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B

Brian O’Rourke

johns hopkins university

93H指数
449论文数
2.8W被引数
收录论文 238
发表时间
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Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19先天免疫激活和线粒体ROS诱导COVID-19后急性及持续性心脏传导系统功能障碍
errJCI Insight
IF6.1
err2025-12-22
err0
PREAI
errAshok, Deepthi; Liu, Ting; Nakanishi-Koakutsu, Misato; Criscione, Joseph; Prakash, Meghana; Tensfeldt, Alexis; Kim, Byunggik; Ho, Bryan; Chow, Julian; Craney, Morgan; Ranek, Mark J.; Lin, Brian L.; Papanicolaou, Kyriakos; Sidor, Agnieszka; Foster, D. Brian; Cho, Hee Cheol; Pekosz, Andrew; Villano, Jason; Kim, Deok-Ho; O'Rourke, Brian
err分享
err收藏
Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response contributing to heart failure心衰心肌细胞中O-GlcNAcylation的丢失触发了整合应激反应，从而加剧了心力衰竭。
errJournal of Biological Chemistry
IF3.9
err2025-10-14
err0
errOAAI
errKyriakos N. Papanicolaou; Wenxi Zhang; Aidan Dunphy; Justin C. Zhong; Clara Y. Cho; Dan R. Turner; Deepthi Ashok; D.Brian Foster; Brian O’Rourke; Natasha E. Zachara
err分享
err收藏
Sex-dependent phosphorylation of Argonaute 2 reduces the mitochondrial translocation of miR-181c and induces cardioprotection in females
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2024-09-01
err0
PREAI
errQuiroga, Diego; Roman, Barbara; Salih, Marwan; Daccarett-Bojanini, William N.; Garbus, Haley; Ebenebe, Obialunanma V.; Dodd-o, Jeffrey M.; O'Rourke, Brian; Kohr, Mark; Das, Samarjit
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Prominent effects of p38 MAPK inhibition on the phosphoproteome of a guinea pig model of heart failure and sudden cardiac death
errCIRCULATION RESEARCH
IF16.2
err2024-08-02
err0
PREAI
errSedighi, Sogol; Liu, Ting; O'Rourke, Brian; Foster, D.
err分享
err收藏
Blocking AMPKaS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-12-01
err3
PREAI
errPearah, Alexia; Ramatchandirin, Balamurugan; Liu, Ting; Wolf, Risa M.; Ikeda, Arisa; Radovick, Sally; Sesaki, Hiromi; Wondisford, Fredric E.; O'Rourke, Brian; He, Ling
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Sex Differences in the Phosphorylation of Argonaute 2 Result in Reduced Translocation of Micro RNA-181c Into the Mitochondria and Cardioprotection in Pre-Menopausal Females
errCIRCULATION
IF38.6
err2023-11-07
err0
PREAI
errQuiroga, Diego T.; Roman, Barbara; Garbus, Haley; Ebenebe, Obialunanma; O'Rourke, Brian; Kohr, Mark J.; Das, Samarjit
err分享
err收藏
Decoding Angiotensin Receptors: TOMAHAQ-Based Detection and Quantification of Angiotensin Type-1 and Type-2 Receptors解码血管紧张素受体: 基于TOMAHAQ的1型和2型血管紧张素受体的检测和定量
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2023-09-19
err1
errOAAI
errCosarderelioglu, Caglar; Kreimer, Simion; Plaza-Rodriguez, Alma I.; Iglesias, Pablo A.; Talbot, C. Conover; Siragy, Helmy M.; Carey, Robert M.; Ubaida-Mohien, Ceereena; O'Rourke, Brian; Ferrucci, Luigi; Bennett, David A.; Walston, Jeremy; Abadir, Peter
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O-GlcNAcylation Regulates Protein Synthesis In Cardiomyocytes Through Effects On The Translational Regulator Eif2α
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errPapanicolaou, Kyriakos; Jung, Jessica; Zhang, Wenxi; Ashok, Deepthi; Foster, D. Brian; O'Rourke, Brian; Zachara, Natasha
err分享
err收藏
Mitochondrial CaMKII Drives Cardiometabolic Dysfunction In Heart Failure
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errFerrero, Kimberly; Cole, Robert; Foster, D. B.; Granger, Jonathan; O'Rourke, Brian; Kass, David A.; Luczak, Elizabeth
err分享
err收藏
Role Of Innate Immune Response And Mitochondrial Ros In The Cardiac And Pulmonary Sequelae Of Covid-19
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errLiu, Ting; Ashok, Deepthi; Craney, Morgan; Wong, Amanda; Foster, D. B.; Pekosz, Andrew; Villano, Jason; O'Rourke, Brian
err分享
err收藏
Effects Of Antiviral Innate Immune Activation On Cytokine Secretion And Function Of Human Ipsc-derived Cardiomyocytes
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errAshok, Deepthi; Liu, Ting; Prakash, Meghana; Kim, Jason; Ho, Bryan; Papanicolaou, Kyriakos; Kim, Deok-Ho; O'Rourke, Brian
err分享
err收藏
Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats线粒体Na /Ca2交换抑制和Ca2单向转运体激活对糖尿病大鼠Ca2火花和心律失常的不同影响
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2023-07-18
err2
errOAAI
errVelmurugan, Sathya; Liu, Ting; Chen, Kuey C.; Despa, Florin; O'Rourke, Brian; Despa, Sanda
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err收藏
Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+uptake缺血后再灌注时线粒体膜电位的不稳定性不依赖于线粒体Ca2的摄取
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-06-01
err12
errOAAI
errAshok, Deepthi; Papanicolaou, Kyriakos; Sidor, Agnieszka; Wang, Michelle; Solhjoo, Soroosh; Liu, Ting; O'Rourke, Brian
err分享
err收藏
Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling
errBIOPHYSICAL JOURNAL
IF3.1
err2023-04-01
err0
errOAAI
errKurz, Felix T.; Aon, Miguel A.; Schlemmer, Heinz-Peter; Jende, Johann M. E.; O'Rourke, Brian; Armoundas, Antonis A.
err分享
err收藏
Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy抑制o-glcnacylation影响p38和Erk1/2信号传导并扰乱心肌细胞肥大
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-03-01
err15
errOAAI
errPapanicolaou, Kyriakos N.; Jung, Jessica; Ashok, Deepthi; Zhang, Wenxi; Modaressanavi, Amir; Avila, Eddie; Foster, D. Brian; Zachara, Natasha E.; O'Rourke, Brian
err分享
err收藏
Growth Differentiation Factor-15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2023-02-07
err8
errOAAI
errBinder, M. Scott; Yanek, Lisa R.; Yang, Wanjun; Butcher, Barbara; Norgard, Sanaz; Marine, Joseph E.; Kolandaivelu, Aravindan; Chrispin, Jonathan; Fedarko, Neal S.; Calkins, Hugh; O'Rourke, Brian; Wu, Katherine C.; Tomaselli, Gordon F.; Barth, Andreas S.
err分享
err收藏
Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-01-01
err7
errOAAI
errSolhjoo, Soroosh; Liu, Ting; Sidor, Agnieszka; Lee, Dong I.; O' Rourke, Brian; Steenbergen, Charles
err分享
err收藏
Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia-Reperfusion Injury in the Isolated Mouse Heart
errANTIOXIDANTS
IF6.6
err2022-05-20
err17
errOAAI
errPharoah, Blaze M.; Khodade, Vinayak S.; Eremiev, Alexander; Bao, Eric; Liu, Ting; O'Rourke, Brian; Paolocci, Nazareno; Toscano, John P.
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err收藏
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
errCIRCULATION RESEARCH
IF16.2
err2022-02-03
err28
errOAAI
errKeceli, Gizem; Gupta, Ashish; Sourdon, Joevin; Gabr, Refaat; Schaer, Michael; Dey, Swati; Tocchetti, Carlo G.; Stuber, Annina; Agrimi, Jacopo; Zhang, Yi; Leppo, Michelle; Steenbergen, Charles; Lai, Shenghan; Yanek, Lisa R.; O'Rourke, Brian; Gerstenblith, Gary; Bottomley, Paul A.; Wang, Yibin; Paolocci, Nazareno; Weiss, Robert G.
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The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure
errFEBS LETTERS
IF3
err2021-11-19
err12
errOAAI
errZhu, Guangshuo; Ueda, Kazutaka; Hashimoto, Masaki; Zhang, Manling; Sasaki, Masayuki; Kariya, Taro; Sasaki, Hideyuki; Kaludercic, Nina; Lee, Dong-Ik; Bedja, Djahida; Gabrielson, Matthew; Yuan, Yuan; Paolocci, Nazareno; Blanton, Robert M.; Karas, Richard H.; Mendelsohn, Michael E.; O'Rourke, Brian; Kass, David A.; Takimoto, Eiki
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研究方向

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