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J

Junchao Xu

University of Pennsylvania
H指数:24
被引数:3,101
浏览量:0

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Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy

前体药物栓系脂质纳米粒用于协同信使RNA癌症免疫治疗

Nature Nanotechnology
IF34.9
2026-03-180
PRE
Qiangqiang Shi; Ningqiang Gong; Jinjin Wang; Rohan Palanki; Qiuxian Zheng; Mohamad-Gabriel Alameh; Garima Dwivedi; Benjamin Davis; Jilian Melamed; Zhangyi Luo; Junchao Xu; Christian G. Figueroa-Espada; Lulu Xue; Ye Zeng; Xuexiang Han; Dongyoon Kim; Qinyuan Chen; Hannah Yamagata; Hannah C. Geisler; Rakan El-Mayta; Il-Chul Yoon; Drew Weissman; Michael J. Mitchell
Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines

下一代疫苗中可电离脂质纳米颗粒和mRNA元件的全面工程化

ACS Nano
IF16
2026-02-150
PRE
Jung Gi Kim; Junchao Xu; Dongjae Lee; Jeongah Song; Seongjun Lee; Min Hwa Hong; Jingcheng Zhu; Audrey Zhu; Korey Patwari; Eun-hyeon Shim; Jeong Eun Shin; Ok Hyun Park; Jinhyung Rho; Kyong-Cheol Ko; Eun Gyo Lee; On-Yu Kang; Eun-Jeong Won; Bo Hyeon Kim; Jun-Pil Jang; Jae-Hyuk Jang; Doo-Jin Kim; Jeong Ho Hwang; Michael J. Mitchell; Hyunjoo Cha-Molstad
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

作者更正：基于曼尼希反应的组合库鉴定用于mRNA递送、抗氧化且免疫原性降低的离子izable脂质

Nature Biomedical Engineering
IF26.6
2025-07-310
PREAI
Ningqiang Gong; Dongyoon Kim; Mohamad-Gabriel Alameh; Rakan El-Mayta; Emily L. Han; Garima Dwivedi; Rohan Palanki; Qiangqiang Shi; Xuexiang Han; Lulu Xue; Junchao Xu; Zilin Meng; Tianyu Luo; Christian G. Figueroa-Espada; Drew Weissman; Jinghong Li; Michael J. Mitchell
Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

基于Mannich反应的组合库识别用于mRNA递送的低免疫原性抗氧化可电离脂质

Nature Biomedical Engineering
IF26.6
2025-07-180
PRE
Ningqiang Gong; Dongyoon Kim; Mohamad-Gabriel Alameh; Rakan El-Mayta; Emily L. Han; Garima Dwivedi; Rohan Palanki; Qiangqiang Shi; Xuexiang Han; Lulu Xue; Junchao Xu; Zilin Meng; Tianyu Luo; Christian G. Figueroa-Espada; Drew Weissman; Jinghong Li; Michael J. Mitchell
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications

通过PEG脂质比例和磷脂修饰来定制脂质纳米颗粒的佐剂性

Nature Nanotechnology
IF34.9
2025-06-230
PRE
Máté Vadovics; Wenchen Zhao; Emily F. Daley; Kieu Lam; Owen Daly; Khalid Rashid; Hailey R. Lee; Petra Schreiner; Kendall A. Lundgreen; Brian T. Gaudette; Vladimir V. Shuvaev; Evguenia Arguiri; Hiromi Muramatsu; András Sárközy; Thandiswa Mdluli; Junchao Xu; Xuexiang Han; Nina De Luna; Diana Castaño; Emily Bettini; Edit Ábrahám; Zoltan Lipinszki; Giuseppe Carlucci; Avinash Haridas Bansode; Katelyn Nguyen; Thuc M. Le; Tony Luu; Vladimir R. Muzykantov; Paul Bates; David Allman; Michael J. Mitchell; Michela Locci; Caius G. Radu; James Heyes; Norbert Pardi
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

结合硅氧烷的脂质纳米颗粒的组合设计增强了组织特异性mRNA治疗递送的细胞内加工

NATURE NANOTECHNOLOGY
IF34.9
2024-10-011
PRE
Xue, Lulu; Zhao, Gan; Gong, Ningqiang; Han, Xuexiang; Shepherd, Sarah J.; Xiong, Xinhong; Xiao, Zebin; Palanki, Rohan; Xu, Junchao; Swingle, Kelsey L.; Warzecha, Claude C.; El-Mayta, Rakan; Chowdhary, Vivek; Yoon, Il-Chul; Xu, Jingcheng; Cui, Jiaxi; Shi, Yi; Alameh, Mohamad-Gabriel; Wang, Karin; Wang, Lili; Pochan, Darrin J.; Weissman, Drew; Vaughan, Andrew E.; Wilson, James M.; Mitchell, Michael J.
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

肿瘤来源的小细胞外囊泡是治疗性纳米颗粒递送的屏障

NATURE MATERIALS
IF38.5
2024-09-021
PRE
Gong, Ningqiang; Zhong, Wenqun; Alameh, Mohamad-Gabriel; Han, Xuexiang; Xue, Lulu; El-Mayta, Rakan; Zhao, Gan; Vaughan, Andrew E.; Qin, Zhiyuan; Xu, Fengyuan; Hamilton, Alex G.; Kim, Dongyoon; Xu, Junchao; Kim, Junhyong; Teng, Xucong; Li, Jinghong; Liang, Xing-Jie; Weissman, Drew; Guo, Wei; Mitchell, Michael J.
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo

快速简便地合成掺入脒的可降解脂质，用于体内通用mRNA递送

NATURE CHEMISTRY
IF20.2
2024-07-096
OA
Han, Xuexiang; Alameh, Mohamad-Gabriel; Gong, Ningqiang; Xue, Lulu; Ghattas, Majed; Bojja, Goutham; Xu, Junchao; Zhao, Gan; Warzecha, Claude C.; Padilla, Marshall S.; El-Mayta, Rakan; Dwivedi, Garima; Xu, Ying; Vaughan, Andrew E.; Wilson, James M.; Weissman, Drew; Mitchell, Michael J.
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

纳米颗粒的高通量条形码识别阳离子，可降解的脂质样材料，用于在女性临床前模型中将mRNA递送到肺部

NATURE COMMUNICATIONS
IF15.7
2024-02-2917
OAAI
Xue, Lulu; Hamilton, Alex G.; Zhao, Gan; Xiao, Zebin; El-Mayta, Rakan; Han, Xuexiang; Gong, Ningqiang; Xiong, Xinhong; Xu, Junchao; Figueroa-Espada, Christian G.; Shepherd, Sarah J.; Mukalel, Alvin J.; Alameh, Mohamad-Gabriel; Cui, Jiaxi; Wang, Karin; Vaughan, Andrew E.; Weissman, Drew; Mitchell, Michael J.
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors

用于全身递送mRNA治疗剂和基因编辑器的可降解分支类脂质的原位组合合成

NATURE COMMUNICATIONS
IF15.7
2024-02-2612
OAAI
Han, Xuexiang; Xu, Junchao; Xu, Ying; Alameh, Mohamad-Gabriel; Xue, Lulu; Gong, Ningqiang; El-Mayta, Rakan; Palanki, Rohan; Warzecha, Claude C.; Zhao, Gan; Vaughan, Andrew E.; Wilson, James M.; Weissman, Drew; Mitchell, Michael J.

研究方向

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聂
聂广军
H 指数:96论文数:443被引数:3.0万
M
Michael J. Mitchell
H 指数:63论文数:252被引数:2.3万
X
Xuexiang Han
H 指数:48论文数:89被引数:7,061
Y
Yinlong Zhang
H 指数:50论文数:118被引数:9,936
薛璐璐 封面图
薛璐璐
H 指数:33论文数:112被引数:3,115
宫
宫宁强
H 指数:46论文数:100被引数:7,127
M
Mohamad‐Gabriel Alameh
H 指数:48论文数:173被引数:8,751
D
Drew Weissman
H 指数:86论文数:386被引数:3.8万
R
Rakan El‐Mayta
H 指数:22论文数:33被引数:2,210
G
Guangna Liu
H 指数:20论文数:59被引数:2,525