Charles Pin‐Kuang Lai - Publications, H-index & Citations

Charles Pin‐Kuang Lai

institute of atomic and molecular sciences academia sinica

34H指数

84论文数

8.7K被引数

收录论文 40

发表时间

Stress-Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis 压力诱导的小型细胞外囊泡分泌转变：从组成型‘撕裂袋机制’到胞吐作用

Journal of Extracellular Vesicles

IF14.5

2026-09-24

OAAI

Dorina Lenzinger; Lilla Lankovics; István Dudás; Tünde Bárkai; Zsófia Szász; Mirjam Balbisi; Anthony Yan-Tang Wu; Krisztina V. Vukman; Kelsey Fletcher; Attila Csomos; Zoltán Mucsi; Edina Bugyik; Csaba Cserép; Ádám Dénes; Szilvia Bősze; Lilla Turiák; Charles Pin-Kuang Lai; Edit I. Buzás; Tamás Visnovitz

Integrated microRNA–protein plasma biomarkers improve discrimination of multiple system atrophy from Parkinson’s disease 整合的miRNA-蛋白质血浆生物标志物可提高对多系统萎缩与帕金森病的鉴别诊断

npj Parkinsons Disease

IF8.2

2026-09-07

OAAI

Hsiang-Hsuan Lin-Wang; Yi-Tzang Tsai; Jing-Wen Huang; Ming-Che Kuo; Yung-Tsai Chu; Chia-Chen Lu; Yan-Hong Chen; Frederick Kin Hing Phoa; Pin-Jui Kung; Elisha Wei-Chun Ho; Charles Pin-Kuang Lai; Chien-Tai Hong; Seong Wook Yang; Chai-Ching Wu; Koji Ueda; Takahiro Ochiya; Ruey-Meei Wu; Shau-Ping Lin

The overlooked pillars of medical education: addressing the mental health and well-being of medical school administrative staff 医学教育中被忽视的支柱：关注医学院行政人员的心理健康和福祉

Frontiers in Psychiatry

IF3.2

2025-11-06

OAAI

Jonathan Shaw†; Charles Lai†; Peter Bota†; Jonathan Townsend

Stroma-Targeted Gene Delivery for Efficient Immunogene Therapy against Pancreatic Cancer 靶向基质的高效基因递送用于胰腺癌免疫基因治疗

Molecular Therapy

IF12

2025-09-27

PREAI

Hsi-Chien Huang; Yi-Ju Chen; Mei-Wei Lin; Chih-I Huang; Chia-Yueh Hsiung; Sheng Yang; Yi-Yu Ke; Yu-Ting Yen; Hsin-Tzu Hsieh; Yen-Fei Lu; Yun-Chieh Sung; Fu-Fei Hsu; Anthony Yan-Tang Wu; Charles Pin-Kuang Lai; Jane Wang; Min-Yuan Chou; Chung-Pin Li; Shu-Yi Lin; Yunching Chen

Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies Bro1蛋白通过调控多泡体的分泌或降解来决定肿瘤免疫逃逸和转移。

Developmental Cell

IF8.7

2025-04-03

PREAI

Nai Yang Yeat; Li-Heng Liu; Yu-Hsuan Chang; Charles Pin-Kuang Lai; Ruey-Hwa Chen

Chromatograms and Mass Spectra of High-Mannose and Paucimannose N-Glycans for Rapid Isomeric Identifications

JOURNAL OF PROTEOME RESEARCH

IF3.6

2024-02-16

OAAI

Liew, Chia Yen; Chen, Jien-Lian; Lin, Yen-Ting; Luo, Hong-Sheng; Hung, An-Ti; Magoling, Bryan John Abel; Nguan, Hock-Seng; Lai, Charles Pin-Kuang; Ni, Chi-Kung

Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells

COMMUNICATIONS BIOLOGY

IF5.1

2023-06-15

OAAI

Kao, Yi-Chun; Chang, Yi-Wen; Lai, Charles P.; Chang, Nai-Wen; Huang, Chen-Hao; Chen, Chien-Sheng; Huang, Hsuan-Cheng; Juan, Hsueh-Fen

Identification of the High Mannose N-Glycan Isomers Undescribed by Conventional Multicellular Eukaryotic Biosynthetic Pathways

ANALYTICAL CHEMISTRY

IF6.7

2023-05-26

OAAI

Liew, Chia Yen; Luo, Hong-Sheng; Yang, Ting-Yi; Hung, An-Ti; Magoling, Bryan John Abel; Lai, Charles Pin-Kuang; Ni, Chi-Kung

Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo 膜蛋白修饰在体内调节乳腺癌大小胞外囊泡的生物分布和致瘤潜力

ADVANCED MATERIALS

IF26.8

2023-02-13

OAAI

Magoling, Bryan John Abel; Wu, Anthony Yan-Tang; Chen, Yen-Ju; Wong, Wendy Wan-Ting; Chuo, Steven Ting-Yu; Huang, Hsi-Chien; Sung, Yun-Chieh; Hsieh, Hsin Tzu; Huang, Poya; Lee, Kang-Zhang; Huang, Kuan-Wei; Chen, Ruey-Hwa; Chen, Yunching; Lai, Charles Pin-Kuang

Isolation and digital counting of extracellular vesicles from blood via membrane-integrated microfluidics 通过膜集成微流体对血液中的细胞外囊泡进行隔离和数字计数

SENSORS AND ACTUATORS B-CHEMICAL

IF7.7

2022-05-01

PREAI

Chen, Yi-Sin; Chen, Chihchen; Lai, Charles Pin-Kuang; Lee, Gwo-Bin

Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza

NPJ VACCINES

IF6.5

2021-12-16

OAAI

Chivukula, Sudha; Plitnik, Timothy; Tibbitts, Timothy; Karve, Shrirang; Dias, Anusha; Zhang, Donghui; Goldman, Rebecca; Gopani, Hardip; Khanmohammed, Asad; Sarode, Ashish; Cooper, Dustin; Yoon, Heesik; Kim, Younghoon; Yan, Yanhua; Mundle, Sophia T.; Groppo, Rachel; Beauvais, Adrien; Zhang, Jinrong; Anosova, Natalie G.; Lai, Charles; Li, Lu; Ulinski, Gregory; Piepenhagen, Peter; DiNapoli, Joshua; Kalnin, Kirill, V; Landolfi, Victoria; Swearingen, Ron; Fu, Tong-Ming; DeRosa, Frank; Casimiro, Danilo

The power of imaging to understand extracellular vesicle biology in vivo 成像在体内了解细胞外囊泡生物学的力量

NATURE METHODS

IF32.1

2021-08-26

134

OAAI

Verweij, Frederik J.; Balaj, Leonora; Boulanger, Chantal M.; Carter, David R. F.; Compeer, Ewoud B.; D'Angelo, Gisela; El Andaloussi, Samir; Goetz, Jacky G.; Gross, Julia Christina; Hyenne, Vincent; Kramer-Albers, Eva-Maria; Lai, Charles P.; Loyer, Xavier; Marki, Alex; Momma, Stefan; Nolte-'t Hoen, Esther N. M.; Pegtel, D. Michiel; Peinado, Hector; Raposo, Graca; Rilla, Kirsi; Tahara, Hidetoshi; Thery, Clotilde; van Royen, Martin E.; Vandenbroucke, Roosmarijn E.; Wehman, Ann M.; Witwer, Kenneth; Wu, Zhiwei; Wubbolts, Richard; van Niel, Guillaume

Multiplexed bioluminescence-mediated tracking of DNA double-strand break repairs in vitro and in vivo

NATURE PROTOCOLS

IF16

2021-06-23

OAAI

Chien, Jasper Che-Yung; Badr, Christian E.; Lai, Charles Pin-Kuang

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles 开发用于间充质基质细胞衍生的小细胞外囊泡治疗应用的效力测试的关键考虑因素

CYTOTHERAPY

IF3.2

2021-05-01

159

OAAI

Gimona, Mario; Brizzi, Maria Felice; Choo, Andre Boon Hwa; Dominici, Massimo; Davidson, Sean M.; Grillari, Johannes; Hermann, Dirk M.; Hill, Andrew F.; de Kleijn, Dominique; Lai, Ruenn Chai; Lai, Charles P.; Lim, Rebecca; Monguio-Tortajada, Marta; Muraca, Maurizio; Ochiya, Takahiro; Ortiz, Luis A.; Toh, Wei Seong; Yi, Yong Weon; Witwer, Kenneth W.; Giebel, Bernd; Lim, Sai Kiang

Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform

LAB ON A CHIP

IF5.4

2021-01-01

PREAI

Chen, Yi-Sin; Lai, Charles Pin-Kuang; Chen, Chihchen; Lee, Gwo-Bin

Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism 使用生物发光共振能量转移的多分辨率成像可识别具有重定向向性的细胞外囊泡和外泌体的不同生物分布

ADVANCED SCIENCE

IF14.1

2020-08-16

OAAI

Wu, Anthony Yan-Tang; Sung, Yun-Chieh; Chen, Yen-Ju; Chou, Steven Ting-Yu; Guo, Vanessa; Chien, Jasper Che-Yung; Ko, John Jun-Sheng; Yang, Alan Ling; Huang, Hsi-Chien; Chuang, Ju-Chen; Wu, Syuan; Ho, Meng-Ru; Ericsson, Maria; Lin, Wan-Wan; Cheung, Chantal Hoi Yin; Juan, Hsueh-Fen; Ueda, Koji; Chen, Yunching; Lai, Charles Pin-Kuang

A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo

NUCLEIC ACIDS RESEARCH

IF13.1

2020-08-14

OAAI

Chien, Jasper Che-Yung; Tabet, Elie; Pinkham, Kelsey; da Hora, Cintia Carla; Chang, Jason Cheng-Yu; Lin, Steven; Badr, Christian E.; Lai, Charles Pin-Kuang

Glioblastoma hijacks microglial gene expression to support tumor growth

JOURNAL OF NEUROINFLAMMATION

IF10.1

2020-04-16

OAAI

Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, Joana; Sen, Pritha; Prabhakar, Shilpa; Hickman, Suzanne E.; Lai, Charles P.; Ting, David T.; Breakefield, Xandra O.; Broekman, Marike L. D.; El Khoury, Joseph

Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein

NANO LETTERS

IF9.1

2019-12-29

OAAI

Huang, Yao-Shen; Fan, Ching-Hsiang; Hsu, Ning; Chiu, Nai-Hua; Wu, Chun-Yao; Chang, Chu -Yuan; Wu, Bing-Huan; Hong, Shi-Rong; Chan, Ya-Chu; Wu, Anthony Yan-Tang; Guo, Vanessa; Chiang, Yueh-Chen; Hsu, Wei -Chia; Chen, Linyi; Lai, Charles Pin-Kuang; Yeh, Chih-Kuang; Lin, Yu-Chun

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles

SCIENTIFIC REPORTS

IF3.9

2019-11-22

OAAI

Zaborowski, Mikolaj Piotr; Cheah, Pike See; Zhang, Xuan; Bushko, Isabella; Lee, Kyungheon; Sammarco, Alessandro; Zappulli, Valentina; Maas, Sybren Lein Nikola; Allen, Ryan M.; Rumde, Purva; Gyorgy, Bence; Aufiero, Massimo; Schweiger, Markus W.; Lai, Charles Pin-Kuang; Weissleder, Ralph; Lee, Hakho; Vickers, Kasey C.; Tannous, Bakhos A.; Breakefield, Xandra O.

研究方向