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J

Jiean Xu

Guangzhou University of Chinese Medicine
H指数:17
被引数:1,288
浏览量:0

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PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

PFKFB3激活CAD以增强从头嘧啶合成促进细胞生长

Cell Reports
IF6.9
2026-04-150
OAAI
Qingen Da; Yongfeng Cai; Qian Ma; Qiuhua Yang; Yapeng Cao; Yaqi Zhou; Dingwei Zhao; Zhiping Liu; Jiean Xu; Junming Quan; Liang Zhang; Rui Wang; Xuejun Jiang; Xiao Liu; Kunfu Ouyang; Zhen Han; Jikui Liu; Tao Wang; Chunxiang Zhang; Neal L. Weintraub
Erchen Decoction and its active flavonoids hesperidin and quercetin alleviate high-fat diet-induced neuroinflammation by targeting HK2-mediated microglial glycolysis

二陈汤及其活性黄酮类物质橙皮苷和槲皮素通过靶向HK2介导的小胶质细胞糖酵解，缓解高脂饮食诱导的神经炎症。

Journal of Ethnopharmacology
IF5.4
2026-03-300
PRE
Mincheng Zheng; Kanlin Yang; Yongjie Ma; Wenting Suo; Jieyuan Li; Yueli Huang; Pengxin Gao; Kundong Liu; Yaxing Zhang; Haimei Liu; Li Guan; Fuman Yan; Jiean Xu; Tejin Liu; Jinwen Xu
Development of a Long-Acting and Stapled Dual Amylin and Calcitonin Receptor Agonist as Monotherapy and Combination with GLP-1R Agonists for the Treatment of Obesity
BIOCONJUGATE CHEMISTRY
IF3.9
2025-12-010
PRE
Zhou, Yaqi; Xu, Pu; Lu, Jiang; Xu, Shujing; Qiu, Wenting; Ning, Xiao; Xu, Jiean; Zheng, Nan
Targeting adenosine 2 A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation

靶向腺苷2A受体信号传导通过抑制平滑肌细胞的成骨分化来抑制血管钙化

Pharmacological Research
IF10.5
2025-10-250
OAAI
Yaqi Zhou; Dingwei Zhao; Qian Ma; Sujin Lee; Kangsan Roh; Yongfeng Cai; Jiean Xu; Qiuhua Yang; Qingen Da; Zhiping Liu; Kunfu Ouyang; Eric J Belin de Chantemele; Mei Hong; Clint L. Miller; Rajeev Malhotra; Chunxiang Zhang; Suowen Xu; Yuqing Huo
Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcification by blocking CREB1-SNAI1-driven EndMT

内皮腺苷受体2A缺失通过阻断CREB1-SNAI1驱动的EndMT来缓解糖尿病血管钙化

Pharmacological Research
IF10.5
2025-10-090
OAAI
Yaqi Zhou; Dingwei Zhao; Qian Ma; Jiean Xu; Yongfeng Cai; Qiuhua Yang; Qingen Da; Kian Sheridan; Chunxiang Zhang; Clint L. Miller; Rajeev Malhotra; Suowen Xu; Mei Hong; Yuqing Huo
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

PFKFB3激活CAD以增强从头嘧啶合成以促进细胞生长

Cell Reports
IF6.9
2025-07-290
OA
Qingen Da; Yongfeng Cai; Qian Ma; Qiuhua Yang; Yapeng Cao; Yaqi Zhou; Dingwei Zhao; Zhiping Liu; Jiean Xu; Junming Quan; Liang Zhang; Rui Wang; Xuejun Jiang; Xiao Liu; Kunfu Ouyang; Zhen Han; Jikui Liu; Tao Wang; Chunxiang Zhang; Neal L. Weintraub; David J.R. Fulton; Jun Zhao; Mei Hong; Zigang Li; Yuqing Huo
Long-Acting and Stapled GLP-1R/GIPR/GCGR Triple Agonist for the Treatment of Obesity and Atherosclerosis

长效和 Stapled GLP-1R/GIPR/GCGR 三重激动剂用于治疗肥胖和动脉粥样硬化

Journal of Medicinal Chemistry
IF6.8
2025-07-240
PRE
Yaqi Zhou; Longfang Tu; Xueying Wang; Jiean Xu; Shujing Xu; Xiao Ning; Xiaochun Xiong; Nan Zheng
Paeonol prevents sepsis-associated encephalopathy via regulating the HIF1A pathway in microglia
INTERNATIONAL IMMUNOPHARMACOLOGY
IF4.7
2024-12-010
PRE
Zhang, Ning; Ma, Yongjie; Li, Yuqing; Wang, Yiqi; Zhang, Lisheng; Zheng, Mincheng; Tian, Yu; Zhang, Ruiying; Yang, Kanlin; Li, Jieyuan; Yan, Fuman; Liu, Haimei; Zhang, Yaxing; Xu, Jinwen; Yu, Cong; Xu, Jiean
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition

阻断内皮细胞腺苷受体2 a通过抑制CREB-ALK5-mediated内皮细胞向间充质细胞转化抑制体内动脉粥样硬化

PHARMACOLOGICAL RESEARCH
IF10.5
2024-05-013
OAAI
Cai, Yongfeng; Zhou, Yaqi; Yang, Qiuhua; Xu, Jiean; Da, Qingen; Ma, Qian; Zhao, Dingwei; Lu, Tammy; Kim, Ha Won; Fulton, David; Jiang, Xuejun; Weintraub, Neal L.; Dong, Kunzhe; Xu, Suowen; Hong, Mei; Liu, Zhiping; Huo, Yuqing
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models
EUROPEAN HEART JOURNAL
IF35.6
2023-01-317
OA
Ma, Qian; Yang, Qiuhua; Xu, Jiean; Sellers, Hunter G.; Brown, Zach L.; Liu, Zhiping; Bordan, Zsuzsanna; Shi, Xiaofan; Zhao, Dingwei; Cai, Yongfeng; Pareek, Vidhi; Zhang, Chunxiang; Wu, Guangyu; Dong, Zheng; Verin, Alexander D.; Gan, Lin; Du, Quansheng; Benkovic, Stephen J.; Xu, Suowen; Asara, John M.; Ben-Sahra, Issam; Barman, Scott; Su, Yunchao; Fulton, David J. R.; Huo, Yuqing
Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
2023-01-013
OAAI
Zhang, Min; Wang, Caiping; Wang, Rongning; Xu, Jiean; Wang, Zhefeng; Yan, Jianlong; Cai, Yongfeng; Li, Liangping; Huo, Yuqing; Dong, Shaohong
Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
JCI INSIGHT
IF6.1
2022-12-0826
OA
Liu, Zhiping; Shi, Huidong; Xu, Jiean; Yang, Qiuhua; Ma, Qian; Mao, Xiaoxiao; Xu, Zhimin; Zhou, Yaqi; Da, Qingen; Cai, Yongfeng; Fulton, David J. R.; Dong, Zheng; Sodhi, Akrit; Caldwell, Ruth B.; Huo, Yuqing
ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

与ATIC相关的从头嘌呤合成在增生性动脉疾病中至关重要

CIRCULATION
IF38.6
2022-11-0818
OA
Ma, Qian; Yang, Qiuhua; Xu, Jiean; Zhang, Xiaoyu; Kim, David; Liu, Zhiping; Da, Qingen; Mao, Xiaoxiao; Zhou, Yaqi; Cai, Yongfeng; Pareek, Vidhi; Kim, Ha Won; Wu, Guangyu; Dong, Zheng; Song, Wen-Liang; Gan, Lin; Zhang, Chunxiang; Hong, Mei; Benkovic, Stephen J.; Weintraub, Neal L.; Fulton, David, Jr.; Asara, John M.; Ben-Sahra, Issam; Huo, Yuqing
Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization

抑制髓样PFKFB3-driven糖酵解保护小鼠脉络膜新生血管

BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2022-08-0923
OAAI
Liu, Zhiping; Mao, Xiaoxiao; Yang, Qiuhua; Zhang, Xiaoyu; Xu, Jiean; Ma, Qian; Zhou, Yaqi; Da, Qingen; Cai, Yongfeng; Sopeyin, Anu; Dong, Zheng; Hong, Mei; Caldwell, Ruth B.; Sodhi, Akrit; Huo, Yuqing
ATIC-associated De Novo Purine Biosynthesis Is Critically Involved In Proliferative Arterial Disease
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
2022-05-010
PRE
Ma, Qian; Yang, Qiuhua; Xu, Jiean; Liu, Zhiping; Kim, David; Kim, Ha W.; Weintraub, Neal L.; Fulton, David; Huo, Yuqing
A Novel Her2/VEGFR2/CD3 trispecific antibody with an optimal structural design showed improved T-cell-redirecting antitumor efficacy
THERANOSTICS
IF13.3
2022-01-017
OAAI
Liu, Dong; Qi, Xuexiu; Wei, Xiaoyi; Zhao, Lijun; Wang, Xuechun; Li, Shuhong; Wang, Zhidong; Shi, Licai; Xu, Jiean; Hong, Mei; Liu, Zhong; Zhao, Lili; Wang, Xiankun; Zhang, Bo; Zhang, Yuhan; Wang, Feng; Cao, Yu J.
Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2021-12-277
OA
Yang, Qiuhua; Ma, Qian; Xu, Jiean; Liu, Zhiping; Mao, Xiaoxiao; Zhou, Yaqi; Cai, Yongfeng; Da, Qingen; Hong, Mei; Weintraub, Neal L.; Fulton, David J.; de Chantemele, Eric J. Belin; Huo, Yuqing
Disruption of endothelial Pfkfb3 ameliorates diet-induced murine insulin resistance
JOURNAL OF ENDOCRINOLOGY
IF3.9
2021-09-018
OA
Yang, Qiuhua; Xu, Jiean; Ma, Qian; Liu, Zhiping; Zhou, Yaqi; Cai, Yongfeng; Mao, Xiaoxiao; Stepp, David; Weintraub, Neal; Fulton, David J.; Hong, Mei; Huo, Yuqing
Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2021-02-0129
OAAI
Wang, Lina; Zhang, Xiaoyu; Cao, Yapeng; Ma, Qian; Mao, Xiaoxiao; Xu, Jiean; Yang, Qiuhua; Zhou, Yaqi; Lucas, Rudolf; Fulton, David J.; Su, Yunchao; Barman, Scott A.; Hong, Mei; Liu, Zhiping; Huo, Yuqing
Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-08-0576
OAAI
Liu, Zhiping; Xu, Jiean; Ma, Qian; Zhang, Xiaoyu; Yang, Qiuhua; Wang, Lina; Cao, Yapeng; Xu, Zhimin; Tawfik, Amany; Sun, Ye; Weintraub, Neal L.; Fulton, David J.; Hong, Mei; Dong, Zheng; Smith, Lois E. H.; Caldwell, Ruth B.; Sodhi, Akrit; Huo, Yuqing

研究方向

暂未获取到该数据
Y
Yuqing Huo
H 指数:60论文数:228被引数:1.5万
Q
Qiuhua Yang
H 指数:22论文数:77被引数:1,929
刘志平 封面图
刘志平
H 指数:41论文数:223被引数:5,783
Y
Yaqi Zhou
H 指数:19论文数:91被引数:1,551
M
Mei Hong
H 指数:43论文数:160被引数:6,555
Q
Qian Ma
H 指数:19论文数:69被引数:1,479
D
David Fulton
H 指数:73论文数:398被引数:1.9万
N
Neal L. Weintraub
H 指数:70论文数:417被引数:1.6万
Y
Yapeng Cao
H 指数:14论文数:33被引数:1,332
Y
Yongfeng Cai
H 指数:11论文数:41被引数:371