi; Descloux, Sandrine; Garofolo, Fabio; Johnson, Jay; Kaur, Surinder; Lassman, Michael; Mcgregor, Jessica; O'callaghan, Lisa; Sikorski, Timothy; Wan, Katty; Wang, Shunhai; Zheng, Naiyu; Zhang, Guodong; Hoover, Michael; Wang, Jian; Yuan, Long; Ji, Qin; Jones, Barry; Boyanapalli, Ramakrishna; Chen, Jian; Dobson, Christine; Dong, Linlin; Ferrari, Luca; Fu, Yunlin; Gong, Chao; Ivanova, Dany; Li, Jing; Licea-Perez, Hermes; Liu, Aihua; Tang, Xiaonan; Tao, Lin; Tweed, Joseph; Eddy, John; Francis, Jennifer; Kavetska, Olga; Araya, Marcela; Foley, Timothy; Andisik, Matthew; Belfast, Mary; Borbridge, Lisa; Cho, Seongeun (julia); Colligan, Liliana; Dasgupta, Arindam; Edmison, Anna; Fandozzi, Christine; Galliccia, Fabrizio; Kim, Yeoun Jin; Lu, Yang; Massip, Anne-Marie; Shakleya, Diaa; Tampal, Nilufer; Neto, Joao Tavares; Thomas, Justina; Wang, Jin; Wang, Linna; Wang, Ying; Whale, Emma; Wiberg, Megan; Yang, Li 分享 收藏 Disease burden, diagnosis pathways and treatment patterns in patients with eosinophilic esophagitis: a real-world study嗜酸性食管炎患者疾病负担、诊断路径和治疗模式的真实世界研究Ma, Christopher; von Arm, Ulrike; Zerbib, Frank; Pela, Tiffany; Radwan, Amr; Jacob-Nara, Juby A.; Parikh, Rohan C.; Borsos, Kinga; Bello, Fareedat; Thomas, Ryan B.; Tilton, Sarette T. 分享 收藏 The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during Tcell leukemogenesis造血干细胞MYB增强子对于T细胞白血发生至关重要且在其过程中反复扩增Mullin, Carea; Lin, Karena; Choe, Elizabeth; Sha, Cher; Shukla, Zeel; Campbell, Koral; McCarter, Anna C.; Wang, Annie; Nieves-Salva, Jannaldo; Khan, Sarah; Keeley, Theresa M.; Liang, Shannon; Wang, Qing; Melnick, Ashley F.; Evans, Pearl; Monovich, Alexander C.; Iyer, Ashwin; Kodgule, Rohan; Deng, Yamei; Leprevost, Felipe Da Veiga; Barnett, Kelly R.; Polonen, Petri; Khoriaty, Rami; Savic, Daniel; Teachey, David T.; Mullighan, Charles G.; Cieslik, Marcin; Nesvizhskii, Alexey I.; Samuelson, Linda C.; Jones, Morgan; Li, Qing; Ryan, Russell J. H.; Chiang, Mark Y. 分享 收藏 分享 收藏 The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot ChorioretinitisERAP1和ERAP2单倍型组合对鸟枪脉络膜视网膜炎易感性和严重程度的影响Loeliger, Jordan; Gelfman, Sahar; Stahl, Eli A.; Moscati, Arden; Bai, Xiaodong; Monnet, Dominique; Imikirene, Linda; Kecili, Souhila; Tabary, Thierry; Cohen, Jacques; Brezin, Antoine P. 分享 收藏 分享 收藏 2025 White Paper on Recent Issues in Bioanalysis: Biomarkers Calibrators & Stability; Evaluation of NULISA; Neurofilament & Autoantibody Biomarker Assays; Removing IgM Interference; ELISpot & FluoroSpot Best Practices; Modular HD Cytometry; Single-cell Analysis Imaging Cytometry (PART 2A-Recommendations on Biomarkers Discovery, Development, Validation & Regulatory Approval, Ligand-Binding Assays (LBA) and Cell-Based Assays (CBA) PART 2B-Regulatory Agencies' Input on Biomarkers, IVD/CDx and Biomarker Assay Validation (BAV))2025年生物分析近期问题白皮书：生物标志物校准与稳定性；NULISA评估；神经丝蛋白与自身抗体生物标志物检测；去除IgM干扰；ELISpot与FluoroSpot最佳实践；模块化高维度细胞计数；单细胞分析成像细胞计数（第二部分A-关于生物标志物发现、开发、验证与监管批准、配体结合检测（LBA）和细胞基础检测（CBA）的建议；第二部分B-监管机构对生物标志物、体外诊断（IVD）/伴随诊断（CDx）和生物标志物检测验证（BAV）的反馈）Hersey, Sarah; McGuire, Kristina; Kholmanskikh, Olga; Bivi, Nicoletta; Bandukwala, Abbas; Gong, Binsheng; Irwin, Chad; Ray, Soma; Gunsior, Michele; Avanesov, Andrei; Baker, Brian; Bond, Sarah; Braun, Alexander; Buoninfante, Alessandra; Dessy, Francis; Fang, Xiaodong; Garofolo, Fabio; Gomme, Emily; Hays, Amanda; King, Lindsay; Mayer, Christian; McGregor, Jessica; McHenry, Melis; Nowocin, Anna; Rubel, Carrie; Sanderink, Gerard; Scott, Bradley; Scully, Ingrid; Seyda, Agnes; Stoop, Jeroen; Tang, Huaping; Tavares Neto, Joao; Walravens, Karl; Wang, Kai; Wassmer, Sarah; Xiao, Wenming; Zhu, Liang; Zoghbi, Jad; Brockus, Catherine; Petit-Frere, Corinne; Coble, Kelly; Fischer, Sally; Yearwood, Graham; Cao, Liching; Dysinger, Mark; Grimaldi, Christine; Jiang, Yong; Joyce, Alison; Kerridge, Claire; Lu, Kun; McCush, Fred; Nolan, Katrina; O'Connor, Ellen; Palmer, Rachel; Reese, Kimberly; Stubenrauch, Kay-Gunnar; Verch, Thorsten; Beaver, Christopher; Mendez, Luis; Decman, Vilma; Bhavaraju, Kamala; Huleatt, James; Trampont, Paul C.; Eck, Steven; Goihberg, Polina; Alcaide, Enrique Gomez; Hedrick, Michael Nathan; Jalah, Rashmi; McGrath, Shannon; Ogorman, William; Prior, Sandra; Sehra, Sarita; Shaik, Saleem; Standifer, Nathan; Stevens, Chad; Stevens, Erin; Sun, Yongliang (Steve) 分享 收藏 Three-Year Outcomes of Intravitreal Aflibercept versus Laser Therapy for Retinopathy of Prematurity: Interim Analysis of the Efficacy and Safety Outcomes in the FIREFLEYE next Trial早产儿视网膜病变玻璃体腔注射阿柏西普与激光疗法三年疗效和安全性的中期分析：FIREFLEYE next试验结果Stahl, Andreas; Nakanishi, Hidehiko; Lepore, Domenico; Wu, Wei-Chi; Azuma, Noriyuki; Jacas, Carlos; Athanikar, Aditya; Vitti, Robert; Chu, Karen; Iveli, Pablo; Zhao, Fei; Schlief, Sarah; Leal, Sergio; Niesen, Tobias; Brandau, Katja; Miller, Thomas; Kofuncu, Evra; Fielder, Alistair R. 分享 收藏 Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference WorkshopsCyt-Geist: 细胞计量学当前与未来挑战：CYTO 2025会议研讨会报告Wallace, Paul K.; Jellison, Evan R.; Thornton, Sherry; Kluepfel, Kathleen; Back, Jessica; Beadnell, Thomas C.; Bebes, Attila; Behrends, Jochen; Belkina, Anna C.; Black, Michele; Bogdanoski, Goce; Bollati-fogolin, Mariela; Bonte, Sarah; Van Der Borght, Katrien; Brinkman, Ryan R.; Brundage, Kathleen; Bushnell, Tim; Chiu, Daniel T.; Chow, Norman; Ciccolella, Christopher O.; Cochran, Matthew; Czechowska, Kamila; Dagla, Kleopatra; Daniel, Benjamin; De La Cruz, Gelo; Van Duyse, Julie; Font, Laura Ferrer; Fornas, Oscar; Garcia-garcia, Sara; Gardner, Rui; Van Gassen, Sofie; Gimenes, Daniel; Grenfell, Richard; Grider-hayes, Madeline J.; Grose, Randall; Hall, Christopher; Hally, Kathryn E.; Hameetman, Marjolijn; Hogg, Karen; Houston, Jessica; Irish, Jonathan M.; Isterdael, Gert Van; Jaimes, Maria; Janetzki, Sylvia; Kim, Cheryl; Koladiya, Abhishek; Lamote, Jochen; Lannigan, Joanne; Leconte, Julien; Litwin, Virginia; Longhini, Ana; Loof, Nicolas; Lozano-andres, Estefania; Lundsten, Kelly; Mage, Peter; Mair, Florian; Martins, Catarina Gregorio; Mccausland, Megan; Mcguire, Helen M.; Meskas, Justin; Murphy, William; Nolan, John; Oliveira, Barbara; Ordonez-rueda, Diana; Orlowski-oliver, Eva; Petersen, Charlotte Christie; Poulton, Nicole J.; Putri, Givanna; Quadrini, Karen J.; Ramasz, Beata; Ruhrmund, Donald; Singh, Vikas V.; Small, Sam J.; Smith, Natalie J.; Spidlen, Josef; Stegen, Camille; Tak, Tamar; Thompson, Sam; Thomson, Michael; Vocelle, Daniel; Walker, Rachael V.; Walsh, Robin E.; Wang, Lili; Wang, Yu-fen; Weglarz, Meredith; Winker, Moritz; Wood, James C. S.; Woolard, Stacie; Yeh, Nai-yu; Yuecel, Raif; Rajwa, Bartek 分享 收藏 
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