Seth A. Darst - Publications, H-index & Citations

Seth A. Darst

The Rockefeller University

77H指数

332论文数

1.9W被引数

收录论文 83

发表时间

Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis 脱水促进结核分枝杆菌DNA损伤和利福平耐药性

Nature Microbiology

IF19.4

2026-08-26

OAAI

Christopher D. Brown; Brendon M. Lee; Hannah M. Liu; Amy M. Wu; Andrea Tellez; Harry Zou; Prabhat Ranjan Singh; Kohta Saito; Saurabh Mishra; Megan Brown; Anas Saleh; Narineh M. Odjourian; Melissa Cristaldo; Mingyu Gan; Qingyun Liu; Martin Gengenbacher; Seth A. Darst; Elizabeth A. Campbell; Carl Nathan; Kyu Y. Rhee

Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity 多亚基DNA依赖性RNA聚合酶催化活性的结构基础

Molecular Cell

IF16.6

2026-04-30

OAAI

Andreas U. Mueller; Seth A. Darst

Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase 分枝杆菌RNA聚合酶对从头启动子逃逸的结构见解

Nature Communications

IF15.7

2025-11-13

OAAI

Joshua Brewer; Madeleine Delbeau; Winston Bates Zoullas; Seth A. Darst; Elizabeth A. Campbell

Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding Σ n转录起始中间体的实时捕获揭示了通过有限的展开来激活ATPase驱动的机制

Nature Communications

IF15.7

2025-08-04

OAAI

Andreas U. Mueller; Nina Molina; B. Tracy Nixon; Seth A. Darst

The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved SARS-CoV-2 NiRAN结构域介导的GTP依赖性RNA加帽机制尚未解决

Cell

IF42.5

2025-06-25

PREAI

Gabriel I. Small; Seth A. Darst; Elizabeth A. Campbell

The yin and yang of the universal transcription factor NusG

CURRENT OPINION IN MICROBIOLOGY

IF7.5

2024-10-01

PREAI

Delbeau, Madeleine; Froom, Ruby; Landick, Robert; Darst, Seth A.; Campbell, Elizabeth A.

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2024-07-01

PREAI

Saecker, Ruth M.; Mueller, Andreas U.; Malone, Brandon; Chen, James; Budell, William C.; Dandey, Venkata P.; Maruthi, Kashyap; Mendez, Joshua H.; Molina, Nina; Eng, Edward T.; Yen, Laura Y.; Potter, Clinton S.; Carragher, Bridget; Darst, Seth A.

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain

MOLECULAR CELL

IF16.6

2023-11-01

OAAI

Small, Gabriel I.; Fedorova, Olga; Olinares, Paul Dominic B.; Chandanani, Joshua; Banerjee, Anoosha; Choi, Young Joo; Molina, Henrik; Chait, Brian T.; Darst, Seth A.; Campbell, Elizabeth A.

Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter

JOURNAL OF NATURAL PRODUCTS

IF3.6

2023-10-23

OAAI

Carson, Drew V.; Zhang, Yi; So, Larry; Cheung-Lee, Wai Ling; Cartagena, Alexis Jaramillo; Darst, Seth A.; Link, A. James

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

MBIO

IF4.7

2023-06-20

OAAI

Grimes, Samantha L. L.; Choi, Young J. J.; Banerjee, Anoosha; Small, Gabriel; Anderson-Daniels, Jordan; Gribble, Jennifer; Pruijssers, Andrea J. J.; Agostini, Maria L. L.; Abu-Shmais, Alexandra; Lu, Xiaotao; Darst, Seth A. A.; Campbell, Elizabeth; Denison, Mark R. R.

Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis

MOLECULAR CELL

IF16.6

2023-05-01

OAAI

Delbeau, Madeleine; Omollo, Expery O.; Froom, Ruby; Koh, Steven; Mooney, Rachel A.; Lilic, Mirjana; Brewer, Joshua J.; Rock, Jeremy; Darst, Seth A.; Campbell, Elizabeth A.; Landick, Robert

A general mechanism for transcription bubble nucleation in bacteria 细菌中转录气泡成核的一般机制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-27

OAAI

Mueller, Andreas U.; Chen, James; Wu, Mengyu; Chiu, Courtney; Nixon, B. Tracy; Campbell, Elizabeth A.; Darst, Seth A.

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options 元素暂停转录复合物的相互转换构象的集合创建了调节选项

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-02-16

OAAI

Kang, Jin Young; V. Mishanina, Tatiana; Bao, Yu; Chen, James; Llewellyn, Eliza; Liu, James; Darst, Seth A.; Landick, Robert

Polarity of the CRISPR roadblock to transcription

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-12-05

OAAI

Hall, Porter M.; Inman, James T.; Fulbright, Robert M.; Le, Tung T.; Brewer, Joshua J.; Lambert, Guillaume; Darst, Seth A.; Wang, Michelle D.

Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-03-08

OAAI

Chen, James; Wang, Qi; Malone, Brandon; Llewellyn, Eliza; Pechersky, Yakov; Maruthi, Kashyap; Eng, Ed T.; Perry, Jason K.; Campbell, Elizabeth A.; Shaw, David E.; Darst, Seth A.

Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

MSPHERE

IF3.1

2021-12-22

OAAI

Piscotta, Frank J.; Hoffmann, Hans-Heinrich; Choi, Young Joo; Small, Gabriel, I; Ashbrook, Alison W.; Koirala, Bimal; Campbell, Elizabeth A.; Darst, Seth A.; Rice, Charles M.; Brady, Sean F.

Structural origins of Escherichia coli RNA polymerase open promoter complex stability

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-10-01

OAAI

Saecker, Ruth M.; Chen, James; Chiu, Courtney E.; Malone, Brandon; Sotiris, Johanna; Ebrahim, Mark; Yen, Laura Y.; Eng, Edward T.; Darst, Seth A.

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7

MOLECULAR CELL

IF16.6

2021-07-01

OAAI

Lilic, Mirjana; Darst, Seth A.; Campbell, Elizabeth A.

Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-04-21

OAAI

Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B.; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T.; Chait, Brian T.; Shaw, David E.; Landick, Robert; Darst, Seth A.; Campbell, Elizabeth A.

Structural basis for transcription complex disruption by the Mfd translocase

ELIFE

IF0

2021-01-22

OAAI

Kang, Jin Young; Llewellyn, Eliza; Chen, James; Olinares, Paul Dominic B.; Brewer, Joshua; Chait, Brian T.; Campbell, Elizabeth A.; Darst, Seth A.

研究方向