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Usage of lipid-lowering therapies in patients at high and very high cardiovascular risk from Spain: one-year follow-up of the Spanish subpopulation from the European SANTORINI study 西班牙高和极高心血管风险患者中降脂药物的使用情况：欧洲SANTORINI研究西班牙亚人群的1年随访结果 Mostaza, J. M.; Lahoz, C.; Castro, M. Garcia de Yebenes; Campal, J. M. Rubio; Velasquez, E.; Gutierrez, A. Ibarra; Diaz, J. F.; Plana, N.; Rodriguez-Manero, M.; Garcia-Diaz, J. D. de Dios; Deben, F. Martinez; de Paz, I. Pavon; Catapano, A. L.; Moya, G. Diaz; Ray, K. K. 分享 收藏
Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide Kalnins, Toms; Vitkovska, Viktorija; Kazak, Mihail; Zelencova-Gopejenko, Diana; Ozola, Melita; Narvaiss, Nauris; Makrecka-Kuka, Marina; Domraceva, Ilona; Kinens, Artis; Gukalova, Baiba; Konrad, Nele; Aav, Riina; Bonato, Francesca; Lucena-Agell, Daniel; Diaz, J. Fernando; Liepinsh, Edgars; Suna, Edgars 分享 收藏
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PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin Lucena-Agell, Daniel; Guillen, Maria Jose; Matesanz, Ruth; Alvarez-Bernad, Beatriz; Hortiguela, Rafael; Aviles, Pablo; Martinez-Diez, Marta; Santamaria-Nunez, Gema; Contreras, Julia; Plaza-Menacho, Ivan; Gimenez-Abian, Juan F.; Oliva, Maria A.; Cuevas, Carmen; Diaz, J. Fernando 分享 收藏
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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency Ma, Yuntao; Josa-Prado, Fernando; Essif, Jacob Nathaniel; Liu, Shuqi; Li, Shuo; Lucena-Agell, Daniel; Chan, Peter YW.; Goossens, Kenneth; Hortiguela, Rafael; Matesanz, Ruth; Wang, Yingjie; Gago, Federico; Wang, Hongbo; Risinger, April; Diaz, J. Fernando; Fang, Wei-Shuo 分享 收藏
Probing a distinct druggable tubulin binding site with gatorbulins 1-7, their metabolic and physicochemical properties, and pharmacological consequences Chen, Qi-Yin; Ratnayake, Ranjala; Hortiguela, Rafael; Seabra, Gustavo M.; Cameron, Michael D.; Diaz, J. Fernando; Oliva, Maria Angela; Luesch, Hendrik 分享 收藏
Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(-)-Zampanolide Analogs Bruetsch, Tobias M.; Cotter, Etienne; Lucena-Agell, Daniel; Redondo-Horcajo, Mariano; Davies, Carolina; Pfeiffer, Bernhard; Pagani, Sandro; Berardozzi, Simone; Fernando Diaz, J.; Miller, John H.; Altmann, Karl-Heinz 分享 收藏
PM534 is a novel microtubule-destabilizing agent with high affinity and potent antineoplastic properties PM534是一种新型的微管去稳定剂，具有高亲和力和强大的抗肿瘤特性 Oliva, Maria Angela; Alvarez-Bernad, Beatriz; Lucena-Agell, Daniel; Diez, Marta Martinez; Guillen, Maria Jose; Nunez, Gema Santamaria; Munoz-Alonso, Maria Jose; Garrido-Martin, Eva M.; Aviles, Pablo; Cuevas, Carmen; Diaz, J. Fernando 分享 收藏
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Structural insight into the stabilization of microtubules by taxanes 紫杉烷类化合物对微管稳定的结构见解 Prota, Andrea E.; Lucena-Agell, Daniel; Ma, Yuntao; Estevez-Gallego, Juan; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Muhlethaler, Tobias; Gago, Federico; Oliva, Maria A.; Steinmetz, Michel O.; Fang, Wei-Shuo; Diaz, J. Fernando 分享 收藏
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics Boiarska, Zlata; Perez-Pena, Helena; Abel, Anne-Catherine; Marzullo, Paola; Alvarez-Bernad, Beatriz; Bonato, Francesca; Santini, Benedetta; Horvath, Dragos; Lucena-Agell, Daniel; Vasile, Francesca; Sironi, Maurizio; Diaz, J. Fernando; Prota, Andrea E.; Pieraccini, Stefano; Passarella, Daniele 分享 收藏
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Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics Boiarska, Zlata; Perez-Pena, Helena; Abel, Anne-Catherine; Marzullo, Paola; Alvarez-Bernad, Beatriz; Bonato, Francesca; Santini, Benedetta; Horvath, Dragos; Lucena-Agell, Daniel; Vasile, Francesca; Sironi, Maurizio; Fernando Diaz, J.; Prota, Andrea E.; Pieraccini, Stefano; Passarella, Daniele 分享 收藏
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy Campiani, Giuseppe; Khan, Tuhina; Ulivieri, Cristina; Staiano, Leopoldo; Papulino, Chiara; Magnano, Stefania; Nathwani, Seema; Ramunno, Anna; Lucena-Agell, Daniel; Relitti, Nicola; Federico, Stefano; Pozzetti, Luca; Carullo, Gabriele; Casagni, Alice; Brogi, Simone; Vanni, Francesca; Galatello, Paola; Ghanim, Magda; McCabe, Niamh; Lamponi, Stefania; Valoti, Massimo; Ibrahim, Ola; O'Sullivan, Jeffrey; Turkington, Richard; Kelly, Vincent P.; VanWemmel, Ruben; Diaz, J. Fernando; Gemma, Sandra; Zisterer, Daniela; Altucci, Lucia; De Matteis, Antonella; Butini, Stefania; Benedetti, Rosaria 分享 收藏
Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes 微管稳定剂诱导的晶格缺陷通过促进突变对微管生长产生长期影响 Rai, Ankit; Liu, Tianyang; Katrukha, Eugene A.; Estevez-Gallego, Juan; Manka, Szymon W.; Paterson, Ian; Diaz, J. Fernando; Kapitein, Lukas C.; Moores, Carolyn A.; Akhmanova, Anna 分享 收藏
CLIP-170S is a microtubule plus TIP variant that confers resistance to taxanes by impairing drug-target engagement Thakkar, Prashant, V; Kita, Katsuhiro; Del Castillo, Urko; Galletti, Giuseppe; Madhukar, Neel; Navarro, Elena Vila; Barasoain, Isabel; Goodson, Holly, V; Sackett, Dan; Diaz, Jose Fernando; Lu, Yao; RoyChoudhury, Arindam; Molina, Henrik; Elemento, Olivier; Shah, Manish A.; Giannakakou, Paraskevi 分享 收藏
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