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M

Michael J. Mitchell

University of Pennsylvania

63H指数
251论文数
2.3W被引数
收录论文 159
发表时间
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Structural evolution of ionizable lipids for nucleic acid delivery可离子化脂质在核酸递送中的结构演变
errNature Reviews Chemistry
IF51.7
err2026-09-11
err0
PREAI
errLulu Xue; Melgious Jin Yan Ang; Kelsey L. Swingle; Emily Fitzgerald; Ori Chalom; Ning Gu; Michael J. Mitchell
err分享
err收藏
Author Correction: Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis作者更正：蛋白质聚集物、外泌体和脂蛋白融合对可电离脂质纳米颗粒蛋白冠分析的影响
errNature Communications
IF15.7
err2026-09-10
err0
errOAAI
errBabak Borhan; Amanda M. Murray; Amir Ata Saei; Bahareh Ghaffari; James E. Jackson; Naseeha Mohammed; Michael J. Mitchell; Hojatollah Vali; Kathryn A. Whitehead; Morteza Mahmoudi
err分享
err收藏
A boost for CAR T cell therapyCAR T细胞疗法的助推
errNature Materials
IF38.5
err2026-09-08
err0
PREAI
errEmily Fitzgerald; Marshall S. Padilla; Michael J. Mitchell
err分享
err收藏
Targeted lipid nanoparticles unlock in vivo human haematopoietic stem cell gene editing靶向脂质纳米颗粒解锁体内人造血干细胞基因编辑
errNature Biomedical Engineering
IF26.6
err2026-08-21
err0
PREAI
errZhangyi Luo; Audrey T. Zhu; Michael J. Mitchell
err分享
err收藏
Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis蛋白质聚集物、外泌体及脂蛋白融合对可电离脂质纳米颗粒蛋白冠分析的影响
errNature Communications
IF15.7
err2026-06-12
err0
errOAAI
errBabak Borhan; Amanda M. Murray; Amir Ata Saei; Bahareh Ghaffari; James E. Jackson; Naseeha Mohammed; Michael J. Mitchell; Hojatollah Vali; Kathryn A. Whitehead; Morteza Mahmoudi
err分享
err收藏
HITE: HIV Inspired Lipid Nanoparticle Platform for CAR T Cell EngineeringHITE: 艾滋病病毒启发脂质纳米颗粒平台用于CAR-T细胞工程
errNano Letters
IF9.1
err2026-04-21
err0
PREAI
errDongyoon Kim; So-Jeong Moon; Emily L. Han; Ellie Feng; Amanda M. Murray; Jinjin Wang; Wei Liu; Gu Kong; Carl H. June; Michael J. Mitchell
err分享
err收藏
Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity肝脏靶向解除的芳香族生物还原性mRNA脂质纳米颗粒赋予淋巴结趋向性和强大的抗原特异性免疫
errJournal of the American Chemical Society
IF15.6
err2026-03-24
err0
PREAI
errHannah M. Yamagata; Marshall S. Padilla; Alex G. Hamilton; Kelsey L. Swingle; Ajay S. Thatte; Adele S. Ricciardi; Anushka Agrawal; Emily Fitzgerald; Alexandre J. Poirier; Hannah C. Geisler; Ryann A. Joseph; Ori Z. Chalom; Sherry Du; Jacqueline J. Li; Dongyoon Kim; Ricardo C. Whitaker; Christian G. Figueroa-Espada; Emily L. Han; Amanda M. Murray; Mohamad-Gabriel Alameh; Drew Weissman; Michael J. Mitchell
err分享
err收藏
Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states破坏胰腺癌中的WNT/Notch信号通路揭示了肿瘤依赖于恶性细胞状态之间精妙的平衡。
errDevelopmental Cell
IF8.7
err2026-03-23
err0
PREAI
errStefan R. Torborg; Jung Yun Kim; Anupriya Singhal; Olivera Grbovic-Huezo; Matilda Holm; Katherine Wu; Xuexiang Han; Yu-Jui Ho; Caj Haglund; Michael J. Mitchell; Scott W. Lowe; Lukas E. Dow; Kenneth L. Pitter; Francisco J. Sanchez-Rivera; Andre Levchenko; Tuomas Tammela
err分享
err收藏
Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy前体药物栓系脂质纳米粒用于协同信使RNA癌症免疫治疗
errNature Nanotechnology
IF34.9
err2026-03-18
err0
PREAI
errQiangqiang Shi; Ningqiang Gong; Jinjin Wang; Rohan Palanki; Qiuxian Zheng; Mohamad-Gabriel Alameh; Garima Dwivedi; Benjamin Davis; Jilian Melamed; Zhangyi Luo; Junchao Xu; Christian G. Figueroa-Espada; Lulu Xue; Ye Zeng; Xuexiang Han; Dongyoon Kim; Qinyuan Chen; Hannah Yamagata; Hannah C. Geisler; Rakan El-Mayta; Il-Chul Yoon; Drew Weissman; Michael J. Mitchell
err分享
err收藏
Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination交联的可电离脂质重新编程树突状细胞代谢以进行有效的mRNA疫苗接种
errNature Materials
IF38.5
err2026-03-17
err0
PREAI
errDongyoon Kim; Ningqiang Gong; Mohamad-Gabriel Alameh; Emily L. Han; Hanxun Wang; Jinjin Wang; Ellie Feng; Il-Chul Yoon; Amanda M. Murray; Qiangqiang Shi; So-Jeong Moon; Kaitlin Mrksich; Drew Weissman; Michael J. Mitchell
err分享
err收藏
Preparation of placenta-tropic mRNA lipid nanoparticles for pregnancy disorders胎盘靶向mRNA脂质纳米粒的制备及其在妊娠并发症中的应用
errNature Protocols
IF16
err2026-03-10
err0
PREAI
errKelsey L. Swingle; Michael J. Mitchell
err分享
err收藏
Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines下一代疫苗中可电离脂质纳米颗粒和mRNA元件的全面工程化
errACS Nano
IF16
err2026-02-15
err0
PREAI
errJung Gi Kim; Junchao Xu; Dongjae Lee; Jeongah Song; Seongjun Lee; Min Hwa Hong; Jingcheng Zhu; Audrey Zhu; Korey Patwari; Eun-hyeon Shim; Jeong Eun Shin; Ok Hyun Park; Jinhyung Rho; Kyong-Cheol Ko; Eun Gyo Lee; On-Yu Kang; Eun-Jeong Won; Bo Hyeon Kim; Jun-Pil Jang; Jae-Hyuk Jang; Doo-Jin Kim; Jeong Ho Hwang; Michael J. Mitchell; Hyunjoo Cha-Molstad
err分享
err收藏
High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering使用条形码mRNA的高通量体内筛选可鉴定具有肝外嗜性的脂质纳米颗粒，用于原位免疫工程
errAdvanced Materials
IF26.8
err2026-01-28
err0
errOAAI
errAlex G. Hamilton; Ajay S. Thatte; Junchao Xu; Zhangyi Luo; Hannah C. Safford; Kelsey L. Swingle; Jenna Muscat-Rivera; Michael Kegel; Xuexiang Han; Ryann A. Joseph; Amanda M. Murray; Hannah C. Geisler; Ricardo C. Whitaker; Lulu Xue; Roman Spektor; Jilian R. Melamed; Drew Weissman; Michael J. Mitchell
err分享
err收藏
A material toolbox for engineering targeted lipid nanoparticles for RNA therapies用于RNA治疗的靶向脂质纳米颗粒工程的材料工具箱
errMaterials Today
IF22
err2026-01-24
err0
errOAAI
errSoyeon Yoo; Melgious Jin Yan Ang; Amanda M. Murray; Michael J. Mitchell
err分享
err收藏
Author Correction: Elucidating lipid nanoparticle properties and structure through biophysical analyses作者更正: 通过生物物理分析阐明脂质纳米颗粒的性质和结构
errNature Biotechnology
IF41.7
err2026-01-22
err0
PREAI
errMarshall S. Padilla; Sarah J. Shepherd; Andrew R. Hanna; Martin Kurnik; Xujun Zhang; Michelle Chen; James Byrnes; Ryann A. Joseph; Hannah M. Yamagata; Adele S. Ricciardi; Kaitlin Mrksich; David Issadore; Kushol Gupta; Michael J. Mitchell
err分享
err收藏
High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain高通量体内筛选确定驱动mRNA脂质纳米颗粒递送至大脑的结构因素
errACS Nano
IF16
err2026-01-19
err0
PREAI
errEmily L. Han; Dongyoon Kim; Amanda M. Murray; Kaitlin Mrksich; Alex G. Hamilton; Sophia Tang; Soyeon Yoo; Audrey T. Zhu; Elaine R. Tong; Rohan Palanki; Michelle L. Hall; Sean K. Bedingfield; Michael J. Mitchell
err分享
err收藏
Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-12-01
err0
errOAAI
errNachod, Benjamin E.; Thatte, Ajay S.; Palanki, Rohan; Mitchell, Michael J.
err分享
err收藏
Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries由负载白细胞介素-4 mRNA的脂质纳米颗粒实现的巨噬细胞细胞疗法，以维持炎症损伤中的修复性表型
errBiomaterials
IF12.9
err2025-11-25
err0
errOAAI
errErin M. O'Brien; Tina Tylek; Hannah C. Geisler; Alvin J. Mukalel; Ricardo C. Whitaker; Samuel Sung; Benjamin I. Binder-Markey; Drew Weissman; Michael J. Mitchell; Kara L. Spiller
err分享
err收藏
Dual switches ignite tumour-specific mRNA therapeutics双开关点燃肿瘤特异性mRNA疗法
errNature Nanotechnology
IF34.9
err2025-11-12
err0
PREAI
errZhangyi Luo; Michael J. Mitchell
err分享
err收藏
Emerging Nucleic Acid Cargos for Next-Generation RNA Vaccines and Therapeutics新兴核酸载体用于下一代RNA疫苗和治疗药物
errBioconjugate Chemistry
IF3.9
err2025-11-04
err0
PREAI
errHannah C. Safford; Rohan Palanki; Melgious Ang; Michael J. Mitchell
err分享
err收藏

研究方向

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合作学者
合作期刊
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Róbert Langer
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James M. Wilson
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