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Clinical validation of an AI-based pathology tool for scoring of metabolic dysfunction-associated steatohepatitis 基于AI的病理学工具对代谢功能障碍相关的脂肪性肝炎进行评分的临床验证 Pulaski, Hanna; Harrison, Stephen A.; Mehta, Shraddha S.; Sanyal, Arun J.; Vitali, Marlena C.; Manigat, Laryssa C.; Hou, Hypatia; Christudoss, Susan P. Madasu; Hoffman, Sara M.; Stanford-Moore, Adam; Egger, Robert; Glickman, Jonathan; Resnick, Murray; Patel, Neel; Taylor, Cristin E.; Myers, Robert P.; Chung, Chuhan; Patterson, Scott D.; Sejling, Anne-Sophie; Minnich, Anne; Baxi, Vipul; Subramaniam, G. Mani; Anstee, Quentin M.; Loomba, Rohit; Ratziu, Vlad; Montalto, Michael C.; Anderson, Nick P.; Beck, Andrew H.; Wack, Katy E. 分享 收藏
AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases 基于AI的肝病临床试验中纳入标准和终点评估的自动化 Iyer, Janani S.; Juyal, Dinkar; Le, Quang; Shanis, Zahil; Pokkalla, Harsha; Pouryahya, Maryam; Pedawi, Aryan; Stanford-Moore, S. Adam; Biddle-Snead, Charles; Carrasco-Zevallos, Oscar; Lin, Mary; Egger, Robert; Hoffman, Sara; Elliott, Hunter; Leidal, Kenneth; Myers, Robert P.; Chung, Chuhan; Billin, Andrew N.; Watkins, Timothy R.; Patterson, Scott D.; Resnick, Murray; Wack, Katy; Glickman, Jon; Burt, Alastair D.; Loomba, Rohit; Sanyal, Arun J.; Glass, Ben; Montalto, Michael C.; Taylor-Weiner, Amaro; Wapinski, Ilan; Beck, Andrew H. 分享 收藏
Cilofexor in Patients With Compensated Cirrhosis Due to Primary Sclerosing Cholangitis: An Open-Label Phase 1B Study Levy, Cynthia; Caldwell, Stephen; Mantry, Parvez; Luketic, Velimir; Landis, Charles S.; Huang, Jonathan; Mena, Edward; Maheshwari, Rahul; Rank, Kevin; Xu, Jun; Malkov, Vladislav A.; Billin, Andrew N.; Liu, Xiangyu; Lu, Xiaomin; Barchuk, William T.; Watkins, Timothy R.; Chung, Chuhan; Myers, Robert P.; Kowdley, Kris V. 分享 收藏
Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740-A Phase 1 Study Gane, Edward; Huss, Ryan S.; Sur, Jane; Murakami, Eisuke; Weng, Steve; Kirby, Brian J.; Shah, Amrik; Shulman, Gerald I.; Subramanian, Mani; Vijayakumar, Archana; Myers, Robert P. 分享 收藏
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Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats Vijayakumar, Archana; Murakami, Eisuke; Huss, Ryan S.; Sroda, Natalie; Shimazaki, Atsuyuki; Kashiwagi, Yuto; Myers, Robert P.; Subramanian, Mani; Shulman, Gerald I. 分享 收藏
Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC 法尼醇X受体 (FXR) 激动剂Cilofexor在PSC患者中进行96周开放标签扩展的安全性和持续疗效 Trauner, Michael; Bowlus, Christopher L.; Gulamhusein, Aliya; Hameed, Bilal; Caldwell, Stephen H.; Shiffman, Mitchell L.; Landis, Charles; Muir, Andrew J.; Billin, Andrew; Xu, Jun; Liu, Xiangyu; Lu, Xiaomin; Chung, Chuhan; Myers, Robert P.; V. Kowdley, Kris 分享 收藏
Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH 基于深度学习的组织病理学和转录组学的整合揭示了与晚期NASH患者纤维化相关的关键基因 Conway, Jake; Pouryahya, Maryam; Gindin, Yevgeniy; Pan, David Z.; Carrasco-Zevallos, Oscar M.; Mountain, Victoria; Subramanian, G. Mani; Montalto, Michael C.; Resnick, Murray; Beck, Andrew H.; Huss, Ryan S.; Myers, Robert P.; Taylor-Weiner, Amaro; Wapinski, Ilan; Chung, Chuhan 分享 收藏
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Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate 乙酰辅酶a羧化酶抑制剂增加肝硬化NASH的ldl-apob产生率: 非诺贝特的预防 Dandan, Mohamad; Han, Julia; Mann, Sabrina; Kim, Rachael; Li, Kelvin; Mohammed, Hussein; Chuang, Jen-Chieh; Zhu, Kaiyi; Billin, Andrew N.; Huss, Ryan S.; Chung, Chuhan; Myers, Robert P.; Hellerstein, Marc 分享 收藏
Enhanced diagnosis of advanced fibrosis and cirrhosis in individuals with NAFLD using FibroScan-based Agile scores 使用基于fibrosscan的敏捷评分增强NAFLD患者晚期纤维化和肝硬化的诊断 Sanyal, Arun J.; Foucquier, Julie; Younossi, Zobair M.; Harrison, Stephen A.; Newsome, Philip N.; Chan, Wah-Kheong; Yilmaz, Yusuf; De Ledinghen, Victor; Costentin, Charlotte; Zheng, Ming-Hua; Wong, Vincent Wai-Sun; Elkhashab, Magdy; Huss, Ryan S.; Myers, Robert P.; Roux, Marine; Labourdette, Aymeric; Destro, Marie; Fournier-Poizat, Celine; Miette, Veronique; Sandrin, Laurent; Boursier, Jerome 分享 收藏
Performance of Noninvasive Tests of Fibrosis Among Asians, Hispanic, and non-Hispanic Whites in the STELLAR Trials Wong, Vincent Wai-Sun; Tak, Won Young; Goh, George Boon Bee; Cheng, Pin-Nan; Lawitz, Eric J.; Younossi, Zobair M.; Vuppalanchi, Raj; Younes, Ziad; Alkhouri, Naim; Wang, Lulu; Liu, Jialuo; Kersey, Kathryn; Myers, Robert P.; Harrison, Stephen A.; Goodman, Zachary; Trauner, Michael; Romero-Gomez, Manuel; Anstee, Quentin M.; Nguyen, Mindie H.; Okanoue, Takeshi 分享 收藏
Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat Lawitz, Eric J.; Bhandari, Bal Raj; Ruane, Peter J.; Kohli, Anita; Harting, Eliza; Ding, Dora; Chuang, Jen-Chieh; Huss, Ryan S.; Chung, Chuhan; Myers, Robert P.; Loomba, Rohit 分享 收藏
Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients Lawitz, Eric J.; Li, Kelvin W.; Nyangau, Edna; Field, Tyler John; Chuang, Jen-Chieh; Billin, Andrew; Wang, Lulu; Wang, Ya; Huss, Ryan S.; Chung, Chuhan; Subramanian, G. Mani; Myers, Robert P.; Hellerstein, Marc K. 分享 收藏
Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial Alkhouri, Naim; Herring, Robert; Kabler, Heidi; Kayali, Zeid; Hassanein, Tarek; Kohli, Anita; Huss, Ryan S.; Zhu, Yanni; Billin, Andrew N.; Damgaard, Lars Holm; Buchholtz, Kristine; Kjaer, Mette Skalshoi; Balendran, Clare; Myers, Robert P.; Loomba, Rohit; Noureddin, Mazen 分享 收藏
IL-31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH Xu, Jun; Wang, Ya; Khoshdeli, Mina; Peach, Matt; Chuang, Jen-Chieh; Lin, Julie; Tsai, Wen-Wei; Mahadevan, Sangeetha; Minto, Wesley; Diehl, Lauri; Gupta, Ruchi; Trauner, Michael; Patel, Keyur; Noureddin, Mazen; Kowdley, Kris, V; Gulamhusein, Aliya; Bowlus, Christopher L.; Huss, Ryan S.; Myers, Robert P.; Chung, Chuhan; Billin, Andrew N. 分享 收藏
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