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Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification 稳定的人酸性-β-葡萄糖苷酶的设计: 改善戈谢病的治疗和突变分类 Pokorna, Sarka; Khersonsky, Olga; Lipsh-Sokolik, Rosalie; Goldenzweig, Adi; Nielsen, Rebekka; Ashani, Yacov; Peleg, Yoav; Unger, Tamar; Albeck, Shira; Dym, Orly; Tirosh, Asa; Tarayra, Rana; Hocquemiller, Michael; Laufer, Ralph; Ben-Dor, Shifra; Silman, Israel; Sussman, Joel L. L.; Fleishman, Sarel J. J.; Futerman, Anthony H. H. 分享 收藏
A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion 鱼类疱疹病毒突出了与相分离诱导和A到Z转换有关的Z α 结构域之间的功能多样性 Diallo, Mamadou Amadou; Pirotte, Sebastien; Hu, Yunlong; Morvan, Lea; Rakus, Krzysztof; Suarez, Nicolas M.; PoTsang, Lee; Saneyoshi, Hisao; Xu, Yan; Davison, Andrew J.; Tompa, Peter; Sussman, Joel L.; Vanderplasschen, Alain 分享 收藏
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Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition Ben-David, Moshe; Soskine, Misha; Dubovetskyi, Artem; Cherukuri, Kesava-Phaneendra; Dym, Orly; Sussman, Joel L.; Liao, Qinghua; Szeler, Klaudia; Kamerlin, Shina Caroline Lynn; Tawfik, Dan S. 分享 收藏
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 Oukoloff, Killian; Coquelle, Nicolas; Bartolini, Manuela; Naldi, Marina; Le Guevel, Remy; Bach, Stephane; Josselin, Beatrice; Ruchaud, Sandrine; Catto, Marco; Pisani, Leonardo; Denora, Nunzio; Lacobazzi, Rosa Maria; Silman, Israel; Sussman, Joel L.; Buron, Frederic; Colletier, Jacques-Philippe; Jean, Ludovic; Routier, Sylvain; Renard, Pierre-Yves 分享 收藏
Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model Dighe, Satish N.; De la Mora, Eugenio; Chan, Stephen; Kantham, Srinivas; McColl, Gawain; Miles, Jared A.; Veliyath, Suresh Kumar; Sreenivas, B. Yogi; Nassar, Zeyad D.; Silman, Israel; Sussman, Joel L.; Weik, Martin; McGeary, Ross P.; Parat, Marie-Odile; Brazzolotto, Xavier; Ross, Benjamin P. 分享 收藏
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase Lalut, Julien; Santoni, Gianluca; Karila, Delphine; Lecoutey, Cedric; Davis, Audrey; Nachon, Florian; Silman, Israel; Sussman, Joel; Weik, Martin; Maurice, Tangui; Dallemagne, Patrick; Rochais, Christophe 分享 收藏
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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents Santoni, Gianluca; de Sousa, Julien; de la Mora, Eugenio; Dias, Jose; Jean, Ludovic; Sussman, Joel L.; Silman, Israel; Renard, Pierre-Yves; Brown, Richard C. D.; Weik, Martin; Baati, Rachid; Nachon, Florian 分享 收藏
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration Zorbaz, Tamara; Braiki, Anissa; Marakovic, Nikola; Renou, Julien; de la Mora, Eugenio; Hrvat, Nikolina Macek; Katalinic, Maja; Silman, Israel; Sussman, Joel L.; Mercey, Guillaume; Gomez, Catherine; Mougeot, Romain; Perez, Belen; Baati, Rachid; Nachon, Florian; Weik, Martin; Jean, Ludovic; Kovarik, Zrinka; Renard, Pierre-Yves 分享 收藏
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (vol 63, pg 337, 2016) Goldenzweig, Adi; Goldsmith, Moshe; Hill, Shannon E.; Gertman, Or; Laurino, Paola; Ashani, Yacov; Dym, Orly; Unger, Tamar; Albeck, Shira; Prilusky, Jaime; Lieberman, Raquel L.; Aharoni, Amir; Silman, Israel; Sussman, Joel L.; Tawfik, Dan S.; Fleishman, Sarel J. 分享 收藏
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Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability 基于结构和序列的蛋白质的自动化设计，以实现高细菌表达和稳定性 Goldenzweig, Adi; Goldsmith, Moshe; Hill, Shannon E.; Gertman, Or; Laurino, Paola; Ashani, Yacov; Dym, Orly; Unger, Tamar; Albeck, Shira; Prilusky, Jaime; Lieberman, Raquel L.; Aharoni, Amir; Silman, Israel; Sussman, Joel L.; Tawfik, Dan S.; Fleishman, Sarel J. 分享 收藏
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro Goldsmith, Moshe; Eckstein, Simone; Ashani, Yacov; Greisen, Per, Jr.; Leader, Haim; Sussman, Joel L.; Aggarwal, Nidhi; Ovchinnikov, Sergey; Tawfik, Dan S.; Baker, David; Thiermann, Horst; Worek, Franz 分享 收藏
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pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins Varadi, Mihaly; Kosol, Simone; Lebrun, Pierre; Valentini, Erica; Blackledge, Martin; Dunker, A. Keith; Felli, Isabella C.; Forman-Kay, Julie D.; Kriwacki, Richard W.; Pierattelli, Roberta; Sussman, Joel; Svergun, Dmitri I.; Uversky, Vladimir N.; Vendruscolo, Michele; Wishart, David; Wright, Peter E.; Tompa, Peter 分享 收藏
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