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Safety, Pharmacokinetics, and Lipid Lowering Effects of the Oral, Liver- Targeted Liver X Receptor (LXR) Inverse Agonist TLC2716 in Healthy Volunteers 口服肝靶向肝X受体 (LXR) 反向激动剂TLC2716在健康志愿者中的安全性，药代动力学和降脂作用 Gane, Edward J.; Huss, Ryan S.; Sur, Jane; Weng, Steve; Murakami, Eisuke; Vijayakumar, Archana; Kirby, Brian J.; Subramanian, G. Mani; Myers, Robert P. 分享 收藏
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Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH 基于深度学习的组织病理学和转录组学的整合揭示了与晚期NASH患者纤维化相关的关键基因 Conway, Jake; Pouryahya, Maryam; Gindin, Yevgeniy; Pan, David Z.; Carrasco-Zevallos, Oscar M.; Mountain, Victoria; Subramanian, G. Mani; Montalto, Michael C.; Resnick, Murray; Beck, Andrew H.; Huss, Ryan S.; Myers, Robert P.; Taylor-Weiner, Amaro; Wapinski, Ilan; Chung, Chuhan 分享 收藏
Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients Lawitz, Eric J.; Li, Kelvin W.; Nyangau, Edna; Field, Tyler John; Chuang, Jen-Chieh; Billin, Andrew; Wang, Lulu; Wang, Ya; Huss, Ryan S.; Chung, Chuhan; Subramanian, G. Mani; Myers, Robert P.; Hellerstein, Marc K. 分享 收藏
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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues Ponia, Sanket S.; Robertson, Shelly J.; McNally, Kristin L.; Subramanian, Gayatri; Sturdevant, Gail L.; Lewis, Matthew; Jessop, Forrest; Kendall, Catherine; Gallegos, Dylan; Hay, Arielle; Schwartz, Cindi; Rosenke, Rebecca; Saturday, Greg; Bosio, Catherine M.; Martens, Craig; Best, Sonja M. 分享 收藏
A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH 机器学习方法可以定量测量NASH中的肝脏组织学和疾病监测 Taylor-Weiner, Amaro; Pokkalla, Harsha; Han, Ling; Jia, Catherine; Huss, Ryan; Chung, Chuhan; Elliott, Hunter; Glass, Benjamin; Pethia, Kishalve; Carrasco-Zevallos, Oscar; Shukla, Chinmay; Khettry, Urmila; Najarian, Robert; Taliano, Ross; Subramanian, G. Mani; Myers, Robert P.; Wapinski, Ilan; Khosla, Aditya; Resnick, Murray; Montalto, Michael C.; Anstee, Quentin M.; Wong, Vincent Wai-Sun; Trauner, Michael; Lawitz, Eric J.; Harrison, Stephen A.; Okanoue, Takeshi; Romero-Gomez, Manuel; Goodman, Zachary; Loomba, Rohit; Beck, Andrew H.; Younossi, Zobair M. 分享 收藏
Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis Trivedi, Palak J.; Muir, Andrew J.; Levy, Cynthia; Bowlus, Christopher L.; Manns, Michael P.; Lu, Xiaomin; Crans, Gerald; Chung, Chuhan; Subramanian, G. Mani; Myers, Robert P.; Goodman, Zachary; Chalasani, Naga; Vierling, John M.; Guha, Indra Neil; Hirschfield, Gideon M. 分享 收藏
The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis Younossi, Zobair M.; Anstee, Quentin M.; Wong, Vincent Wai-Sun; Trauner, Michael; Lawitz, Eric J.; Harrison, Stephen A.; Camargo, Marianne; Kersey, Kathryn; Subramanian, G. Mani; Myers, Robert P.; Stepanova, Maria 分享 收藏
Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH 包括Cilofexor和Firsocostat在内的联合疗法可桥接NASH引起的纤维化和肝硬化 Loomba, Rohit; Noureddin, Mazen; Kowdley, Kris V.; Kohli, Anita; Sheikh, Aasim; Neff, Guy; Bhandari, Bal Raj; Gunn, Nadege; Caldwell, Stephen H.; Goodman, Zachary; Wapinski, Ilan; Resnick, Murray; Beck, Andrew H.; Ding, Dora; Jia, Catherine; Chuang, Jen-Chieh; Huss, Ryan S.; Chung, Chuhan; Subramanian, G. Mani; Myers, Robert P.; Patel, Keyur; Borg, Brian B.; Ghalib, Reem; Kabler, Heidi; Poulos, John; Younes, Ziad; Elkhashab, Magdy; Hassanein, Tarek; Iyer, Rajalakshmi; Ruane, Peter; Shiffman, Mitchell L.; Strasser, Simone; Wong, Vincent Wai-Sun; Alkhouri, Naim 分享 收藏
DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection Gindin, Yevgeniy; Gaggar, Anuj; Lok, Anna S.; Janssen, Harry L. A.; Ferrari, Carlo; Subramanian, G. Mani; Jiang, Zhaoshi; Masur, Henry; Emmanuel, Benjamin; Poonia, Bhawna; Kottilil, Shyam 分享 收藏
Cilofexor, a NonsteroidalFXRAgonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial Cilofexor，一种非类固醇醛酮受体激动剂，用于非肝硬化NASH患者: 一项2期随机对照试验 Patel, Keyur; Harrison, Stephen A.; Elkhashab, Magdy; Trotter, James F.; Herring, Robert; Rojter, Sergio E.; Kayali, Zeid; Wong, Vincent Wai-Sun; Greenbloom, Susan; Jayakumar, Saumya; Shiffman, Mitchell L.; Freilich, Bradley; Lawitz, Eric J.; Gane, Edward J.; Harting, Eliza; Xu, Jun; Billin, Andrew N.; Chung, Chuhan; Djedjos, C. Stephen; Subramanian, G. Mani; Myers, Robert P.; Middleton, Michael S.; Rinella, Mary; Noureddin, Mazen 分享 收藏
Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials Harrison, Stephen A.; Wong, Vincent Wai-Sun; Okanoue, Takeshi; Bzowej, Natalie; Vuppalanchi, Raj; Younes, Ziad; Kohli, Anita; Sarin, Shiv; Caldwell, Stephen H.; Alkhouri, Naim; Shiffman, Mitchell L.; Camargo, Marianne; Li, Georgia; Kersey, Kathryn; Jia, Catherine; Zhu, Yanni; Djedjos, C. Stephen; Subramanian, G. Mani; Myers, Robert P.; Gunn, Nadege; Sheikh, Aasim; Anstee, Quentin M.; Romero-Gomez, Manuel; Trauner, Michael; Goodman, Zachary; Lawitz, Eric J.; Younossi, Zobair 分享 收藏
Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis Caussy, Cyrielle; Chuang, Jen-Chieh; Billin, Andrew; Hu, Tao; Wang, Ya; Subramanian, G. Mani; Djedjos, C. Stephen; Myers, Robert P.; Dennis, Edward A.; Loomba, Rohit 分享 收藏
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Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study Lampertico, Pietro; Buti, Maria; Fung, Scott; Ahn, Sang Hoon; Chuang, Wan-Long; Tak, Won Young; Ramji, Alnoor; Chen, Chi-Yi; Tam, Edward; Bae, Ho; Ma, Xiaoli; Flaherty, John F.; Gaggar, Anuj; Lau, Audrey; Liu, Yang; Wu, George; Suri, Vithika; Tan, Susanna K.; Subramanian, G. Mani; Trinh, Huy; Yoon, Seung-Kew; Agarwal, Kosh; Lim, Young-Suk; Chan, Henry L. Y. 分享 收藏
High Throughput Screening of FDA-Approved Drug Library Reveals the Compounds that Promote IRF3-Mediated Pro-Apoptotic Pathway Inhibit Virus Replication Glanz, Anna; Chawla, Karan; Fabry, Stephanie; Subramanian, Gayatri; Garcia, Julie; Jay, Bryanna; Ciricillo, Jacob; Chakravarti, Ritu; Taylor, R. Travis; Chattopadhyay, Saurabh 分享 收藏
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